LOCUS       NM_001347505            3501 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus neuronal tyrosine-phosphorylated phosphoinositide
            3-kinase adaptor 1 (Nyap1), transcript variant 2, mRNA.
ACCESSION   NM_001347505 XM_006504575
VERSION     NM_001347505.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3501)
  AUTHORS   Kurz,J., Weiss,A.C., Thiesler,H., Qasrawi,F., Deuper,L., Kaur,J.,
            Rudat,C., Ludtke,T.H., Wojahn,I., Hildebrandt,H., Trowe,M.O. and
            Kispert,A.
  TITLE     Notch signaling is a novel regulator of visceral smooth muscle cell
            differentiation in the murine ureter
  JOURNAL   Development 149 (4) (2022)
   PUBMED   35103284
REFERENCE   2  (bases 1 to 3501)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3501)
  AUTHORS   Wang,S., Li,X., Zhang,Q., Chai,X., Wang,Y., Forster,E., Zhu,X. and
            Zhao,S.
  TITLE     Nyap1 Regulates Multipolar-Bipolar Transition and Morphology of
            Migrating Neurons by Fyn Phosphorylation during Corticogenesis
  JOURNAL   Cereb Cortex 30 (3), 929-941 (2020)
   PUBMED   31609430
  REMARK    GeneRIF: Nyap1 Regulates Multipolar-Bipolar Transition and
            Morphology of Migrating Neurons by Fyn Phosphorylation during
            Corticogenesis.
REFERENCE   4  (bases 1 to 3501)
  AUTHORS   Yokoyama,K., Tezuka,T., Kotani,M., Nakazawa,T., Hoshina,N.,
            Shimoda,Y., Kakuta,S., Sudo,K., Watanabe,K., Iwakura,Y. and
            Yamamoto,T.
  TITLE     NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling
            in neurons
  JOURNAL   EMBO J 30 (23), 4739-4754 (2011)
   PUBMED   21946561
  REMARK    GeneRIF: Phosphorylated NYAPs interact with PI3K p85 and activate
            PI3K, Akt, and Rac1. Moreover, the NYAPs interact with the WAVE1
            complex which mediates remodelling of the actin cytoskeleton after
            activation by PI3K-produced PIP3 and Rac1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3501)
  AUTHORS   Lin,J.C., Ho,W.H., Gurney,A. and Rosenthal,A.
  TITLE     The netrin-G1 ligand NGL-1 promotes the outgrowth of
            thalamocortical axons
  JOURNAL   Nat Neurosci 6 (12), 1270-1276 (2003)
   PUBMED   14595443
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125063.4 and AC124730.5.
            
            On Dec 1, 2016 this sequence version replaced XM_006504575.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and uses
            an alternate in-frame splice junction compared to variant 1. The
            resulting isoform (2) has the same N- and C-termini but is 1 aa
            shorter compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK080821.1, SRR7652917.123277.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AC125063.4         144840-144957
            119-270             AC125063.4         146206-146357
            271-617             AC125063.4         147853-148199
            618-2132            AC125063.4         149654-151168
            2133-2339           AC125063.4         152086-152292
            2340-2449           AC125063.4         152848-152957
            2450-3501           AC124730.5         191994-193045       c
FEATURES             Location/Qualifiers
     source          1..3501
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.62 cM"
     gene            1..3501
                     /gene="Nyap1"
                     /gene_synonym="6430598A04Rik"
                     /note="neuronal tyrosine-phosphorylated phosphoinositide
                     3-kinase adaptor 1"
                     /db_xref="GeneID:243300"
                     /db_xref="MGI:MGI:2443880"
     exon            1..118
                     /gene="Nyap1"
                     /gene_synonym="6430598A04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            119..270
