LOCUS       NM_176940               7732 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus NACHT and WD repeat domain containing 1 (Nwd1), mRNA.
ACCESSION   NM_176940 XM_982297
VERSION     NM_176940.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7732)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7732)
  AUTHORS   Yamada,S. and Sakakibara,S.I.
  TITLE     Expression profile of the STAND protein Nwd1 in the developing and
            mature mouse central nervous system
  JOURNAL   J Comp Neurol 526 (13), 2099-2114 (2018)
   PUBMED   30004576
  REMARK    GeneRIF: Nwd1 might be involved in the neuronal lineage as a new
            STAND gene, including having a pro-apoptotic or nonapoptotic role,
            similar to Apaf1
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK087622.1 and BC082552.1.
            
            On Apr 29, 2010 this sequence version replaced NM_176940.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082552.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AK087622.1         2-61
            61-7732             BC082552.1         1-7672
FEATURES             Location/Qualifiers
     source          1..7732
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 35.08 cM"
     gene            1..7732
                     /gene="Nwd1"
                     /gene_synonym="A230063L24Rik"
                     /note="NACHT and WD repeat domain containing 1"
                     /db_xref="GeneID:319555"
                     /db_xref="MGI:MGI:2442268"
     exon            1..299
                     /gene="Nwd1"
                     /gene_synonym="A230063L24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            300..385
                     /gene="Nwd1"
                     /gene_synonym="A230063L24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             302..4867
                     /gene="Nwd1"
                     /gene_synonym="A230063L24Rik"
                     /codon_start=1
                     /product="NACHT domain- and WD repeat-containing protein
                     1"
                     /protein_id="NP_795914.3"
                     /db_xref="CCDS:CCDS22418.2"
                     /db_xref="GeneID:319555"
                     /db_xref="MGI:MGI:2442268"
                     /translation="MDTEREALQCTAYPEVQSFCQRHGLAFEVVDLRWGIPNTQATDY
                     LTTELCLEELERCQKTSIGPAFVALLGDQYGPCPVPRRIEEKEWEALRAQLTSRPRDL
                     ELVTRHFQRDDNTIPPTYVLQPSGSLVVPGPEEATLTSVLRGGAQEAWRLGLISQEQW
                     MCYHRSVIEWEIELGLLSSARGDQGATVFLRDVQDLNKHILDDCSLKMVDRLVDGCLD
                     TNAQSLLSGLKGRILDAQPGALKSHHLSWSRDLVNPKNKAHARYLKQLSEQFVARTNH
                     QVLEQLRELELARQELGWLYQEIRHHLWQSTESTKVFCGHQELLAQLRQQLRQDESRT
                     HTPLVLFGPPGIGKTSLMCKLAQQVPELLGHKTVVVLRLLGTSKLSLDARSLLRSLSF
                     QVCLAYGLPLPPAQVLEAHSRVGHFFHTLLHTVSQRNFESLVLLLDSVDDLDSICHSP
                     RVSWLPLKCPPRVHLILSTCSGQQVLHNLQQTLKDPSTYWEVKALSGSQGQEFIQLLL
                     AAEKRMLSPGQRDVLWASLPECGHPGRLRLAFEEARKWASFTVPVPLATTAEEATHQL
                     CIRLEETHGALLVAHVLGYIVSSRYGLSEAELKDVLSLDDEVLQAVYRDWTPPSKELL
                     RFPPLLWVRLRRDLGHCLVRRPVDGCMLLAIAHRQLSQVIQVRYLSGPERAKRHGVLA
                     EFFSGAWSQGIKKLITLPLVGKPLNLDRKVAPQPLWFSSTVANLRKLTELPFHLLHAG
                     RLEELKQEVLGNMSWISCRGISGGIEVLLDDFDMCAPHMNSPEVDLVREAIQLCGPAV
                     ELRGLEKSVLYTELLARLLFFAASHPAMIGQLCQQAQSWFRACPYPMLVPLAGFLQPP
