LOCUS       NM_172521               3731 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus NUT midline carcinoma, family member 1 (Nutm1), mRNA.
ACCESSION   NM_172521
VERSION     NM_172521.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3731)
  AUTHORS   Zheng,D., Elnegiry,A.A., Luo,C., Bendahou,M.A., Xie,L., Bell,D.,
            Takahashi,Y., Hanna,E., Mias,G.I., Tsoi,M.F. and Gu,B.
  TITLE     Brd4::Nutm1 fusion gene initiates NUT carcinoma in vivo
  JOURNAL   Life Sci Alliance 7 (7), e202402602 (2024)
   PUBMED   38724194
  REMARK    GeneRIF: Brd4::Nutm1 fusion gene initiates NUT carcinoma in vivo.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3731)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3731)
  AUTHORS   Durall,R.T., Huang,J., Wojenski,L., Huang,Y., Gokhale,P.C.,
            Leeper,B.A., Nash,J.O., Ballester,P.L., Davidson,S., Shlien,A.,
            Sotirakis,E., Bertaux,F., Dubus,V., Luo,J., Wu,C.J., Keskin,D.B.,
            Eagen,K.P., Shapiro,G.I. and French,C.A.
  TITLE     The BRD4-NUT Fusion Alone Drives Malignant Transformation of NUT
            Carcinoma
  JOURNAL   Cancer Res 83 (23), 3846-3860 (2023)
   PUBMED   37819236
  REMARK    GeneRIF: The BRD4-NUT Fusion Alone Drives Malignant Transformation
            of NUT Carcinoma.
REFERENCE   4  (bases 1 to 3731)
  AUTHORS   Huang,Y., Durall,R.T., Luong,N.M., Hertzler,H.J., Huang,J.,
            Gokhale,P.C., Leeper,B.A., Persky,N.S., Root,D.E., Anekal,P.V.,
            Montero Llopis,P.D.L.M., David,C.N., Kutok,J.L., Raimondi,A.,
            Saluja,K., Luo,J., Zahnow,C.A., Adane,B., Stegmaier,K.,
            Hawkins,C.E., Ponne,C., Le,Q., Shapiro,G.I., Lemieux,M.E.,
            Eagen,K.P. and French,C.A.
  TITLE     EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma Growth by
            Silencing Key Tumor Suppressor Genes
  JOURNAL   Cancer Res 83 (23), 3956-3973 (2023)
   PUBMED   37747726
  REMARK    GeneRIF: EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma
            Growth by Silencing Key Tumor Suppressor Genes.
REFERENCE   5  (bases 1 to 3731)
  AUTHORS   Shiota,H., Barral,S., Buchou,T., Tan,M., Coute,Y., Charbonnier,G.,
            Reynoird,N., Boussouar,F., Gerard,M., Zhu,M., Bargier,L.,
            Puthier,D., Chuffart,F., Bourova-Flin,E., Picaud,S.,
            Filippakopoulos,P., Goudarzi,A., Ibrahim,Z., Panne,D.,
            Rousseaux,S., Zhao,Y. and Khochbin,S.
  TITLE     Nut Directs p300-Dependent, Genome-Wide H4 Hyperacetylation in Male
            Germ Cells
  JOURNAL   Cell Rep 24 (13), 3477-3487 (2018)
   PUBMED   30257209
  REMARK    GeneRIF: Inactivation of Nut induces male sterility with
            spermatogenesis arrest at the histone-removal stage.  Nut uses p300
            and/or CBP to enhance H4 acetylation.
REFERENCE   6  (bases 1 to 3731)
  AUTHORS   Inagawa,M., Nakajima,K., Makino,T., Ogawa,S., Kojima,M., Ito,S.,
            Ikenishi,A., Hayashi,T., Schwartz,R.J., Nakamura,K., Obayashi,T.,
            Tachibana,M., Shinkai,Y., Maeda,K., Miyagawa-Tomita,S. and
            Takeuchi,T.
