LOCUS       NM_172410               2965 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus nucleoporin 93 (Nup93), transcript variant 1, mRNA.
ACCESSION   NM_172410 XM_001472320
VERSION     NM_172410.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2965)
  AUTHORS   Monwan W, Kawasaki T, Hasan MZ, Ori D and Kawai T.
  TITLE     Identification of nucleoporin 93 (Nup93) that mediates antiviral
            innate immune responses
  JOURNAL   Biochem Biophys Res Commun 521 (4), 1077-1082 (2020)
   PUBMED   31733835
  REMARK    GeneRIF: Nup93 regulates antiviral innate immunity by enhancing
            TBK1 activity and IRF3 nuclear translocation.
REFERENCE   2  (bases 1 to 2965)
  AUTHORS   Beckers A, Ott T, Schuster-Gossler K, Boldt K, Alten L, Ueffing M,
            Blum M and Gossler A.
  TITLE     The evolutionary conserved FOXJ1 target gene Fam183b is essential
            for motile cilia in Xenopus but dispensable for ciliary function in
            mice
  JOURNAL   Sci Rep 8 (1), 14678 (2018)
   PUBMED   30279523
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2965)
  AUTHORS   Braun DA, Sadowski CE, Kohl S, Lovric S, Astrinidis SA, Pabst WL,
            Gee HY, Ashraf S, Lawson JA, Shril S, Airik M, Tan W, Schapiro D,
            Rao J, Choi WI, Hermle T, Kemper MJ, Pohl M, Ozaltin F, Konrad M,
            Bogdanovic R, Buscher R, Helmchen U, Serdaroglu E, Lifton RP,
            Antonin W and Hildebrandt F.
  TITLE     Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause
            steroid-resistant nephrotic syndrome
  JOURNAL   Nat Genet 48 (4), 457-465 (2016)
   PUBMED   26878725
REFERENCE   4  (bases 1 to 2965)
  AUTHORS   Suntharalingam M and Wente SR.
  TITLE     Peering through the pore: nuclear pore complex structure, assembly,
            and function
  JOURNAL   Dev Cell 4 (6), 775-789 (2003)
   PUBMED   12791264
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131733.3 and AK028864.1.
            
            [WARNING] On Sep 25, 2023 this sequence was replaced by
            NM_172410.4.
            
            On Oct 25, 2017 this sequence version replaced NM_172410.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028864.1, SRR7652917.941858.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AC131733.3         149246-149282
            38-2965             AK028864.1         2-2929
FEATURES             Location/Qualifiers
     source          1..2965
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 46.4 cM"
     gene            1..2965
                     /gene="Nup93"
                     /gene_synonym="2410008G02Rik"
                     /note="nucleoporin 93"
                     /db_xref="GeneID:71805"
                     /db_xref="MGI:MGI:1919055"
     exon            1..68
                     /gene="Nup93"
                     /gene_synonym="2410008G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            69..120
                     /gene="Nup93"
                     /gene_synonym="2410008G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            121..313
                     /gene="Nup93"
                     /gene_synonym="2410008G02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2594
                     /gene="Nup93"
                     /gene_synonym="2410008G02Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear pore complex protein Nup93; nucleoporin Nup93; 93
                     kDa nucleoporin; CBP-interacting protein 4"
                     /codon_start=1
                     /product="nuclear pore complex protein Nup93 isoform 1"
                     /protein_id="NP_765998.1"
                     /db_xref="CCDS:CCDS22540.1"
                     /db_xref="GeneID:71805"
                     /db_xref="MGI:MGI:1919055"
                     /translation="MDTEGFGELLQQAEQLAAETEGISELPHVERNLQEIQQAGERLR
                     SRTLTRTSQETADVKASVLLGSRGLDISHISQRLESLSAATTFEPLEPVKDTDIQGFL
                     KNEKDNALLSAIEESRKRTFGMAEEYHRESMLVEWEQVKQRILHTLLASGEDALDFTQ
                     ESEPSYIGDVNPPGRSSLDSIEMAYARQIYIYNEKIVSGHLQPNLVDLCASVAELDDK
                     SISDMWAMVKQMTDVVLTPATDALKSRSSVEVRMDFVKQALGYLEQSYKNYTLVTVFG
                     NLHQAQLGGVPGTYQLVRSFLNIKLPAPSPGLQDGEVEGHPVWALIYYCMRCGDLLAA
                     SQVVSRAQHQLGEFKTWFQEYMNSKDRRLSPATENKLRLHYRRALRNNTDPYKRAVYC
                     IIGRCDITDNQSEVADKTEDYLWLKLNQVCFDDDGTSSPQDRLTLSQFQKQLLEDYGE
                     SHFTVNQQPFLYFQVLFLTAQFEAAIAFLFRMERLRCHAVHVALVLFELKLLLKSSGQ
                     SAQLLSHEPGDPPCMRRLNFVRLLMLYTRKFESTDPREALQYFYFLRDEKDSQGENMF
                     LRCVSELVIESREFDMILGKLENDGSRKPGVIDKFTSDTKPIINKVASVAENKGLFEE