                     GGPLRATLTGCHKGITAIAWSLEEKLLVVGTQDGAMVVWDVEEQQVVHVLMGHTAEVK
                     CVRVFAQGTLAISASKDHTLRLWSLLSGQEKVTILDGGSQNPTEPQSWDLHVDERNNV
                     VYSTSGARINMWNLETSKLVFCITGDVSDPWVCVALLAAQGLLLALSKGGQVSLWSSA
                     MGKLQEKHQLSSIKEETPTCAVSIQSRARLVAGFSSGSIALVSAGEDRLLEKLPEAVG
                     FLVVSEDDSLLVAGFGRFVRIFLADSQGFHRFMASDLEHEDMVETAVLGPENNLIITG
                     SRDALIQVWDLKSTKKLQSPTPFLDRTGLAAVSHHGSFVYFPKVGDKNKVTIWDLAEG
                     EEQDCLDTSNEVRCLEVAEQAKLLFTGLVSGIVLVFPLNSRQDVLCIPPPEARKAVNC
                     MSLSKSENRLAIAYDNIVLVLDISPGDPCPAIEGPTYTFYTQLPETIVSVAVLADYRV
                     VYGMSDGSLFLYDCACSKVFPLEAHGSRVSCVEVSHSEQLAVSGAEDALLCLWDLQAC
                     RGMFEMSYENSCCRGVRCACFSRDDKHVFAGMEDRSVTAWSTVDGTLLAVQFVHAVIN
                     RIIPTSNGFMAPTSHGYLIRERFQCPSVRASQQDPLKNFKKAVWLVKTRQREELAAAE
                     ASQDAEPVAVEGKESKSNKRSQVCLIL"
     exon            386..502
                     /gene="Nwd1"
                     /gene_synonym="A230063L24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            503..800
                     /gene="Nwd1"
                     /gene_synonym="A230063L24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            801..2070
                     /gene="Nwd1"
                     /gene_synonym="A230063L24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2274
                     /gene="Nwd1"
                     /gene_synonym="A230063L24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2434
                     /gene="Nwd1"
                     /gene_synonym="A230063L24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2552
                     /gene="Nwd1"
                     /gene_synonym="A230063L24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2711
                     /gene="Nwd1"
                     /gene_synonym="A230063L24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..2909
                     /gene="Nwd1"
                     /gene_synonym="A230063L24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..3032
                     /gene="Nwd1"
                     /gene_synonym="A230063L24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3033..3241
                     /gene="Nwd1"
                     /gene_synonym="A230063L24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3242..3514
                     /gene="Nwd1"
                     /gene_synonym="A230063L24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3515..3605
                     /gene="Nwd1"
                     /gene_synonym="A230063L24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3606..3760
                     /gene="Nwd1"
                     /gene_synonym="A230063L24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3761..3911
                     /gene="Nwd1"
                     /gene_synonym="A230063L24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3912..4462
                     /gene="Nwd1"
                     /gene_synonym="A230063L24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4463..4568
                     /gene="Nwd1"
                     /gene_synonym="A230063L24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4569..7722
                     /gene="Nwd1"
                     /gene_synonym="A230063L24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7648..7653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nwd1"
