LOCUS       NM_001287164            6662 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Mus musculus nucleoporin 98 (Nup98), transcript variant 1, mRNA.
ACCESSION   NM_001287164
VERSION     NM_001287164.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6662)
  AUTHORS   Noura,M., Tomita,S., Yasuda,T., Tsuzuki,S., Kiyoi,H. and
            Hayakawa,F.
  TITLE     NUP98-BPTF promotes oncogenic transformation through PIM1
            upregulation
  JOURNAL   Cancer Med 13 (13), e7445 (2024)
   PUBMED   38940430
  REMARK    GeneRIF: NUP98-BPTF promotes oncogenic transformation through PIM1
            upregulation.
REFERENCE   2  (bases 1 to 6662)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6662)
  AUTHORS   Heikamp,E.B., Henrich,J.A., Perner,F., Wong,E.M., Hatton,C.,
            Wen,Y., Barwe,S.P., Gopalakrishnapillai,A., Xu,H., Uckelmann,H.J.,
            Takao,S., Kazansky,Y., Pikman,Y., McGeehan,G.M., Kolb,E.A.,
            Kentsis,A. and Armstrong,S.A.
  TITLE     The menin-MLL1 interaction is a molecular dependency in
            NUP98-rearranged AML
  JOURNAL   Blood 139 (6), 894-906 (2022)
   PUBMED   34582559
  REMARK    GeneRIF: The menin-MLL1 interaction is a molecular dependency in
            NUP98-rearranged AML.
REFERENCE   4  (bases 1 to 6662)
  AUTHORS   Monlish,D.A., Greenberg,Z.J., Bhatt,S.T., Leonard,K.M.,
            Romine,M.P., Dong,Q., Bendesky,L., Duncavage,E.J., Magee,J.A. and
            Schuettpelz,L.G.
  TITLE     TLR2/6 signaling promotes the expansion of premalignant
            hematopoietic stem and progenitor cells in the NUP98-HOXD13 mouse
            model of MDS
  JOURNAL   Exp Hematol 88, 42-55 (2020)
   PUBMED   32652111
  REMARK    GeneRIF: TLR2/6 signaling promotes the expansion of premalignant
            hematopoietic stem and progenitor cells in the NUP98-HOXD13 mouse
            model of MDS.
REFERENCE   5  (bases 1 to 6662)
  AUTHORS   Khalaf,B., Roncador,A., Pischedda,F., Casini,A., Thomas,S.,
            Piccoli,G., Kiebler,M. and Macchi,P.
  TITLE     Ankyrin-G induces nucleoporin Nup358 to associate with the axon
            initial segment of neurons
  JOURNAL   J Cell Sci 132 (18) (2019)
   PUBMED   31427429
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6662)
  AUTHORS   Wu,X., Kasper,L.H., Mantcheva,R.T., Mantchev,G.T., Springett,M.J.
            and van Deursen,J.M.
  TITLE     Disruption of the FG nucleoporin NUP98 causes selective changes in
            nuclear pore complex stoichiometry and function
  JOURNAL   Proc Natl Acad Sci U S A 98 (6), 3191-3196 (2001)
   PUBMED   11248054
REFERENCE   7  (bases 1 to 6662)
  AUTHORS   von Kobbe,C., van Deursen,J.M., Rodrigues,J.P., Sitterlin,D.,
            Bachi,A., Wu,X., Wilm,M., Carmo-Fonseca,M. and Izaurralde,E.
  TITLE     Vesicular stomatitis virus matrix protein inhibits host cell gene
            expression by targeting the nucleoporin Nup98
  JOURNAL   Mol Cell 6 (5), 1243-1252 (2000)
   PUBMED   11106761
REFERENCE   8  (bases 1 to 6662)
  AUTHORS   Shaughnessy,J.D. Jr., Largaespada,D.A., Tian,E., Fletcher,C.F.,
            Cho,B.C., Vyas,P., Jenkins,N.A. and Copeland,N.G.
