LOCUS       NM_001040072            7422 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus NYN domain and retroviral integrase containing
            (Nynrin), mRNA.
ACCESSION   NM_001040072 XM_001476299 XM_147850
VERSION     NM_001040072.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7422)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7422)
  AUTHORS   Youngson,N.A., Kocialkowski,S., Peel,N. and Ferguson-Smith,A.C.
  TITLE     A small family of sushi-class retrotransposon-derived genes in
            mammals and their relation to genomic imprinting
  JOURNAL   J Mol Evol 61 (4), 481-490 (2005)
   PUBMED   16155747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC151043.1 and BC057379.1.
            
            On or before Aug 21, 2009 this sequence version replaced
            XM_001476299.1, XM_147850.7.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC151043.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6968              BC151043.1         23-6990
            6969-7422           BC057379.1         3802-4255
FEATURES             Location/Qualifiers
     source          1..7422
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..7422
                     /gene="Nynrin"
                     /gene_synonym="mKIAA1305"
                     /note="NYN domain and retroviral integrase containing"
                     /db_xref="GeneID:277154"
                     /db_xref="MGI:MGI:2652872"
     exon            1..312
                     /gene="Nynrin"
                     /gene_synonym="mKIAA1305"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..5637
                     /gene="Nynrin"
                     /gene_synonym="mKIAA1305"
                     /note="pol-like protein; NYN domain and retroviral
                     integrase catalytic domain-containing protein"
                     /codon_start=1
                     /product="protein NYNRIN"
                     /protein_id="NP_001035161.1"
                     /db_xref="CCDS:CCDS49501.1"
                     /db_xref="GeneID:277154"
                     /db_xref="MGI:MGI:2652872"
                     /translation="MLLSGGKPPAQEWFMVQTKSKPRVHRQRLQVQRIFRVKVTAFQS
                     RPDTPYFWLQLEGPRENTGKAKEYLKGLCNPELWKEVRYPPVLHCAFLGAQGLFLDCL
                     CWSTLAYLVPGPPGSLMVGGLTESFTMTQNWLEELVARLRWGPAPMITPRGVWETEVT
                     RAFGALVWIRCDKYAGDLLQLPPAVQELLLSLVRDAAGKEDIIEWLGHFGISGTCPNP
                     EILICLARQQKESASLVTIKESPGTLQEIGALNRASENSKKTTSSGAAGSLTQAQSPP
                     AQETADQLARDQSNKQGDETNSVGEEGTATQDTSSQDSENPTQALLQQKQVPKNEERI
                     SLLLPVSALSAYTSWKVWAPGTAFGPSWPGTIAATFWKINELQSLHLAWLLSQACLNF
                     PFWQRPTGPIQLKLPGRNPLPLKLEWKQKELVPLSSAGSPACRPGGDLGRETALKHSP
                     RPEIPSKIISLSVVPGGCGIKEKVSPGLLQVGQSSTSVGDKGISLSDCKGLEKPFSLA
                     LSTEQGGSTAQERPLAQVPEAPTVSETLQVATAAEVSNVEHPPTGEGLPATPKVPTAL
                     KKPAVYTEPTAPKVPSAPTEPAAPATPTAPQTPTAQKTPSVKTLAGLQTPKVQSETIA
                     TAGSEVPKAPAASAVAGPTVDVAQLLSEVQASKNRAIMLKVQGKPGRQGFQPSSTVPS
