LOCUS       NM_008750               2728 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus nucleoredoxin (Nxn), mRNA.
ACCESSION   NM_008750 XM_983613
VERSION     NM_008750.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2728)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2728)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2728)
  AUTHORS   Valek,L., Tran,B.N. and Tegeder,I.
  TITLE     Cold avoidance and heat pain hypersensitivity in neuronal
            nucleoredoxin knockout mice
  JOURNAL   Free Radic Biol Med 192, 84-97 (2022)
   PUBMED   36126861
REFERENCE   4  (bases 1 to 2728)
  AUTHORS   Tran,B.N., Valek,L., Wilken-Schmitz,A., Fuhrmann,D.C.,
            Namgaladze,D., Wittig,I. and Tegeder,I.
  TITLE     Reduced exploratory behavior in neuronal nucleoredoxin knockout
            mice
  JOURNAL   Redox Biol 45, 102054 (2021)
   PUBMED   34198070
  REMARK    GeneRIF: Reduced exploratory behavior in neuronal nucleoredoxin
            knockout mice.
REFERENCE   5  (bases 1 to 2728)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2728)
  AUTHORS   Babaya,N., Ikegami,H., Fujisawa,T., Nojima,K., Itoi-Babaya,M.,
            Inoue,K., Ohno,T., Shibata,M. and Ogihara,T.
  TITLE     Susceptibility to streptozotocin-induced diabetes is mapped to
            mouse chromosome 11
  JOURNAL   Biochem Biophys Res Commun 328 (1), 158-164 (2005)
   PUBMED   15670764
REFERENCE   7  (bases 1 to 2728)
  AUTHORS   Kile,B.T., Hentges,K.E., Clark,A.T., Nakamura,H., Salinger,A.P.,
            Liu,B., Box,N., Stockton,D.W., Johnson,R.L., Behringer,R.R.,
            Bradley,A. and Justice,M.J.
  TITLE     Functional genetic analysis of mouse chromosome 11
  JOURNAL   Nature 425 (6953), 81-86 (2003)
   PUBMED   12955145
REFERENCE   8  (bases 1 to 2728)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2728)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 2728)
  AUTHORS   Kurooka,H., Kato,K., Minoguchi,S., Takahashi,Y., Ikeda,J., Habu,S.,
            Osawa,N., Buchberg,A.M., Moriwaki,K., Shisa,H. and Honjo,T.
  TITLE     Cloning and characterization of the nucleoredoxin gene that encodes
            a novel nuclear protein related to thioredoxin
  JOURNAL   Genomics 39 (3), 331-339 (1997)
   PUBMED   9119370
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC058244.1, AK075628.1 and AI425633.1.
            
            On Dec 11, 2007 this sequence version replaced NM_008750.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058244.1, AK048109.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1996              BC058244.1         1-1996
            1997-2715           AK075628.1         884-1602
            2716-2728           AI425633.1         431-443
FEATURES             Location/Qualifiers
     source          1..2728
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.92 cM"
     gene            1..2728
                     /gene="Nxn"
                     /gene_synonym="l11Jus13"
                     /note="nucleoredoxin"
                     /db_xref="GeneID:18230"
                     /db_xref="MGI:MGI:109331"
     exon            1..441
                     /gene="Nxn"
                     /gene_synonym="l11Jus13"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1389
                     /gene="Nxn"
                     /gene_synonym="l11Jus13"
                     /EC_number="1.8.1.8"
                     /note="protein Red-1"
                     /codon_start=1
                     /product="nucleoredoxin"
                     /protein_id="NP_032776.1"
                     /db_xref="CCDS:CCDS25064.1"
                     /db_xref="GeneID:18230"
                     /db_xref="MGI:MGI:109331"
                     /translation="MSGFLEELLGDKLVTGGGEEVDVHSLGARGIALLGLYFGCSLSA
                     PCAQLSASLAAFYGRLRGDAAAGPGAGAGAGAAAEPEPRHRLEIVFVSSDQDQRQWQD
                     FVRDMPWLALPYKEKHRKLKLWNKYRVSNIPSLIFLDATTGKVVCRNGLLVIRDDPEG
                     LEFPWGPKPFREVIAGPLLRNNGQSLESSSLEGSHVGVYFSAHWCPPCRSLTRVLVES
                     YRKIKEAGQEFEIIFVSADRSEESFKQYFSEMPWLAVPYTDEARRSRLNRLYGIQGIP
                     TLIVLDPQGEVITRQGRVEVLNDEDCREFPWHPKPVLELSDSNAVQLNEGPCLVLFVD
                     SEDDGESEAAKQLIQPIAEKIIAKYKAKEEEAPLLFFVAGEDDMTDSLRDYTNLPEAA
                     PLLTILDMSARAKYVMDVEEITPAIVETFVNDFLAEKLKPEPI"
     exon            442..559
                     /gene="Nxn"
                     /gene_synonym="l11Jus13"
                     /inference="alignment:Splign:2.1.0"
     exon            560..693
                     /gene="Nxn"
                     /gene_synonym="l11Jus13"
                     /inference="alignment:Splign:2.1.0"
     exon            694..794
                     /gene="Nxn"