  TITLE     Histone H3 lysine 9 methyltransferases, G9a and GLP are essential
            for cardiac morphogenesis
  JOURNAL   Mech Dev 130 (11-12), 519-531 (2013)
   PUBMED   23892084
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK077049.1 and BC125332.1.
            
            On Jan 17, 2019 this sequence version replaced NM_172521.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077049.1, BC125334.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AK077049.1         1-20
            21-3531             BC125332.1         1-3511
            3532-3731           AK077049.1         3532-3731
FEATURES             Location/Qualifiers
     source          1..3731
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 56.97 cM"
     gene            1..3731
                     /gene="Nutm1"
                     /gene_synonym="4932438M10; Nut"
                     /note="NUT midline carcinoma, family member 1"
                     /db_xref="GeneID:213765"
                     /db_xref="MGI:MGI:2661384"
     exon            1..126
                     /gene="Nutm1"
                     /gene_synonym="4932438M10; Nut"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..3491
                     /gene="Nutm1"
                     /gene_synonym="4932438M10; Nut"
                     /note="protein NUT; nuclear protein in testis (Nut)"
                     /codon_start=1
                     /product="NUT family member 1"
                     /protein_id="NP_766109.1"
                     /db_xref="CCDS:CCDS16549.1"
                     /db_xref="GeneID:213765"
                     /db_xref="MGI:MGI:2661384"
                     /translation="MASDGTSPLPGPDMSMKPGTGLSPFSALPFAPPPPVPPDQPLWE
                     PSPQPPIPPVFSPSNPLLLSAFPSPLLVTGEGGPGPSVAGTGQVIVKVKTDVGPAESS
                     QTQNLIVTQTALNWIPSGAPCGSQEGPPPPRYVTASNVKTILPAVAVGVSQEGLAGLP
                     LQVLPPAAQLAPIVPLEKPWPGTQATTMEGGPVAARKPSQGDLAYASKGVYENYRRWQ
                     RYKVLARTHLSQSPDVEALSCFLIPVLRSLARLKPTMTLEEGLPRALQEWERTSNFDR
                     MIFYEMAEKFMEFEAEEETQIQNAQLMNGSPGLSPIAPLKLDPPGSMVPEACQQPVYI
                     PKKAASKTRAPRRRQRKPQRPPVPEAPKEIPPEAVQEYVDIMDGLMGSYVDTGKTEEE
                     EEGQQEGAGMYPDPSLLSYIDELCSQEVFVSKVEAVIHPQFLADLLSPEEQRDPLSLL
                     EELEQEEGLNLAQLVQKRLLALEEEDAQTPPSCSGAQSDSSPSVSDEDEDGGQRRRPS
                     PGLQGAAGIVRIGKSASPGKQAREIHGGQEQTLGGPAGIHKDGNNLPSPSSWDVQLEL
                     TASQGMPVLLGMERKMSGKAIKQLSATQDGHLGRTGSPGYYPVADRNPEVLPCCWQED
                     PQHMRAPNFDVGLTEPVPLQGLGLEKQALTLQIGKRIGGAGMLTRGREPPSVVSQKGS
                     SRAVRGDDRGPGMLQSYSQNHSPGAAGNLDRVSLSPGLWLSSDMGAVGLELPLQIETV
                     IDSIQDEACRREDQALNSRNSASLGPRKNTVPKDVGNSVIPSGGPDTTAVPEKRNPCS
                     LPGSLMASGPGLRSKEKISKENQALSPKTIQNPSDLWAEACPPLLPTLVSSTLGSSKD
                     TLIPTCQGNLLIIGTQDASSLAQTSQKAESRGNLLFPLLENIDQVTILDVKDDSCPQP
