LOCUS       NM_001356397            7677 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus neuronal tyrosine-phophorylated phosphoinositide
            3-kinase adaptor 2 (Nyap2), transcript variant 1, mRNA.
ACCESSION   NM_001356397 XM_006496487
VERSION     NM_001356397.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7677)
  AUTHORS   Catela,C., Chen,Y., Weng,Y., Wen,K. and Kratsios,P.
  TITLE     Control of spinal motor neuron terminal differentiation through
            sustained Hoxc8 gene activity
  JOURNAL   Elife 11, e70766 (2022)
   PUBMED   35315772
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7677)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7677)
  AUTHORS   Steinmetz,C.C., Tatavarty,V., Sugino,K., Shima,Y., Joseph,A.,
            Lin,H., Rutlin,M., Lambo,M., Hempel,C.M., Okaty,B.W., Paradis,S.,
            Nelson,S.B. and Turrigiano,G.G.
  TITLE     Upregulation of mu3A Drives Homeostatic Plasticity by Rerouting
            AMPAR into the Recycling Endosomal Pathway
  JOURNAL   Cell Rep 16 (10), 2711-2722 (2016)
   PUBMED   27568566
REFERENCE   4  (bases 1 to 7677)
  AUTHORS   Yokoyama,K., Tezuka,T., Kotani,M., Nakazawa,T., Hoshina,N.,
            Shimoda,Y., Kakuta,S., Sudo,K., Watanabe,K., Iwakura,Y. and
            Yamamoto,T.
  TITLE     NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling
            in neurons
  JOURNAL   EMBO J 30 (23), 4739-4754 (2011)
   PUBMED   21946561
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7677)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   6  (bases 1 to 7677)
  AUTHORS   Boettger-Tong,H.L., Rohozinski,J., Agoulnik,A.I., Dohmae,K.,
            Nishimune,Y., Levy,N. and Bishop,C.E.
  TITLE     Identification and sequencing the juvenile spermatogonial depletion
            critical interval on mouse chromosome 1 reveals the presence of
            eight candidate genes
  JOURNAL   Biochem Biophys Res Commun 288 (5), 1129-1135 (2001)
   PUBMED   11700028
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131336.9, AC116105.12 and AC163450.5.
            
            On Oct 2, 2017 this sequence version replaced XM_006496487.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043512.1, AB429290.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-487               AC131336.9         28716-29202
            488-724             AC131336.9         38566-38802
            725-1026            AC116105.12        141190-141491       c
            1027-2112           AC116105.12        91273-92358         c
            2113-2322           AC116105.12        63989-64198         c
            2323-2426           AC116105.12        35177-35280         c
            2427-7677           AC163450.5         79831-85081
FEATURES             Location/Qualifiers
     source          1..7677
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 41.75 cM"
     gene            1..7677
                     /gene="Nyap2"
                     /gene_synonym="9430031J16Rik; Jr6; Kiaa1486"
                     /note="neuronal tyrosine-phophorylated phosphoinositide
                     3-kinase adaptor 2"
                     /db_xref="GeneID:241134"
