LOCUS       NM_008751               1783 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus neurexophilin 1 (Nxph1), mRNA.
ACCESSION   NM_008751 XM_001474333
VERSION     NM_008751.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1783)
  AUTHORS   Cheffer,A., Garcia-Miralles,M., Maier,E., Akol,I., Franz,H.,
            Srinivasan,V.S.V. and Vogel,T.
  TITLE     DOT1L deletion impairs the development of cortical
            parvalbumin-expressing interneurons
  JOURNAL   Cereb Cortex 33 (19), 10272-10285 (2023)
   PUBMED   37566909
REFERENCE   2  (bases 1 to 1783)
  AUTHORS   Moreau,M.X., Saillour,Y., Cwetsch,A.W., Pierani,A. and Causeret,F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   3  (bases 1 to 1783)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1783)
  AUTHORS   Wu,D., Schieren,I., Qian,Y., Zhang,C., Jessell,T.M. and de
            Nooij,J.C.
  TITLE     A Role for Sensory end Organ-Derived Signals in Regulating Muscle
            Spindle Proprioceptor Phenotype
  JOURNAL   J Neurosci 39 (22), 4252-4267 (2019)
   PUBMED   30926747
REFERENCE   5  (bases 1 to 1783)
  AUTHORS   Loo,L., Simon,J.M., Xing,L., McCoy,E.S., Niehaus,J.K., Guo,J.,
            Anton,E.S. and Zylka,M.J.
  TITLE     Single-cell transcriptomic analysis of mouse neocortical
            development
  JOURNAL   Nat Commun 10 (1), 134 (2019)
   PUBMED   30635555
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1783)
  AUTHORS   Batista-Brito,R., Machold,R., Klein,C. and Fishell,G.
  TITLE     Gene expression in cortical interneuron precursors is prescient of
            their mature function
  JOURNAL   Cereb Cortex 18 (10), 2306-2317 (2008)
   PUBMED   18250082
REFERENCE   7  (bases 1 to 1783)
  AUTHORS   Beglopoulos,V., Montag-Sallaz,M., Rohlmann,A., Piechotta,K.,
            Ahmad,M., Montag,D. and Missler,M.
  TITLE     Neurexophilin 3 is highly localized in cortical and cerebellar
            regions and is functionally important for sensorimotor gating and
            motor coordination
  JOURNAL   Mol Cell Biol 25 (16), 7278-7288 (2005)
   PUBMED   16055736
REFERENCE   8  (bases 1 to 1783)
  AUTHORS   Clarris,H.J., McKeown,S. and Key,B.
  TITLE     Expression of neurexin ligands, the neuroligins and the
            neurexophilins, in the developing and adult rodent olfactory bulb
  JOURNAL   Int J Dev Biol 46 (4), 649-652 (2002)
   PUBMED   12141453
  REMARK    GeneRIF: Study on the expression of NXPH1 in the developing and
            adult olfactory bulb
REFERENCE   9  (bases 1 to 1783)
  AUTHORS   Missler,M., Hammer,R.E. and Sudhof,T.C.
  TITLE     Neurexophilin binding to alpha-neurexins. A single LNS domain
            functions as an independently folding ligand-binding unit
  JOURNAL   J Biol Chem 273 (52), 34716-34723 (1998)
   PUBMED   9856994
REFERENCE   10 (bases 1 to 1783)
  AUTHORS   Petrenko,A.G., Ullrich,B., Missler,M., Krasnoperov,V., Rosahl,T.W.
            and Sudhof,T.C.
  TITLE     Structure and evolution of neurexophilin
  JOURNAL   J Neurosci 16 (14), 4360-4369 (1996)
   PUBMED   8699246
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC145955.1.
