LOCUS       NM_173415               5591 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus nyctalopin (Nyx), mRNA.
ACCESSION   NM_173415 XM_006527612 XM_908942
VERSION     NM_173415.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5591)
  AUTHORS   Holzel,M.B., Howlett,M.H.C. and Kamermans,M.
  TITLE     Receptive Field Sizes of Nyxnob Mouse Retinal Ganglion Cells
  JOURNAL   Int J Mol Sci 23 (6), 3202 (2022)
   PUBMED   35328623
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5591)
  AUTHORS   Hasan,N., Pangeni,G., Ray,T.A., Fransen,K.M., Noel,J.,
            Borghuis,B.G., McCall,M.A. and Gregg,R.G.
  TITLE     LRIT3 is Required for Nyctalopin Expression and Normal ON and OFF
            Pathway Signaling in the Retina
  JOURNAL   eNeuro 7 (1) (2020)
   PUBMED   31959619
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5591)
  AUTHORS   Winkelman,B.H.J., Howlett,M.H.C., Holzel,M.B., Joling,C.,
            Fransen,K.H., Pangeni,G., Kamermans,S., Sakuta,H., Noda,M.,
            Simonsz,H.J., McCall,M.A., De Zeeuw,C.I. and Kamermans,M.
  TITLE     Nystagmus in patients with congenital stationary night blindness
            (CSNB) originates from synchronously firing retinal ganglion cells
  JOURNAL   PLoS Biol 17 (9), e3000174 (2019)
   PUBMED   31513577
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5591)
  AUTHORS   Tarchick,M.J., Bassiri,P., Rohwer,R.M. and Samuels,I.S.
  TITLE     Early Functional and Morphologic Abnormalities in the Diabetic
            Nyxnob Mouse Retina
  JOURNAL   Invest Ophthalmol Vis Sci 57 (7), 3496-3508 (2016)
   PUBMED   27367517
REFERENCE   5  (bases 1 to 5591)
  AUTHORS   Chakraborty,R., Lacy,K.D., Tan,C.C., Park,H.N. and Pardue,M.T.
  TITLE     Refractive index measurement of the mouse crystalline lens using
            optical coherence tomography
  JOURNAL   Exp Eye Res 125, 62-70 (2014)
   PUBMED   24939747
REFERENCE   6  (bases 1 to 5591)
  AUTHORS   Zeitz,C., Scherthan,H., Freier,S., Feil,S., Suckow,V., Schweiger,S.
            and Berger,W.
  TITLE     NYX (nyctalopin on chromosome X), the gene mutated in congenital
            stationary night blindness, encodes a cell surface protein
  JOURNAL   Invest Ophthalmol Vis Sci 44 (10), 4184-4191 (2003)
   PUBMED   14507859
  REMARK    GeneRIF: Human and mouse nyctalopin are membrane-bound
            extracellular proteins and are functionally conserved.
REFERENCE   7  (bases 1 to 5591)
  AUTHORS   Pesch,K., Zeitz,C., Fries,J.E., Munscher,S., Pusch,C.M., Kohler,K.,
            Berger,W. and Wissinger,B.
  TITLE     Isolation of the mouse nyctalopin gene nyx and expression studies
            in mouse and rat retina
  JOURNAL   Invest Ophthalmol Vis Sci 44 (5), 2260-2266 (2003)
   PUBMED   12714669
  REMARK    GeneRIF: These data suggest an important function of the Nyx
            protein in the inner retina and provide evidence that CSNB1 is
            based on a defect in the inner retinal circuitry.
REFERENCE   8  (bases 1 to 5591)
  AUTHORS   Gregg,R.G., Mukhopadhyay,S., Candille,S.I., Ball,S.L., Pardue,M.T.,
            McCall,M.A. and Peachey,N.S.
  TITLE     Identification of the gene and the mutation responsible for the
            mouse nob phenotype
  JOURNAL   Invest Ophthalmol Vis Sci 44 (1), 378-384 (2003)
   PUBMED   12506099
  REMARK    GeneRIF: The nob phenotype is caused by an 85-bp deletion in the
            mouse nyx gene, which encodes the nyctalopin protein.
REFERENCE   9  (bases 1 to 5591)
  AUTHORS   Krishna,V.R., Alexander,K.R. and Peachey,N.S.
  TITLE     Temporal properties of the mouse cone electroretinogram
  JOURNAL   J Neurophysiol 87 (1), 42-48 (2002)
   PUBMED   11784728
REFERENCE   10 (bases 1 to 5591)
  AUTHORS   Pardue,M.T., McCall,M.A., LaVail,M.M., Gregg,R.G. and Peachey,N.S.