                     /gene="Nyap1"
                     /gene_synonym="6430598A04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..2701
                     /gene="Nyap1"
                     /gene_synonym="6430598A04Rik"
                     /note="isoform 2 is encoded by transcript variant 2;
                     neuronal tyrosine phosphorylated adaptor for
                     phosphoinositide 3-kinase adaptor 1; neuronal
                     tyrosine-phosphorylated phosphoinositide-3-kinase adapter
                     1"
                     /codon_start=1
                     /product="neuronal tyrosine-phosphorylated
                     phosphoinositide-3-kinase adapter 1 isoform 2"
                     /protein_id="NP_001334434.1"
                     /db_xref="CCDS:CCDS84980.1"
                     /db_xref="GeneID:243300"
                     /db_xref="MGI:MGI:2443880"
                     /translation="MNLLYRKTKLEWRQHKEEEAKRSSSKEAAPTGPVGPGAVPGPGV
                     RVRDIASLRRSLRMGFMTMPASQEHTPHPCRSTMAPRSLSCHSVGSMDSVGGGPGGGL
                     TEDSSTRRPPAKPRRHPSTKLSMAGPGAETPPSKKAGSQKPAPECRESSRKVPPQKPR
                     RSPNTQLSVSFDESCAPAPSPRGANLPLQRLSRASRITGDLDAGAQEEEPVYIEMVGD
                     VFRGGGRSGGGLAGPPLGSGGPTPPAAADSDSEDSEAIYEEMKYPLPEEAGDGRANGP
                     PPLTAPSPPQQTHILQPHPHPHRRPASALPSRRDGTPTKTTPCEIPPPFPNLLQHRPP
                     LLAFPQAKSASRAPGDGVSRLPVLCHSKEPAGSTPAPQVPARERETPPLPPPPPAANL
                     LLLGPSGRARSHSTPLPPQGSGQTRGERELPNSHSMICPKAAGVPAAHPAPAALLPGP
                     PKDKAVSYTMVYSAVKVTTHSVLPAGPPLGVGEPKTEEISVLHGMLCASSRPPVPGKS
                     SPHSGAMGSAAGVLHHRSCLASPHSLPDPTGGSLTPLWTYPATAAGLKRPPAYDSLKA
                     GGVLNKGCGMGAPSPMVKIQLQEQGTDGGAFASISCAHVIASAGTPEEEEEMGAAFGA
                     GWALQRKVLYGGRKAKEVDKEDGARAWNGSTEGPGKVEHEDRGPVPSGIPVRSQGAEG
                     LLARIHHDRGGSRTALPVPCQTFPACHRNGDFTGGYRLGRSASTSGVRQAALHTPRPC
                     SQPRDALSQTHPVLPLPLPPQPARERDGKLLEVIERKRCVCKEIKARHRPDRGLCKQE
                     SMPILPSWRRVPEPRKSGTPPCRRQHTVLWDTAI"
     exon            271..617
                     /gene="Nyap1"
                     /gene_synonym="6430598A04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            618..2132
                     /gene="Nyap1"
                     /gene_synonym="6430598A04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2339
                     /gene="Nyap1"
                     /gene_synonym="6430598A04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2449
                     /gene="Nyap1"
                     /gene_synonym="6430598A04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..3501
                     /gene="Nyap1"
                     /gene_synonym="6430598A04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3481..3486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nyap1"
                     /gene_synonym="6430598A04Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3501
                     /gene="Nyap1"
                     /gene_synonym="6430598A04Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggggctgtct ctgcggcagg gcccagttcg gctcccccag tctctctctg tctctcctcc
       61 tccctcctcc tgctccgggc ggagcccggc atgggggggc cggcgcccgg caggccagtg
      121 gatccgggac ccagggaggg ccgccccccg ggcctggtgg cattaagcag ggcccctcag
      181 cccccacctc ttgccccacg acatgaacct tctctaccga aaaaccaagc tggagtggag
      241 acagcacaaa gaagaggagg ccaaacggag ctccagtaag gaagcagccc ccacaggccc
      301 ggtggggcct ggggctgtcc cagggcctgg ggttcgagtg cgagacattg cctcgcttcg
      361 acgatccctc aggatgggtt tcatgacgat gcccgcgtcc caggaacaca cccctcaccc
      421 ctgccgcagc accatggccc cacgctctct ctcctgccac tcggtgggca gcatggacag
      481 tgtaggtggt gggcctgggg gagggctcac ggaggacagc agcacccgga gacccccagc