                     /gene_synonym="A230063L24Rik"
                     /note="hexamer: AATATA"
     polyA_site      7670
                     /gene="Nwd1"
                     /gene_synonym="A230063L24Rik"
                     /note="major polyA site"
     regulatory      7696..7701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nwd1"
                     /gene_synonym="A230063L24Rik"
                     /note="hexamer: AATATA"
     polyA_site      7722
                     /gene="Nwd1"
                     /gene_synonym="A230063L24Rik"
                     /note="major polyA site"
ORIGIN      
        1 gacttccaaa tgacgccctc catggcagca agagggaagc gggcatcttg gagagagcct
       61 ggagtagacg ctgcaaaagg gcccttgaag atgcctcatt cttgctgagg tgtttgcagt
      121 taacatacag gagccaaaat gatgggcagc tgcccaagca ctcactgagc tcaagatttg
      181 tcagtgagcc cctactgtgt gctgggcatg ctgacgcatg gttttaggat ttatgcacct
      241 gtgggtccca cacttcccag ggagcagaca ctgaacatgg agagccttgg gagctgagga
      301 tatggacaca gagcgagaag ccctgcagtg cacagcctac cctgaggttc agagcttctg
      361 ccaaaggcac ggcttggcgt ttgaggtggt tgatctgagg tggggtattc cgaatacgca
      421 ggccactgac tacctgacca cggaactctg cttagaagaa ctggagcgct gtcagaaaac
      481 atccatagga ccagcttttg tggccctcct gggtgaccag tacggcccct gcccggttcc
      541 ccggaggatt gaggaaaagg agtgggaggc actaagagct cagctgacct ccaggcctcg
      601 agatctggag ctggtgacca gacatttcca gagagacgac aacaccattc ctccaaccta
      661 cgtcttgcag ccttcaggct cactggtggt cccagggcct gaggaggcca ccttaacctc
      721 tgtcctgaga ggtggagccc aggaggcctg gaggctaggc ctcatcagcc aggagcaatg
      781 gatgtgctat caccgatcag ttattgagtg ggagatcgag cttggcctac tgagctcagc
      841 aagaggggac cagggagcta ccgtcttcct gagagatgta caggacctca ataaacacat
      901 cttggatgat tgctctctga agatggtgga tcggctggta gatggctgcc tggataccaa
      961 tgcccagagt cttctcagtg gtcttaaagg gcgcatacta gatgctcagc ctggagccct
     1021 aaagtcccac cacctgtcct ggagccgaga cctggtcaac cccaagaaca aggctcacgc
     1081 tcgttaccta aagcagttga gcgagcagtt cgtggccagg accaaccatc aggtcctgga
     1141 gcagcttcga gagctggagt tggccagaca ggagctgggt tggctctacc aagagatccg
     1201 ccaccacctc tggcagagca cagagtctac caaggtcttc tgcggccacc aggagctcct
     1261 ggcccagctc aggcagcagc tcagacagga tgagagccgg acacatactc ccttggttct
     1321 ctttggacca ccaggcatcg ggaagacctc tctcatgtgc aagctagccc agcaggtacc
     1381 agagctactt ggccacaaga cagtggttgt cctgaggctg ctagggacat caaagctgag
     1441 cctggatgcc cgcagcctcc tcaggagcct gtccttccaa gtgtgcttgg catatgggct
     1501 gccactgccc ccagcccagg tcctggaggc ccacagcagg gtgggccatt tcttccatac
     1561 tctcctccac accgtgtcac agaggaactt tgagtccctg gtgttgctcc tggactccgt
     1621 ggatgacctg gactccatat gccattctcc gagggtctct tggctgcccc tcaagtgtcc
     1681 tccaagggtg cacctcatcc tctctacatg ctcaggccag caggttttac ataacctgca
     1741 acagaccctc aaggacccca gcacctactg ggaggtgaag gccctgtctg gaagtcaagg
     1801 ccaggagttc atacagctgc tgctggctgc agagaagagg atgctgagcc cgggtcagag
     1861 agatgtcctc tgggccagcc tcccagagtg tggccaccca gggaggctaa ggctggcctt
     1921 tgaggaggcc cggaagtggg cctccttcac tgtgccagtg cccttggcca ctacagcaga
     1981 ggaagccaca caccagctct gtatacgcct ggaggagaca catggggcac tgctggtggc
     2041 tcatgtactg ggctatattg tgtcttccag gtacggtctc tcagaagcag agctgaagga
     2101 tgtgttgtct ttggatgatg aagtcttgca ggctgtgtac cgggactgga cgccacctag
     2161 caaagagctg ctgcgcttcc cgcccctgct gtgggtgcgg ctccgccggg acctgggaca
     2221 ctgcctagtc aggaggcccg tggatggctg catgctactg gccattgcac acagacagct