                     RSKHQFLKEGLLGAWEGSQRLSPHSQGTNIVTSFQRYNEALNTPFEMNLSEEPGNPGL
                     RRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREITVFVPTWQLKKNRRVRES
                     HFLTKLHRLKMLSITPSQLENGKKITTYDYRFMVKLAEETDGVIVTNEQIHILMNNSK
                     KLMVKDRLLPFTFAGSLFMVPDDPLGRDGPTLEEFLKKPNRLDMDIGNFLKVWKTLPP
                     SSASISELSDDADAEPLEDPQDVEEAGKEEGSLEEEPGIPKPDEEDEQDTNPVSVFGV
                     ECPSFSEEILQCLSLHDPSEGTLDIDLLPVVSSPYLDVPWDGKAPCQQVLAQLAQLNI
                     PSNFTALSFFMGFMDSHRDVISDYEDLVGPLHGLLKQKPDWQWNQEHEKSFLALKRAL
                     VCALCLSTPNPNLPFYLEVTVSQVSLTASLHQEHSGRKHPIAYTSKPLLPDEDSEGPQ
                     SGGDSPYAVAWALKHFARCVGDNPVVLRLSYASRTTVDNEAWDSRRASKAWLIRWSLL
                     LQDKGKRELELSLLQGLLGENQLLTPPSSMPRVFQPLPPSSDLSTFICVHVSGYCFYR
                     DDELCAGFGLYILSPTSPPVSLAFSCSPYTTTYAHLAAVACGLERFGQSQHPVVFLTH
                     CNWIFSVLWELLPLWRVRGFLSSDGASLPHPSLLSYIISLTSGFSPLPFIYRTSYRGS
                     LFAVTVDTLAKQGAQGGGQWWDLPKDVPVPMVTPHPKGRKPNLLALQLSDTTLADIIA
                     KLQAGQKLSGPSPFSSAFNSLSLDQDSGLLMFKGERHPRVWVVPRQLRRDLIFSVHDS
                     PIGEHQGLEDTYKTVRLLGWWPGMQDHVRDYCRSCLFCIPRNLIGGELKVIESPWPLR
                     STAPWSSLQIEVVGPVTVSEEGHKHVLIVADANTRWVEAFPLKPYTHVAVAQVLLQHV
                     FARWGVPIRLEAAQGPQFARHVLVSCGLALGAQVTTLSRALQFPCLMSSEAYWEFKRA
                     LKEFIFLYGKKWAASLPLLHLAFRASTTEATPFQVLTGGEMKLMEPVWWEMSRANIEG
                     LKMDAFLLQLMRELLDLHWRVAEKASEKAENRRFKRESQENEWSVGDQVLLLSLPRNG
                     SSAKWMGPFYIGDRLSLSLYRVWGFPVPDKLGCVYPSSLMKAFPKHDTPLSLDVEQ"
     exon            313..971
                     /gene="Nynrin"
                     /gene_synonym="mKIAA1305"
                     /inference="alignment:Splign:2.1.0"
     exon            972..2372
                     /gene="Nynrin"
                     /gene_synonym="mKIAA1305"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2503
                     /gene="Nynrin"
                     /gene_synonym="mKIAA1305"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2600
                     /gene="Nynrin"
                     /gene_synonym="mKIAA1305"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2702
                     /gene="Nynrin"
                     /gene_synonym="mKIAA1305"
                     /inference="alignment:Splign:2.1.0"
     exon            2703..2804
                     /gene="Nynrin"
                     /gene_synonym="mKIAA1305"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..7413
                     /gene="Nynrin"
                     /gene_synonym="mKIAA1305"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7394..7399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nynrin"
                     /gene_synonym="mKIAA1305"
                     /note="hexamer: AATAAA"
     polyA_site      7413
                     /gene="Nynrin"
                     /gene_synonym="mKIAA1305"
                     /note="major polyA site"
ORIGIN      
        1 gggcgcgcct caaggagggg aggcgtggct taggctgcag ggctaggtgg ctgggggcct
