LOCUS       NM_008752               2579 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus neurexophilin 2 (Nxph2), mRNA.
ACCESSION   NM_008752
VERSION     NM_008752.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2579)
  AUTHORS   Morarach,K., Mikhailova,A., Knoflach,V., Memic,F., Kumar,R., Li,W.,
            Ernfors,P. and Marklund,U.
  TITLE     Diversification of molecularly defined myenteric neuron classes
            revealed by single-cell RNA sequencing
  JOURNAL   Nat Neurosci 24 (1), 34-46 (2021)
   PUBMED   33288908
REFERENCE   2  (bases 1 to 2579)
  AUTHORS   Bierut,L.J., Agrawal,A., Bucholz,K.K., Doheny,K.F., Laurie,C.,
            Pugh,E., Fisher,S., Fox,L., Howells,W., Bertelsen,S.,
            Hinrichs,A.L., Almasy,L., Breslau,N., Culverhouse,R.C., Dick,D.M.,
            Edenberg,H.J., Foroud,T., Grucza,R.A., Hatsukami,D.,
            Hesselbrock,V., Johnson,E.O., Kramer,J., Krueger,R.F., Kuperman,S.,
            Lynskey,M., Mann,K., Neuman,R.J., Nothen,M.M., Nurnberger,J.I. Jr.,
            Porjesz,B., Ridinger,M., Saccone,N.L., Saccone,S.F., Schuckit,M.A.,
            Tischfield,J.A., Wang,J.C., Rietschel,M., Goate,A.M. and Rice,J.P.
  CONSRTM   Gene, Environment Association Studies Consortium
  TITLE     A genome-wide association study of alcohol dependence
  JOURNAL   Proc Natl Acad Sci U S A 107 (11), 5082-5087 (2010)
   PUBMED   20202923
  REMARK    GeneRIF: NXPH2 is 200 kb upstream of SNP rs10803574 that has been
            associated with alcoholism in two human cohorts (p <10e-6) and is a
            strong positional candidate.
REFERENCE   3  (bases 1 to 2579)
  AUTHORS   Missler,M., Hammer,R.E. and Sudhof,T.C.
  TITLE     Neurexophilin binding to alpha-neurexins. A single LNS domain
            functions as an independently folding ligand-binding unit
  JOURNAL   J Biol Chem 273 (52), 34716-34723 (1998)
   PUBMED   9856994
REFERENCE   4  (bases 1 to 2579)
  AUTHORS   Petrenko,A.G., Ullrich,B., Missler,M., Krasnoperov,V., Rosahl,T.W.
            and Sudhof,T.C.
  TITLE     Structure and evolution of neurexophilin
  JOURNAL   J Neurosci 16 (14), 4360-4369 (1996)
   PUBMED   8699246
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK038402.1 and
            U56650.1.
            
            On Apr 6, 2007 this sequence version replaced NM_008752.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK038402.1, BC106864.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2579              AK038402.1         2-2580
FEATURES             Location/Qualifiers
     source          1..2579
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 15.28 cM"
     gene            1..2579
                     /gene="Nxph2"
                     /note="neurexophilin 2"
                     /db_xref="GeneID:18232"
                     /db_xref="MGI:MGI:107491"
     exon            1..294
                     /gene="Nxph2"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..1029
                     /gene="Nxph2"
                     /codon_start=1
                     /product="neurexophilin-2 precursor"
                     /protein_id="NP_032778.1"
                     /db_xref="CCDS:CCDS15729.1"
                     /db_xref="GeneID:18232"
                     /db_xref="MGI:MGI:107491"
                     /translation="MSLRPLPLLVVPGLLQLLFCDSEEVIHNTESVDWEDRTVPETLV
                     GNLFHSRITSPLRLFVKQPPDPKPSYADNTKNFWDWLANITEIQEQLARTKRRPIVKT
                     GKFKKMFGWGDFHSNIKTVKLNLLITGKIVDHGNGTFSVYFRHNSTGLGNVSVSLVPP
                     SKVVEFEISPQSTLETKESKSFNCHIEYEKTDRAKKTALCNFDPSKICYQEQTQSHVS
