LOCUS       NM_001289735            2395 bp    mRNA    linear   ROD 17-APR-2022
DEFINITION  Mus musculus nuclear RNA export factor 2 (Nxf2), transcript variant
            1, mRNA.
ACCESSION   NM_001289735 XM_006528632
VERSION     NM_001289735.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2395)
  AUTHORS   Zhou J, McCarrey JR and Wang PJ.
  TITLE     A 1.1-Mb segmental deletion on the X chromosome causes meiotic
            failure in male mice
  JOURNAL   Biol Reprod 88 (6), 159 (2013)
   PUBMED   23677977
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2395)
  AUTHORS   Vanmarsenille L, Verbeeck J, Belet S, Roebroek AJ, Van de Putte T,
            Nevelsteen J, Callaerts-Vegh Z, D'Hooge R, Marynen P and Froyen G.
  TITLE     Generation and characterization of an Nxf7 knockout mouse to study
            NXF5 deficiency in a patient with intellectual disability
  JOURNAL   PLoS One 8 (5), e64144 (2013)
   PUBMED   23675524
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2395)
  AUTHORS   Zhou J, Pan J, Eckardt S, Leu NA, McLaughlin KJ and Wang PJ.
  TITLE     Nxf3 is expressed in Sertoli cells, but is dispensable for
            spermatogenesis
  JOURNAL   Mol Reprod Dev 78 (4), 241-249 (2011)
   PUBMED   21308854
REFERENCE   4  (bases 1 to 2395)
  AUTHORS   Pan J, Eckardt S, Leu NA, Buffone MG, Zhou J, Gerton GL, McLaughlin
            KJ and Wang PJ.
  TITLE     Inactivation of Nxf2 causes defects in male meiosis and
            age-dependent depletion of spermatogonia
  JOURNAL   Dev Biol 330 (1), 167-174 (2009)
   PUBMED   19345203
  REMARK    GeneRIF: These studies demonstrate that Nxf2 plays a dual function
            in spermatogenesis: regulation of meiosis and maintenance of
            spermatogonial stem cells.
REFERENCE   5  (bases 1 to 2395)
  AUTHORS   Zhang M, Wang Q and Huang Y.
  TITLE     Fragile X mental retardation protein FMRP and the RNA export factor
            NXF2 associate with and destabilize Nxf1 mRNA in neuronal cells
  JOURNAL   Proc Natl Acad Sci U S A 104 (24), 10057-10062 (2007)
   PUBMED   17548835
  REMARK    GeneRIF: FMRP and Nxf2 associate with and destabilize Nxf1 mRNA in
            neuronal cells.
REFERENCE   6  (bases 1 to 2395)
  AUTHORS   Tretyakova I, Zolotukhin AS, Tan W, Bear J, Propst F, Ruthel G and
            Felber BK.
  TITLE     Nuclear export factor family protein participates in cytoplasmic
            mRNA trafficking
  JOURNAL   J Biol Chem 280 (36), 31981-31990 (2005)
   PUBMED   16014633
  REMARK    GeneRIF: Exhibits mRNA export activity similar to that of
            Tip-associated protein/NXF1.
REFERENCE   7  (bases 1 to 2395)
  AUTHORS   Tan W, Zolotukhin AS, Tretyakova I, Bear J, Lindtner S, Smulevitch
            SV and Felber BK.
  TITLE     Identification and characterization of the mouse nuclear export
            factor (Nxf) family members
  JOURNAL   Nucleic Acids Res 33 (12), 3855-3865 (2005)
   PUBMED   16027110
  REMARK    GeneRIF: The NXF2 protein is found in the nucleus, the nuclear
            envelope and cytoplasm, and is an active mRNA export receptor.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2395)
  AUTHORS   Sasaki M, Takeda E, Takano K, Yomogida K, Katahira J and Yoneda Y.
  TITLE     Molecular cloning and functional characterization of mouse Nxf
            family gene products
  JOURNAL   Genomics 85 (5), 641-653 (2005)
   PUBMED   15820316
REFERENCE   9  (bases 1 to 2395)
  AUTHORS   Jun L, Frints S, Duhamel H, Herold A, Abad-Rodrigues J, Dotti C,
            Izaurralde E, Marynen P and Froyen G.
  TITLE     NXF5, a novel member of the nuclear RNA export factor family, is
            lost in a male patient with a syndromic form of mental retardation
  JOURNAL   Curr Biol 11 (18), 1381-1391 (2001)
   PUBMED   11566096
REFERENCE   10 (bases 1 to 2395)
  AUTHORS   Wang PJ, McCarrey JR, Yang F and Page DC.
  TITLE     An abundance of X-linked genes expressed in spermatogonia
  JOURNAL   Nat Genet 27 (4), 422-426 (2001)
   PUBMED   11279525
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB178900.1 and AK015471.1.