                     /db_xref="MGI:MGI:2443135"
     exon            1..487
                     /gene="Nyap2"
                     /gene_synonym="9430031J16Rik; Jr6; Kiaa1486"
                     /inference="alignment:Splign:2.1.0"
     exon            488..724
                     /gene="Nyap2"
                     /gene_synonym="9430031J16Rik; Jr6; Kiaa1486"
                     /inference="alignment:Splign:2.1.0"
     CDS             504..2654
                     /gene="Nyap2"
                     /gene_synonym="9430031J16Rik; Jr6; Kiaa1486"
                     /note="isoform 1 is encoded by transcript variant 1;
                     neuronal tyrosine phosphorylated adaptor for
                     phosphoinositide 3-kinase adaptor 2; neuronal
                     tyrosine-phosphorylated phosphoinositide-3-kinase adapter
                     2"
                     /codon_start=1
                     /product="neuronal tyrosine-phosphorylated
                     phosphoinositide-3-kinase adapter 2 isoform 1"
                     /protein_id="NP_001343326.1"
                     /db_xref="CCDS:CCDS87851.1"
                     /db_xref="GeneID:241134"
                     /db_xref="MGI:MGI:2443135"
                     /translation="MIPSKMMSANPEEDPLDTFFQYIEDMGMKAYDGLVIQNASDIAR
                     ENDRLRNETNLAYLKEKNEKRRRQEETIKRIGGEVGRGQDASYAGKHFRMGFMTMPAP
                     QDRLPHPCSSGFTVRSQSLHSVGGTEDDSSCGSRRQPPPKPKRDPSTKLSTSSETVNS
                     TAASKSGRSLERAEVSAKPRPHSDEYSKKIPPPKPKRNPNTQLSTSFDETYIKKHVPR
                     RTSLPRDSSLSQVCSPAADPEEEEPVYIEMVGNILRDFRKEEDDQSEAVYEEMKYPIF
                     DDLGHDSKCDFDHHSCSSQCATPTVPDLDFVKSSGPCTPKGLLCDIPPPFPNLLSHRP
                     PLLVFPPAPVHCSPNSDESPLTPLEVTKLPVLENVSYMKQPPGACPSSLPSHGSSHAK
                     DQTGALGPAPGASILSSSPPPPSTLYRTQSPHGYPKSHSTSPSPVSMGRSLTPLSLKR
                     PPPYDAVHSGSLSRSSSSVPHTTPRPVSQDGAKMVNAAVNTYSAAQSGSRSRTPTSPL
                     EELTSLFTSGRSLLRKSSSGRRSKEPAEKSTEELKVRSHSTEPLPKLDSKERGHYGSS
                     SSREPVKAQEWDGTPGPPVVTSRMGRCSVSPTLLAGNHSSEPKVSCKLGRSASTSGVP
                     PPSVTPLRQASDLQQSQVACMQWFHGDHTMLEMIEKKRCLCKEIKARQKTEKGLCKQD
                     SMPILPSWKKNAGAKKYSPPPYSKQQTVFWDTAI"
     exon            725..1026
                     /gene="Nyap2"
                     /gene_synonym="9430031J16Rik; Jr6; Kiaa1486"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..2112
                     /gene="Nyap2"
                     /gene_synonym="9430031J16Rik; Jr6; Kiaa1486"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2322
                     /gene="Nyap2"
                     /gene_synonym="9430031J16Rik; Jr6; Kiaa1486"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2426
                     /gene="Nyap2"
                     /gene_synonym="9430031J16Rik; Jr6; Kiaa1486"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..7677
                     /gene="Nyap2"
                     /gene_synonym="9430031J16Rik; Jr6; Kiaa1486"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacatgatca aatgaggtac cttagccagc ttggtgactg cttcgggtct tgtaatcatc
       61 tgtgtagcaa agtgggtaaa atcattcagt ttcgtccctg ctggacctgg aaggagaggg
