LOCUS       NM_183297               1675 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus neurexophilin 4 (Nxph4), mRNA.
ACCESSION   NM_183297
VERSION     NM_183297.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1675)
  AUTHORS   Munz,M., Bharioke,A., Kosche,G., Moreno-Juan,V., Brignall,A.,
            Rodrigues,T.M., Graff-Meyer,A., Ulmer,T., Haeuselmann,S.,
            Pavlinic,D., Ledergerber,N., Gross-Scherf,B., Rozsa,B., Krol,J.,
            Picelli,S., Cowan,C.S. and Roska,B.
  TITLE     Pyramidal neurons form active, transient, multilayered circuits
            perturbed by autism-associated mutations at the inception of
            neocortex
  JOURNAL   Cell 186 (9), 1930-1949 (2023)
   PUBMED   37071993
REFERENCE   2  (bases 1 to 1675)
  AUTHORS   Wang,Q., Wang,Y., Kuo,H.C., Xie,P., Kuang,X., Hirokawa,K.E.,
            Naeemi,M., Yao,S., Mallory,M., Ouellette,B., Lesnar,P., Li,Y.,
            Ye,M., Chen,C., Xiong,W., Ahmadinia,L., El-Hifnawi,L., Cetin,A.,
            Sorensen,S.A., Harris,J.A., Zeng,H. and Koch,C.
  TITLE     Regional and cell-type-specific afferent and efferent projections
            of the mouse claustrum
  JOURNAL   Cell Rep 42 (2), 112118 (2023)
   PUBMED   36774552
REFERENCE   3  (bases 1 to 1675)
  AUTHORS   Xu,P., He,H., Gao,Q., Zhou,Y., Wu,Z., Zhang,X., Sun,L., Hu,G.,
            Guan,Q., You,Z., Zhang,X., Zheng,W., Xiong,M. and Chen,Y.
  TITLE     Human midbrain dopaminergic neuronal differentiation markers
            predict cell therapy outcomes in a Parkinson's disease model
  JOURNAL   J Clin Invest 132 (14) (2022)
   PUBMED   35700056
REFERENCE   4  (bases 1 to 1675)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1675)
  AUTHORS   Wang,Q., Ding,S.L., Li,Y., Royall,J., Feng,D., Lesnar,P.,
            Graddis,N., Naeemi,M., Facer,B., Ho,A., Dolbeare,T., Blanchard,B.,
            Dee,N., Wakeman,W., Hirokawa,K.E., Szafer,A., Sunkin,S.M., Oh,S.W.,
            Bernard,A., Phillips,J.W., Hawrylycz,M., Koch,C., Zeng,H.,
            Harris,J.A. and Ng,L.
  TITLE     The Allen Mouse Brain Common Coordinate Framework: A 3D Reference
            Atlas
  JOURNAL   Cell 181 (4), 936-953 (2020)
   PUBMED   32386544
REFERENCE   6  (bases 1 to 1675)
  AUTHORS   Hoerder-Suabedissen,A., Oeschger,F.M., Krishnan,M.L., Belgard,T.G.,
            Wang,W.Z., Lee,S., Webber,C., Petretto,E., Edwards,A.D. and
            Molnar,Z.
  TITLE     Expression profiling of mouse subplate reveals a dynamic gene
            network and disease association with autism and schizophrenia
  JOURNAL   Proc Natl Acad Sci U S A 110 (9), 3555-3560 (2013)
   PUBMED   23401504
REFERENCE   7  (bases 1 to 1675)
  AUTHORS   Boyle,M.P., Bernard,A., Thompson,C.L., Ng,L., Boe,A., Mortrud,M.,
            Hawrylycz,M.J., Jones,A.R., Hevner,R.F. and Lein,E.S.
  TITLE     Cell-type-specific consequences of Reelin deficiency in the mouse
            neocortex, hippocampus, and amygdala
  JOURNAL   J Comp Neurol 519 (11), 2061-2089 (2011)
   PUBMED   21491433
REFERENCE   8  (bases 1 to 1675)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   9  (bases 1 to 1675)
  AUTHORS   Schilling,K. and Oberdick,J.
  TITLE     The treasury of the commons: making use of public gene expression
            resources to better characterize the molecular diversity of
            inhibitory interneurons in the cerebellar cortex
  JOURNAL   Cerebellum 8 (4), 477-489 (2009)
   PUBMED   19554387
REFERENCE   10 (bases 1 to 1675)
  AUTHORS   Missler,M., Hammer,R.E. and Sudhof,T.C.
  TITLE     Neurexophilin binding to alpha-neurexins. A single LNS domain
            functions as an independently folding ligand-binding unit
  JOURNAL   J Biol Chem 273 (52), 34716-34723 (1998)
   PUBMED   9856994
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK004130.1 and BE862089.1.