            
            On Jan 27, 2014 this sequence version replaced XM_006528632.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB178900.1, BC145056.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849380 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2390              AB178900.1         1-2390
            2391-2395           AK015471.1         1811-1815
FEATURES             Location/Qualifiers
     source          1..2395
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 56.31 cM"
     gene            1..2395
                     /gene="Nxf2"
                     /gene_synonym="4930455N06Rik; Nxf-b"
                     /note="nuclear RNA export factor 2"
                     /db_xref="GeneID:83454"
                     /db_xref="MGI:MGI:1933192"
     exon            1..127
                     /gene="Nxf2"
                     /gene_synonym="4930455N06Rik; Nxf-b"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..2168
                     /gene="Nxf2"
                     /gene_synonym="4930455N06Rik; Nxf-b"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="nuclear RNA export factor 5 isoform 1"
                     /protein_id="NP_001276664.1"
                     /db_xref="CCDS:CCDS72433.1"
                     /db_xref="GeneID:83454"
                     /db_xref="MGI:MGI:1933192"
                     /translation="MWSSPKENLQGRSSMFVQKNINSETYKQRYGLPYKRSERFYHSE
                     YKMNYNHGFQGRKRGVNYIWSQFDRKNNHFDHYGAPYAMGMKRRRERCSYDDQYFLNV
                     WDDSKTEEGETDLDAENETEEKWYKVTIPSGRKYEKTWLMRSIQNFCSEPFIPVDFHY
                     DKTQARFFVQNAKTASALKDVSYRICDETSRKIAIFVSPSVVPYSVQNKFTSEQMEYI
                     RESMMNRYDASQKALDLEKFRFDQDLMDKDIDMMLNRRSCMVATLQIIQSDIPELLSL
                     NLTNNKLYQLDGLSDMTEKAPHVKILNLSRNKLKSFTELEKVKELKLEELWLEGNPFC
                     NCFLDHFEYISTIHDLFPKLLRLDGEDIIVPKRNLQNGKGLIVPTRNLQNGKDLIVPT
                     GNPQDGKDLIVPTGNPQDGKDLIVPTGNPQDGKDLIVPTKMDIEVPQPCKESCNTSEV
                     IKNLVLQFLKEYYLFYDNGDRLRLLDAYHDQACFSLSVPFDVSDPNLNNLEEYFKYSR
                     DLKRQQDSSMRMQLLKHTKHDIVNSLSLLPKTQHDLCSFLVDLFLHTEMMLCFSVNGL
                     FMEVEGKCRGCIRAFTRIFIAIPCSDSRVHSSFRICIMNDELIVRNASPKEIQKAFTS
                     LPAPDTSFKPLLSEEQQEMVKSFSVQSGMKLDWSQKCLQDNEWDYTKAGEAFTALQNE
                     GKIPKEFFK"
     exon            128..222
                     /gene="Nxf2"
                     /gene_synonym="4930455N06Rik; Nxf-b"
                     /inference="alignment:Splign:2.1.0"
     exon            223..325
                     /gene="Nxf2"
                     /gene_synonym="4930455N06Rik; Nxf-b"
                     /inference="alignment:Splign:2.1.0"
     exon            326..479
                     /gene="Nxf2"
                     /gene_synonym="4930455N06Rik; Nxf-b"
                     /inference="alignment:Splign:2.1.0"
     exon            480..563
                     /gene="Nxf2"
                     /gene_synonym="4930455N06Rik; Nxf-b"
                     /inference="alignment:Splign:2.1.0"
     exon            564..668
                     /gene="Nxf2"
                     /gene_synonym="4930455N06Rik; Nxf-b"
                     /inference="alignment:Splign:2.1.0"
     exon            669..749
                     /gene="Nxf2"
                     /gene_synonym="4930455N06Rik; Nxf-b"
                     /inference="alignment:Splign:2.1.0"
     exon            750..819
                     /gene="Nxf2"
                     /gene_synonym="4930455N06Rik; Nxf-b"
                     /inference="alignment:Splign:2.1.0"
     exon            820..908
                     /gene="Nxf2"
                     /gene_synonym="4930455N06Rik; Nxf-b"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1016
                     /gene="Nxf2"
                     /gene_synonym="4930455N06Rik; Nxf-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1126
                     /gene="Nxf2"
                     /gene_synonym="4930455N06Rik; Nxf-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1163
                     /gene="Nxf2"
                     /gene_synonym="4930455N06Rik; Nxf-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1418
                     /gene="Nxf2"
                     /gene_synonym="4930455N06Rik; Nxf-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1474