      121 gctgtgcgct catccccacc cattagctat gccctctttt ctccgaatgt cgatttaacg
      181 aagcaagcac ctgtcttctg ccactgcctc ttccttgcaa actttaaaag gcattttatc
      241 cgatagaaag aacaacgaaa atgctctgat ctctagtgat gaagaatctt ggattcgaca
      301 cttttcacat ccagatataa tgcactttaa ttgaagaaat actgaactga acctacaagt
      361 ctctttctta tggtgctgga ttactcctcc cgaactgccc cgagaccagc cctgagagag
      421 ggctctgaca gacccaactc acctcctgac tattccactt agttctcccc cggggactta
      481 atttttgaaa gcatcctgtc tccatgatac catccaagat gatgagtgct aatcctgaag
      541 aagaccctct ggacaccttt ttccaatata ttgaggatat gggaatgaaa gcatacgatg
      601 gcctggttat tcaaaatgca tccgacattg ctcgcgagaa tgatcgcctg agaaatgaga
      661 caaacctggc ttacttgaag gagaagaacg agaaacgtcg acgacaggaa gaaacaatca
      721 aacgcatagg aggagaagtg gggcgaggcc aggacgccag ttacgcgggc aagcatttcc
      781 gcatggggtt catgacgatg cctgcacctc aggacagact cccacatccc tgctccagtg
      841 gcttcactgt gagatctcag tccctgcact ctgtaggggg cactgaagat gacagcagct
      901 gtggatcacg aagacaacca cctcccaagc ccaagcgaga ccccagcact aagcttagca
      961 cttcgtctga gacagtcaac agcactgcag ccagtaagag tggaagatct ctggagagag
     1021 cagaagtgtc tgccaagcca agaccccaca gtgatgaata ttcaaagaaa attccccctc
     1081 cgaaaccaaa acggaatcct aatactcaac ttagcacgtc tttcgatgaa acctacatca
     1141 aaaagcatgt gccaaggaga acctctctcc cgcgagattc atccctgtcc caggtttgca
     1201 gccccgcggc agaccccgaa gaagaggagc ctgtgtacat cgagatggtg gggaacatcc
     1261 tcagagactt caggaaggaa gaggatgacc agagcgaggc tgtgtatgag gagatgaaat
     1321 atcccatttt cgacgacctg ggccatgatt ccaaatgtga ctttgatcat cacagttgct
     1381 cttcgcagtg tgctactccc acggtgcctg acctggactt tgtcaagtct tcaggaccat
     1441 gtactcccaa gggtctgctt tgtgacatac ccccgccctt ccccaacttg ctttctcata
     1501 gaccacccct gctggtgttc ccaccggccc cagtacactg ctctcccaat tccgatgagt
     1561 ctccactgac ccctctggag gtcacaaagc ttcctgtgtt ggaaaacgtg tcttacatga
     1621 aacagccacc tggagcatgt ccatcctcac tgccatctca tggctccagc catgctaaag
     1681 accagacagg agccttgggt cctgctcctg gagcatccat tctctcttct tcccctccac
     1741 ctccatccac tttgtacaga acccagtctc cccatggcta tccaaaaagt cactccacct
     1801 ccccatcccc tgtaagcatg gggaggtccc tgacgccctt gagtctcaag aggcctcccc
     1861 cttatgatgc tgtgcattct ggcagcctct caaggagttc ttcctcagtg cctcacacga
     1921 ccccaagacc cgtgtcacag gatggggcca agatggtcaa tgctgcggtg aatacataca
     1981 gcgctgcgca gagtgggtcc aggtccagga cacccaccag tcctttggaa gagctcacca
     2041 gcctctttac ctcagggcgg agcctgctgc ggaagtcatc cagcggccga aggtccaaag
     2101 agccagcaga gaaatccaca gaggagctga aagttcgaag ccacagcacg gagccgttac
     2161 caaagttgga cagcaaagag agaggtcatt atggatcgtc ttcctctaga gagccagtga
     2221 aagctcaaga atgggatgga accccgggtc cacctgtggt caccagcaga atgggcagat
     2281 gctctgtgag ccccacactg ttggcaggaa accacagctc agaacctaaa gtaagctgca
     2341 agctggggcg gtctgcatct acatcaggag tccctcctcc ttcagtcact cctctcaggc
     2401 aagccagtga tctgcaacag agccaggtgg catgcatgca gtggtttcat ggagaccata
     2461 caatgcttga gatgattgag aaaaagcgtt gcttgtgcaa agaaataaag gctagacaga
     2521 aaacggaaaa gggcctttgc aaacaggata gcatgccaat cctacccagc tggaagaaga
     2581 acgcaggagc aaagaagtac agtcctccac cgtattctaa acagcaaacg gtattctggg