      541 taagccccgg agacacccca gcaccaagct cagcatggca ggaccagggg cagagacacc
      601 tccaagtaag aaagcaggct cccagaagcc agctcccgaa tgccgtgagt ccagccggaa
      661 ggttccccca cagaaaccca ggcgaagccc caatacccag ctgtctgtgt cctttgatga
      721 gtcttgtgcc ccagccccat ctcctcgagg ggcgaacctg cccctgcaac gcctcagtag
      781 ggcttctcga ataactggag acctggatgc aggggcccag gaagaagagc cagtgtacat
      841 tgagatggta ggggatgtct ttcgaggagg aggacgaagt ggaggaggcc tggcgggacc
      901 tcctcttgga agtggaggcc caacccctcc agctgctgcc gattcggact ctgaagacag
      961 tgaggctatc tatgaagaga tgaagtaccc cttgcctgaa gaagcaggag atggcagggc
     1021 caacgggcct cctccattga cggcaccctc ccctccacaa cagacccata tcctccagcc
     1081 tcacccccac ccccatcgcc gtccagcttc agccctccca agccggaggg atgggacacc
     1141 caccaagacc acaccttgtg aaataccgcc accctttcct aacctccttc agcaccggcc
     1201 tccacttctg gccttccctc aagccaagtc tgcttcacga gcccctggtg atggggtctc
     1261 aaggctaccg gtcctctgcc actccaagga gccagctggt tccaccccag ctccccaagt
     1321 gcctgcacga gagcgggaga cgcctcccct accacctccg cctcctgctg ccaacctgct
     1381 attgctggga ccatcaggcc gagcccggag ccactcgaca ccgttgccac cccagggctc
     1441 tggccagacc aggggagagc gggaactccc gaactctcac agcatgatct gccccaaggc
     1501 ggcaggggta cccgcagccc accctgcccc agctgccttg ctccccggcc ctcccaagga
     1561 caaggccgtg tcgtacacta tggtgtattc tgcggtaaaa gtgaccacac actcggtcct
     1621 gccagctggt ccacccctgg gtgttggaga gccaaagaca gaggagattt cagtacttca
     1681 tggaatgctg tgtgccagtt cgaggccccc tgtcccaggg aaatccagcc cccatagcgg
     1741 ggctatgggt tcagcagctg gggtcctcca ccaccgcagc tgcctggcct ccccccacag
     1801 ccttccggat ccaactggag gttccctgac tcccctctgg acctacccag ccacagcagc
     1861 tgggctcaag agaccccctg cctatgacag cctcaaggct gggggggtgt tgaataaggg
     1921 ctgtggaatg ggggcaccat cccccatggt caagatccag ctgcaagagc aagggactga
     1981 tgggggtgcc tttgccagca tctcctgtgc ccatgtcatt gccagtgcgg ggacgccaga
     2041 agaggaagaa gagatggggg ccgcgtttgg ggcaggctgg gctctgcaga ggaaggtcct
     2101 gtatggagga cggaaggcaa aggaagtgga caaagaggac ggtgcccgag cctggaatgg
     2161 cagtacagaa ggtccaggca aagtcgaaca tgaggacagg ggccctgtgc catcagggat
     2221 tcctgtgagg agccaggggg cagagggtct gctggccagg atccaccatg atcgaggagg
     2281 gagccgcaca gcgctgcctg tcccttgcca gactttccct gcctgccacc ggaatggaga
     2341 tttcacggga gggtaccgcc tgggccgttc tgcgtccacc tctggagtcc gtcaggctgc
     2401 actccatacc ccacggccct gcagccagcc cagggatgcc ctgagccaga cacaccctgt
     2461 gctgcccctg cccctgccgc cccagccggc tcgggagcgc gatggcaaac tcctagaggt
     2521 gatcgagcgc aaacgctgcg tgtgcaagga gatcaaggca cgccaccgtc ccgaccgggg
     2581 gctctgcaag caagagagca tgcccatcct ccccagctgg cggcgggtcc ctgaaccccg
     2641 caagtctggt accccgccct gccggcggca gcacacggtc ctctgggaca ctgccatctg
     2701 aggaatacag gggcggctgg gactcctgga ttgggagggg aggggcctgc ctaggtctcc
     2761 ttgaggcttg agagatggag gaagtaggag aaagttccta ctaggcccat catgggggct
     2821 tggggtgcca gcagcagccc aagtaatttg ggggaggagg agggtttgct tgatgttgga
     2881 aggaagggtc taagtgtgta ggctcctctt gaagtgaagg ccaaggtgga gatctctgtg
     2941 gggtaaaagg gtttgaaaga agcgggggtg gggcatatag gagtctgact ggagtaacag
     3001 ggaaactcgg ctcttttatt gagagccagg ggagtgggga agggtattta ttttgctatt
     3061 tattttagtc tggagggcaa tttctgggcc cttctgacct actcctgagc aggaggtgga
     3121 gaaccaaggc taaatttgca ctctccccaa ggccagtgcc tacaggcctc tgccatcctt
     3181 gcccagtcaa cgggagggag ggaatgtggc tgcctccgga gcagagtcag aaggcagaga
     3241 ggcccagaca gtgacagtat ttatagtttt cccagaattt ggtagtgagt gtggtctgct
     3301 gtaaaacagg cattttattt agttctgggg taagggtcta gccagggatg ggtgggatgt
     3361 tcggggaaga gggagaacgt aagcgggtgg agggaggagc ggggtattta tttaaattaa
     3421 aaaaaaaaaa aaaaagctgt caggaacttt ttttaaattc ctttcttttc agaataatat
     3481 attaaaagac tcatgatcct a
//