       61 cggtgctggg acccgtgaca cttctcacgc tttccagggg ccggagggac agccatgctt
      121 ttgtcggggg gtaaaccccc agcgcaggaa tggttcatgg tgcagacaaa atcgaagccc
      181 cgggtacacc ggcagcggct gcaagtccag cgcatcttca gggtcaaggt gaccgctttc
      241 cagagccgtc ctgacacccc ttacttttgg ctgcagctgg aggggccccg ggaaaatacg
      301 ggcaaagcca aggaatatct gaaaggtctg tgcaacccag agctatggaa ggaggttcgc
      361 tacccaccag tcctgcactg cgccttcctt ggggcacaag gcttgttcct ggactgcctc
      421 tgctggagta ccctggccta cctggtgcct ggtccccctg gctccttaat ggtgggtggg
      481 ctgaccgagt cttttaccat gacacagaac tggctggagg agctggtggc acggttgcgc
      541 tggggccctg ccccaatgat cacccctcga ggggtttggg agacagaggt gacccgggct
      601 tttggggctc tggtgtggat ccgttgtgac aagtatgcag gagacttgct gcagcttcct
      661 ccagcagtcc aggagctgct tctcagtttg gtccgagatg ctgccggcaa ggaagacatc
      721 attgagtggc tcggccattt tggcatctct ggtacttgcc ccaacccaga gatcctgatc
      781 tgccttgccc ggcagcagaa ggaaagcgca tccctggtga ccataaaaga gagccccggg
      841 acgctccaag agataggagc cttgaatcgg gcttcagaaa attcaaagaa aacaacaagt
      901 tcgggagccg ctgggtccct gacccaagct cagagccctc cggcgcagga gacagcagac
      961 cagctagcac gggaccagtc taacaagcaa ggtgacgaaa cgaacagtgt tggagaggaa
     1021 gggaccgcta cacaagacac cagcagccag gactctgaga atcccacaca agccctcttg
     1081 cagcaaaagc aggtaccgaa gaatgaagag agaatctcat tgctgttgcc agtgtcagct
     1141 ctgagcgcgt acacatcctg gaaggtctgg gcccctggga cagcctttgg gccctcgtgg
     1201 ccagggacca ttgctgccac cttctggaag atcaatgaac tgcagtctct tcacctagcc
     1261 tggctcctgt cccaggcttg cttaaatttc cccttctggc agaggcccac gggccccatt
     1321 cagctgaagc tgccaggacg gaatcctttg cccttaaagc tggaatggaa gcagaaagag
     1381 ctggttcctc tgtccagtgc aggaagccca gcttgtagac caggtgggga cctagggagg
     1441 gagacagccc taaagcatag cccgaggccg gagattccct ccaaaatcat cagtttatcg
     1501 gtggtgccag ggggttgtgg tatcaaagag aaggttagcc cgggacttct gcaagtaggg
     1561 cagtcttcaa catctgtggg agataaagga atttcactgt cagattgtaa aggcctggaa
     1621 aagccgttct ctctagcact gtccacagag caagggggat ccacagctca agagaggcca
     1681 ctggctcaag tacccgaagc tccaacggtg tctgaaactc ttcaagtggc cacggctgca
     1741 gaggtgtcca acgttgaaca cccacccacc ggggaggggc tgcctgcaac ccccaaagtg
     1801 cctacagccc taaagaagcc agcagtgtac acagagccca cagctcccaa agtgccttcg
     1861 gctccaacag aaccagcagc tcctgccacg cccacagccc cacaaactcc tacagctcag
     1921 aaaacacctt cagtgaaaac actcgcaggc ctccagaccc ccaaagttca aagtgagacc
     1981 atagctacag cagggtctga agttcccaaa gcgcctgcag cttcagcagt tgcggggccg
     2041 accgtggatg tagcccaact cctgagtgag gttcaggctt caaagaatag agccatcatg
     2101 ttgaaggtcc agggaaagcc cggaaggcag ggtttccagc ccagtagcac cgtgccctcc
     2161 agaagtaagc atcagttcct aaaggaagga cttcttgggg cttgggaggg gtcccagagg
     2221 ctgtcacctc actcccaggg caccaacata gtgaccagct tccagaggta caacgaggcc
     2281 ttgaacacac cgttcgagat gaacttgtct gaggagcctg gaaatccagg gctgaggaga
     2341 gtggtcattg acggcagcag tgtggccatg gtacatggcc tgcagcactt cttctcgtgc
     2401 cgaggcatcg ccatggccgt gcagtacttc tggaatcgcg gacaccgaga gatcaccgtg
     2461 ttcgtaccca cctggcagct gaagaaaaac cggagggtga gagagagcca ctttctgacg