     2641 atactgccat atgagtgtgt actggcatga gctccacatt gcttaattca agggaggtcg
     2701 acttggcctt gtgataatta attgttccat atattctttg ttgatgtgga ataccacagg
     2761 aagctgtgag tactgtggca tacccgagat aaaatgtgtt tgtccttgaa gttaaggcac
     2821 acttacttat cctggattgt tttgaatcca gaacatatta aattgtaaat attttgctag
     2881 tttatgagtg acacctgaaa taataatcat tatacatatt taagtttcag aaacatgaga
     2941 aaagtttaat agatgatata atttggtatg aactggtttg ttatctcttt tatatgtaac
     3001 ccctggatgc cttttcttat taatttttgc atttaaaatg tctttgtcct ccaacccaca
     3061 tttggcttct atagaagagc tgacaggtag aagtcctatt taaatacata atatgtgatc
     3121 tggtgctagc aacacagaag ttgaatatcc tgtttgtaaa gtttatctgc tgctttctaa
     3181 atgtgaaagg gattgattgg aagtgaaacc aagcaggacc ccagtctgaa ggcccgtgtt
     3241 ccatggacag tctttctaca gtgacttcat aaggattcca ttcatatcct tgagtctgca
     3301 cttggtatta gcaagtcaga ctacagagaa aggaagtagg atacattggg acattgcggc
     3361 agcaaacttt cctacagaaa gaaggtttgg gatatgtgtc cttgcagcat tgatctgatt
     3421 ggaggagacc agggttcact gtgacattgg aaataacaaa gattcaaaac cataagagca
     3481 cagctgttta taagaaagga ggagcagaga catcgtagac ataatatatt ttataggcat
     3541 ggttttccac aagaaataaa gaaatacaca ttcaacttac aaatttgcat attctagtat
     3601 actccatgcc agccttcctc aaaatttaag cccatttatg gaaaaatatt ccttgccaat
     3661 cttttaaacc taatcattat atttttgggt cataatcttc tgtccataac tattttacct
     3721 gttcttactg attatgacac catgaccaaa gaattatgac tacttcattg ttttattttg
     3781 ttttaaggaa gaaataggaa atgtagggga taaaggatag ggtggactca actttatgtg
     3841 gtggtaaaat ttaagttaaa aaatttaatt taagaaaaat ggtatatatc ttttaaaagt
     3901 aacttgttag ttgaaaataa atattgccac ggataaataa aaatgaaact atcacatata
     3961 ttttgtatat ttaaattact atttatgctt cctaaaatgg acagtatgcg gttcttcagt
     4021 aacaatcaat ttagtattat atttctgaga ggaaaaaagt gtgtttgaag ttattatcat
     4081 agcagttttt ctcttaaggg tattgacagc aatagcttca tgctgctcaa taaaaccaac
     4141 tatgacagaa gttaaggaat ttttgtaatc tatattgata aaaaaatcta gtaattcttt
     4201 atcagtaata gttcctcaaa gagagtttga aatgttataa cataattttt taatgtttta
     4261 taattaatgt atattttgat gtccaattat aatgctgaaa gaataaggga aacagtaagt
     4321 gggagcatgt gttgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta tgaacaatca
     4381 gtgggagaac tgtatctata aaatgcttac agaagctgta agttctgctt gtacaagtaa
     4441 gatggcgacg aaggcaaaat aacaaatata gcgaaccaca gagttcttaa gcagtttaaa
     4501 cagatacctt cgctgtgttt caccagctat gtagacctac aattcaaacc caacagccaa
     4561 cacagcacag atctaagagt gaaggaaaca tcttcagatg aaagcataat tgaaatcaaa
     4621 tgtgtttatg gctcaagttg ctatcttgac ttgagcagtt atgacctcat agatttaaac
     4681 caatcaaaca caaggcacca tccttcatca tttctatgac cttagtgcac gtgtattctg
     4741 gctattgcag taaatatgac ccctctcttg acatttaagt gtaggcaata tatttctaag
     4801 tgtgtctttc gaatgctgat cttacacata tcactatgcg ttaggcagaa gataactgtt
     4861 aatgttggtc acttgttcag aaggaaacag gtactaaatt gatttgtgtt ggactcagcc
     4921 attcatgtgt gttctgtcac gctcatgcca tggccacatg tcatactcct tcaaatatgt
     4981 taattttttt aaaggagtta cctttttttg acaatttgaa cttaggcaac catttccatt
     5041 tatttcttca aatctctctc tacatgagaa agaattggaa tatctgggaa aatggcttca
     5101 cttggattag acttcagatc tgttactctg tgcctataca atatttaatt gtccactgtg