  TITLE     A naturally occurring mouse model of X-linked congenital stationary
            night blindness
  JOURNAL   Invest Ophthalmol Vis Sci 39 (12), 2443-2449 (1998)
   PUBMED   9804152
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK031854.1, BC035244.1 and AI661272.1.
            
            On or before Jul 27, 2018 this sequence version replaced
            XM_006527612.3, NM_173415.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC035244.1, BI732501.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849388, SAMN01164136 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1956              AK031854.1         2-1957
            1957-5577           BC035244.1         1-3621
            5578-5591           AI661272.1         1-14                c
FEATURES             Location/Qualifiers
     source          1..5591
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 8.37 cM"
     gene            1..5591
                     /gene="Nyx"
                     /gene_synonym="CLNP; CSNB1; CSNB4; nob"
                     /note="nyctalopin"
                     /db_xref="GeneID:236690"
                     /db_xref="MGI:MGI:2448607"
     exon            1..394
                     /gene="Nyx"
                     /gene_synonym="CLNP; CSNB1; CSNB4; nob"
                     /inference="alignment:Splign:2.1.0"
     exon            395..2116
                     /gene="Nyx"
                     /gene_synonym="CLNP; CSNB1; CSNB4; nob"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2194
                     /gene="Nyx"
                     /gene_synonym="CLNP; CSNB1; CSNB4; nob"
                     /inference="alignment:Splign:2.1.0"
     CDS             2173..3603
                     /gene="Nyx"
                     /gene_synonym="CLNP; CSNB1; CSNB4; nob"
                     /note="no b wave"
                     /codon_start=1
                     /product="nyctalopin precursor"
                     /protein_id="NP_775591.1"
                     /db_xref="CCDS:CCDS40877.1"
                     /db_xref="GeneID:236690"
                     /db_xref="MGI:MGI:2448607"
                     /translation="MLILLLHAVVFSLPYTRATEACLRACPAACTCSHVERGCSVRCD
                     RAGLQRVPQEFPCEAASIDLDRNGLRILGERAFGTLPSLRRLSLRHNNLSFITPGAFK
                     GLPRLAELRLAHNGELRYLHVRTFAALGRLRRLDLAACRLFSVPERLLAELPALRELT
                     AFDNLFRRVPGALRGLANLTHAHFERSRIEAVASGSLLGMRRLRSLSLQANRVRAVHA
                     GAFGDCGALEDLLLNDNLLATLPAAAFRGLRRLRTLNLGGNALGSVARAWFSDLAELE
                     LLYLDRNSITFVEEGAFQNLSGLLALHLNGNRLTVLSWAAFQPGFFLGRLFLFRNPWR
                     CDCQLEWLRDWMEGSGRVADVACASPGSVAGQDLSQVVFERSSDGLCVDPDELNFTTS
                     SPGPSPEPVATTVSRFSSLLSKLLAPRAPVEEVANTTWELVNVSLNDSFRSHAVMVFC
                     YKATFLFTSCVLLSLAQYVVVGLQRE"
     exon            2195..5585
                     /gene="Nyx"
                     /gene_synonym="CLNP; CSNB1; CSNB4; nob"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5559..5564
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nyx"
                     /gene_synonym="CLNP; CSNB1; CSNB4; nob"
                     /note="hexamer: AATAAA"
     polyA_site      5577
                     /gene="Nyx"
                     /gene_synonym="CLNP; CSNB1; CSNB4; nob"
                     /note="major polyA site"
ORIGIN      
        1 aggtccataa ctactgattt caactgttgt ctggccgtgc tgctggtggc ttaggaaacc
       61 tgtcccagga cctctttcac ctcttagcat gtgtcagcgc catcaaccat tgtttcagag
