LOCUS       NM_145598               2764 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus nucleoredoxin-like 1 (Nxnl1), mRNA.
ACCESSION   NM_145598 XM_985532 XM_985570
VERSION     NM_145598.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2764)
  AUTHORS   Kim,K.M. and Jang,W.G.
  TITLE     NXNL1 negatively regulates osteoblast differentiation via
            GDF15-induced PP2A Calpha dependent manner in MC3T3-E1 cells
  JOURNAL   Biofactors 48 (1), 239-248 (2022)
   PUBMED   34932831
  REMARK    GeneRIF: NXNL1 negatively regulates osteoblast differentiation via
            GDF15-induced PP2A Calpha dependent manner in MC3T3-E1 cells.
REFERENCE   2  (bases 1 to 2764)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2764)
  AUTHORS   Mei,X., Chaffiol,A., Kole,C., Yang,Y., Millet-Puel,G., Clerin,E.,
            Ait-Ali,N., Bennett,J., Dalkara,D., Sahel,J.A., Duebel,J. and
            Leveillard,T.
  TITLE     The Thioredoxin Encoded by the Rod-Derived Cone Viability Factor
            Gene Protects Cone Photoreceptors Against Oxidative Stress
  JOURNAL   Antioxid Redox Signal 24 (16), 909-923 (2016)
   PUBMED   27025156
  REMARK    GeneRIF: RdCVFL is a cell-autonomous mechanism of protection.
REFERENCE   4  (bases 1 to 2764)
  AUTHORS   Ait-Ali,N., Fridlich,R., Millet-Puel,G., Clerin,E., Delalande,F.,
            Jaillard,C., Blond,F., Perrocheau,L., Reichman,S., Byrne,L.C.,
            Olivier-Bandini,A., Bellalou,J., Moyse,E., Bouillaud,F., Nicol,X.,
            Dalkara,D., van Dorsselaer,A., Sahel,J.A. and Leveillard,T.
  TITLE     Rod-derived cone viability factor promotes cone survival by
            stimulating aerobic glycolysis
  JOURNAL   Cell 161 (4), 817-832 (2015)
   PUBMED   25957687
  REMARK    GeneRIF: Study shows that RdCVF acts through binding to Basigin-1
            (BSG1), a transmembrane protein expressed specifically by
            photoreceptors. BSG1 binds to the glucose transporter GLUT1,
            resulting in increased glucose entry into cones.
REFERENCE   5  (bases 1 to 2764)
  AUTHORS   Elachouri,G., Lee-Rivera,I., Clerin,E., Argentini,M., Fridlich,R.,
            Blond,F., Ferracane,V., Yang,Y., Raffelsberger,W., Wan,J.,
            Bennett,J., Sahel,J.A., Zack,D.J. and Leveillard,T.
  TITLE     Thioredoxin rod-derived cone viability factor protects against
            photooxidative retinal damage
  JOURNAL   Free Radic Biol Med 81, 22-29 (2015)
   PUBMED   25596499
  REMARK    GeneRIF: The Nxnl1 gene, through the thioredoxin RdCVF-long
            isoform, is part of an endogenous defense mechanism against
            photooxidative stress.
REFERENCE   6  (bases 1 to 2764)
  AUTHORS   Fridlich,R., Delalande,F., Jaillard,C., Lu,J., Poidevin,L.,
            Cronin,T., Perrocheau,L., Millet-Puel,G., Niepon,M.L., Poch,O.,
            Holmgren,A., Van Dorsselaer,A., Sahel,J.A. and Leveillard,T.
  TITLE     The thioredoxin-like protein rod-derived cone viability factor
            (RdCVFL) interacts with TAU and inhibits its phosphorylation in the
            retina
  JOURNAL   Mol Cell Proteomics 8 (6), 1206-1218 (2009)
   PUBMED   19279044
  REMARK    GeneRIF: functional interaction between RdCVFL and TAU described
            here is the first characterization of the RdCVFL signaling pathway
            involved in neuronal cell death mediated by oxidative stress
REFERENCE   7  (bases 1 to 2764)
  AUTHORS   Chalmel,F., Leveillard,T., Jaillard,C., Lardenois,A., Berdugo,N.,
            Morel,E., Koehl,P., Lambrou,G., Holmgren,A., Sahel,J.A. and Poch,O.