     2521 aagcttcaca gactgaagat gctgtctatc actccctcgc agctggagaa tggcaaaaag
     2581 atcaccactt acgattacag gttcatggta aagctggcag aggagacaga tggagtcatt
     2641 gtcaccaatg agcagatcca catcctcatg aataattcca agaaactgat ggtcaaagat
     2701 cgcctgctgc ccttcacctt tgccgggagt ctctttatgg taccagatga ccccctgggc
     2761 cgtgacggcc ccaccttgga ggaatttctg aagaagccaa acaggttgga catggacatt
     2821 ggcaatttct tgaaggtgtg gaagaccctg cctcccagct cagccagcat ctctgaactg
     2881 agtgatgacg ctgacgccga acctttggag gatccacagg acgtagaaga agcagggaag
     2941 gaggagggaa gcctggaaga ggagccagga atcccaaagc ccgatgaaga agatgagcag
     3001 gacactaacc ctgtgtcggt gtttggggtc gagtgccctt cattttccga ggaaatcctc
     3061 cagtgtctca gcctgcatga cccctctgag gggactttag acatcgacct tctgcctgtg
     3121 gtgtcctctc cgtacctgga tgtcccctgg gatgggaagg ctccctgtca gcaggttctg
     3181 gcccagctgg cgcagcttaa catcccgagc aacttcaccg cgctatcctt cttcatgggc
     3241 ttcatggatt cccaccggga tgttatctct gactatgaag atctcgtggg ccccctgcac
     3301 ggcctcctca agcagaagcc ggactggcag tggaaccagg agcacgagaa gtccttcctg
     3361 gccctgaaac gagccctagt gtgcgccctc tgcctgtcaa cccccaaccc caacctgccc
     3421 ttctacctgg aagtgactgt cagccaagtg tcactgacag ctagcttgca ccaggagcac
     3481 tcaggaagga agcaccccat cgcttatacc tcgaaacctc tcctccccga tgaagacagc
     3541 gagggtcctc agtcaggggg ggacagcccc tatgctgtgg cttgggccct caagcatttt
     3601 gcccgatgcg ttggagacaa tccagtggtt ctacgtcttt cctatgcctc ccggaccacg
     3661 gtggataatg aggcatggga tagccgtagg gcttcgaaag cgtggttgat tcggtggtct
     3721 ctcttgctgc aggacaaagg caagagggaa ttggaattgt cccttctcca gggcctgctg
     3781 ggggagaacc agctgctgac acccccttcc tccatgcccc gagttttcca gcctctgcct
     3841 ccttcttctg acctgtctac ttttatctgt gtccatgtgt ctggctattg cttctaccgt
     3901 gacgatgagt tgtgtgctgg ctttggtctc tacatcttgt cgcccaccag ccctccagtc
     3961 tcccttgcct tttcctgttc tccttacaca accacatacg cccacctggc agccgtggcc
     4021 tgcggcttag agcgcttcgg ccagtcccag caccctgtgg ttttcctcac ccactgcaac
     4081 tggatcttca gcgttctctg ggagctcctg cccctctgga gagtccgggg cttcctgtca
     4141 tctgacgggg cttcactacc tcatccaagc ctgctgtcct acatcatctc tctcacgtct
     4201 ggcttttcac cccttccctt tatctaccga acctcttatc ggggctctct gtttgctgtg
     4261 acagtggaca ctctggccaa gcagggtgcc caagggggcg ggcagtggtg ggatttgcca
     4321 aaggatgtgc cagtgccaat ggtgactccc catcctaaag gcaggaagcc caacttgctg
     4381 gccttacagc tgagtgatac caccctggcc gatatcattg ccaagttgca ggcaggacag
     4441 aaattgtccg ggccctcccc tttcagttct gcctttaact cactcagcct ggaccaagac
     4501 agtggcctgc tcatgttcaa gggggaaagg catcccaggg tttgggtagt cccaaggcaa
     4561 cttcggaggg atctgatttt ctctgtgcat gacagcccca ttggggaaca ccaggggcta
     4621 gaggacacct ataagacggt gaggctgctg ggatggtggc ctgggatgca ggaccacgtg
     4681 agagattact gcaggagctg tttgttctgc atcccccgga atctcatagg cggggagctg
     4741 aaagttatcg agtccccatg gcctctcagg tcgacagccc cttggtccag tctgcagatt
     4801 gaggtggtgg gtccagtcac tgtaagtgag gagggacata agcacgtgct cattgtggcc
     4861 gatgccaaca cccggtgggt ggaggcattc cctctgaagc cctatacgca cgtggctgtg
     4921 gcccaggtgc tcctccagca tgtgtttgca aggtggggcg ttcccatcag actggaggcc
