LOCUS       NM_130888               2233 bp    mRNA    linear   ROD 24-FEB-2022
DEFINITION  Mus musculus nuclear RNA export factor 7 (Nxf7), transcript variant
            1, mRNA.
ACCESSION   NM_130888 XM_006528510
VERSION     NM_130888.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2233)
  AUTHORS   Callaerts-Vegh Z, Ahmed T, Vermaercke B, Marynen P, Balschun D,
            Froyen G and D'Hooge R.
  TITLE     Nxf7 deficiency impairs social exploration and spatio-cognitive
            abilities as well as hippocampal synaptic plasticity in mice
  JOURNAL   Front Behav Neurosci 9, 179 (2015)
   PUBMED   26217206
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2233)
  AUTHORS   Esposito T, Lea RA, Maher BH, Moses D, Cox HC, Magliocca S, Angius
            A, Nyholt DR, Titus T, Kay T, Gray NA, Rastaldi MP, Parnham A,
            Gianfrancesco F and Griffiths LR.
  TITLE     Unique X-linked familial FSGS with co-segregating heart block
            disorder is associated with a mutation in the NXF5 gene
  JOURNAL   Hum Mol Genet 22 (18), 3654-3666 (2013)
   PUBMED   23686279
REFERENCE   3  (bases 1 to 2233)
  AUTHORS   Zhou J, McCarrey JR and Wang PJ.
  TITLE     A 1.1-Mb segmental deletion on the X chromosome causes meiotic
            failure in male mice
  JOURNAL   Biol Reprod 88 (6), 159 (2013)
   PUBMED   23677977
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2233)
  AUTHORS   Vanmarsenille L, Verbeeck J, Belet S, Roebroek AJ, Van de Putte T,
            Nevelsteen J, Callaerts-Vegh Z, D'Hooge R, Marynen P and Froyen G.
  TITLE     Generation and characterization of an Nxf7 knockout mouse to study
            NXF5 deficiency in a patient with intellectual disability
  JOURNAL   PLoS One 8 (5), e64144 (2013)
   PUBMED   23675524
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2233)
  AUTHORS   Katahira J, Miki T, Takano K, Maruhashi M, Uchikawa M, Tachibana T
            and Yoneda Y.
  TITLE     Nuclear RNA export factor 7 is localized in processing bodies and
            neuronal RNA granules through interactions with shuttling hnRNPs
  JOURNAL   Nucleic Acids Res 36 (2), 616-628 (2008)
   PUBMED   18063567
  REMARK    GeneRIF: Results suggest that NXF7 plays a role in sorting,
            transport and/or storage of mRNAs through interactions with hnRNP
            A3.
REFERENCE   6  (bases 1 to 2233)
  AUTHORS   Tretyakova I, Zolotukhin AS, Tan W, Bear J, Propst F, Ruthel G and
            Felber BK.
  TITLE     Nuclear export factor family protein participates in cytoplasmic
            mRNA trafficking
  JOURNAL   J Biol Chem 280 (36), 31981-31990 (2005)
   PUBMED   16014633
  REMARK    GeneRIF: NXF7 colocalizes with Staufen1, polyA, and 28 S RNA within
            mobile cytoplasmic granules in neurites and in extended cytoplasmic
            processes of non-neuronal cells
REFERENCE   7  (bases 1 to 2233)
  AUTHORS   McKee AE, Minet E, Stern C, Riahi S, Stiles CD and Silver PA.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2233)
  AUTHORS   Tan W, Zolotukhin AS, Tretyakova I, Bear J, Lindtner S, Smulevitch
            SV and Felber BK.
  TITLE     Identification and characterization of the mouse nuclear export
            factor (Nxf) family members
  JOURNAL   Nucleic Acids Res 33 (12), 3855-3865 (2005)
   PUBMED   16027110
  REMARK    GeneRIF: NXF7 localizes exclusively to cytoplasmic granules and
            lacks mRNA export activity.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2233)
  AUTHORS   Sasaki M, Takeda E, Takano K, Yomogida K, Katahira J and Yoneda Y.
