LOCUS       NM_019738                639 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Mus musculus nuclear protein transcription regulator 1 (Nupr1),
            mRNA.
ACCESSION   NM_019738
VERSION     NM_019738.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 639)
  AUTHORS   Shigesawa,I., Nakamura,A., Yamauchi,Y., Kawata,S., Miyazaki,A.,
            Nomoto,H., Kameda,H., Terauchi,Y. and Atsumi,T.
  TITLE     Effects of glucokinase haploinsufficiency on the pancreatic
            beta-cell mass and function of long-term high-fat, high-sucrose
            diet-fed mice
  JOURNAL   J Diabetes Investig 15 (12), 1732-1742 (2024)
   PUBMED   39305123
REFERENCE   2  (bases 1 to 639)
  AUTHORS   Cui,Y., Yang,G., Li,H., Sun,J., Liu,X. and Xia,X.
  TITLE     Reduced expression of NUPR1 alleviates epilepsy progression via
            attenuating ER stress
  JOURNAL   Biochem Biophys Res Commun 730, 150365 (2024)
   PUBMED   38996786
  REMARK    GeneRIF: Reduced expression of NUPR1 alleviates epilepsy
            progression via attenuating ER stress.
REFERENCE   3  (bases 1 to 639)
  AUTHORS   Liao,T., Shi,L., He,C., Liu,D., Wei,Y., Ma,Z., Wang,P., Mao,J. and
            Wu,P.
  TITLE     Suppression of NUPR1 in fibroblast-like synoviocytes reduces
            synovial fibrosis via the Smad3 pathway
  JOURNAL   J Transl Med 22 (1), 715 (2024)
   PUBMED   39090667
  REMARK    GeneRIF: Suppression of NUPR1 in fibroblast-like synoviocytes
            reduces synovial fibrosis via the Smad3 pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 639)
  AUTHORS   Santofimia-Castano,P., Fraunhoffer,N., Liu,X., Bessone,I.F., di
            Magliano,M.P., Audebert,S., Camoin,L., Estaras,M., Breniere,M.,
            Modesti,M., Lomberk,G., Urrutia,R., Soubeyran,P., Neira,J.L. and
            Iovanna,J.
  TITLE     Targeting NUPR1-dependent stress granules formation to induce
            synthetic lethality in KrasG12D-driven tumors
  JOURNAL   EMBO Mol Med 16 (3), 475-505 (2024)
   PUBMED   38360999
  REMARK    GeneRIF: Targeting NUPR1-dependent stress granules formation to
            induce synthetic lethality in Kras[G12D]-driven tumors.
REFERENCE   5  (bases 1 to 639)
  AUTHORS   Murayama,M., Hirata,H., Shiraki,M., Iovanna,J.L., Yamaza,T.,
            Kukita,T., Komori,T., Moriishi,T., Ueno,M., Morimoto,T.,
            Mawatari,M. and Kukita,A.
  TITLE     Nupr1 deficiency downregulates HtrA1, enhances SMAD1 signaling, and
            suppresses age-related bone loss in male mice
  JOURNAL   J Cell Physiol 238 (3), 566-581 (2023)
   PUBMED   36715607
  REMARK    GeneRIF: Nupr1 deficiency downregulates HtrA1, enhances SMAD1
            signaling, and suppresses age-related bone loss in male mice.
REFERENCE   6  (bases 1 to 639)
  AUTHORS   Buttitta,L., Tanaka,T.S., Chen,A.E., Ko,M.S. and Fan,C.M.
  TITLE     Microarray analysis of somitogenesis reveals novel targets of
            different WNT signaling pathways in the somitic mesoderm
  JOURNAL   Dev Biol 258 (1), 91-104 (2003)
   PUBMED   12781685
REFERENCE   7  (bases 1 to 639)
  AUTHORS   Quirk,C.C., Seachrist,D.D. and Nilson,J.H.
  TITLE     Embryonic expression of the luteinizing hormone beta gene appears
            to be coupled to the transient appearance of p8, a high mobility
            group-related transcription factor
  JOURNAL   J Biol Chem 278 (3), 1680-1685 (2003)
   PUBMED   12429736
REFERENCE   8  (bases 1 to 639)
  AUTHORS   Vasseur,S., Hoffmeister,A., Garcia-Montero,A., Mallo,G.V., Feil,R.,
            Kuhbandner,S., Dagorn,J.C. and Iovanna,J.L.