  TITLE     Rod-derived Cone Viability Factor-2 is a novel
            bifunctional-thioredoxin-like protein with therapeutic potential
  JOURNAL   BMC Mol Biol 8, 74 (2007)
   PUBMED   17764561
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2764)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 2764)
  AUTHORS   Leveillard,T., Mohand-Said,S., Lorentz,O., Hicks,D., Fintz,A.C.,
            Clerin,E., Simonutti,M., Forster,V., Cavusoglu,N., Chalmel,F.,
            Dolle,P., Poch,O., Lambrou,G. and Sahel,J.A.
  TITLE     Identification and characterization of rod-derived cone viability
            factor
  JOURNAL   Nat Genet 36 (7), 755-759 (2004)
   PUBMED   15220920
REFERENCE   10 (bases 1 to 2764)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162033.11.
            
            On Aug 31, 2022 this sequence version replaced NM_145598.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.59828.1,
                                           SRR17784649.835989.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-394               AC162033.11        21857-22250         c
            395-2764            AC162033.11        16170-18539         c
FEATURES             Location/Qualifiers
     source          1..2764
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.43 cM"
     gene            1..2764
                     /gene="Nxnl1"
                     /gene_synonym="A930031O08Rik; RdCVF; Txnl6"
                     /note="nucleoredoxin-like 1"
                     /db_xref="GeneID:234404"
                     /db_xref="MGI:MGI:1924446"
     exon            1..394
                     /gene="Nxnl1"
                     /gene_synonym="A930031O08Rik; RdCVF; Txnl6"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..722
                     /gene="Nxnl1"
                     /gene_synonym="A930031O08Rik; RdCVF; Txnl6"
                     /note="thioredoxin-like 6; thioredoxin-like protein 6;
                     rod-derived cone viability factor"
                     /codon_start=1
                     /product="nucleoredoxin-like protein 1"
                     /protein_id="NP_663573.1"
                     /db_xref="CCDS:CCDS40385.1"
                     /db_xref="GeneID:234404"
                     /db_xref="MGI:MGI:1924446"
                     /translation="MASLFSGRILIRNNSDQDEVETEAELSRRLENRLVLLFFGAGAC
                     PQCQAFAPVLKDFFVRLTDEFYVLRAAQLALVYVSQDPTEEQQDLFLRDMPEKWLFLP
                     FHDELRRDLGRQFSVRQLPAVVVLKPGGDVLTSDATEEIQRLGPACFANWQEAAELLD
                     RSFLQPEDLDEPARRSITEPLRRRKYRVDRDVGRERGRNGRDSGDPQGDAGTRAELW"
     exon            395..2764
                     /gene="Nxnl1"
                     /gene_synonym="A930031O08Rik; RdCVF; Txnl6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2250..2255
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nxnl1"
                     /gene_synonym="A930031O08Rik; RdCVF; Txnl6"
                     /note="hexamer: AATAAA"
     polyA_site      2276
                     /gene="Nxnl1"
                     /gene_synonym="A930031O08Rik; RdCVF; Txnl6"
                     /note="major polyA site"
     regulatory      2745..2750
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nxnl1"
                     /gene_synonym="A930031O08Rik; RdCVF; Txnl6"
                     /note="hexamer: AGTAAA"
     polyA_site      2764
                     /gene="Nxnl1"
                     /gene_synonym="A930031O08Rik; RdCVF; Txnl6"
ORIGIN      