  TITLE     Molecular cloning and functional characterization of mouse Nxf
            family gene products
  JOURNAL   Genomics 85 (5), 641-653 (2005)
   PUBMED   15820316
REFERENCE   10 (bases 1 to 2233)
  AUTHORS   Jun L, Frints S, Duhamel H, Herold A, Abad-Rodrigues J, Dotti C,
            Izaurralde E, Marynen P and Froyen G.
  TITLE     NXF5, a novel member of the nuclear RNA export factor family, is
            lost in a male patient with a syndromic form of mental retardation
  JOURNAL   Curr Biol 11 (18), 1381-1391 (2001)
   PUBMED   11566096
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671911.12.
            
            On or before Nov 10, 2017 this sequence version replaced
            XM_006528510.1, NM_130888.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB178901.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               AL671911.12        68214-68313         c
            101-181             AL671911.12        63349-63429         c
            182-211             AL671911.12        61802-61831         c
            212-365             AL671911.12        58853-59006         c
            366-516             AL671911.12        58467-58617         c
            517-600             AL671911.12        58112-58195         c
            601-705             AL671911.12        57909-58013         c
            706-786             AL671911.12        57718-57798         c
            787-856             AL671911.12        57503-57572         c
            857-945             AL671911.12        57269-57357         c
            946-1053            AL671911.12        57054-57161         c
            1054-1163           AL671911.12        56773-56882         c
            1164-1200           AL671911.12        55302-55338         c
            1201-1269           AL671911.12        54817-54885         c
            1270-1325           AL671911.12        54677-54732         c
            1326-1433           AL671911.12        54433-54540         c
            1434-1492           AL671911.12        54240-54298         c
            1493-1608           AL671911.12        54023-54138         c
            1609-1651           AL671911.12        53889-53931         c
            1652-1718           AL671911.12        53259-53325         c
            1719-1901           AL671911.12        52620-52802         c
            1902-1962           AL671911.12        49491-49551         c
            1963-2233           AL671911.12        49091-49361         c
FEATURES             Location/Qualifiers
     source          1..2233
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 57.25 cM"
     gene            1..2233
                     /gene="Nxf7"
                     /gene_synonym="nfx-a1; Nx7; nxf-a; nxf-a2; Nxf6"
                     /note="nuclear RNA export factor 7"
                     /db_xref="GeneID:170722"
                     /db_xref="MGI:MGI:2159343"
     exon            1..100
                     /gene="Nxf7"
                     /gene_synonym="nfx-a1; Nx7; nxf-a; nxf-a2; Nxf6"
                     /inference="alignment:Splign:2.1.0"
     exon            101..181
                     /gene="Nxf7"
                     /gene_synonym="nfx-a1; Nx7; nxf-a; nxf-a2; Nxf6"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..2001
                     /gene="Nxf7"
                     /gene_synonym="nfx-a1; Nx7; nxf-a; nxf-a2; Nxf6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear export factor a; nuclear RNA export factor 6"
                     /codon_start=1
                     /product="nuclear RNA export factor 7 isoform 1"
                     /protein_id="NP_570958.1"
                     /db_xref="CCDS:CCDS30406.1"
