LOCUS       NM_001418760            1052 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus nucleoredoxin-like 2 (Nxnl2), transcript variant 2,
            mRNA.
ACCESSION   NM_001418760
VERSION     NM_001418760.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1052)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1052)
  AUTHORS   Jaillard,C., Ouechtati,F., Clerin,E., Millet-Puel,G., Corsi,M.,
            Ait-Ali,N., Blond,F., Chevy,Q., Gales,L., Farinelli,M., Dalkara,D.,
            Sahel,J.A., Portais,J.C., Poncer,J.C. and Leveillard,T.
  TITLE     The metabolic signaling of the nucleoredoxin-like 2 gene supports
            brain function
  JOURNAL   Redox Biol 48, 102198 (2021)
   PUBMED   34856436
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 1052)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1052)
  AUTHORS   Elachouri,G., Lee-Rivera,I., Clerin,E., Argentini,M., Fridlich,R.,
            Blond,F., Ferracane,V., Yang,Y., Raffelsberger,W., Wan,J.,
            Bennett,J., Sahel,J.A., Zack,D.J. and Leveillard,T.
  TITLE     Thioredoxin rod-derived cone viability factor protects against
            photooxidative retinal damage
  JOURNAL   Free Radic Biol Med 81, 22-29 (2015)
   PUBMED   25596499
REFERENCE   5  (bases 1 to 1052)
  AUTHORS   Jaillard,C., Mouret,A., Niepon,M.L., Clerin,E., Yang,Y.,
            Lee-Rivera,I., Ait-Ali,N., Millet-Puel,G., Cronin,T., Sedmak,T.,
            Raffelsberger,W., Kinzel,B., Trembleau,A., Poch,O., Bennett,J.,
            Wolfrum,U., Lledo,P.M., Sahel,J.A. and Leveillard,T.
  TITLE     Nxnl2 splicing results in dual functions in neuronal cell survival
            and maintenance of cell integrity
  JOURNAL   Hum Mol Genet 21 (10), 2298-2311 (2012)
   PUBMED   22343139
  REMARK    GeneRIF: This study shows that Nxnl2 is a bi-functional gene
            involved in the maintenance of both the function and the viability
            of sensory neurons.
REFERENCE   6  (bases 1 to 1052)
  AUTHORS   Lambard,S., Reichman,S., Berlinicke,C., Niepon,M.L., Goureau,O.,
            Sahel,J.A., Leveillard,T. and Zack,D.J.
  TITLE     Expression of rod-derived cone viability factor: dual role of CRX
            in regulating promoter activity and cell-type specificity
  JOURNAL   PLoS One 5 (10), e13075 (2010)
   PUBMED   20949100
  REMARK    GeneRIF: regulation of the Nucleoredoxin-like genes involves a CRX
            responsive element that can act as both as a positive regulator of
            promoter activity and as a modulator of cell-type specificity
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1052)
  AUTHORS   Chalmel,F., Leveillard,T., Jaillard,C., Lardenois,A., Berdugo,N.,
            Morel,E., Koehl,P., Lambrou,G., Holmgren,A., Sahel,J.A. and Poch,O.
  TITLE     Rod-derived Cone Viability Factor-2 is a novel
            bifunctional-thioredoxin-like protein with therapeutic potential
  JOURNAL   BMC Mol Biol 8, 74 (2007)
   PUBMED   17764561
  REMARK    GeneRIF: RdCVF2 shares many similarities with Rod-derived Cone
            Viability Factor in terms of gene structure, expression in a
            rod-dependent manner and protein 3D structure.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160122.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784646.917326.1,
                                           SRR17784650.769842.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AC160122.2         152277-152394
            119-488             AC160122.2         152693-153062
            489-1052            AC160122.2         156063-156626
FEATURES             Location/Qualifiers
     source          1..1052
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 26.08 cM"
     gene            1..1052
                     /gene="Nxnl2"
                     /gene_synonym="4930519N16Rik; Rdcvf2"
                     /note="nucleoredoxin-like 2"
                     /db_xref="GeneID:75124"
                     /db_xref="MGI:MGI:1922374"
     exon            1..118
                     /gene="Nxnl2"
                     /gene_synonym="4930519N16Rik; Rdcvf2"
                     /inference="alignment:Splign:2.1.0"
     exon            119..488
                     /gene="Nxnl2"
                     /gene_synonym="4930519N16Rik; Rdcvf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..657
                     /gene="Nxnl2"
                     /gene_synonym="4930519N16Rik; Rdcvf2"
                     /EC_number="1.8.1.8"
                     /note="rod-derived cone viability factor 2"
                     /codon_start=1
                     /product="nucleoredoxin-like protein 2"
                     /protein_id="NP_001405689.1"
                     /db_xref="GeneID:75124"
                     /db_xref="MGI:MGI:1922374"
                     /translation="MVDVLGGRRLVTREGTVVEAEVALQNKVVALYFAAGRCSPSRDF
                     TPLLCDFYTELVSEARRPAPFEVVFVSADGSAEEMLDFMRELHGSWLALPFHDPYRHE
                     LKKRYEITAIPKLVVIKQNGAVITNKGRKQIRERGLACFQNWVEAADVFQNFSG"
     exon            489..1052
                     /gene="Nxnl2"
                     /gene_synonym="4930519N16Rik; Rdcvf2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1029..1034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nxnl2"
                     /gene_synonym="4930519N16Rik; Rdcvf2"
                     /note="hexamer: AATAAA"
     polyA_site      1052
                     /gene="Nxnl2"
                     /gene_synonym="4930519N16Rik; Rdcvf2"
                     /note="major polyA site"
ORIGIN      
        1 aacagaactc cggtccgcag aacagagcag gagtggatta ggtggtgtgg aactgggccc
       61 gtggggtggg atgggggcgt ggacccgaac aagcctcgga tgtccggact agttgtggct
      121 aacaggtggc cgtgcagccc agggctcgtc tctccactgt gtcctcttca cgccgagctc
      181 gtggcgatgg tggacgtgct gggcgggcgg cgcctggtga cccgggaggg cacggtggtg
      241 gaggccgagg tggcgctgca gaacaaggtg gtagctttgt actttgcggc gggccggtgc
      301 tcgcccagcc gcgacttcac gccgctgctc tgcgacttct acacggagct ggtgagcgag
      361 gcgcggcggc ccgctccctt cgaggtggtt ttcgtgtcgg cagacggcag tgcggaggag
      421 atgttggact tcatgcgcga gctgcacggc tcctggctgg cattgccctt ccacgacccc
      481 taccggcatg aactgaagaa gaggtacgaa atcaccgcca tccccaagct ggtggtcatc
      541 aagcagaacg gagctgtcat caccaacaaa gggcggaagc agatccgaga gcgcgggcta
      601 gcttgctttc agaactgggt ggaagcagcc gatgttttcc aaaacttctc ggggtgacca
      661 gggcagttgc tggaagttca gggcaactat cttcaaaaag ggcttagctg gttcccttct
      721 ctgctgagga atgtcattgt agagtcacca tgctgtgaca gagagcataa actgctcagg
      781 aaagaactac gtctgccccc tgtgggtcct agagctccgt tgaatgttta tttcttacac
      841 ctttctccac cggtgcctag gatccaggac acatcagcca cgagttaaca gaactctatg
      901 caagatgctc tttcctacag gaaatttctt tgataaattg acctatggag gtgatacatt
      961 ttctgatgac atttttgtga tgctttggta aacgtattta ttactcaggt ttgtagactg
     1021 tgtaatttaa taaaccaaca ctcacacttt ga
//
