LOCUS       NM_145211               1889 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus 2'-5' oligoadenylate synthetase 1A (Oas1a), transcript
            variant 1, mRNA.
ACCESSION   NM_145211 XM_994107
VERSION     NM_145211.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1889)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1889)
  AUTHORS   Birdwell,L.D., Zalinger,Z.B., Li,Y., Wright,P.W., Elliott,R.,
            Rose,K.M., Silverman,R.H. and Weiss,S.R.
  TITLE     Activation of RNase L by Murine Coronavirus in Myeloid Cells Is
            Dependent on Basal Oas Gene Expression and Independent of
            Virus-Induced Interferon
  JOURNAL   J Virol 90 (6), 3160-3172 (2016)
   PUBMED   26739051
  REMARK    GeneRIF: Thus, activation of RNase L does not require mouse
            hepatitis virus virus-induced interferon but rather correlates with
            adequate levels of basal Oas gene expression, maintained by basal
            interferon signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1889)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 1889)
  AUTHORS   Zhao,L., Jha,B.K., Wu,A., Elliott,R., Ziebuhr,J., Gorbalenya,A.E.,
            Silverman,R.H. and Weiss,S.R.
  TITLE     Antagonism of the interferon-induced OAS-RNase L pathway by murine
            coronavirus ns2 protein is required for virus replication and liver
            pathology
  JOURNAL   Cell Host Microbe 11 (6), 607-616 (2012)
   PUBMED   22704621
  REMARK    GeneRIF: Mouse hepatitis virus Ns2 cleaves 2',5'-oligoadenylate,
            the product of 2',5'-oligoadenylate synthetase, to prevent
            activation of the cellular endoribonuclease RNase L and
            consequently block viral RNA degradation.
REFERENCE   5  (bases 1 to 1889)
  AUTHORS   Pulit-Penaloza,J.A., Scherbik,S.V. and Brinton,M.A.
  TITLE     Activation of Oas1a gene expression by type I IFN requires both
            STAT1 and STAT2 while only STAT2 is required for Oas1b activation
  JOURNAL   Virology 425 (2), 71-81 (2012)
   PUBMED   22305621
  REMARK    GeneRIF: Activation of Oas1a gene expression by type I IFN requires
            both STAT1 and STAT2
REFERENCE   6  (bases 1 to 1889)
  AUTHORS   Perelygin,A.A., Scherbik,S.V., Zhulin,I.B., Stockman,B.M., Li,Y.
            and Brinton,M.A.
  TITLE     Positional cloning of the murine flavivirus resistance gene
  JOURNAL   Proc Natl Acad Sci U S A 99 (14), 9322-9327 (2002)
   PUBMED   12080145
REFERENCE   7  (bases 1 to 1889)
  AUTHORS   Phillips,R.L., Ernst,R.E., Brunk,B., Ivanova,N., Mahan,M.A.,
            Deanehan,J.K., Moore,K.A., Overton,G.C. and Lemischka,I.R.
  TITLE     The genetic program of hematopoietic stem cells
  JOURNAL   Science 288 (5471), 1635-1640 (2000)
   PUBMED   10834841
REFERENCE   8  (bases 1 to 1889)
  AUTHORS   Rutherford,M.N., Kumar,A., Nissim,A., Chebath,J. and Williams,B.R.
  TITLE     The murine 2-5A synthetase locus: three distinct transcripts from
            two linked genes
  JOURNAL   Nucleic Acids Res 19 (8), 1917-1924 (1991)
   PUBMED   1709495
REFERENCE   9  (bases 1 to 1889)
  AUTHORS   Coccia,E.M., Romeo,G., Nissim,A., Marziali,G., Albertini,R.,
            Affabris,E., Battistini,A., Fiorucci,G., Orsatti,R., Rossi,G.B. et
            al.
  TITLE     A full-length murine 2-5A synthetase cDNA transfected in NIH-3T3
            cells impairs EMCV but not VSV replication
  JOURNAL   Virology 179 (1), 228-233 (1990)
   PUBMED   2171206
REFERENCE   10 (bases 1 to 1889)
  AUTHORS   Ichii,Y., Fukunaga,R., Shiojiri,S. and Sokawa,Y.
  TITLE     Mouse 2-5A synthetase cDNA: nucleotide sequence and comparison to
            human 2-5A synthetase
  JOURNAL   Nucleic Acids Res 14 (24), 10117 (1986)
   PUBMED   3808949
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU699042.1, AK149613.1 and AC015535.11.