                     /db_xref="GeneID:170722"
                     /db_xref="MGI:MGI:2159343"
                     /translation="MCSNERKQGSFRYTGTTNAWQSPMGRKKDRVSSLSYAGKRTDHY
                     EHTGHTILPFKAQSDGGNLEMRAVLWNPSVRHTPYVGQHRSREEEHMEDQIHVTAQRD
                     DKPEQREAGQFTEDGELGSWFKVTVPCGRKYDKTQLMNSIHSLCSVPFTPVDFHCDKH
                     RIQFFVPDFRIASALKDISYKIHNEYFQKIPIFVNPSVAPYSVQNRFTKEEMEQLKLA
                     MRKRYDVSQHALCLKKLRFDPDLMKNNIHMILNHRSCMAATLQIIQENFPKLLSLNLS
                     SNKLFQLDSLIDVVKKAPQLKILNLSKNMLRTVWELEKMKGLKLEQLWLEGNPLCSTF
                     PDRSSYIRAVLECFPELSYLDGRKLLLPTVMNTQERKLMKPCKDIFMGSEVIKNQVHR
                     FLREYYLMYDSEERQGLLNIYHDQACFSLTIPFNPNDPDLNSMYVYFKDENDMKNFKE
                     FHIQRQLLKYTKQDIVECLRGFPQTLHAFSSFQVNICFQMETMLCFSVCGLFKEEGTP
                     KECVRAFMRIFIALLGSSNMYIVNDQLFVRNPSSEEINSAFVIPSPTSYSNFKLVLSQ
                     EQQRMVQAFSTQSGMKLEWSQKCLEDNKWDYARAAEVFTMLQTKCKIPKEFFKQ"
     exon            182..211
                     /gene="Nxf7"
                     /gene_synonym="nfx-a1; Nx7; nxf-a; nxf-a2; Nxf6"
                     /inference="alignment:Splign:2.1.0"
     exon            212..365
                     /gene="Nxf7"
                     /gene_synonym="nfx-a1; Nx7; nxf-a; nxf-a2; Nxf6"
                     /inference="alignment:Splign:2.1.0"
     exon            366..516
                     /gene="Nxf7"
                     /gene_synonym="nfx-a1; Nx7; nxf-a; nxf-a2; Nxf6"
                     /inference="alignment:Splign:2.1.0"
     exon            517..600
                     /gene="Nxf7"
                     /gene_synonym="nfx-a1; Nx7; nxf-a; nxf-a2; Nxf6"
                     /inference="alignment:Splign:2.1.0"
     exon            601..705
                     /gene="Nxf7"
                     /gene_synonym="nfx-a1; Nx7; nxf-a; nxf-a2; Nxf6"
                     /inference="alignment:Splign:2.1.0"
     exon            706..786
                     /gene="Nxf7"
                     /gene_synonym="nfx-a1; Nx7; nxf-a; nxf-a2; Nxf6"
                     /inference="alignment:Splign:2.1.0"
     exon            787..856
                     /gene="Nxf7"
                     /gene_synonym="nfx-a1; Nx7; nxf-a; nxf-a2; Nxf6"
                     /inference="alignment:Splign:2.1.0"
     exon            857..945
                     /gene="Nxf7"
                     /gene_synonym="nfx-a1; Nx7; nxf-a; nxf-a2; Nxf6"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1053
                     /gene="Nxf7"
                     /gene_synonym="nfx-a1; Nx7; nxf-a; nxf-a2; Nxf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1163
                     /gene="Nxf7"
                     /gene_synonym="nfx-a1; Nx7; nxf-a; nxf-a2; Nxf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1200
                     /gene="Nxf7"
                     /gene_synonym="nfx-a1; Nx7; nxf-a; nxf-a2; Nxf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1269
                     /gene="Nxf7"
                     /gene_synonym="nfx-a1; Nx7; nxf-a; nxf-a2; Nxf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1325
                     /gene="Nxf7"
                     /gene_synonym="nfx-a1; Nx7; nxf-a; nxf-a2; Nxf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1433
                     /gene="Nxf7"
                     /gene_synonym="nfx-a1; Nx7; nxf-a; nxf-a2; Nxf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1492
                     /gene="Nxf7"
                     /gene_synonym="nfx-a1; Nx7; nxf-a; nxf-a2; Nxf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1608
                     /gene="Nxf7"