        1 gagaatcagc aggctccagg ccacatcgga tccctctctg ggtccccagc tccttgcata
       61 ctgctaccat ggcatctctc ttctctggac gcatcttgat caggaacaac agcgaccagg
      121 atgaagtgga gacagaggca gagctgagcc gtaggttaga gaatcgtctg gtgttgctgt
      181 tcttcggcgc cggcgcctgt ccccagtgcc aggcctttgc cccagtcctc aaagacttct
      241 tcgtgcggct cactgacgag ttctacgtgc tgcgggcagc acagctggcc ctggtctatg
      301 tgtcccagga ccctacagag gagcaacagg acctcttcct cagggacatg cctgaaaaat
      361 ggctcttcct gccgttccat gatgaactga ggagggacct cgggcgccag ttctctgtcc
      421 gtcaactgcc agcggttgtg gtacttaagc ctggtgggga cgtgctgaca agcgacgcca
      481 cggaggagat ccagcgtctg ggacccgcct gctttgccaa ctggcaggag gccgcagagc
      541 tcctggaccg cagcttcctg caaccggagg atttggatga gcctgcgcgg cgcagcatca
      601 ccgagcctct gcgccgtcgc aagtaccgag tagaccggga tgtcggccgg gagcggggcc
      661 gaaacggccg cgactctggt gacccccagg gggacgcggg tacaagggcg gagctctggt
      721 gactcccagg gtaggagtgg ggacggagct ctggtgaccc ccaaagtacc cgggtgcagg
      781 gacagaggtc tgatgacccc ctccccgcaa ggtacccggg tgcagtggta cctccagagg
      841 aactcggtgt aggggcaagg ctcagattat ccttgtcctc ttctaagttc agtatgttcc
      901 ctaaacagca gcccagggtg gccttgaact caccattctc atgcctcagt ggaagagtag
      961 ctggaatgcc agccaaaaag agacaagagg tttctttccc agatctcctc tagtctttga
     1021 aagaacatag actcccacga acagataccc tgagcaagat tcccaggtct taatcatgca
     1081 ctaaaaatcc atagaacccc aaactcaaaa ctcccatcca aaacaaaaca aaagaagcaa
     1141 aaaagcactc ctgccaggcg cactctgtga tgcacccatg tcattcagcg ctctggttgc
     1201 aagagagggc cagcaagctg actctgtgca gataggctca tgttgtcaag actgacaacc
     1261 caagttcaat tcctggaacc cactgagtgg aagaaagact gacttccgca agtcagttct
     1321 ttacacacac gattgtaagt gcatgcccac acagtgacaa atgagtatat ctagcaaaaa
     1381 tagttgggat tttgttttgt tttgtattga gacagggtct ctgtatagcc ctggctgtcc
     1441 tcgaattcgt gctgtaaacc aggctggcct cgaactcaga tcctcctgcc tctgtcttcc
     1501 aagtgctggg attaaaggca tgcactaccg ccacctacaa aaaagaaaaa agaaaaaaga
     1561 aaggaagaaa ggaaggaaga aagtgtgtgt gtgcagaagg tcaaggccat ttttcgctac
     1621 atagagagag cactaggccg gctgcggcta ggtgagacct cgatctaagc ctctgagact
     1681 tccggacagg acccttgttt ctctcaaagg ctaagtgtgt gcgatgtttt tgcttttgcc
     1741 tacggcgtcc cctggcgacc gaatcgggat agtgcgtgag tttaaaaccc tcctgcacca
     1801 agcaagtcca cggaagcttg caaacctgac tttctgggat caagaatctg actagaggga
     1861 gtaagaaagc tgtgaaccag gggaatcgga ccctgccaac ctctcatctg cctccgctcc
     1921 caagggagta gtgggggaaa caggttcaag actgaataag cctgacaacc tgtattcgat
     1981 cccggggaac ccacatagcg ctactcaaac aagttgtccc ttgacttgca ctcatgtccc
     2041 ctcaaagagt aattaatgga gaatttaaaa ttattatttt gctttttcaa gacagggttt
     2101 ctctgtgttg ccctgtaggc tcgaactcag agatcctcct gcctttgcct cccgagtgct
     2161 aggacttaag gcatgtacta ccactgccca agagaaaatt taaaatgtta attaaaggaa
     2221 atagaaatcc tcactcaccc cttttaggaa ataaaatgtg tacagttgca tgggaatctg
     2281 ctttgtaatc cacaaccgtg agatggagtt ggcctgggaa ccggcgttgt gactcagaac
     2341 ctcactgctg gcggctgggc tcccaggctt gcttatgtgt gttcctggct ttgtagctga
     2401 ccctggttga aaggtagaca catcccaaat gtccatcaat agatcaatgg atcaacacct
     2461 gtgggatgtc cagagtggac tattgctcag ccacgaacag gaatgaagca ctgacacagg
     2521 ctaccatacc agagattgag tggcagcagc cagacacaaa acacttcact tggcaggaag
     2581 tgtccccaac agggacagcc acaaatggag ctgccagggc cttgaggaca gtggagcatg
     2641 attgatagga gggactctct taaagagata gaatgcttcc aaactagata gatataggca
     2701 gggttgctct gtaaatgtgc tttaaaaaca aacacaaaac agcgagtaaa aactggatac
     2761 tcta
//