            
            On Dec 17, 2009 this sequence version replaced NM_145211.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013715.1, M33863.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                BU699042.1         1-40
            41-1425             AK149613.1         2-1386
            1426-1889           AC015535.11        112889-113352       c
FEATURES             Location/Qualifiers
     source          1..1889
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 60.65 cM"
     gene            1..1889
                     /gene="Oas1a"
                     /gene_synonym="L3"
                     /note="2'-5' oligoadenylate synthetase 1A"
                     /db_xref="GeneID:246730"
                     /db_xref="MGI:MGI:2180860"
     exon            1..232
                     /gene="Oas1a"
                     /gene_synonym="L3"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1153
                     /gene="Oas1a"
                     /gene_synonym="L3"
                     /EC_number="2.7.7.84"
                     /note="isoform 1 is encoded by transcript variant 1;
                     2'-5'-oligoadenylate synthase 1A; p42 OAS; 2-5A synthetase
                     1A; (2-5')oligo(A) synthetase 1A; 2-5A synthase 1A;
                     (2-5')oligo(A) synthase 1A"
                     /codon_start=1
                     /product="2'-5'-oligoadenylate synthase 1A isoform 1"
                     /protein_id="NP_660212.2"
                     /db_xref="CCDS:CCDS19630.1"
                     /db_xref="GeneID:246730"
                     /db_xref="MGI:MGI:2180860"
                     /translation="MEHGLRSIPAWTLDKFIEDYLLPDTTFGADVKSAVNVVCDFLKE
                     RCFQGAAHPVRVSKVVKGGSSGKGTTLKGKSDADLVVFLNNLTSFEDQLNRRGEFIKE
                     IKKQLYEVQHERRFRVKFEVQSSWWPNARSLSFKLSAPHLHQEVEFDVLPAFDVLGHV
                     NTSSKPDPRIYAILIEECTSLGKDGEFSTCFTELQRNFLKQRPTKLKSLIRLVKHWYQ
                     LCKEKLGKPLPPQYALELLTVFAWEQGNGCYEFNTAQGFRTVLELVINYQHLRIYWTK
                     YYDFQHQEVSKYLHRQLRKARPVILDPADPTGNVAGGNPEGWRRLAEEADVWLWYPCF
                     IKKDGSRVSSWDVPTVVPVPFEQVEENWTCILL"
     exon            233..521
                     /gene="Oas1a"
                     /gene_synonym="L3"
                     /inference="alignment:Splign:2.1.0"
     exon            522..706
                     /gene="Oas1a"
                     /gene_synonym="L3"
                     /inference="alignment:Splign:2.1.0"
     exon            707..939
                     /gene="Oas1a"
                     /gene_synonym="L3"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1093
                     /gene="Oas1a"
                     /gene_synonym="L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1120
                     /gene="Oas1a"
                     /gene_synonym="L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1889
                     /gene="Oas1a"
                     /gene_synonym="L3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttcccatt tcagctaggc tgggagaccc aggaagctcc agacttagca tggagcacgg
       61 actcaggagc atcccagcct ggacgctgga caagttcata gaggattacc tccttcccga
      121 caccaccttt ggtgctgatg tcaaatcagc cgtcaatgtc gtgtgtgatt tcctgaagga
      181 gagatgcttc caaggtgctg cccacccagt gagggtctcc aaggtggtga agggtggctc
      241 ctcaggcaaa ggcaccacac tcaagggcaa gtcagacgct gacctggtgg tgttccttaa
      301 caatctcacc agctttgagg atcagttaaa ccgacgggga gagttcatca aggaaattaa
      361 gaaacagctg tacgaggttc agcatgagag acgttttaga gtcaagtttg aggtccagag
      421 ttcatggtgg cccaacgccc ggtctctgag cttcaagctg agcgcccccc atctgcatca
      481 ggaggtggag tttgatgtgc tgccagcctt tgatgtcctg ggtcatgtta atacttccag
      541 caagcctgat cccagaatct atgccatcct catcgaggaa tgtacctccc tggggaagga
      601 tggcgagttc tctacctgct tcacggagct ccagcggaac ttcctgaagc agcgcccaac
      661 caagctgaag agtctcatcc gcctggtcaa gcactggtac caactgtgta aggagaagct
      721 ggggaagcca ttgcctccac agtacgccct agagttgctc actgtctttg cctgggaaca
      781 agggaatgga tgttatgagt tcaacacagc ccagggcttc cggaccgtct tggaactggt
      841 catcaattat cagcatcttc gaatctactg gacaaagtat tatgactttc aacaccagga
      901 ggtctccaaa tacctgcaca gacagctcag aaaagccagg cctgtgatcc tggacccagc
      961 tgacccaaca gggaatgtgg ccggtgggaa cccagagggc tggaggcggt tggctgaaga
     1021 ggctgatgtg tggctatggt acccatgttt tattaaaaag gatggttccc gagtgagctc
     1081 ctgggatgtg ccgacggtgg ttcctgtacc ttttgagcag gtagaagaga actggacatg
     1141 tatcctgctg tgagcacagc agcacctgcc caggagactg ctggtcaggg gcatttgctg
     1201 ctctgctgca ggcccatgac ccagtgaggg agggccccac ctggcatcag actccgtgct
     1261 tctgatgcct gccagccatg tttgactcct gtccaatcac agccagcctt cctcaacaga
     1321 ttcagaagga gaggaaagaa cacacgcttg gtgtccatct gtccacctgt tggaaggttc
     1381 tgtctgacaa agtctgatca acaataaacc acagcaggtg ccgtcatggt gtgtgaactc
     1441 tgaggagtgg gccatacaag aacagtgcag gtgtgtgagc gtgtgtgtgc ccatgcacat
     1501 gcgtgtgtgt cttcacggtt caactagatg catttagtga gcacttacta catatgctac
     1561 atgattcaga tgttcagcag tggttagagc aaagcctaac tgctaggctt tttgatgcaa
     1621 gttggattgg gatccttcca ggtctcttct tatacataca cacaagagag gaacccttgg
     1681 tttcttctgc ccatgacccc aagacaagat tctagccctg ccctatctga cacattagcg
     1741 gttctctggc tacacatgga catggaacac tgagattgtg gcctgtgctc tcagggtgcc
     1801 cttgagtggc tacaacatgc aggctggggg accatagata tgatgaaaat aaaaggtacc
     1861 tggaattttt gacacatgta actttgaaa
//