                     /gene_synonym="nfx-a1; Nx7; nxf-a; nxf-a2; Nxf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1651
                     /gene="Nxf7"
                     /gene_synonym="nfx-a1; Nx7; nxf-a; nxf-a2; Nxf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1718
                     /gene="Nxf7"
                     /gene_synonym="nfx-a1; Nx7; nxf-a; nxf-a2; Nxf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1901
                     /gene="Nxf7"
                     /gene_synonym="nfx-a1; Nx7; nxf-a; nxf-a2; Nxf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1962
                     /gene="Nxf7"
                     /gene_synonym="nfx-a1; Nx7; nxf-a; nxf-a2; Nxf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2233
                     /gene="Nxf7"
                     /gene_synonym="nfx-a1; Nx7; nxf-a; nxf-a2; Nxf6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcttctcct gcttgccttg tgagactgag caactgctag atccttggac ttccattcac
       61 agctgctgct gaccactgtt gaggagttgg actacagact cttcatcgga agactacaaa
      121 ggccaaaaga caagaaagat gtgctctaat gaaaggaagc aggggtcctt cagatacaca
      181 ggaacaacta atgcctggca aagccccatg ggaagaaaga aagacagggt ttcttccctg
      241 agctatgctg gcaagaggac cgatcattat gagcatactg ggcacacgat tctgcctttc
      301 aaagcccaga gtgatggtgg aaatctggag atgagagctg ttctctggaa cccgtcagta
      361 agacacacac cttatgttgg gcaacatagg agtagggagg aagagcatat ggaagaccaa
      421 atccatgtca cggcgcagag agatgacaaa cctgaacaga gagaagcagg gcagttcaca
      481 gaagacggag aactggggag ctggttcaag gtcacggttc catgtgggag gaagtatgac
      541 aagacacagc taatgaattc aatccacagc ctttgcagcg tgcccttcac acctgtggat
      601 ttccattgtg acaaacaccg gatccagttc tttgtcccag actttcgcat tgcctctgca
      661 ttgaaggata tcagctataa gatacataat gagtactttc agaagattcc tatttttgtc
      721 aatccctcgg ttgcacccta ctctgtgcag aatagattca caaaagaaga aatggaacag
      781 ctgaagctgg ccatgaggaa aagatatgat gtttcccagc atgctctctg cctcaaaaag
      841 ctccgctttg atccagactt gatgaaaaac aacatccaca tgatcctaaa tcacagaagc
      901 tgcatggctg ccacccttca gatcatccaa gagaattttc ctaagctgtt atccttgaac
      961 ttgagcagca acaaactgtt ccaattagat agcctgattg atgtggtaaa gaaggcaccg
     1021 caactcaaga tcttgaacct ctccaaaaac atgctaagaa cagtgtggga gttggagaag
     1081 atgaaagggc tgaagctgga gcagctgtgg ctagaaggga acccattgtg cagcaccttc
     1141 ccagaccgat cttcctatat aagagcagtc ctggaatgtt ttccggagtt gtcatacctg
     1201 gatggcagga agttattact tccaactgta atgaacactc aagaacgcaa gttaatgaag
     1261 ccctgcaagg acatctttat gggttcagag gtgataaaga atcaagtaca cagattcctg
     1321 cgagagtatt acttgatgta cgactctgaa gagcgacagg gtctcctgaa catttaccat
     1381 gaccaggcct gcttctccct gaccattccc ttcaacccca atgatccaga tctgaatagc
     1441 atgtatgtct acttcaagga tgaaaatgat atgaagaatt tcaaggagtt ccacattcag
     1501 aggcagctac tgaagtacac aaaacaagat attgtggagt gtctgagggg atttccccaa
     1561 actctacatg ccttcagctc tttccaagtg aacatctgtt ttcagatgga aacgatgctc
     1621 tgcttctctg tttgtgggtt gttcaaggaa gagggcaccc ccaaggaatg tgttcgtgcc
     1681 tttatgagga tcttcattgc tctccttggc agttcaaaca tgtatattgt gaatgaccag
     1741 ctttttgtga ggaatccaag ctctgaagag atcaatagtg cctttgtcat accctcgccc
     1801 acatcatact ccaacttcaa gcttgtcctt tctcaagagc agcaaagaat ggtgcaggct
     1861 ttctccaccc agtcggggat gaaacttgaa tggtctcaga agtgccttga agataacaag
     1921 tgggactatg ccagagctgc tgaagtcttc actatgcttc agaccaagtg caagatccca
     1981 aaggaattct tcaaacaatg acataaaaac acacggctgg atgttatctt cctcttgttc
     2041 acattcttgt ttctctgttt cttacttatg acccctgctg ttagcctggc taaccacaaa
     2101 gccaaagtta tcatgtaagc caggcaacat aggccatccc cccccccccc cccgccaact
     2161 aggtaacttg ctctgtgtat ttctcttgag aaaagccagt ttattttcat aataaaagtt
     2221 acttggcact ttg
//