     2281 gtcccaggta atccaagttc gatatctgtc tgggcctgag agagccaaga ggcatggcgt
     2341 gctagctgaa ttcttctctg gagcctggag ccaggggatc aagaaactta tcaccctgcc
     2401 gcttgtaggg aagcccctga acctggaccg caaggtggcc ccacagccac tgtggttctc
     2461 aagcacagtg gccaacctga ggaagctgac cgaactgccc ttccatctgc tgcatgcagg
     2521 ccgcttggag gagttgaagc aggaggttct ggggaacatg agttggatct catgtcgggg
     2581 catctctgga ggcattgagg tcctgctgga tgattttgac atgtgtgccc ctcacatgaa
     2641 ctctcctgag gttgatctgg ttagagaagc catccagctg tgtggccctg ctgtggagct
     2701 ccggggcctg gagaagagcg tcctatacac cgagctcctg gccagactcc ttttctttgc
     2761 tgcatcacat ccagcaatga tcggacaact gtgccaacaa gcccagagct ggttccgtgc
     2821 ctgcccctac ccaatgctgg tgcccctggc aggattcctg cagccacctg gtggacctct
     2881 tcgagccact cttactgggt gtcacaaagg catcaccgcc atagcatgga gcctggagga
     2941 gaaactcctg gtggtgggca cccaggatgg tgccatggtc gtgtgggacg tggaggaaca
     3001 acaggtggta cacgttctaa tgggacacac agctgaagtg aagtgtgtgc gagtgtttgc
     3061 ccaagggact cttgccatct ctgcatcaaa ggaccatacc ctgcgtctgt ggagtctgct
     3121 ttccggccag gagaaagtca ccattttgga tggagggtca caaaatccca cagagcccca
     3181 gagttgggac cttcatgtgg atgagagaaa caatgttgta tactcgacat ctggtgcaag
     3241 gatcaacatg tggaatctgg aaacttcgaa gctggttttc tgtatcacag gagatgtgtc
     3301 tgatccctgg gtctgtgtgg ctttgttggc tgcccagggt ttgctgcttg ccctgtccaa
     3361 gggtggccag gtcagtctgt ggagctcagc catgggaaaa ctgcaggaga aacaccagtt
     3421 atccagcatc aaagaagaga cacccacctg tgccgtctcc atccagtccc gggcaaggct
     3481 ggtcgctggc ttcagcagtg gctccattgc cctggtctcc gctggagaag acaggctgct
     3541 ggagaagctc ccagaagctg tggggttcct ggtggtttct gaagacgatt cccttcttgt
     3601 ggcaggcttt ggaagatttg tgcggatttt cttggctgac tcgcaaggct tccaccggtt
     3661 catggcttcg gatctggaac acgaggacat ggtggagaca gcagtcttgg gtcctgagaa
     3721 caatctgatc atcacagggt cccgggatgc acttatccag gtctgggatc tcaagtccac
     3781 taagaagctg cagtctccga ctccatttct ggaccgcacc ggcctcgctg cagtgtccca
     3841 ccatggcagc tttgtctact tccctaaggt tggggacaaa aacaaagtca caatttggga
     3901 cttggcagaa ggtgaggagc aagattgcct ggacacgtcc aatgaggtcc gctgtctgga
     3961 ggtggccgag caggccaagc tcctcttcac aggcctggtt tctgggatcg tgcttgtgtt
     4021 ccccctgaat tccaggcaag atgtactgtg catcccccca cctgaggcac gcaaagctgt
     4081 caactgcatg tccctgagca agagtgagaa tcgtctggcc attgcctatg acaacattgt
     4141 cctggtgctt gacatcagcc ctggggaccc atgtccggcc attgaaggcc ccacctacac
     4201 cttttacacc cagctgcctg agaccatagt gagtgtggct gtcctggctg actatcgtgt
     4261 ggtctacggc atgagcgatg gcagcctctt cctgtacgac tgtgcatgct ctaaagtgtt
     4321 ccctctggag gcccatggga gcagggtgag ctgtgtagag gtcagccaca gtgagcagct
     4381 agcagtgagc ggggctgaag atgcactgct atgcctctgg gacctgcagg cttgcagggg
     4441 gatgttcgag atgagctatg agaactcctg ctgcagaggg gtgcggtgtg cctgcttctc
     4501 cagggatgac aagcatgtat ttgcaggcat ggaggaccgc tctgtcactg cctggagcac
     4561 ggtggatggc actcttttgg ctgtccagtt tgttcatgct gtgatcaacc gaatcatccc
     4621 tacctccaat ggcttcatgg cccccacaag ccacggctat ctcatccgtg agcgcttcca
     4681 gtgcccgtca gtcagagcct cccagcaaga ccctctcaag aacttcaaga aggcagtgtg
     4741 gctggtaaag accaggcaga gggaagagct ggctgcagca gaagcctccc aggatgcaga
     4801 accagtggcc gtagagggaa aggaatcaaa gtcaaataaa cgctcacagg tctgcctcat
     4861 actctgaaag cctaccaagg caggggcttc agtgacttag ccatggctca cctggttgaa
     4921 gccaactgac tctctctgct ggtgccatgt ggaccccccc ttcccctcaa ccatcttcca
