LOCUS       NP_001019312             553 aa            linear   ROD 22-APR-2022
DEFINITION  nuclear RNA export factor 3 [Mus musculus].
ACCESSION   NP_001019312
VERSION     NP_001019312.1
DBSOURCE    REFSEQ: accession NM_001024141.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 553)
  AUTHORS   Li MW, Sletten AC, Lee J, Pyles KD, Matkovich SJ, Ory DS and
            Schaffer JE.
  TITLE     Nuclear export factor 3 regulates localization of small nucleolar
            RNAs
  JOURNAL   J Biol Chem 292 (49), 20228-20239 (2017)
   PUBMED   29021253
  REMARK    GeneRIF: evidence of a new role for NXF3 in regulating the
            distribution of snoRNAs between the nuclear and cytoplasmic
            compartments.
REFERENCE   2  (residues 1 to 553)
  AUTHORS   Zhou J, McCarrey JR and Wang PJ.
  TITLE     A 1.1-Mb segmental deletion on the X chromosome causes meiotic
            failure in male mice
  JOURNAL   Biol Reprod 88 (6), 159 (2013)
   PUBMED   23677977
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 553)
  AUTHORS   Yin Y, Wang G, Liang N, Zhang H, Liu Z, Li W and Sun F.
  TITLE     Nuclear export factor 3 is involved in regulating the expression of
            TGF-beta3 in an mRNA export activity-independent manner in mouse
            Sertoli cells
  JOURNAL   Biochem J 452 (1), 67-78 (2013)
   PUBMED   23438076
  REMARK    GeneRIF: Mechanistic insights into the roles of NXF3 are implicated
            in transforming growth factor (TGF)-beta-mediated expression of
            Tgfbeta3 and other genes.
REFERENCE   4  (residues 1 to 553)
  AUTHORS   Vanmarsenille L, Verbeeck J, Belet S, Roebroek AJ, Van de Putte T,
            Nevelsteen J, Callaerts-Vegh Z, D'Hooge R, Marynen P and Froyen G.
  TITLE     Generation and characterization of an Nxf7 knockout mouse to study
            NXF5 deficiency in a patient with intellectual disability
  JOURNAL   PLoS One 8 (5), e64144 (2013)
   PUBMED   23675524
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 553)
  AUTHORS   Zhou J, Pan J, Eckardt S, Leu NA, McLaughlin KJ and Wang PJ.
  TITLE     Nxf3 is expressed in Sertoli cells, but is dispensable for
            spermatogenesis
  JOURNAL   Mol Reprod Dev 78 (4), 241-249 (2011)
   PUBMED   21308854
  REMARK    GeneRIF: The Nxf3 is expressed exclusively in Sertoli cells of the
            postnatal testis, in a developmentally regulated manner.
REFERENCE   6  (residues 1 to 553)
  AUTHORS   Sasaki M, Takeda E, Takano K, Yomogida K, Katahira J and Yoneda Y.
  TITLE     Molecular cloning and functional characterization of mouse Nxf
            family gene products
  JOURNAL   Genomics 85 (5), 641-653 (2005)
   PUBMED   15820316
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671914.9.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB178899.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..553
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 57.38 cM"
     Protein         1..553
                     /product="nuclear RNA export factor 3"
                     /calculated_mol_wt=63522
     Region          102..179
                     /region_name="Tap-RNA_bind"
                     /note="Tap, RNA-binding; pfam09162"
                     /db_xref="CDD:462696"
     Region          192..230
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275382"
     Region          249..279
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275382"
     Region          314..470
                     /region_name="NTF2_like"
                     /note="Nuclear transport factor 2 (NTF2-like) superfamily.
                     This family includes members of the NTF2 family,
                     Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases,
                     and the beta subunit of Ring hydroxylating dioxygenases.
                     This family is a classic example of...; cl09109"
                     /db_xref="CDD:471850"
     Region          485..547
                     /region_name="TAP_C"
                     /note="C-terminal domain of vertebrate Tap protein;
                     smart00804"
                     /db_xref="CDD:197882"
     Site            order(509,513,516..517,519..522,527,531,535,540,542)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:270527"
     CDS             1..553
                     /gene="Nxf3"
                     /gene_synonym="Gm384"
                     /coded_by="NM_001024141.4:156..1817"
                     /db_xref="CCDS:CCDS41132.1"
                     /db_xref="GeneID:245610"
                     /db_xref="MGI:MGI:2685230"
ORIGIN      
        1 mgrssetnpl rrrmrcrrif qqrflnspah vsdtvhtsfy qqpamsnppm htrrytpygi
       61 psryqrvsvq kwnqtdvnme ggskpperkm qrdkqddtse nwfkvtipfg ikydkkwlln
      121 liqsqcsipf tpvqfhyekm qahffvdnpn iafmlkaisd kildetdnkp qshrtpsvil
      181 qlttnqqcat sqrvlnrqrl pfdqdlmtrp tdlalvprry mtpslsihke dmtqvnsege
      241 vakvhapdle kicadqssls ttmpdkssni nsilelfpkl lsldgqeshk ptlcgpedhk
      301 tlsackeiff gsesiktmvl qflkqyyfiy dngdrqglln ayhpeacftl tipfssidls
      361 mnslceyfkf srnmkilkdp ymrrqllkhk kcdiihflrt lpktqhdlts fvvdiclqte
      421 kmlcfsvsgl fkevdnsaqg cmhaftrifv vthdnsselc iindklsvtn vhevpsastp
      481 vatsstsylp sfsqdqqemv ptfcaqsgvn vdrsqkslhd dqwnynraiq slallkvedt
      541 isedkftqtd prs
//
