LOCUS       NM_130858               2083 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus neurexophilin 3 (Nxph3), mRNA.
ACCESSION   NM_130858
VERSION     NM_130858.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2083)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2083)
  AUTHORS   Loo,L., Simon,J.M., Xing,L., McCoy,E.S., Niehaus,J.K., Guo,J.,
            Anton,E.S. and Zylka,M.J.
  TITLE     Single-cell transcriptomic analysis of mouse neocortical
            development
  JOURNAL   Nat Commun 10 (1), 134 (2019)
   PUBMED   30635555
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2083)
  AUTHORS   Nishimura,K., Murayama,S. and Takahashi,J.
  TITLE     Identification of Neurexophilin 3 as a Novel Supportive Factor for
            Survival of Induced Pluripotent Stem Cell-Derived Dopaminergic
            Progenitors
  JOURNAL   Stem Cells Transl Med 4 (8), 932-944 (2015)
   PUBMED   26041738
  REMARK    GeneRIF: We report that a secreted peptide, neurexophilin 3
            (NXPH3), supports the survival of mouse induced pluripotent stem
            cell-derived (iPSC-derived) dopaminergic (DA) neurons in vitro and
            in vivo
REFERENCE   4  (bases 1 to 2083)
  AUTHORS   Hupe,M., Li,M.X., Gertow Gillner,K., Adams,R.H. and Stenman,J.M.
  TITLE     Evaluation of TRAP-sequencing technology with a versatile
            conditional mouse model
  JOURNAL   Nucleic Acids Res 42 (2), e14 (2014)
   PUBMED   24165879
REFERENCE   5  (bases 1 to 2083)
  AUTHORS   Beglopoulos,V., Montag-Sallaz,M., Rohlmann,A., Piechotta,K.,
            Ahmad,M., Montag,D. and Missler,M.
  TITLE     Neurexophilin 3 is highly localized in cortical and cerebellar
            regions and is functionally important for sensorimotor gating and
            motor coordination
  JOURNAL   Mol Cell Biol 25 (16), 7278-7288 (2005)
   PUBMED   16055736
  REMARK    GeneRIF: Neurexophilin 3 has a role as a locally and temporally
            regulated neuropeptide-like molecule, presumably acting in a
            complex with alpha-neurexins in select neuronal circuits
REFERENCE   6  (bases 1 to 2083)
  AUTHORS   Missler,M., Hammer,R.E. and Sudhof,T.C.
  TITLE     Neurexophilin binding to alpha-neurexins. A single LNS domain
            functions as an independently folding ligand-binding unit
  JOURNAL   J Biol Chem 273 (52), 34716-34723 (1998)
   PUBMED   9856994
REFERENCE   7  (bases 1 to 2083)
  AUTHORS   Missler,M. and Sudhof,T.C.
  TITLE     Neurexophilins form a conserved family of neuropeptide-like
            glycoproteins
  JOURNAL   J Neurosci 18 (10), 3630-3638 (1998)
   PUBMED   9570794
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662875.14.
            
            On Mar 18, 2023 this sequence version replaced NM_130858.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158760.1, BC007167.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-395               AL662875.14        141965-142359       c
            396-2083            AL662875.14        137650-139337       c
FEATURES             Location/Qualifiers
     source          1..2083
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.01 cM"
     gene            1..2083
                     /gene="Nxph3"
                     /note="neurexophilin 3"
                     /db_xref="GeneID:104079"
                     /db_xref="MGI:MGI:1336188"
     exon            1..395
                     /gene="Nxph3"
                     /inference="alignment:Splign:2.1.0"
     CDS             342..1100
                     /gene="Nxph3"
                     /codon_start=1