  TITLE     Mrvi1, a common MRV integration site in BXH2 myeloid leukemias,
            encodes a protein with homology to a lymphoid-restricted membrane
            protein Jaw1
  JOURNAL   Oncogene 18 (12), 2069-2084 (1999)
   PUBMED   10321731
REFERENCE   9  (bases 1 to 6662)
  AUTHORS   Shaughnessy,J.D. Jr., Jenkins,N.A. and Copeland,N.G.
  TITLE     cDNA cloning, expression analysis, and chromosomal localization of
            a gene with high homology to wheat eIF-(iso)4F and mammalian eIF-4G
  JOURNAL   Genomics 39 (2), 192-197 (1997)
   PUBMED   9027506
REFERENCE   10 (bases 1 to 6662)
  AUTHORS   Zhu,Y., Lambert,K., Corless,C., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A. and D'Andrea,A.D.
  TITLE     DUB-2 is a member of a novel family of cytokine-inducible
            deubiquitinating enzymes
  JOURNAL   J Biol Chem 272 (1), 51-57 (1997)
   PUBMED   8995226
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118592.7.
            
            On Apr 8, 2022 this sequence version replaced NM_001287164.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.2587819.1,
                                           SRR13948564.845943.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AC118592.7         111391-111519       c
            130-233             AC118592.7         97158-97261         c
            234-335             AC118592.7         96322-96423         c
            336-512             AC118592.7         96034-96210         c
            513-652             AC118592.7         93276-93415         c
            653-760             AC118592.7         88005-88112         c
            761-941             AC118592.7         87234-87414         c
            942-1105            AC118592.7         86179-86342         c
            1106-1243           AC118592.7         84836-84973         c
            1244-1382           AC118592.7         81750-81888         c
            1383-1475           AC118592.7         77686-77778         c
            1476-1616           AC118592.7         70736-70876         c
            1617-1750           AC118592.7         65062-65195         c
            1751-1938           AC118592.7         61914-62101         c
            1939-2055           AC118592.7         58425-58541         c
            2056-2354           AC118592.7         55168-55466         c
            2355-2468           AC118592.7         54509-54622         c
            2469-2607           AC118592.7         53691-53829         c
            2608-2785           AC118592.7         48573-48750         c
            2786-2950           AC118592.7         46930-47094         c
            2951-3133           AC118592.7         40841-41023         c
            3134-3287           AC118592.7         40105-40258         c
            3288-3717           AC118592.7         35937-36366         c
            3718-3947           AC118592.7         34005-34234         c
            3948-4214           AC118592.7         31189-31455         c
            4215-4372           AC118592.7         30317-30474         c
            4373-4516           AC118592.7         29137-29280         c
            4517-4659           AC118592.7         27823-27965         c
            4660-4881           AC118592.7         26476-26697         c
            4882-5123           AC118592.7         25526-25767         c
            5124-5278           AC118592.7         24911-25065         c
            5279-5390           AC118592.7         22132-22243         c
            5391-6662           AC118592.7         20773-22044         c