     4981 tttttcctca tagctttttc tgtgggttct gaaggcctac ttccttcaag tgagcagcag
     5041 cctgcatctc ccaccttact ctaagaactt ggctcaaagg cttggctctg cctcttagtt
     5101 gtactggtgc aattcttatc cctgagccag ttactagctg tgagaggatc tgaaatcatt
     5161 gtagggacca agagtgacct tgtcaaagtg ttgtgtgatg gagagtgaaa gactgctggg
     5221 atgtgatggg tgctgtcctg tcttcatagc agtgagcctc cagtaatagc ccataatcca
     5281 tactgcaaag ccacacagag catagttaaa cacacagcat agttagtctg tctgcagctc
     5341 ctgctgtgag actcaaaatg gtgtgtaaaa aaaatcctcc taggatctgg tggtggcata
     5401 gctttcaatc ccagcactca ggaggcagag gcaggaggat tcctgtgagt ttgaggccag
     5461 ccttaggtta catagtaagt ttcaggacag ccagagctat gtagagagaa aagactggtg
     5521 ctggctcagg gcttaaatca ccttgcatcc cagaatacaa gaacattgta cacactgtca
     5581 ccaacctgta agcctagcct cagggaacag gctatttttg tttcttccac tgctgtgact
     5641 gaaaaactcg accaaaagca acttagagga ggaaatggtt catctggctt tcacccccag
     5701 gccacacacc cagttcttta cttagggaag tcagggaacg aactcaagca ggaactgaag
     5761 gcaagcctgc tggctattgc acacagcatg acctctgact aggggactca gccgcggtca
     5821 tacagcagtg tctccgtcat tatcaattag tgatggtcaa gagacaccat gaccatggca
     5881 aagcagttaa tggggttggg agaactgttt atagtttcaa aggcttagtc cactgtcatc
     5941 acgacaggga gcctggtggc acacatggca ggcatggtgc tgcaggaata gctgaaagat
     6001 atatcatgag aatcctttta aacagttccc tctccggtgg ccagacactc aaatatatat
     6061 gcctctggga gccattctca ctcaagacac aagcctgaac cacagaggat gtagtttctg
     6121 ccgttctcct gattagctaa gctttttcat aagccccaga accacttacc actcacagtg
     6181 ggctccctcc tccatcagct agcagtcaag acaatgcccc atggacaggc ccacacacca
     6241 gtctgacctg ggcaaccctt caattaagac ttgcttctca ggtgactcta ggctatgtga
     6301 agttgacagt taaagctaat aaggtcatag aggatcctga gcattctggc tagctagcta
     6361 gacacatctg tgagctctgg gtttgattaa gagaccctgc cacaatgaat aaggtagaag
     6421 agaagtcaat gattattcct gactcaacct catgccttca gatacacatc acatgtaccc
     6481 acatgggtgc tcaggcacac atgaacactc atgatgccca caccagcctc catgtgtagc
     6541 caaaagtgct ggcacagtct tatcctcctg cctccatttc ctgcttggac aactataacc
     6601 actgtgccca gctaagatgc tgtctcactc agttccctga cacatcagga catgctagca
     6661 tctacctgct ttgctgccag accttctgcc ttgaaatggc tttctccaca gtgctcacag
     6721 ccatctagtg agccggtctt gtgcctggag ccttgctaca gccagacctt agaggtgaga
     6781 ggcccccttc acgccatggg acactagaca gactcagtga aagcagcagt agaaacagct
     6841 tgtttttctg tgttggatac agaaccagga cttgaaggca agtgctatat ctcaagccat
     6901 accctgagcc cttactgggg gaatccagga aggggcttta ctgctcagtc acattccagc
     6961 ttcaaaatga ggcctttgaa gataccttgt tcagttactt cccaaataag gattccaatg
     7021 catgctttag caattctgaa aatgttagtg tcaaatttta tttttttaaa aaaattactg
     7081 gttatggcaa acagaggttg tgtgcacctt taatcatagc acttgagagg cagtggcagt
     7141 ggcagtggca gtggcagtgg cagtggcaga agcagaggca ggcagatttc tgagatcaag
     7201 gccagcctgg tctacaaagt gagttcagga cagccagggc tatacagaga attcctgtct
     7261 ccaacagcag cagcagcagc agcaacaaca acaaaggtct ggagagatgg ctcagcagtt
     7321 tgatccatct tagcccccac atcagatggc acacaaaagg ccttttggcc tttggagata
     7381 cctgcccaaa catacacaca cacacacaca cacacacaca cagaattaag atcaatattt
     7441 ttaaaaatta tgggccaatg agctgactca gttggtaaca gcacttgcta ctcagtcccg
     7501 atgggctgag ttcaatccct ggcactcaga gagtggaagt agagagccga cttcagagtt
     7561 gctctctgac tccacacatt cactaaggta agcaccatgg tgatgacacc cccaccatgc
     7621 actcatatgc ataccaatag tagtaataat ataataacaa taaaattaaa gatctatttt
     7681 aagctgtaat ttaaaaatat atgcacatgt attgaacaat aaaaaaaaaa aa
//