                     GVSKDSCLSNFNSYNLQGEGREDTVSSKPTDLVPLQDNQESYTHETTKLTNGQGQGST
                     SPRWATRDAYILRETPIKEKCTSADRAKRRETEKEEEDEELSNFSYLLASKLSLSSGG
                     LPLSTRQASGGQGIVKTSRHSTEVDDLGQPSPPPKSGKQALVGSPATVVERDQQGAQF
                     NGSGQKPLALGMAQLPQPRKRRRDGFVTSKRKKRRRSQ"
     exon            127..835
                     /gene="Nutm1"
                     /gene_synonym="4932438M10; Nut"
                     /inference="alignment:Splign:2.1.0"
     exon            836..964
                     /gene="Nutm1"
                     /gene_synonym="4932438M10; Nut"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1104
                     /gene="Nutm1"
                     /gene_synonym="4932438M10; Nut"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1382
                     /gene="Nutm1"
                     /gene_synonym="4932438M10; Nut"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1499
                     /gene="Nutm1"
                     /gene_synonym="4932438M10; Nut"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..3731
                     /gene="Nutm1"
                     /gene_synonym="4932438M10; Nut"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttccttagat atcatctgtt ggagctgggt tattgcctgg atcctagact caagtgtttc
       61 attctggagc cttccagact gtcactgttg gagtacctaa acctcggatt atggcatcag
      121 atggaacctc tccattacca ggaccagata tgtccatgaa acctggcact ggcctgtccc
      181 ctttcagtgc gcttcctttt gccccacctc ctcctgttcc accagatcaa cccctctggg
      241 agccatcacc acagccccct atacctcctg tcttctctcc aagcaatcct ctgctccttt
      301 ctgctttccc cagcccattg ttggtgacag gagaaggagg ccctggcccc agtgtggctg
      361 gaactggcca ggtcattgtc aaagtcaaga ctgatgtggg gccagctgag tcctctcaaa
      421 cccagaacct tatagttact cagactgccc taaactggat tccctcaggg gctccttgtg
      481 ggagccagga ggggcctcct cctcctcggt atgtgaccgc ctctaatgtg aagaccatcc
      541 tgcctgctgt agcagttgga gtgagccagg agggccttgc aggacttcct ctgcaggtcc
      601 taccaccagc tgcccaactg gctcccattg tgcccctgga aaagccctgg ccaggaacac
      661 aagcaacaac catggaagga ggccccgtgg ctgctcggaa gccctctcaa ggtgaccttg
      721 cctatgcttc caagggtgtt tatgagaact atcgtcgctg gcagcgctac aaagtcttgg
      781 cccggactca cctatcccag agtcctgatg tagaagctct ttcatgcttc cttatcccag
      841 tgcttcgttc cctggcccga ctgaagccta ctatgacctt ggaggaggga ctgccgaggg
      901 ctctgcagga atgggagcgg accagcaact ttgaccggat gatcttttat gagatggcag
      961 agaagttcat ggagtttgag gccgaggaag aaacacagat acagaatgca cagttgatga
     1021 atggctcccc gggtctgtcc cctatagccc ctttgaaact tgatcctcca gggtccatgg
     1081 tccctgaggc ttgccagcag ccagtgtaca tccctaagaa ggcagcctct aagactcggg
     1141 ctcctcggcg gcggcaacgc aaacctcaaa ggcctcctgt tcccgaggca cccaaagaga
     1201 tcccacctga agctgtgcaa gaatatgttg acatcatgga tgggctgatg ggaagctacg
     1261 tggacactgg gaagacagaa gaggaggagg aggggcagca ggaaggtgca gggatgtatc
     1321 cagatccaag tcttctgagc tacattgatg aactctgttc tcaggaagtc tttgtctcca