FEATURES             Location/Qualifiers
     source          1..6662
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.71 cM"
     gene            1..6662
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /note="nucleoporin 98"
                     /db_xref="GeneID:269966"
                     /db_xref="MGI:MGI:109404"
     exon            1..129
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            130..233
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..5608
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; nuclear pore complex protein Nup98-Nup96"
                     /codon_start=1
                     /product="nuclear pore complex protein Nup98-Nup96 isoform
                     1 precursor"
                     /protein_id="NP_001274093.1"
                     /db_xref="CCDS:CCDS85358.1"
                     /db_xref="GeneID:269966"
                     /db_xref="MGI:MGI:109404"
                     /translation="MFNKSFGTPFGGSTGGFGTTSTFGQNTGFGTTSGGAFGTSAFGS
                     SNNTGGLFGNSQTKPGGLFGTSSFSQPATSTSTGFGFGTSTGTSNSLFGTASTGTSLF
                     SSQNNAFAQNKPTGFGNFGTSTSSGGLFGTTNTTSNPFGSTSGSLFGPSSFTAAPTGT
                     TIKFNPPTGTDTMVKAGVSTNISTKHQCITAMKEYESKSLEELRLEDYQANRKGPQNQ
                     VGGGTTAGLFGSSPATSSATGLFSSSTTNSAFSYGQNKTAFGTSTTGFGTNPGGLFGQ
                     QNQQTTSLFSKPFGQATTTPNTGFSFGNTSTLGQPSTNTMGLFGVTQASQPGGLFGTA
                     TNTSTGTAFGTGTGLFGQPNTGFGAVGSTLFGNNKLTTFGTSTTSAPSFGTTSGGLFG
                     NKPTLTLGTNTNTSNFGFGTNNSGSSIFGSKPAAGTLGTGLGTGFGTALGAGQASLFG
                     NNQPKIGGPLGTGAFGAPGFNTSTAILGFGAPQAPVALTDPNASAAQQAVLQQHLNSL
                     TYSPFGDSPLFRNPMSDPKKKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQ
                     TTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKLVLKNLNNSNLFSPVNHDSEDLASP
                     SEYPENGERFSFLSKPVDENNQQDGEDDSLVSRFYTNPIAKPIPQTPESVGNKNNSSS
                     NVEDTIVALNMRAALRNGLEGSSEETSFHDESLQDDREEIENNAYHIHPAGIVLTKVG
                     YYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKE
                     VIVYVDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVS
                     RKQGAQFKEYRPETGSWVFKVSHFSKYGLQDSDEEEEEHPPKTTSKKLKTAPLPPAGQ
                     ATTFQMTLNGKPAPPPQSQSPEVEQLGRVVELDSDMVDITQEPVPDSVLEESVPEDQE
                     PVSASTHIASSLGINPHVLQIMKASLLVDEEDVDAMDQRFGHIPSKGETVQEICSPRL
                     PISASHSSKSRSIVGGLLQSKFASGTFLSPSASVQECRTPRTSSRMNIPSTSPWSVPL
                     PLATVFTVPSPAPEVQLKTVGIRRQPGLVPLEKSITYGKGKLLMDMALFMGRSFRVGW
                     GPNWTLANSGEQLHGSHELENHQVADSMEYGFLPNPVAVKSLSESPFKVHLEKLGLRQ
                     RKLDEDLQLYQTPLELKLKHSTVHVDELCPLIVPNPGVSVIHDYADWVKDSPGDFLEL
                     PIVKHWSLTWTLCEALWGHLKELDGQLDEPSEYIQTLERRRAFSRWLSHTAAPQIEEE
                     VSLTRRDSPVEAVFSYLTGSRISEACCLAQQSGDHRLALLLSQLVGSQSVRELLTMQL
                     ADWHQLQADSFIHDERLRIFALLAGKPVWQLSEQKQINVCSQLDWKRTLAIHLWYLLP
                     PTASISRALSMYEEAFQNTPEGDKYACSPLPSYLEGCGCMVEEEKDSRRPLQDVCFHL
                     LKLYSDRHYELNQLLEPRSITADPLDYRLSWHLWEVLRALNYTHLSEQCEGVLQASYA
                     GQLESEGLWEWAIFVFLHIDNSGMREKAVRELLTRHCQLSETPESWAKEAFLTQKLCV
                     PAEWIHEAKAVRAHMESNKHLEALYLFKAGHWNRCHKLVIRHLASDAIINENYDYLKG
                     FLEDLAPPERSSLIQDWETSGLVYLDYIRVIEMLHRIQQVDCSGYELEHLHTKVTSLC
                     NRIEQIPCYNAKDRLAQSDMAKRVANLLRVVLSLQHAPDATSNSTPDPQRVPLRLLAP
                     HIGRLPMPEDYALEELRGLTQSYLRELTVGSQ"
     exon            234..335
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            336..512