            
            On Nov 10, 2006 this sequence version replaced NM_183297.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004130.1, BY704372.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-701               AK004130.1         2-702
            702-923             BE862089.1         122-343
            924-1675            AK004130.1         923-1674
FEATURES             Location/Qualifiers
     source          1..1675
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.51 cM"
     gene            1..1675
                     /gene="Nxph4"
                     /gene_synonym="1110036M10Rik"
                     /note="neurexophilin 4"
                     /db_xref="GeneID:104080"
                     /db_xref="MGI:MGI:1336197"
     exon            1..184
                     /gene="Nxph4"
                     /gene_synonym="1110036M10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1042
                     /gene="Nxph4"
                     /gene_synonym="1110036M10Rik"
                     /codon_start=1
                     /product="neurexophilin-4"
                     /protein_id="NP_899120.2"
                     /db_xref="CCDS:CCDS36081.1"
                     /db_xref="GeneID:104080"
                     /db_xref="MGI:MGI:1336197"
                     /translation="MRLLPEWLLLLFGPWLLRKAVCGQIVESGRPQYLDLRPAMAGGG
                     ARGQQLPAPASSEGLGMARSWSWAWPANHTGALAKPGTAGGPSVPRTKRKPSIKAARA
                     KKIFGWGDFYFRVHTLKFSLLVTGKIVDHVNGTFSVYFRHNSSSLGNLSVSIVPPSKR
                     VEFGGVWLPGPASHPLQSTLALEGVLPGLGPPLGMAGQGLGSNLGGALAGPLGSALGV
                     PGAKESRAFNCHVEYEKTNRARKHRPCLYDPSQVCFTEHTQSQAAWLCAKPFKVICIF
                     VSFLSFDYKLVQKVCPDYNFQSEHPYFG"
     exon            185..1675
                     /gene="Nxph4"
                     /gene_synonym="1110036M10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1661..1666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nxph4"
                     /gene_synonym="1110036M10Rik"
                     /note="putative"
     polyA_site      1675
                     /gene="Nxph4"
                     /gene_synonym="1110036M10Rik"
                     /note="putative"
ORIGIN      
        1 gtccgcgggc cgagccgccc gctcccgctg ctcgcgccgc cgccctctgc ccggcgtccc
       61 tcaccctgag cccagtcctg ccggactcgg gacccgccct gcccgacccg ctcgaccgct
      121 cgggaagatg cggctgctcc cggaatggct cctcttgctc tttggtcctt ggctccttag
      181 gaaggctgtc tgtggccaga tcgtggagtc cgggaggccc cagtacctag acttgcgtcc
      241 cgccatggcc ggagggggcg cccgcggcca gcagctccca gcgcccgcat cttccgaggg
      301 cctgggcatg gcgcgctcct ggagctgggc ttggccggct aaccacaccg gggcgctggc
      361 caagccaggg acagccggtg gcccgtccgt gccgcgcacc aagaggaagc catccattaa
      421 agcggcccga gccaagaaga ttttcggctg gggggacttt tactttcgtg tgcataccct
      481 caagttctcg ctgttggtga ccggcaagat cgtggaccat gtgaacggta ccttcagtgt
      541 gtacttccgt cacaattcgt ccagcctggg taacctaagc gtcagtatcg tgccgccctc
      601 caagcgtgtg gagttcgggg gcgtctggtt gcctgggcct gcctcccacc ctctacagtc
      661 cacgctggca cttgaagggg tgcttcctgg attggggccc cctctgggga tggcggggca
      721 ggggctgggg agcaaccttg ggggcgcact tgccggccca ctcggaagcg cgctaggagt
      781 tcctggggcc aaagagtcgc gcgcttttaa ttgccacgtg gaatatgaga agacaaaccg
      841 cgctcgcaag caccgcccgt gcctgtacga cccgtcgcag gtgtgcttca ccgagcacac
      901 gcagagccag gccgcctggc tctgcgccaa gcccttcaaa gtcatctgta tcttcgtctc
      961 cttcctcagt tttgactaca aactggtgca gaaggtgtgc ccagactata acttccagag
     1021 tgagcacccc tactttggat aacgcccctg tcctgggccc cgagcttccc accagatcgc
     1081 agtctcacta ggtgggaccc ctccctgtat accccgtgct cctgtgactg cccccacttc
     1141 ttccactatg gtggagaaaa acagccttcc ccgggactat cagccagtgt ggccctctat
     1201 ttccttgtgg taccgagtgt ccctgaggct ggggtggtct ttttcaaacg gtaaattgca
     1261 ggggcaagag catagcccca cgataggtgg ggcttgaggt cttcttaggg ttccctacga
     1321 atgcgtattg cccacgccgc agtattaatg gctcctggcc tggcactctt tccccaagcc
     1381 ctggtcctcc cctcccctaa gactgtaaat gtctaaaagc gcccagccca tccaatcctc
     1441 tcccgttctg cgtgccccat gtcagtcctg ccttcttcct aaccttgcta aagcaaaagt
     1501 cctgatcagg gggctctgcc tggcccttgt gctctgccca ccccttccct cccccgccct
     1561 cagtccggct acacctgccc tctctggctg cttcctctcg gtgttttttg ttttttgttt
     1621 tgtttttttt tcaacgccaa aacagacggg gagggaacaa aataaagcga aatcc
//