     1381 aggtggaggc agtcatacac cctcagtttc tggcagatct gctgtctcca gaagagcaga
     1441 gagatccttt gtctttactt gaggaactag agcaagaaga aggactgaat cttgcccagc
     1501 tggtccagaa acgactcttg gccttggagg aggaagatgc acagacacct ccaagttgca
     1561 gcggagctca gtcagactca agtccttctg tttctgatga agatgaagac gggggtcaaa
     1621 ggcgtcggcc ctcacctggg cttcaggggg ctgcgggcat tgttcgcatt ggaaaatctg
     1681 cttctccagg caagcaggca agagaaatac atggtgggca ggaacaaaca ctaggtggtc
     1741 cagcggggat tcacaaggat ggaaataatc tgccatcccc tagcagctgg gatgtacagc
     1801 tagagctcac agcttcacag gggatgccag tactcttggg tatggagaga aaaatgtctg
     1861 ggaaggctat aaaacagcta tctgcaactc aggatggcca cctgggaagg actgggtccc
     1921 ctgggtacta cccagtagca gataggaatc cagaggtttt accttgttgt tggcaagaag
     1981 atccccaaca catgagagcc cccaattttg atgttggact tacagagcca gttcctctgc
     2041 aaggacttgg gttagaaaaa caggctttga cattgcagat aggaaagcgg atcgggggag
     2101 ctgggatgct tactcgagga agagaaccac cttcagtggt ttcccagaag ggctcttcaa
     2161 gggccgtgcg gggagatgac agaggtcctg gtatgcttca gagttacagt caaaaccatt
     2221 cccctggagc agctggcaac ctagacaggg tttctctcag cccaggactg tggctgagca
     2281 gtgacatggg tgctgtaggt ttagagcttc ccttacaaat tgagactgtc atagacagca
     2341 tccaagatga ggcatgcaga agagaggacc aggcattgaa ttctagaaac agtgcttctc
     2401 taggtcctag aaaaaacaca gtgcccaagg atgtggggaa cagtgtgatt ccctctggag
     2461 gcccagatac aacagctgtc ccagaaaaga gaaacccctg cagcttgcca ggatctttga
     2521 tggccagtgg tccaggtttg aggtccaaag aaaaaatttc caaagaaaat caagcgctga
     2581 gccctaaaac catacagaat cctagtgatc tgtgggctga agcttgcccc ccactgctgc
     2641 caacacttgt ctcttccaca ctggggtctt ccaaagacac cctgataccc acatgccaag
     2701 gcaatcttct tatcattggg acccaggatg cctcctctct tgcccagact agccaaaagg
     2761 cagagagcag aggtaatcta ctttttcctc tgttggaaaa catagatcag gtcaccatac
     2821 tagatgttaa agatgacagt tgcccccaac caggggtcag caaggattcc tgcttatcaa
     2881 attttaattc ttataacctc caaggagagg gcagggaaga tactgtttcc tccaaaccca
     2941 ccgaccttgt tcctttacaa gacaatcaag aatcctatac acatgagaca accaaattga
     3001 caaatggcca gggccaggga agtacttccc caaggtgggc aaccagggat gcttatattt
     3061 tgagagaaac ccctattaaa gaaaaatgca cctcagcaga tagagccaaa agaagagaga
     3121 cagagaagga ggaagaagac gaagagctct ccaacttctc ctaccttttg gcttcaaaac
     3181 tcagcctctc ttcaggaggg cttcccctta gtactcgtca ggcctctgga ggtcagggaa
     3241 ttgtgaaaac atcccgccac tctactgaag tagatgacct tggccagcct tcaccccctc
     3301 ccaagtctgg gaagcaagcc ctagttggga gtccagctac tgttgtagag agagaccagc
     3361 aaggagctca gtttaatggt tctgggcaga agccccttgc tctgggaatg gcccagctcc
     3421 cacagcctcg gaaaaggcgg cgtgacggtt ttgtcaccag caaaaggaag aaacgacgtc
     3481 gtagccagta ggaagcagag ggccaccctg ctccacctag cagcacccaa agtctatttt
     3541 agtgctgctg ctccccctac cccgtggaga agcagtctca gcccaatgct gtttttgttt
     3601 tgttgtgcca gaagctggag atcctggggc aggtcagact ggctaggttg cagaggtcct
     3661 gttagtggga accaaaggga aaagttggct ttcggaagtt atgtggagaa ataaagattg
     3721 tttttggttg g
//