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            513..652
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            653..760
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            761..941
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1105
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1243
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1382
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1475
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1616
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1750
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1938
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2055
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2354
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2468
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2607
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2785
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..2950
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            2951..3133
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..3287
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            3288..3717
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            3718..3947
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            3948..4214
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            4215..4372
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            4373..4516
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            4517..4659
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            4660..4881
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            4882..5123
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            5124..5278
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            5279..5390
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     exon            5391..6662
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6640..6645
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /note="hexamer: AATAAA"
     polyA_site      6662
                     /gene="Nup98"
                     /gene_synonym="4732457F17; Nup96"
                     /note="major polyA site"
ORIGIN      
        1 aggcctctgc gcgctgcgcc cgaagcggcg gtcggtggca gcggcggcgg cgacgacggt
       61 ttttctggag gccgcgcggt gagcggcggg tgacgggcgg acctgggctc tcactccaga
      121 cgcaccgctc tttctgaagc aaacacttgc tttgaagatg tttaacaaat catttggaac
      181 cccctttggg ggtagtacag ggggctttgg cacaacgtca acatttgggc aaaatactgg
      241 ctttggtacg actagtggag gagcatttgg aacatctgca tttggttcta gcaacaatac
      301 tggaggctta tttggaaatt cacagaccaa accaggagga ttatttggta ccagttcatt
      361 tagccagcca gcaacctcca caagcactgg gtttgggttt ggcacatcaa caggaacatc
      421 aaatagctta tttggaactg caagtaccgg gaccagtctt ttctcatccc agaacaatgc
      481 atttgcacaa aataaaccaa ctggctttgg gaattttgga accagtacta gcagtggagg
      541 actctttgga actacaaata ccacctctaa tccttttggt agcacatctg gctccctttt
      601 tgggccaagt agttttacag cagcacctac aggaactacc atcaaattta atcctcccac
      661 tggtacagat actatggtca aagctggagt tagcactaac atcagtacaa agcatcagtg
      721 tattactgct atgaaagaat atgaaagcaa gtcattagag gaactacgtt tggaggatta
      781 tcaggctaac cggaaaggcc cacagaacca agtgggagga ggcaccacgg ctggcttatt
      841 tgggtcttct ccagcaactt ccagtgcaac agggctcttc agctcctcca ccactaattc
      901 agccttttca tatggtcaga acaaaactgc ctttggaact agcacaactg gatttggaac
      961 aaatccaggt ggtctctttg gccaacagaa tcaacagact accagtctct tcagcaaacc