     4981 gcccaaggcc cccagtttgc ccgccatgtt ctggtgagct gtgggctggc cctgggagcc
     5041 caagtgacta cactgagtag ggccctccag ttcccctgcc tgatgagttc agaggcctac
     5101 tgggaattca agagggccct gaaggagttc atctttctgt atggcaagaa gtgggcggcc
     5161 tctctgccct tgctgcacct ggcttttagg gcctccacca cagaggccac accgttccag
     5221 gtgctgaccg ggggcgagat gaagctgatg gagcccgtgt ggtgggagat gagccgggcg
     5281 aacattgaag ggctcaagat ggacgctttc ttgctgcagc tgatgcggga gctgttggac
     5341 ctccactgga gagtggccga gaaggccagc gagaaggccg agaacaggcg tttcaagagg
     5401 gagagccagg agaacgagtg gagtgtgggc gaccaggtcc tcttgttgtc tctccccagg
     5461 aatggcagca gtgccaaatg gatgggtcct ttctatattg gggaccggtt gagcctatca
     5521 ctctataggg tgtggggctt cccagtccca gacaagctgg gctgtgtcta tcctagcagt
     5581 ctgatgaagg cctttcccaa gcatgacacg cccctgtccc tcgacgtgga gcagtgagtc
     5641 agagcagcca gggatctgcc cgctcgggtc cccgcatttc tgctgctagt cctcccttct
     5701 gatctgagca gtgctctcag ctcttcgggg gcccccctca gttgtgcctt gtgcggagaa
     5761 gttccctttg taaagctttg ctgaattgcc ttgagctagg ggtggatgtc cctataacac
     5821 atccccaggt aggggtactt ggagaatgtg ccaaaggttg tcctgtgggg gctctgggct
     5881 ctggcagttc tacccttggg agcaaaggag tctccttaac aaagttggcc gggctcacga
     5941 tcttccccaa gtgccacctt tcccctctta cacgctcagg tgtagattgg tgtgtgcacc
     6001 cctctccagt gtctttcacc caacacacta cacttcacag tgtggatttg gacctccggg
     6061 tgggtatcac agctctcccc ctatgctagt gcctccccgt acattctgca tctggcaagc
     6121 ctctgctctt ggagttctca atggcacaga cactggcagc aagaaggtag cagttctcca
     6181 gtcggcctcc tttgccagca ccgggacagc agtagccttc ccgtgcctcc aggatgcttg
     6241 ctgtctctgg gtggaggtga tcagccataa gccacctacc tgttcttaag gggaggtggt
     6301 gggaggggat gaattggcct acctcatttg attccagtca acagagatga ttcctgaccc
     6361 ctgctgtgat ggtggtcacc tcacaggagt cgaggacttt gataccaagc gtggcctctg
     6421 tactggaaga gctgcttcta ttaggttcag tggtgttcac gctctgcttt aaggggaggg
     6481 catctgatgt gtgtagtttg acacgcggcc gggcactggg tggcttttcc tcttgttcct
     6541 ctgactcctc tcacccactg ccaaagctca caaccctcta ctgcgtgcag tttacccatc
     6601 tccttcgatg ggactgcttt gttctggtca gctgcagtac cctgaatctg cctctgtgtg
     6661 gcgctccctc acagccggtg tgcccagctc attgtcgcag caggagtggg cttttcatta
     6721 tcatgagggc tgattctcac cgctctgcat ttccacacag ctgagctcgc gatctggaga
     6781 gaaaggtcag caccaggccg ttctggctcc gattcctagt agctcatttc tcgaggagcc
     6841 gatccggtta tctggctgag ctcaggttgc cagacaggac gctgcagaat gctgggtcct
     6901 gaggctaggt tggcgttgag cccagctttc acaacagagc aaagagggaa atgacttgcc
     6961 cgcagtcaca cagctagttg gtggctgagc tgggacccgg atgaaccttc gtgacttcag
     7021 gttcaccacg ataggggttc tagcaacatg tttaagcatg agaatccttt cagattttgt
     7081 acctctgttc cctttgatgc cgtttcgttt cctaaccctt ctagataaac tacctgaatg
     7141 ctgttcttca gccaatccag ctggcaaacc ctgcccagaa atagatgctg ggagctcccc
     7201 ggggtgctga aaggttagct gtagaatttt tagcaggtac tgtttcttcc caccacctta
     7261 gctttgcctc ccctcccccg cccccctttc ctacgttagt cagcctcact ctccagcccc
     7321 agggctatat tcaaacacct ctttctgtta agtacaattc ccatcatatg ctttcaagtg
     7381 atttttattt ttcaataaat cagttaaaat ggaaaaaaaa aa
//