                     WLCSKPFKVICIHIIFYSVDYKLVQKVCPDYNYHSETPYLSFG"
     exon            295..2579
                     /gene="Nxph2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2579
                     /gene="Nxph2"
                     /note="putative"
ORIGIN      
        1 agacctccag ctgctcacga cagagtcaag gcgcagtttg agagaagccc tgcagctctg
       61 cggctttcct accacttgaa agaggctcag ggcacgcaaa ccacacctcc tgcccgtccc
      121 tccttctagg ctctctgtcc actggccgct gggtcctcaa cgtccttagc cttctgcacg
      181 aagtggagat gcgagagatg atggtgaggg agctcagctc ctgagatcgc gccagctggc
      241 acgatgagct tgcggccgct gcctctcctt gtagtcccag gcttgctgca gctgctattt
      301 tgtgacagtg aagaagtgat acacaacaca gagagtgtgg actgggaaga cagaactgtt
      361 cctgaaacat tggttggaaa tctgttccat tcaaggatta ccagtcctct gcgtctgttt
      421 gttaaacagc ctccagatcc aaagccatca tatgcagaca acacgaaaaa cttttgggat
      481 tggctggcaa acataacaga aattcaggag caactagcaa gaactaaaag acggccaata
      541 gtgaagacag gaaaatttaa aaaaatgttt gggtggggtg atttccactc taacattaaa
      601 actgtcaaac ttaacttgct catcacagga aaaattgttg atcatggaaa cggaacattc
      661 agtgtttatt tccgacacaa ttcaacaggt ctgggcaatg tttcagtgag cttggtacct
      721 ccctctaaag tagtagaatt tgaaatatcc ccccagtcta ccttggagac taaggaatcc
      781 aaatctttta actgccatat tgagtatgaa aaaacagatc gggcaaagaa gaccgctttg
      841 tgcaatttcg acccatccaa aatctgctac caggagcaga ctcagagtca tgtgtcctgg
      901 ttatgttcca aaccatttaa ggtcatctgc attcacatta tcttttacag tgttgattat
      961 aaacttgtac aaaaggtttg tcctgactac aattaccata gtgagacacc atacttatct
     1021 tttggataaa tcttttctcc aatagtaata gaaatgaaat attcatgtca ctttacctag
     1081 aatgctcata aaacagtgcc agatttccat ggcaaaaaaa tccttctatt tctggcagtg
     1141 gactgcaatt ccttgtccag atttcaaatt ttaaaaatat attcaaatgt gaagtgcatc
     1201 tgttttggtg agagtaacct gatctaaaac gttaaactga ctgaaaccag cattttcatg
     1261 taagatggta acattctgga aatattgctt ctctgtaaga atcatgagca gtgaccatgt
     1321 gtaaagggag aaaccaaatt gtgtatgcaa taagcactgc tcttcaaatg agcctgcctt
     1381 tgaaatgctt tgtaaggttt ccttagaaag agtaggttca gtaaagtaac tgaagaaatg
     1441 gtatttaaga gatgggttgt gtttttctgg tgttgaaacc tttttaaaaa ttactatctc
     1501 ttgttgccaa ttttaatagc tacagtgtct caagagaatc aaatacaata ccatctgagc
     1561 agtctgagta gaaagtgctt gaagcacttt actattatga ctctcatttg agtggtattg
     1621 gaacatacca tttaggtatt agatatgcaa atgtggattt aagtcaactc aacaatcacg
     1681 aagatgatat ttttcaatgt tgtgggatta ttttttaaat tcttattcat atgaaagttt
     1741 gggacttcat tccattattt aatagtccaa ttttatatat acatttgtgg aacaactctg
     1801 aaattgaaag aaagtatttc tgggcagaaa attccacagt catgggttca ttatatgtaa
     1861 ggcctcagat taggttttcc ttgtgtttga gtaatcacca gaatgagact aagaattctg
     1921 tgtggaaata atgagttata tttcagtatt tctaaatatt aagtgattat atttataatg
     1981 tctgtattac tgagcttttg agattacttt actctcagtg tactcatctt cgagaaaagt
     2041 tgaatggcca tctttatgat gtaccctggc actgtatgag aacagataaa aggaaaaaga
     2101 ctgataggac ttgagacttg tggttattct cctctagtag atattaactt ctatctgact
     2161 tctcatctgt acaatgttaa acaagtaaag tattcaaata ggactcatag aaggtaagtc
     2221 ctaacaaaca aatgcgctct tgtcacattg ttcagaaagt ctacagctct gttctctatt
     2281 ttacattcct attctgttct tttcttggaa ataactatag tgtcttattt tgtcttttgt
     2341 acaggttgtg ttaggcttgt atatggtagt ccgtccatgc ttggtatttc tcctttaaga
     2401 tcatttggtg cttgattttg ttgttggtaa ataatatttt gagacatctt acgttcatct
     2461 agaaacatga atacaaacta attattgtaa aatatatgtg aacatatata cttaggattt
     2521 tcggtataca aatgaagtat gtgtgcattt ttatgtaaat aaaataattt acaaactct
//
