LOCUS       NM_016813               2312 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus nuclear RNA export factor 1 (Nxf1), transcript variant
            1, mRNA.
ACCESSION   NM_016813
VERSION     NM_016813.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2312)
  AUTHORS   Chappaz,S., Law,C.W., Dowling,M.R., Carey,K.T., Lane,R.M.,
            Ngo,L.H., Wickramasinghe,V.O., Smyth,G.K., Ritchie,M.E. and
            Kile,B.T.
  TITLE     Germline heterozygous mutations in Nxf1 perturb RNA metabolism and
            trigger thrombocytopenia and lymphopenia in mice
  JOURNAL   Blood Adv 4 (7), 1270-1283 (2020)
   PUBMED   32236527
  REMARK    GeneRIF: Germline heterozygous mutations in Nxf1 perturb RNA
            metabolism and trigger thrombocytopenia and lymphopenia in mice.
REFERENCE   2  (bases 1 to 2312)
  AUTHORS   Mougel,M., Akkawi,C., Chamontin,C., Feuillard,J.,
            Pessel-Vivares,L., Socol,M. and Laine,S.
  TITLE     NXF1 and CRM1 nuclear export pathways orchestrate nuclear export,
            translation and packaging of murine leukaemia retrovirus unspliced
            RNA
  JOURNAL   RNA Biol 17 (4), 528-538 (2020)
   PUBMED   31918596
  REMARK    GeneRIF: NXF1 and CRM1 nuclear export pathways orchestrate nuclear
            export, translation and packaging of murine leukaemia retrovirus
            unspliced RNA.
REFERENCE   3  (bases 1 to 2312)
  AUTHORS   Saito,S., Cigdem,S., Okuwaki,M. and Nagata,K.
  TITLE     Leukemia-Associated Nup214 Fusion Proteins Disturb the
            XPO1-Mediated Nuclear-Cytoplasmic Transport Pathway and Thereby the
            NF-kappaB Signaling Pathway
  JOURNAL   Mol Cell Biol 36 (13), 1820-1835 (2016)
   PUBMED   27114368
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2312)
  AUTHORS   Concepcion,D., Ross,K.D., Hutt,K.R., Yeo,G.W. and Hamilton,B.A.
  TITLE     Nxf1 natural variant E610G is a semi-dominant suppressor of
            IAP-induced RNA processing defects
  JOURNAL   PLoS Genet 11 (4), e1005123 (2015)
   PUBMED   25835743
  REMARK    GeneRIF: Mutation E610G, quantitatively accounts for the Nxf1
            modifier gene activity toward IAP insertion.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2312)
  AUTHORS   Pessel-Vivares,L., Ferrer,M., Laine,S. and Mougel,M.
  TITLE     MLV requires Tap/NXF1-dependent pathway to export its unspliced RNA
            to the cytoplasm and to express both spliced and unspliced RNAs
  JOURNAL   Retrovirology 11, 21 (2014)
   PUBMED   24597485
  REMARK    GeneRIF: Taken together, the results show for the first time that
            murine leukemia virus requires the Tap/NXF1-mediated export pathway
            for the expression of its spliced and unspliced RNAs and for
            full-legth RNA nuclear export.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2312)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 2312)
  AUTHORS   Lejeune,F., Ishigaki,Y., Li,X. and Maquat,L.E.
  TITLE     The exon junction complex is detected on CBP80-bound but not
            eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling
  JOURNAL   EMBO J 21 (13), 3536-3545 (2002)
   PUBMED   12093754
REFERENCE   8  (bases 1 to 2312)
  AUTHORS   Levesque,L., Guzik,B., Guan,T., Coyle,J., Black,B.E., Rekosh,D.,
            Hammarskjold,M.L. and Paschal,B.M.
  TITLE     RNA export mediated by tap involves NXT1-dependent interactions
            with the nuclear pore complex
  JOURNAL   J Biol Chem 276 (48), 44953-44962 (2001)
   PUBMED   11579093
REFERENCE   9  (bases 1 to 2312)
  AUTHORS   Stutz,F., Bachi,A., Doerks,T., Braun,I.C., Seraphin,B., Wilm,M.,
            Bork,P. and Izaurralde,E.
  TITLE     REF, an evolutionary conserved family of hnRNP-like proteins,
            interacts with TAP/Mex67p and participates in mRNA nuclear export
  JOURNAL   RNA 6 (4), 638-650 (2000)
   PUBMED   10786854
REFERENCE   10 (bases 1 to 2312)
  AUTHORS   Hamilton,B.A., Smith,D.J., Mueller,K.L., Kerrebrock,A.W.,
            Bronson,R.T., van Berkel,V., Daly,M.J., Kruglyak,L., Reeve,M.P.,
            Nemhauser,J.L., Hawkins,T.L., Rubin,E.M. and Lander,E.S.
  TITLE     The vibrator mutation causes neurodegeneration via reduced
            expression of PITP alpha: positional complementation cloning and
            extragenic suppression
  JOURNAL   Neuron 18 (5), 711-722 (1997)
   PUBMED   9182797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC005594.1.
