LOCUS       NM_001289490            1354 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus O-acyl-ADP-ribose deacylase 1 (Oard1), transcript
            variant 1, mRNA.
ACCESSION   NM_001289490 XM_006523454
VERSION     NM_001289490.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1354)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1354)
  AUTHORS   Ito,H., Morishita,R., Mizuno,M., Kawamura,N., Tabata,H. and
            Nagata,K.I.
  TITLE     Biochemical and Morphological Characterization of a
            Neurodevelopmental Disorder-Related Mono-ADP-Ribosylhydrolase,
            MACRO Domain Containing 2
  JOURNAL   Dev Neurosci 40 (3), 278-287 (2018)
   PUBMED   30227424
REFERENCE   3  (bases 1 to 1354)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166164.2, BY741306.1, BC157987.1, AK153512.1 and AW558560.1.
            
            On Jan 23, 2014 this sequence version replaced XM_006523454.1.
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 4. Variants 1-5 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148136.1, CA980634.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC166164.2         17900-17913         c
            15-250              BY741306.1         2-237
            251-900             BC157987.1         1-650
            901-1350            AK153512.1         689-1138
            1351-1354           AW558560.1         1-4                 c
FEATURES             Location/Qualifiers
     source          1..1354
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.99 cM"
     gene            1..1354
                     /gene="Oard1"
                     /note="O-acyl-ADP-ribose deacylase 1"
                     /db_xref="GeneID:106821"
                     /db_xref="MGI:MGI:2146818"
     exon            1..373
                     /gene="Oard1"
                     /inference="alignment:Splign:2.1.0"
     exon            374..450
                     /gene="Oard1"
                     /inference="alignment:Splign:2.1.0"
     CDS             412..870
                     /gene="Oard1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     O-acetyl-ADP-ribose deacetylase 1; terminal ADP-ribose
                     protein glycohydrolase 1; [Protein ADP-ribosylglutamate]
                     hydrolase OARD1; ADP-ribose glycohydrolase OARD1"
                     /codon_start=1
                     /product="ADP-ribose glycohydrolase OARD1 isoform 1"
                     /protein_id="NP_001276419.1"
                     /db_xref="CCDS:CCDS37647.1"
                     /db_xref="GeneID:106821"
                     /db_xref="MGI:MGI:2146818"
                     /translation="MATRLNEDPEGSRITYVKGDLFACPKTDSLAHCISEDCRMGAGI
                     AVLFKKRFGGVQELLSQQKKSGEVAVLKRDGRYIYYLITKKRASHKPTYENLQKSLEA
                     MKSHCLKNGVTDLSMPRIGCGLDRLQWENVSAILEEVFESTDIKITVYTL"
     exon            451..595
                     /gene="Oard1"
                     /inference="alignment:Splign:2.1.0"
     exon            596..654
                     /gene="Oard1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..767
                     /gene="Oard1"
                     /inference="alignment:Splign:2.1.0"
     exon            768..1354
                     /gene="Oard1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1317..1322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oard1"
                     /note="hexamer: AATAAA"
     polyA_site      1343
                     /gene="Oard1"
                     /note="major polyA site"
ORIGIN      
        1 ccccctgccc acctatttct aagcgtccac tgggacccac cctctggggc cgaatgcgca
       61 agcgctcttc ttctccagtc ggggtcggca tctcggtacg catgcctgag cggtagcggg
      121 agcctacgga atttcccgcc ggaaattctg aagcccttac taccgagagc gggcgccgct
      181 acccagctag agaggctcac ttccgccccg ttaagggatg ggggcggcca tcttgagtgt
      241 gcgtacaatc aaaaggcttt ggcgggattt gttgcgtgtc gggactcttc tgttgctttc
      301 ctacctacga gggtttcatc ccgaaccctt ccctgcttgg aggagggcct gctgacggcc
      361 gattcctttg cagaaggaac tcttaaattc tggaaatagc gactcagtag catggccacc
      421 cgccttaatg aagatccaga aggaagtcga atcacttacg tgaaaggaga tcttttcgca
      481 tgtcccaaaa cagactctct agcccattgt atcagtgagg attgtcgaat gggtgctgga
      541 atagctgttc tcttcaagaa gagattcgga ggggtgcagg aactgttaag tcaacaaaag
      601 aagtctggag aagtggctgt tctgaagaga gatgggcgat atatatatta cttgattaca
      661 aagaaacggg cttcacacaa gccaacgtat gagaacctac agaagagttt ggaggccatg
      721 aagtcccatt gtttgaagaa tggcgtcact gacctctcca tgcccaggat tggatgtggt
      781 ctggatcggc tgcagtggga aaatgtatct gcgattctcg aagaggtgtt tgagtcaaca
      841 gacatcaaaa ttactgtgta cacactctga acagatgaag atcttggatg agcccgtggt
      901 cttttgtgtc atctacgaag ctgtgggact aagcagctgt aggacctcag aatgggcaag
      961 gacagtctgt gagagggagt ctctcctagg ccagatgtgg gtttctgtac tccaagagga
     1021 tagggagggc actgcaccca agcaggaggt gaggtctgtc actaggcagg aaaccatgta
     1081 ggtaagtgta ggacctgctt tgcttagcca ctactggatt tgtttggctg gccactgggt
     1141 ggcagcatag gttctaattt tcttttgaag agaaattgtg ggaagggtaa acttttgaga
     1201 tttttttttt taaaacaatt ttatgtttgt gcactttgtg ttaatctcac caaaaatcat
     1261 cataggaaag gattatggtt tttagttatg acatcacaat gtgtcaagag tggaacaata
     1321 aacgtttccc ttgtgttcac tgaggtttgc acac
//