                     /gene_synonym="l11Jus13"
                     /inference="alignment:Splign:2.1.0"
     exon            795..901
                     /gene="Nxn"
                     /gene_synonym="l11Jus13"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1081
                     /gene="Nxn"
                     /gene_synonym="l11Jus13"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1206
                     /gene="Nxn"
                     /gene_synonym="l11Jus13"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..2728
                     /gene="Nxn"
                     /gene_synonym="l11Jus13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1967..1972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nxn"
                     /gene_synonym="l11Jus13"
                     /note="hexamer: AATGAA"
     polyA_site      1996
                     /gene="Nxn"
                     /gene_synonym="l11Jus13"
                     /note="major polyA site"
     regulatory      2696..2701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nxn"
                     /gene_synonym="l11Jus13"
                     /note="hexamer: AATAAA"
     polyA_site      2715
                     /gene="Nxn"
                     /gene_synonym="l11Jus13"
ORIGIN      
        1 cgcccgccgc gcggaccagc gagccggtag ctgttgcgag cccacccgcc cgcccgcgtg
       61 ccggggctgc ggtgggccag gatgtcgggc ttcctggagg agctgctggg agacaagctg
      121 gtgacgggcg gtggcgagga ggtggacgtg cattcgctgg gcgcccgcgg catcgcgctg
      181 ctggggctct acttcgggtg cagcctgagc gccccctgcg cgcagctcag cgccagcctg
      241 gccgccttct acggtcgcct gcgaggggac gcggcggccg ggccgggggc cggggcgggg
      301 gccggcgcag ccgcggagcc agagccccgg caccgcctgg agatcgtctt cgtgtcttcg
      361 gaccaagacc agcggcagtg gcaggacttc gtgcgggaca tgccatggct ggcgctgccc
      421 tacaaggaga agcaccggaa gcttaaactt tggaacaaat accgagtctc caacattcca
      481 tcgctaatat tcctagacgc caccacaggg aaggttgtgt gcaggaatgg gctcctggtg
      541 atccgagatg acccggaagg tctggaattc ccttggggac ctaaaccctt ccgggaagtt
      601 attgcggggc ccttgcttag aaataacggg cagtcgctgg agagcagcag cctggagggg
      661 tctcacgtgg gagtctattt ctctgcacac tggtgtccac cctgccgaag ccttaccaga
      721 gtgctggtgg aatcctaccg gaagatcaag gaggcaggcc aggagtttga gatcatcttc
      781 gttagtgcag acaggtcaga ggagtctttc aaacagtact ttagtgagat gccatggctc
      841 gctgtcccct acactgatga ggcccggcgg tctcgtctca accgactgta tggaatccaa
      901 ggcatcccca cgctcatcgt gctggacccg cagggggagg tgatcactcg gcagggtcgg
      961 gtggaggtgc tcaatgacga ggactgcagg gagttcccgt ggcacccgaa gcccgtgctg
     1021 gagctctctg actccaacgc tgtgcagctc aacgagggcc cctgcctcgt cctttttgta
     1081 gactctgagg acgacggaga gtccgaggca gccaaacagc tgatccagcc aatagctgag
     1141 aagatcattg ccaagtacaa agccaaagaa gaggaggcgc cgctgttgtt ctttgtggcc
     1201 ggggaggatg acatgactga ctccctgaga gattacacca acctgcctga ggcggcgcct
     1261 ctgctcacca ttctggacat gtcagcccgg gccaagtacg tgatggatgt agaagagatc
     1321 accccagcca ttgtggagac ttttgtgaat gacttcctag cagaaaaact caagcctgag
     1381 cccatctagt gggctccggc ctctggagac agtatttaag acacagtctt ctccccttcc
     1441 tcccctctgc ccttggactt ttccagcgtg tcctgaatca cacaatccaa gtgtccaacc
     1501 tctgtggtgc cttgtttcta cattagcaac tcagctagca cccatgggtg tgcatcctca
     1561 cagtggcagc aggtcccacg gtgtttggag atggcttggg gatccgtgag gatggcatga
     1621 ccagctagcc ccgagactgc cacctctcct ggctcatgat ggaggacctt cccgggtctt
     1681 ctgcagagtg agcaagcaag gaccgtggat tgaggccctg actctgactc tgggatcagt
     1741 atacacaccc caagccagag ggaactctcc tgtgacatct gtacccgtgg gagttacaga
     1801 ggaagggtca tgacctcagt ggccatcagc tgagagctgt cggcgaattt gctttgtaag
     1861 gacgtgatct ttcttggtct gagggaaaac cagcgcatca gtgggttctt gggcagggga
     1921 cttccatatc tctaaggaac cttgtgggtg tttgttttgg tgggaaaatg aatagccgag
     1981 ctaacagttc atagaacgct tactgtgtgc ttagtttctt catctcccca ttttcctcct
     2041 gtactcttgg ccatccccag gtttctgctc atacaaaaac ctcccgaaat cttgggattt
     2101 cagaaatgga tttccccctt agccatcttc ccaagattca gccctgagtt cccagagaag
     2161 tgttgcccag ctacccgggc ttctctgtgg gctgcttctc tgccacaatc acctgcagcc
     2221 cctttcatgg tccgttttct tttcaaactg gatccaaaaa gagacgaggg ttttctttcc
     2281 tctaggaacc tgcaaaggta actgtgctct agaaagcagt gagggcactg ggcatgccaa
     2341 ctgcagtcac cctgacttcc tctgctctgc ccaggcagct gaactgacca caacagtgga
     2401 aacatcagcc atgttcttag ggtctgtgct ttggcctagg gatttccagg actttagtct
     2461 gtcacagtct ggtgtcaggg acttcaaagc atctgggcct caccctcagc tcaacccaac
     2521 actttaccag cccaaaccat ttattttgga aaacgcagtt gtcctccccc aacaagctat
     2581 tgacactgct gttccttgct gaattggatt gttggcttgt aattcagagg tacaaaatta
     2641 gttggtaatt acactatcag atgttgccag cctgaagtgc aatcacctag aaagaaataa
     2701 agcagataaa gcaggcctct ctgacctc
//