      121 gcctctttga gactgggaca ttgatttgat acttggcagt tccctgctgc attgagtttg
      181 ggtcttttcc ttgggcaagg cagatgggcc tacagctcta tttttggagg ccacagagag
      241 tggcgatttc acatgcagct cctggaacgt gcattttgga gtattagggc agcgagtctg
      301 ttgagaagca cagcagaaga aatcctgggc caacccttta tgtgctgtgt cagactggct
      361 tattatccac cctcctgact ccagggtcag tcagacctca ctgccagctc taccttcctg
      421 agccacaagg acctttgcaa cactggtggt tacagactgt gtctaccact cccacttaac
      481 ctacggataa ggacttatgt gggatggggg ggggatgctt cattcaccta tgttactttt
      541 actcacccca tcccagtcat tccttcctgt ggttgtttga ttaggaatag gggccctcat
      601 agactcatgt gtttgaatgc taggcccata gggagtggta ctataggagg tgtgaccttg
      661 ttggagtagg tgtggtttgt ctaaggaagg ttgtctctgg gggtgggctt tgaggtctcc
      721 tatgctcaag ctatacccag tgtggcacag tctttccctg ctgctttcga tcatagaact
      781 cttggctcct ccagcaccat gcctgcctag atgctgccat gttcccacct tgatgctaat
      841 ggactgaacc tctgaacctg taagccagct ccaagtaaat gtttgccttt ataagagttg
      901 ccttggtcac ggtgtctcgt cacagcaatg aaaccctaac taagacactt cgtatcagag
      961 gttagaccag ttcagtcata tttttgcttt caaggtccaa atgtaagaaa ctggtaattc
     1021 cccagggtat tgtggccttg atggctgaat ccacaaacag agcccttatt atgggaaggg
     1081 aatgtcaaat ttcctctcag cagagtgaga atttggcatg ttttcatgga tgtcttacaa
     1141 gggaacagca gccaaccctc cacccccact caggcctgga ggagctgctg ggaccaggag
     1201 catgtaggac agctgaactg tggatcagtg gtcagagaaa catgtccctg ctgtctgtcc
     1261 aggaatcagt ctcggcagcc ccttaggcag aggaatctct cagagtctgg gttgcgagca
     1321 ggctgcctga gtttcagcat tcctaaccag ctcccagtac tgctacagct atcgcctctg
     1381 ctgcatccac aaaccaaaca gagcagcaag agcttacatc cttgcctgat gggattgtaa
     1441 gacctcagat tcggaatttg acacaggact taatggcctt aggccaagca tggccgcaag
     1501 cctcaacacc aaagcttctt gcctgctggg aagggcctct gccaccttct gtttggggat
     1561 catccgcctt tccaaagaga tgaaatcagc agtttgcaat ttgggcaaaa cacggttatg
     1621 ttaaactgcc tggtccccac tacagccctc taaagttaca taatgtgtcc ttgttacaaa
     1681 gacctataat accatttggt agcgggaagc ggattgcaga ctgcttattg ctgatgggtg
     1741 gggctagggc tggggtcagg gaactgggca gaatgtggga agggtttaaa gcaaaaaagg
     1801 ggcctggcag atggagaggg caggaaggct ctggtagcca aggcttgggg ataaaactga
     1861 ttggtttgtc agcaaaatct gtcattggct ttggcaattc aaaaggcaga cacgtttgct
     1921 catctctgct aatcctcatc cgataccgag gcttttccag ctactatctg aaagaaaaat
     1981 aaacagtcaa ccctgcatgc atgcacagtc cttgctcttt gcccctgtgt gctccctgct
     2041 ccagccttta tttcttcttt caccatttct tgggagatgg aggggctggg ggcactatgg
     2101 gcagacctcc aggatggtag ggatcctaca gctgagtggc tctaagccac caggtgcaag
     2161 gaaggccaag ggatgctgat cctgcttctt catgcggtgg tcttcagtct gccctacacc
     2221 agggccaccg aggcctgtct gcgggcctgc cctgcggcct gcacctgcag ccacgtggaa
     2281 cgtggctgct cagtgcgctg tgaccgtgcg ggcctccagc gggtgcccca ggagtttccg
     2341 tgcgaggcgg cctccatcga tctggaccgg aatggcctgc gcatcctggg cgagcgggcc
     2401 tttggcacgc tgccgtcgtt gcgccgcctg tcgctgcgcc acaataacct gtccttcatc
     2461 acgcccggcg ccttcaaggg cctgccgcgg ttggccgagc tgcgcctggc gcacaacggt
     2521 gagctgcgct acctgcacgt gcggaccttc gcggcgctgg gccgcctacg ccgcctggac
     2581 ctggcggcct gccgcctctt cagcgtcccc gagcgtctcc tggccgagct gccggccctg
     2641 cgcgagctca cggccttcga caatctcttc cgccgggtgc ccggcgcgct ccggggcctc
     2701 gccaacctga cgcacgctca tttcgagcgc agccgcatcg aggccgtggc ctccggctcg
     2761 ctgctgggca tgcggcgtct gcgctcgctc agcctgcagg ccaaccgcgt gcgcgcggtg
     2821 catgccgggg cctttggcga ctgcggcgcc ctggaggacc tgctgctcaa cgacaacctg