            
            On Jun 19, 2003 this sequence version replaced NM_016813.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005594.1, AK079583.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2312
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.5 cM"
     gene            1..2312
                     /gene="Nxf1"
                     /gene_synonym="Mex67; Mvb1; Tap"
                     /note="nuclear RNA export factor 1"
                     /db_xref="GeneID:53319"
                     /db_xref="MGI:MGI:1858330"
     exon            1..157
                     /gene="Nxf1"
                     /gene_synonym="Mex67; Mvb1; Tap"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1986
                     /gene="Nxf1"
                     /gene_synonym="Mex67; Mvb1; Tap"
                     /note="isoform 1 is encoded by transcript variant 1; tip
                     associating protein; Mex 67 homolog; tip associated
                     protein; mRNA export factor TAP; modifier of vibrator 1;
                     nuclear RNA export factor 1 homolog"
                     /codon_start=1
                     /product="nuclear RNA export factor 1 isoform 1"
                     /protein_id="NP_058093.2"
                     /db_xref="CCDS:CCDS29543.1"
                     /db_xref="GeneID:53319"
                     /db_xref="MGI:MGI:1858330"
                     /translation="MADEGKSYNEHDDRVSFPQRRKKGRGPFRWKCGEGNRRSGRGGS
                     GVQSSRFEEDDGDVAMNDPQDGPRVRYNPYTNRPNRRGDGWHDRDRIHITVRRDRAPA
                     ERGGAGTSQDGTTKNWFKITIPYGRKYDKTWLLSMIQSKCSVPFNPIEFHYENTRAHF
                     FVEDATTASALKGVNHKIQDRENRRISIIINASAPPYTVQNELKPEQIEQLKLIMSKR
                     YDGNQQALDLKGLRSDPDLVAQNIDVVLNRRSCMAATLRIIEENIPELLSLNLSSNRL
                     YKLDDMSSIVQKAPNLKTLNLSGNELKTERELDKIKGLKLEELWLDRNPMCDNFGDQS
                     SYISAIRERFPKLLRLDGHELPPPISFDVEAPTMLPPCKGSYFGTENLKSLVLRFLQQ
                     YYVIYDSGDRQGLLYAYHDGACCSLSIPYNPQNPVRKNLAEYVKDSRNVKKLKEPTQR
                     FRLLKHTRLNVVAFLNELPKTQHDVNAFVVDISAQTSTLLCFSVNGVFKEVDGKSRDS
                     LRAFTRTFIAVPASNSGLCIVNDELFVRNASPEEIQRAFAMSAPTPSSSPVPTLSPEQ
                     QEMLQAFSTQSGMNLEWSQKCLQDNNWDYTRSAQAFTLLKAKGEIPEVAFMK"
     exon            158..341
                     /gene="Nxf1"
                     /gene_synonym="Mex67; Mvb1; Tap"
                     /inference="alignment:Splign:2.1.0"
     exon            342..495
                     /gene="Nxf1"
                     /gene_synonym="Mex67; Mvb1; Tap"
                     /inference="alignment:Splign:2.1.0"
     exon            496..579
                     /gene="Nxf1"
                     /gene_synonym="Mex67; Mvb1; Tap"
                     /inference="alignment:Splign:2.1.0"
     exon            580..684
                     /gene="Nxf1"
                     /gene_synonym="Mex67; Mvb1; Tap"
                     /inference="alignment:Splign:2.1.0"
     exon            685..765
                     /gene="Nxf1"
                     /gene_synonym="Mex67; Mvb1; Tap"
                     /inference="alignment:Splign:2.1.0"
     exon            766..835
                     /gene="Nxf1"
                     /gene_synonym="Mex67; Mvb1; Tap"
                     /inference="alignment:Splign:2.1.0"
     exon            836..924
                     /gene="Nxf1"
                     /gene_synonym="Mex67; Mvb1; Tap"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1032
                     /gene="Nxf1"
                     /gene_synonym="Mex67; Mvb1; Tap"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1142
                     /gene="Nxf1"
                     /gene_synonym="Mex67; Mvb1; Tap"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1179
                     /gene="Nxf1"
                     /gene_synonym="Mex67; Mvb1; Tap"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1248
                     /gene="Nxf1"
                     /gene_synonym="Mex67; Mvb1; Tap"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1304
                     /gene="Nxf1"
                     /gene_synonym="Mex67; Mvb1; Tap"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1412
                     /gene="Nxf1"
                     /gene_synonym="Mex67; Mvb1; Tap"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1471