     1021 atttggccag gctacaacca ccccgaatac tggcttttcc tttggtaata ccagcaccct
     1081 tggacagcca agcaccaata ctatgggcct atttggagta acccaagcct cacaaccagg
     1141 aggtcttttt gggacagcta caaacaccag cactgggaca gcatttggga caggaacagg
     1201 tctctttggg cagcccaata ctggatttgg tgcagttggt tcgaccctgt ttggcaataa
     1261 caagcttaca acttttggaa ccagcacaac cagtgctcct tcatttggta caaccagtgg
     1321 cgggctcttc ggtaacaaac caaccctgac tttaggaacc aatacaaaca cttccaattt
     1381 tgggtttggc acaaataaca gtgggagcag tatttttgga agtaagccag cagctggaac
     1441 tttgggaact ggacttggta caggatttgg aacagctctt ggtgctggac aggcatcttt
     1501 gtttggaaac aaccaaccta agattggagg gcctcttggt acaggagcct ttggggcccc
     1561 tggatttaat acttcgacag ccattttggg ctttggcgcc ccccaggccc cagtagcttt
     1621 gacagatcca aatgcttctg ctgcccagca ggctgttctc cagcagcacc tcaatagcct
     1681 aacatactca ccctttggag actcccccct cttccggaat cctatgtcag atcctaagaa
     1741 gaaagaagag agactgaaac caaccaatcc agctgctcag aaagctctta caacacctac
     1801 tcattataaa cttacacctc gccctgctac cagagtcagg ccaaaggctt tgcaaacaac
     1861 aggcacagcc aaatcacatc tctttgatgg gctggatgac gatgaaccat ctctagccaa
     1921 cggagcattc atgcctaaaa agagcatcaa gaagttggtt ttgaaaaatc tcaacaatag
     1981 caatctcttt tctcctgtta atcatgattc agaagatcta gcttcaccct ctgagtatcc
     2041 agaaaatgga gaaagattta gcttcctgag caaacctgtt gatgagaaca atcagcagga
     2101 tggagaagat gactctcttg tatcacgatt ttacactaat cctattgcca aacccattcc
     2161 acaaactcca gagagtgttg gaaacaaaaa taacagtagc agcaatgtgg aagataccat
     2221 tgttgccttg aacatgcgtg ctgctttgcg caatggattg gaaggaagca gtgaagagac
     2281 gtcattccat gatgagtcat tgcaagatga ccgagaagag atagaaaata atgcttacca
     2341 catacaccca gcaggcattg ttctcacaaa agttggttat tacactatcc catctatgga
     2401 tgaccttgct aaaattacca acgagaaggg agaatgcatt gtttctgact tcaccattgg
     2461 tcgtaaagga tatggctcaa tctattttga aggagatgtg aatttgacaa atctaaattt
     2521 ggatgatatt gtgcatatcc gaaggaaaga agttattgtc tatgtagatg ataaccaaaa
     2581 gccacctgtg ggtgaagggc taaataggaa ggctgaagtt actttggatg gagtttggcc
     2641 aacagataaa acatcccggt gtttaataaa gagtccagat cgacttgctg atatcaacta
     2701 tgaggggaga ttagaagcag tctcaagaaa gcaaggggcc caattcaagg agtatcggcc
     2761 tgaaactggt tcttgggtat ttaaggtctc ccatttttcc aagtatggcc ttcaggattc
     2821 tgatgaagag gaggaggaac acccacccaa aacgacttca aagaagctga agactgcccc
     2881 tttgccccct gcaggccagg caaccacttt ccagatgact cttaatggca agcctgcacc
     2941 cccacctcag agccagagcc cagaagtgga gcagttaggc agggttgtgg aactggacag
     3001 cgacatggta gatatcaccc aggagccagt tccagattct gtgttagaag agagtgtgcc
     3061 cgaggatcag gagcctgtgt ctgcttcaac gcatattgca tcttcactgg gaattaatcc
     3121 acatgtttta cagatcatga aagcatcatt gcttgttgac gaagaagatg tagatgccat
     3181 ggatcaacgc tttggtcaca tcccttccaa aggagagact gtccaggaaa tctgttctcc
     3241 tagactcccc atttcagcct cccactcatc aaaatcccgc tccatagttg gtgggttgct
     3301 gcaatcaaaa tttgcaagtg gaacttttct ttcaccaagt gcctccgtgc aagaatgtcg
     3361 cactcccagg acatcatctc gcatgaacat cccatccaca tccccctggt ctgtccctct
     3421 gcccctggcc actgtgttca cagtgcccag cccagcccct gaggttcagc taaaaacagt
     3481 ggggatacga aggcaaccag gcctagtccc tcttgaaaaa tccattacat atggcaaggg
     3541 gaagctcttg atggacatgg ccctattcat gggacgttca tttcgggttg gttggggtcc
     3601 caactggact cttgctaata gtggagaaca actgcatggc tcccatgaac tggaaaatca
     3661 tcaggttgcc gattctatgg aatatggatt cctgcccaat ccagtagctg ttaaatctct
     3721 atctgaatcc ccattcaaag ttcatttgga aaaactcggc ttaagacaga ggaagctgga
     3781 tgaagatctg cagttatacc agacacctct agagctcaaa ttaaaacata gcactgtcca