  TITLE     p8-deficient fibroblasts grow more rapidly and are more resistant
            to adriamycin-induced apoptosis
  JOURNAL   Oncogene 21 (11), 1685-1694 (2002)
   PUBMED   11896600
  REMARK    GeneRIF: P8 is a growth inhibitor that facilitates apoptosis
            induced in fibroblasts by DNA damage
REFERENCE   9  (bases 1 to 639)
  AUTHORS   Pin,C.L., Rukstalis,J.M., Johnson,C. and Konieczny,S.F.
  TITLE     The bHLH transcription factor Mist1 is required to maintain
            exocrine pancreas cell organization and acinar cell identity
  JOURNAL   J Cell Biol 155 (4), 519-530 (2001)
   PUBMED   11696558
REFERENCE   10 (bases 1 to 639)
  AUTHORS   Vasseur,S., Mallo,G.V., Garcia-Montero,A., Ortiz,E.M., Fiedler,F.,
            Canepa,E., Moreno,S. and Iovanna,J.L.
  TITLE     Structural and functional characterization of the mouse p8 gene:
            promotion of transcription by the CAAT-enhancer binding protein
            alpha (C/EBPalpha) and C/EBPbeta trans-acting factors involves a
            C/EBP cis-acting element and other regions of the promoter
  JOURNAL   Biochem J 343 Pt 2 (Pt 2), 377-383 (1999)
   PUBMED   10510303
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF131196.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF131196.1, BC002109.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..639
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.21 cM"
     gene            1..639
                     /gene="Nupr1"
                     /gene_synonym="2310032H04Rik; Com1; p8"
                     /note="nuclear protein transcription regulator 1"
                     /db_xref="GeneID:56312"
                     /db_xref="MGI:MGI:1891834"
     exon            1..148
                     /gene="Nupr1"
                     /gene_synonym="2310032H04Rik; Com1; p8"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..279
                     /gene="Nupr1"
                     /gene_synonym="2310032H04Rik; Com1; p8"
                     /note="protein p8; nuclear transcriptional regulator
                     protein 1"
                     /codon_start=1
                     /product="nuclear protein 1"
                     /protein_id="NP_062712.1"
                     /db_xref="CCDS:CCDS40127.1"
                     /db_xref="GeneID:56312"
                     /db_xref="MGI:MGI:1891834"
                     /translation="MATLPPTANPSQQPLNLEDEDGILDEYDQYSLAHPCVVGGGRKG
                     RTKREAAANTNRPSPGGHERKLLTKFQNSERKKAWR"
     exon            149..292
                     /gene="Nupr1"
                     /gene_synonym="2310032H04Rik; Com1; p8"
                     /inference="alignment:Splign:2.1.0"
     exon            293..626
                     /gene="Nupr1"
                     /gene_synonym="2310032H04Rik; Com1; p8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      572..577
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nupr1"
                     /gene_synonym="2310032H04Rik; Com1; p8"
                     /note="hexamer: AATAAA"
     polyA_site      624
                     /gene="Nupr1"
                     /gene_synonym="2310032H04Rik; Com1; p8"
                     /note="major polyA site"
ORIGIN      
        1 cacaggcaag actttggaga gagcagacta ggcataatgg ccaccttgcc accaacagcc
       61 aacccttccc agcaacctct aaacctagag gatgaagatg gaatcctgga tgaatatgat
      121 cagtacagcc tggcccatcc ctgtgtcgtc gggggaggtc ggaaaggtcg gaccaagaga
      181 gaagctgctg ccaataccaa ccgccctagc cctggcgggc atgagaggaa gctgctgacc
      241 aagttccaga actctgaaag gaaaaaagcc tggcgctgag acggagctgg agataaggcc
      301 agaccacaga caccacaccc agcaatggat acaggacatc acacccagca atggatacag
      361 gacatcacac ccagcaatgg atacaggacc ttggagaaat taggagttgt aagcaggacc
      421 taggcctgct tgattctttc ccacctaagt gaggttctgg agagggagcc cttccaccct
      481 tccagaccca gcaaaagggc aagatgggag caagaagcag agggtagacg ggcagagcta
      541 ggaagacagc ccccaaaaga actgtggggg aaataaatcg gatgcccttg ggtggcagca
      601 acaataaatc gtacagcagt gacagcaaaa aaaaaaaaa
//