                     /product="neurexophilin-3 precursor"
                     /protein_id="NP_570928.1"
                     /db_xref="CCDS:CCDS25278.1"
                     /db_xref="GeneID:104079"
                     /db_xref="MGI:MGI:1336188"
                     /translation="MQLTRCCFVFLVQGSLYLVICGQDDGPPGSEDPEHDDHEGQPRP
                     RVPRKRGHISPKSRPLANSTLLGLLAPPGEVWGVLGQPPNRPKQSPLPSTKVKKIFGW
                     GDFYSNIKTVALNLLVTGKIVDHGNGTFSVHFRHNATGQGNISISLVPPSKAVEFHQE
                     QQIFIEAKASKIFNCRMEWEKVERGRRTSLCTHDPAKICSRDHAQSSATWSCSQPFKV
                     VCVYIAFYSTDYRLVQKVCPDYNYHSDTPYYPSG"
     exon            396..2083
                     /gene="Nxph3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2059..2064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nxph3"
                     /note="hexamer: AATAAA"
     polyA_site      2076
                     /gene="Nxph3"
                     /note="major polyA site"
ORIGIN      
        1 acatctgggt gagagccgag cctctggaaa caagccgggc gccgagcgcc tgtctggagc
       61 ggcagagtca ccgctcagcc ggagcccctt cgagacgctc cgggcgcaca tctgggactg
      121 ggagaaggga ccgcgcggcg agcagctgga ctcggggagg gggcggcggc tgcacagctg
      181 gaccgaaggg ggcggggtcg gtcccagcaa ctggctgagg ggagggccgc gagccaccgg
      241 ggaccggagc atgggacagc gcgcctgaag gagcagtccg ggacggaggg ggcctgggac
      301 cccgaaagga aaagagagac gggtgagagc aaaggaggaa gatgcaactg acccgttgct
      361 gcttcgtgtt cctagtgcag ggcagcctct atctggtcat ctgcggccaa gacgatggcc
      421 cgcctggctc agaggaccct gaacacgatg accatgaggg ccagcctcgg cctagggtgc
      481 ctcgcaagcg aggtcatatc tcacctaagt cccgcccctt ggccaactcc accctcctag
      541 ggctgttagc cccacccggg gaggtttggg gtgtccttgg gcagcccccc aaccgcccca
      601 aacaaagtcc cttaccctcg accaaggtga aaaaaatatt tggatggggt gatttctact
      661 ccaacatcaa gacagtggcc ctgaacctgc tggtcacagg caagattgtg gaccacggaa
      721 acgggacctt cagcgtccac ttccgccaca acgccacggg ccaaggtaac atctccatca
      781 gccttgtacc ccccagcaaa gctgtggagt ttcaccaaga gcagcagatc ttcatcgaag
      841 ccaaggcatc caaaattttc aactgccgga tggagtggga gaaggtagaa cggggccgcc
      901 ggacctcgct ctgtacccac gacccagcca agatctgttc ccgtgaccac gctcagagct
      961 cggccacctg gagctgctcc cagcccttca aagttgtctg cgtctatatt gccttctata
     1021 gcacggacta tcgactggtg cagaaggtgt gcccagatta caactaccac agtgataccc
     1081 cctactaccc atctgggtga cctagatggg cggcagaggc cggtgcagga ggctggctgg
     1141 ctggacactg ggcagggaaa gggatggacc tcaggtaggg agggggtgga gaggaagaga
     1201 ggcctggtgg gtcaggatca agcgtcaggt gttggggaag ggtccccagt gctgtgccca
     1261 acctgaggtt agaagatact tgttatggaa gagaaatatg ccctgggcag ccttacaggg
     1321 ctttccctcc tatccaaagc agatgctggg ccccgaggcc cctgggcagg gaagccaggc
     1381 aaccccagat caagccacag agaagacctc aacctttgtc tctctccttg ctattcagaa
     1441 ggaggacagt ggtcagcaaa ggggagtcca actgtgtaga caacttagga tggagagctc
     1501 aatggcgtct cccgtgggag ccggcagtgg gcagcccctt cccccccccc ctcccccgca
     1561 ctgaggctga aatggcaacc tcatccccac ccttgggtgt ttgctgtcat gactctcggt
     1621 caccagccag gccattcctt tccagaaatc ccctctccct ccctccagca cctttgtacc
     1681 gctgacacct cttgctgatg gcgcgccacc cttgtccttc agctgagaca ggatgactat
     1741 aggtcctgtt agcatgaggg gcacaaagca gaagtccgcc catgtgctgt atgcccatcc
     1801 tctgccctaa ccacctgctg agagtgctcc ctcccttgac agccagttct tcctgtaaga
     1861 ctggggcatt ctgggatagg gatagagcct cctttgctgg gcggtggggc tatccgcaga
     1921 ggaaggctca ggaggctatg tggccatgct ggaactgtgc cctagtgttg tctgtggggt
     1981 gtgtgtgggg ggaggggtgg gaagtcttgt gagatgccct gtcacttctc tgtgcagagt
     2041 cttgtccttg gagcaggaaa taaagcattc ccaggacact gta
//