     3841 tgtagatgag ctgtgtcctc tcattgtccc caaccctggg gtttcagtca ttcatgatta
     3901 tgcagattgg gttaaggact cacctggaga tttcctggaa ctaccaattg tgaagcactg
     3961 gagcctgaca tggacattat gtgaagccct atggggccac ctgaaggagc ttgacggcca
     4021 gctggatgag cccagcgaat acattcagac tctggagcgt agaagagctt tttcccgctg
     4081 gctgtcacat accgctgcac ctcagattga agaggaagtc tccttaaccc gcagagacag
     4141 tcccgtagag gctgtcttca gctacctcac gggcagtagg attagtgagg cctgttgtct
     4201 ggcacagcag tcaggtgatc atcgccttgc ccttcttctg tctcagttgg tgggaagcca
     4261 gtcagtccgg gagctgctca ccatgcagtt ggccgattgg catcagctcc aggctgactc
     4321 cttcatccac gatgagcgat tgcgcatatt tgccctgttg gctggaaaac cggtgtggca
     4381 gctctcagag cagaaacaaa tcaatgtttg ctcccagcta gattggaaac gaacacttgc
     4441 tatccatctt tggtatttgc ttccgccaac cgcctccatt tccagggctc tcagcatgta
     4501 tgaagaagca tttcagaata ctcctgaggg tgataaatat gcctgctccc ctcttccttc
     4561 ttacctggag ggctgcggct gtatggtaga ggaagaaaaa gactcccgga gaccacttca
     4621 agatgtttgc tttcatcttc taaaactcta cagtgacaga cattatgagc tcaatcagct
     4681 attagaacct cgaagcataa ctgcagatcc tttggactac cgcctgagct ggcacctttg
     4741 ggaagtgcta cgtgctctta actataccca tctctcagaa cagtgtgaag gtgtgctaca
     4801 ggccagttat gctggccaac tggaaagtga aggactctgg gagtgggcca tctttgtctt
     4861 cctacacatt gacaactcgg gcatgcgtga gaaggctgtt cgagagctgc tgacaaggca
     4921 ctgccaactg tcagagaccc ctgagtcttg ggctaaggag gcgttcctca cacagaagct
     4981 ttgtgtgcct gctgagtgga ttcatgaggc caaagcagtt cgagcacaca tggaatccaa
     5041 taagcacttg gaggccctct atttatttaa agctggtcac tggaaccgct gccacaaact
     5101 agtcattcgt cacctagctt ctgatgccat tattaatgag aactatgact acctgaaagg
     5161 attcttagaa gatctggcac ctccagagcg cagcagcctc atccaggact gggaaacatc
     5221 tgggctcgtt tacctggatt atattcgagt gattgaaatg ctccaccgta ttcagcaggt
     5281 ggattgctca ggttatgaac tagagcactt acataccaaa gtgacttcac tgtgcaatcg
     5341 gatagaacag attccgtgtt acaatgccaa ggatcgcctg gctcaatcag atatggccaa
     5401 gcgggtagcc aacttactgc gggtagtgct gagccttcag catgctcctg atgccacctc
     5461 caactcaacg ccagaccctc agcgagtccc tttgcgtctt ttggctcccc acattggcag
     5521 gctccccatg cctgaggact acgccttgga ggaactgcga ggccttaccc agtcctacct
     5581 tcgagaactg actgttggga gccagtgagc ttggctcttg ccaccacact catgcccact
     5641 cacactcgcc acaccacagt ccccagcact gttttagttg acactttgcc aatctctggg
     5701 aatcctccat tcctttctgc tgcatcttct agttattcag gggttttcct aatactgagc
     5761 atagcctaca atagctcata agggcttctg gaacaacaac aaagaagaca ggtctccatt
     5821 tatcaacctc aagacctttt tttttctttt tctttttttt tttttttttt ttcttttgaa
     5881 aaatggtcaa taaaacctct ttggcagaac ctcccaaaac ctagggaatt cttttccaca
     5941 cccagcgttc tggctctcac cccatgccag catctaacct ccaccactgc gatccttttg
     6001 taccgtgact gtttgacaga catctggcat atgactgact gaccttcctt acagatttgt
     6061 ccctcaagta gatttctcag taacggtgga ttttggagtc aaaagagagt tggaccttgt
     6121 tctttggtaa atttaagata gaagggctgt ctgccataga ggtagagatc ttcaaggcct
     6181 ttactcatgc cctgtgtatc ctttggacac catactatca tgcgcagtgg ccccaagcca
     6241 ccgagaacca gtctgagaag ctccagattc gctcaggccc ttgatcatca gtcgtcgtcg
     6301 tcttcgattt gccagaggag tttagatgaa gaatgtcaag gatgttcctc cctgccctcc
     6361 catctagcca agaacatttc caagaagata aaactgtcac tgagacaggt ctggatgcgc
     6421 cctaggggca aatagagaag gcctttacca cattgctgct ggctatagga agtcccaggt
     6481 actagcctga aacagctgat atttggggct gtcacagaca atatggccac cccttggtct
     6541 ttatgcatga agattatgta aaggttttta ttaaaaaata tatatatata tataaatgat
     6601 ctagattatt ttcctctttc tgaagtactt tcttaaaaaa ataaaattaa atgtttatag
     6661 ta
//