            
            On or before Feb 15, 2009 this sequence version replaced
            XM_001474333.1, NM_008751.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145953.1, BC068137.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1783
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 4.38 cM"
     gene            1..1783
                     /gene="Nxph1"
                     /gene_synonym="C130005L03Rik"
                     /note="neurexophilin 1"
                     /db_xref="GeneID:18231"
                     /db_xref="MGI:MGI:107492"
     exon            1..289
                     /gene="Nxph1"
                     /gene_synonym="C130005L03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..1051
                     /gene="Nxph1"
                     /gene_synonym="C130005L03Rik"
                     /codon_start=1
                     /product="neurexophilin-1 precursor"
                     /protein_id="NP_032777.3"
                     /db_xref="CCDS:CCDS39426.1"
                     /db_xref="GeneID:18231"
                     /db_xref="MGI:MGI:107492"
                     /translation="MQAACWYVLLLLQPTVYLVTCANLTNGGKSELLKSGSSKSTLKH
                     IWTESSKDLSISRLLSQTFRGKENDTDLDLRYDTPEPYSEQDLWDWLRNSTDLQEPRP
                     RAKRRPIVKTGKFKKMFGWGDFHSNIKTVKLNLLITGKIVDHGNGTFSVYFRHNSTGQ
                     GNVSVSLVPPTKIVEFDLAQQTVIDAKDSKSFNCRIEYEKVDKATKNTLCNYDPSKTC
                     YQEQTQSHVSWLCSKPFKVICIYISFYSTDYKLVQKVCPDYNYHSDTPYFPSG"
     exon            290..1783
                     /gene="Nxph1"
                     /gene_synonym="C130005L03Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caatctttgc gtcccccttc caagcttttt gactccatca ctccacacca agagcccctt
       61 tcccctcgct tgatcgtcag ccttgtccgc gtggtcatgg gatgtctaat ttcatttgta
      121 tctaggctgc tgagagcgct ccctgctctg taaagtggat gtcaggtgga tctatgtttt
      181 tgaaggaaca aagactcagc caaggcaccg ccaaggaagt ttgagaggag ggaggatgca
      241 ggctgcgtgc tggtacgttc ttctcctcct gcagcccacc gtctacttgg tcacgtgtgc
      301 caacctaaca aatggtggga aatcggaact actgaagtca gggagcagca aatccacgct
      361 aaagcacata tggacagaaa gcagcaaaga cttgtctatc agtcggctcc tctcacagac
      421 tttccgtggt aaagaaaatg acacagattt ggacctgcgc tatgacaccc cagaacctta
      481 ttctgagcaa gacctctggg actggctgag gaactccaca gatcttcagg agcctcggcc
      541 cagggccaaa agacggccca ttgttaaaac tggcaagttt aagaaaatgt ttggatgggg
      601 tgattttcat tccaacatca aaacagtgaa gctaaacctg ttgataactg ggaaaattgt
      661 agatcacggc aatggaacct ttagtgtata tttcaggcat aactccactg gtcaagggaa
      721 tgtatctgtc agcttggtgc ccccaacaaa aatcgtggaa ttcgatttgg cacaacaaac
      781 cgtgattgat gctaaagatt ccaagtcctt caactgtcgc attgagtatg agaaggttga
      841 caaggccacc aagaacacac tctgcaacta cgacccttca aaaacctgtt accaggagca
      901 gacccaaagt cacgtgtcct ggctctgctc taagcccttc aaggtgatct gtatttacat
      961 ttccttttat agtacagact ataaactagt acagaaggta tgccctgact acaactatca
     1021 cagtgacaca ccttactttc cctccggatg aagatgaaca gggcctgaga ctgaagcctg
     1081 cggagttaaa ggtcatagga cagggctgtc accttaagga agaaggtcac atctgttgcc
     1141 tggaatgtgt ctaccttgct gctcttgttg actggtgcac acatgctagt ggaaaacaat
     1201 tgatgtcatt tctgcacagt cagcttcatc tctcagcata gttgtaaatc accatagatc
     1261 tcagagtctc atctgaagac atgctgtcac gaatagaggc ccatgagcat ccattcttgc
     1321 acatttcagc tcacatctat catggttccc tgtgagagag ctttcattgt ctgactcatg
     1381 atggttcagg acaaactatg atcaaacaaa aagaattaac tagacagagg atgtgtctaa
     1441 catgctgtta cggaaatctc ttttaaggtc ttgagtccat gctaatcgat aatccccact
     1501 catgcattcc tactgcttgg agtagctgtg ctggtgaata ctactgtagg agttatatgc
     1561 ttgttaaatg gaaaaaaatg tgtctttaga gctcagtatt ctttatttta tgaacacaac
     1621 acagtgtagt agctttttcc cagcatacag tagacacatt caaggtgata cagggtggct
     1681 tttctttcta tggagggagg agcttgttct cagtaaagat gagcaaacat ttggaattta
     1741 catgtgggcg gacagcttat cttgcctatc accggacctt tgc
//