     2881 ctggccacgc tgcccgccgc cgccttccgc ggccttcgcc gcctgcgcac cctcaacctg
     2941 ggcggcaacg cgctgggcag cgtggcacgc gcctggttct cagacctggc agagctcgag
     3001 ctgctttacc tggaccgcaa cagcatcacc tttgttgagg aaggcgcctt ccagaacctc
     3061 tcgggcctcc tggccctgca tctcaatggc aaccgtctca ctgtgctctc ctgggccgct
     3121 ttccagccag gtttcttcct gggccgcctc ttccttttcc gcaatccttg gcgctgtgac
     3181 tgccaactgg agtggctgcg tgattggatg gagggctctg ggcgtgtggc tgatgtggcg
     3241 tgcgcctccc caggctctgt ggccggccag gacctcagcc aggtggtctt tgagcgctcc
     3301 tctgatggcc tctgtgtgga ccctgatgaa ctgaacttta ccacgtccag tcctggcccg
     3361 agtccggagc cagtggccac cactgtgagc aggttcagca gcctcctctc caagctgctg
     3421 gccccaaggg cccctgtgga ggaggtagcc aataccacct gggagctggt caacgtctcg
     3481 ttgaatgaca gctttcggtc ccatgcagtg atggtcttct gctacaaggc cacgtttctc
     3541 ttcacctctt gcgtcttgct cagcctggcc cagtatgtgg tggtgggcct gcagagggag
     3601 tgactgccac actgaagtga cccaaaccac tttggccaaa agggggaagg tttgcttgac
     3661 tgccatgagt aactgcctgt agtaactgga gagggaatag gaatgggatt ggtagttaaa
     3721 gttcttgctg tgggtggaag aaacagtttg tcaccaaaga tggctctagg cagagagctc
     3781 tggggaatgc cactggagtg ggtatcaatt tctgcttttg tcacatgggc atccattgat
     3841 ttcccgtccc gtgggactca gttattcgtg ggtgcaaggg ggaccgcaat cctgggagaa
     3901 aatgggagga agagaaaaag gagctggaga ccaagtagag ggtgctatcc aggtctctgt
     3961 ttattaggct gaaacgccgg gttttaaagc atacatcgag gggaataggg aggggttgag
     4021 ggggaattaa caaagaacaa agaagtgggc atcaggggac acaagggctg aagtcaggct
     4081 ccaggtggcg ggcactctgc gtcttaactc tggaatttgg atcctcctta acaactttgg
     4141 gtgtcaggcg ggctcagcac gtaactcatg tccttggaag tcttgggagt caggaagagc
     4201 taactaagga agagaggact acaattcagc ttttacagcc tcaggtgcca ggaagggaac
     4261 agggagaagg gagtgacgac cggctcctag cacgagacca tttggcttgt cagggtggga
     4321 gattgtgaaa agctcgcttt ctcatggtat ggtctctaac acattgaaaa agagaagaat
     4381 gaatatgggc ctgggcccac aggcctaaat tatattagga ctcaattggc taagtactaa
     4441 gaactatgtc agctcttctc tgtcagtagc ccataaaccc aatccctgtc ttttctaaca
     4501 tgatacttct tccacacacc ccccctttta tccccaggga cttggggaca acaaggttca
     4561 ggaaggtaga cagggcatta gaaaaagggc atgggaaaaa gacttagatc caagacaggc
     4621 agttgttgct gaggtctgag gtgtgcgttt agaggcattt caaaccagtt tcatttattt
     4681 tatgccacaa ttgatccctc agtataggca ctgtcagaat tatattaatg tgtgtgtttg
     4741 tgggccacat ttataaaacg ctaaagttaa agttaaacca gtttctctaa gccttttcag
     4801 agtctttcaa atgctattgt gagtttccaa tgtattgtga atatccaagg aagcacataa
     4861 tcctcttttc ttagtatctc ttttcgtggg aagagtgtct gttcccacaa catgctctgt
     4921 cagcagcgca gagcatctcc agctgggatg gttctatcag ggatggaagt tattgtgagc
     4981 tgcttgaatg gagactaaca gccaggagag tagaaatcaa agacctgtgt gtgaagggga
     5041 ctcagattcc ccagggtatt cccactgtat tcccaaggac aaagctctac cagcatccat
     5101 gtgaacgttc atggagttct gagtgtggag tgtgtgatgc ccagtcccac tcagggcccc
     5161 tgacacacca gcttttctcg tggtcatgtg gaaaagagca gaggttttgt cagcttcaga
     5221 atccgcagct ctttaggtct tggccatgag ggtaactgtt ggcaggttgc ctcttaaatg
     5281 ttgtctcctg ggctgggggt tgtgggtcag ttttatagtg cttgcctaaa atgggagagg
     5341 ccctggcttc tatactcatg actgaagaaa acaaaaaact agccaggcac cctctcattg
     5401 ttggcagcag aaccagcctg agctgattgc agaagttgca ggttcctaac gggccatcag
     5461 gtgatcaggc caataaacat gccacgtgtc tgcaaaggag atgcttggta agcctcaaca
     5521 ctgtgagcag tgacagctct atttgtcaat gtcctggaaa taaatgtaca gttttcatgc
     5581 tctgaaaaaa a
//