                     /gene="Nxf1"
                     /gene_synonym="Mex67; Mvb1; Tap"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1587
                     /gene="Nxf1"
                     /gene_synonym="Mex67; Mvb1; Tap"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1630
                     /gene="Nxf1"
                     /gene_synonym="Mex67; Mvb1; Tap"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1703
                     /gene="Nxf1"
                     /gene_synonym="Mex67; Mvb1; Tap"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1886
                     /gene="Nxf1"
                     /gene_synonym="Mex67; Mvb1; Tap"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..1947
                     /gene="Nxf1"
                     /gene_synonym="Mex67; Mvb1; Tap"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2284
                     /gene="Nxf1"
                     /gene_synonym="Mex67; Mvb1; Tap"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2266..2271
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nxf1"
                     /gene_synonym="Mex67; Mvb1; Tap"
                     /note="hexamer: GATAAA"
     polyA_site      2284
                     /gene="Nxf1"
                     /gene_synonym="Mex67; Mvb1; Tap"
                     /note="major polyA site"
ORIGIN      
        1 cgacgtgctt cgccggataa atgcggtggc gccggtcgta ggagagattc tgtcctgagc
       61 gctaaggctc cttggcgttt ggtggcgtca ggttctgcgc ctgagcccgc ccctgtacct
      121 gcctgtgcca tggcggacga agggaagtca tacaacgagc atgatgaccg tgttagtttc
      181 cctcaaagaa gaaagaaagg ccgggggcct ttccgatgga agtgtggtga ggggaatcgt
      241 aggtctggaa gaggtggttc tggtgtacag tcttcccgat ttgaggaaga tgatggcgat
      301 gtagcaatga atgatcccca ggatggcccc cgagtaagat acaatcccta taccaaccgg
      361 cctaatcgtc ggggagatgg ttggcatgat cgagatcgaa ttcatattac tgtacggaga
      421 gacagagctc ctgcagagag aggaggggct ggcaccagtc aagatgggac caccaagaac
      481 tggttcaaga ttacaattcc ttatggtaga aagtatgaca aaacgtggct tctgagcatg
      541 attcagagca aatgcagtgt ccccttcaat cccatcgagt ttcactatga aaatacacgg
      601 gcccattttt ttgtggagga tgccactact gcttctgcat taaagggtgt caaccataag
      661 atccaggatc gagaaaacag aaggatatct atcatcatca atgcttctgc tccaccctac
      721 actgtacaga atgaactgaa gcccgaacaa atagagcagc tcaagctgat catgagcaaa
      781 cgatatgatg gcaaccaaca agcacttgac ctcaaggggc tccgctcaga cccagatttg
      841 gtggcccaga acatcgatgt tgttctaaac cgcagaagct gtatggcagc caccctgcgg
      901 atcattgaag agaacattcc tgagctattg tctttgaact tgagcagcaa caggctatac
      961 aagctggatg atatgtctag cattgtgcag aaggcgccaa acctaaagac cctaaatctc
     1021 tccggaaacg aattgaagac tgagcgggaa ttagacaaga taaaagggct gaagctggaa
     1081 gagctgtggc ttgacagaaa ccccatgtgt gacaacttcg gagaccagtc cagctatatc
     1141 agcgccattc gcgaacgatt tcccaagtta ttacgcctgg atggccatga gctaccccct
     1201 ccaatttcct ttgatgtcga agcccctaca atgttaccac cctgcaaggg aagctatttt
     1261 ggaaccgaga acctaaagag tctggtcctg cgcttcttgc agcagtacta tgtaatttat
     1321 gactcaggag accgccaggg tctcctgtat gcctaccatg atggcgcctg ttgctcgcta
     1381 agcattcctt acaaccctca gaatcctgtc cgaaaaaact tagctgaata tgtcaaagac
     1441 agcagaaatg tgaagaagct taaagaaccc acccagcggt tccgactctt aaagcataca
     1501 cgtcttaatg tcgttgcctt cctcaatgag ttacccaaaa ctcaacatga cgttaacgcc
     1561 ttcgtggtag atataagtgc ccaaacaagc acattactgt gtttttctgt caatggagtc
     1621 ttcaaggaag tggatgggaa gtctcgagat tctttacgtg ctttcacaag aacgttcatt
     1681 gctgttcctg ccagcaattc agggctatgt attgtaaatg atgaattatt tgtgcggaat
     1741 gccagccctg aagaaatcca aagagccttc gccatgtctg cacccacacc ttcctccagt
     1801 ccagtaccca cgctttcccc agaacagcag gaaatgttgc aagcattttc tacccagtct
     1861 ggcatgaacc ttgagtggtc tcagaagtgc cttcaagaca ataactggga ctacaccaga
     1921 tctgctcagg ccttcactct tctcaaggcc aagggagaga ttccagaagt agcgtttatg
     1981 aaatgatcac aagaaaagtc cccttgtaaa tagcccctgg ataatattgt ctggctgtca
     2041 tctgccgtct cctgtccagc ccgaggccac cctgtaactg tgactgagga ggaagggctg
     2101 cttcatcctc ctcacctacc ttctggaaga cttagagaag acttccggaa gattgagcct
     2161 catggtgcca ggaagccaaa gcttactttg tagagctgac actaaactac ccgaaggact
     2221 taggtgctct gtgtacttaa ccccaggatt ccctttactt tttaagataa agagtgatat
     2281 tgtaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