                     /gene="Nxf2"
                     /gene_synonym="4930455N06Rik; Nxf-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1582
                     /gene="Nxf2"
                     /gene_synonym="4930455N06Rik; Nxf-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1641
                     /gene="Nxf2"
                     /gene_synonym="4930455N06Rik; Nxf-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1757
                     /gene="Nxf2"
                     /gene_synonym="4930455N06Rik; Nxf-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1800
                     /gene="Nxf2"
                     /gene_synonym="4930455N06Rik; Nxf-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1873
                     /gene="Nxf2"
                     /gene_synonym="4930455N06Rik; Nxf-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2071
                     /gene="Nxf2"
                     /gene_synonym="4930455N06Rik; Nxf-b"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2132
                     /gene="Nxf2"
                     /gene_synonym="4930455N06Rik; Nxf-b"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2395
                     /gene="Nxf2"
                     /gene_synonym="4930455N06Rik; Nxf-b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctggcgtt tgaagagagc acgaggaacg gctcagtttc ctggagacta gacagagcga
       61 gcgagcagcc gttcagtgta gtcgttggtg taatgtggtc ctctccaaaa gagaatctgc
      121 aaggcaggtc ttccatgttt gttcagaaga acattaattc tgagacatat aaacaacgat
      181 atggtttacc atacaagaga tctgagagat tctatcattc agaatacaaa atgaattata
      241 accatggttt tcaaggaaga aagagaggtg tgaattatat ctggagtcaa tttgacagaa
      301 agaacaatca ttttgatcat tatggtgctc catatgccat gggaatgaaa agaaggagag
      361 aaagatgcag ttatgatgac caatattttc ttaatgtgtg ggatgatagt aaaactgagg
      421 agggcgaaac agatctggat gctgaaaatg aaactgagga gaaatggtac aaggtcacaa
      481 ttcccagtgg aagaaagtat gagaagacat ggctaatgag gtcaatccag aacttctgta
      541 gtgagccctt catccctgtt gatttccact atgacaaaac ccaggcccgg ttctttgttc
      601 agaatgctaa gactgcctct gcattgaagg atgtcagcta caggatttgt gatgaaacaa
      661 gcagaaaaat agcgatcttt gtcagtcctt ctgttgtgcc ctattctgtg caaaacaagt
      721 ttacatcaga acaaatggag tacataaggg aatctatgat gaaccggtat gacgcctccc
      781 agaaagctct ggacctcgaa aagttccgat ttgaccagga cttaatggac aaggatattg
      841 acatgatgct gaatcgaaga agctgcatgg ttgccacact acagatcatt caaagtgata
      901 tccctgaact gttgtccttg aacttgacaa acaacaaact gtaccagctg gatgggctgt
      961 cagacatgac agagaaggcc cctcacgtta agatcctgaa cctctcccga aataaactga
     1021 agtcattcac ggaattggag aaggtgaaag aactgaagct ggaagagctg tggctggaag
     1081 ggaacccctt ctgcaactgc ttcttggatc attttgagta tataagtact attcatgacc
     1141 tattccccaa gctgttgcgt ctggatggcg aggacataat agtaccaaaa agaaatcttc
     1201 agaatggcaa gggcctaata gtaccgacaa gaaatcttca gaatggcaag gacttaatag
     1261 taccgacagg aaatcctcag gatggcaagg acttaatagt accgacagga aatcctcagg
     1321 atggcaagga cctaatagta ccaacaggaa atcctcagga tggcaaggac ctaatagtac
     1381 caacaaaaat ggacatcgag gtcccgcaac catgcaagga aagctgtaac acatctgaag
     1441 tcataaaaaa tctagttcta caatttctga aagagtacta cttgttttat gacaatggag
     1501 atcgacttcg tcttctcgat gcttaccatg accaggcctg cttctccttg tcagttcctt
     1561 tcgatgtcag tgacccaaac ctgaacaact tggaagagta tttcaaatac agcagagatc
     1621 taaagaggca gcaagactca agcatgcgaa tgcagttgct gaagcacaca aaacatgaca
     1681 tcgtgaactc tcttagcttg ttacccaaaa ctcagcatga tctttgctct ttcttggtgg
     1741 acttgtttct ccacacggaa atgatgctct gtttttctgt gaatggacta ttcatggaag
     1801 tggaaggaaa atgtcgaggc tgcatccgtg ccttcacgag gatcttcatt gctatccctt
     1861 gcagcgattc aagagtgcac tcttccttca gaatttgcat catgaacgat gagctgattg
     1921 tgaggaatgc cagtcccaaa gagatacaaa aggccttcac ctcattgcct gcacccgaca
     1981 cgtcattcaa gcctttgctc tctgaagaac agcaggaaat ggtgaagtct ttctctgtgc
     2041 agtctggaat gaaacttgac tggtctcaga agtgccttca agataacgag tgggactaca
     2101 ccaaagctgg tgaggccttc actgctctcc agaatgaggg caagatccca aaggaattct
     2161 tcaaataaaa ggatactaaa gatgtcctgt ggatagagta ttcctcctca tccacattat
     2221 ttccctttat aaggcctttc ccacacctgg gaatagagag aggcctttct gaccaagaag
     2281 caaaagttaa catgtaggcc aagtaatata accccctctc cccacattgg caatttttct
     2341 gtctccctcc aaagttgttt gtgatttcat aataaagagt ttctttacct tgctt
//