     5161 acaattagct attctatagt cagcttctcc ttcatataga gtttctcttt gttgtgagaa
     5221 aagagtcatt agtacatagg aaaaaaatca tgctgactct gtctagtggc aataaattag
     5281 ggcacttcac catatgtatc tggccggaag ataacctgca gccagcacat gatgacatga
     5341 taatgctcat atttctagca gtgccaaaga ataaatcata taaaggcatg gttatcaggc
     5401 caagagaact catacttatg acaaatagtc ttttcacagc aaatgttgta gaaacagatt
     5461 tttattggct gtcagtaaga tgcttttacg tgtgaaatac ttcctagtag agaagacacg
     5521 aatttccgtg gaaatgatgg aagaaaagag taaaatactg tgttttcccc atcacagatg
     5581 ccagcactac ttgagaaatc acactttaca gagacactgc caatatctcc ctctgtatgc
     5641 tattgaagca aaagtttgag gtaaaaagtg atttttgcaa ataaggatga atttttagcc
     5701 atgtaataat tgagaaagga aagaaaacag caagagataa agatgtatta atttgtaaag
     5761 tatatacctc tggacacaaa ataattgttt ggacataaga tcacttttca aaatagtgac
     5821 agttttgaat tgctgacaag taacaagatc ttgttagaat gcttctagaa aatcgagata
     5881 ttgacatagg tgtgttcttg tctacaccca gaatttggtt tgagtctttt gaacaattta
     5941 agtagaaatt caacacacct gaagagcccc agcaagttac tgtcctaata cagtcatcag
     6001 aataacacaa ctatagatac aatctttata ttacttacat gttaaactca gtcagattcc
     6061 caatataggg cttggaaatt aaccatgctt ccacctgaca ttaaaacaaa tattccttca
     6121 atttatgaag taagaaattt gaggcaagct ttaagtctca tgtgaaaaag gactgtagat
     6181 aggatagact attctcttct catacactgt atcctaaact ctaatggaag ttaaagagga
     6241 ttgacacata cattgtatag gaatacttgc aacaccttgc agatttggag taataactaa
     6301 caaattacag aatgttgata atttgatagc aatacattgt ttttttaatt cattgtctca
     6361 tttaattata cagtttcagg aacacttaga gtttaacgtt gaacaaaata tgattgttgc
     6421 aattaaggga ctcaagtatg caatcattaa tattttcaca atgaaaaaac cagttgtttc
     6481 caatagtata cacaagtcca ctatgtttgg cagtttttaa gtgcttatat ggagtgttct
     6541 tgttgttttc tggtcaagtg tacagtcaaa ataaaagatg aaaatatact aaatttatgt
     6601 ctgattataa catatgtgta ttgtaagcct ctacgtgtac attacaatat gtactgctat
     6661 ctgtataaat cagtaaagat gacactgttc tatcatgtta aatgtaaaca ttgtggtttg
     6721 gggtttggat ggcttaaagc cctctcatat ttgggtcaat tttattggca caaaatgtgt
     6781 ataatctggg aaaatgtttg gctacatttt atttaattat tgtgaagctt cagatttagg
     6841 gagaaacatt taaaatattg ttgaaattgt ctcaaataaa aatctatgaa taatccttca
     6901 atatattcat ttgttcccaa atataactgg gttttcccac cctaaaagca ttaatattta
     6961 aacatgtaca cattcagata cagaatacat actgtatata atatatatga caatgtttag
     7021 tatgcacttc ttttgtttgg acttaccatt tatagtgtag caatttgtgt aaagtgcact
     7081 gtgattataa aaagaatcaa agcacagtac agtcacactt ttgttatctt gcactaaaag
     7141 cgtgtttacg tatttagcaa ttgtatgttt actttcttga cttttcagat atttgaaaca
     7201 aatagctatg aaaaatgata taaactaatc tgttttttag tggataatga cactacattt
     7261 ttaaaagaca gggtttttaa agaaaaccat taaacatcca ttccaacact aacatgttta
     7321 ccatatctaa agatctgaat gtcatattgc atttttcata actcattagc aatgtcaggt
     7381 atgtgcctga atatttgtgc aaataagcat tagataacag atttctctat tcatgtattc
     7441 ctaggcattt ctatatacat aataatataa acactgatgt tttaatgtct cttaattttt
     7501 gtacttgatt tttttaggtg atatgtaatt atatatgtac tttgatacta ctgaagtaac
     7561 cagatgttgt ttgaaaacaa attgatttct ctctagtgca ttgacaatat tttatgatat
     7621 tttgtgctta tttatttgtg ctcccgtgtt attataataa aagcaatagt ttaaatt
//