                     AAKLYDLAKNADKVLELMNKLLSPVVPQISAPQSNKERLKNMALSIAERYRAQGISAN
                     KFVDSTFYLLLDLITFFDEYHSGHIDRAFDIIDRLKLVPLNQESVEERVAAFRNFSDE
                     IRHNLSEVLLATMNILFTQFKRLKGTSPSSATRPQRVIEDRDSQLRSQARALITFAGM
                     IPYRTSGDTNARLVQMEVLMN"
     exon            314..431
                     /gene="Nup93"
                     /gene_synonym="2410008G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            432..494
                     /gene="Nup93"
                     /gene_synonym="2410008G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            495..623
                     /gene="Nup93"
                     /gene_synonym="2410008G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            624..698
                     /gene="Nup93"
                     /gene_synonym="2410008G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            699..788
                     /gene="Nup93"
                     /gene_synonym="2410008G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            789..928
                     /gene="Nup93"
                     /gene_synonym="2410008G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1061
                     /gene="Nup93"
                     /gene_synonym="2410008G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1219
                     /gene="Nup93"
                     /gene_synonym="2410008G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1385
                     /gene="Nup93"
                     /gene_synonym="2410008G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1479
                     /gene="Nup93"
                     /gene_synonym="2410008G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1671
                     /gene="Nup93"
                     /gene_synonym="2410008G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1798
                     /gene="Nup93"
                     /gene_synonym="2410008G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1871
                     /gene="Nup93"
                     /gene_synonym="2410008G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1916
                     /gene="Nup93"
                     /gene_synonym="2410008G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2033
                     /gene="Nup93"
                     /gene_synonym="2410008G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2152
                     /gene="Nup93"
                     /gene_synonym="2410008G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2270
                     /gene="Nup93"
                     /gene_synonym="2410008G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2354
                     /gene="Nup93"
                     /gene_synonym="2410008G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2483
                     /gene="Nup93"
                     /gene_synonym="2410008G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2965
                     /gene="Nup93"
                     /gene_synonym="2410008G02Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgagcggcg cgagaagcgg cggcggcggc gtagtgaaga agccggcagc gggcggcgac
       61 ggaggcagga cttcaaacga attttgaagg gccacagttc aatccacagg acccagaaag
      121 catctgcatc tctaatggat actgaggggt ttggtgagct ccttcagcaa gctgaacagc
      181 ttgctgctga gactgaaggc atctctgagc ttccacatgt agaacgaaat ttacaggaga
      241 tccagcaagc tggtgagcgc ctgcgttccc gtaccctcac acgcacatcc caggagacag
      301 cagatgtcaa ggcatcagtt cttctcgggt caaggggact tgacatatcc catatctccc
      361 agagactgga gagtctgagc gcagccacca cttttgaacc tctcgagcct gtgaaggaca
      421 cggacattca gggcttcctg aagaatgaga aagataatgc cttgttgtct gctattgaag
      481 agtcccggaa gaggaccttt ggcatggctg aggagtatca tcgagaatca atgctggtcg
      541 agtgggaaca agtgaaacaa aggattctgc acacactgct ggcgtcggga gaggatgccc
      601 ttgacttcac ccaagaaagt gagccgagtt acatcggtga tgtgaatccc cctgggcgaa
      661 gctctctgga tagcattgag atggcctatg cccggcagat ctatatctat aacgagaaga
      721 ttgtgagtgg acacctacag cctaacctgg tggacctgtg tgcctctgtc gcagagctgg
      781 atgacaagag catttctgac atgtgggcca tggtaaaaca aatgacagat gtggtgctga
      841 caccagcaac tgacgccctg aagagccgga gcagtgtgga agtgcgtatg gactttgtca
      901 agcaagcctt gggatatctt gagcagagtt ataagaatta cacccttgtg actgtcttcg
      961 gaaatctgca tcaggcacag ctgggcggtg tgcctgggac ttaccagctg gttcggagtt
     1021 tcctaaacat taaactgcca gctccttcac caggacttca ggatggagag gtagaaggcc
     1081 atcctgtctg ggcattaatt tattactgca tgcgctgtgg agacctgctt gccgcatcac
     1141 aagtcgtcag tcgagcccag caccagcttg gggaatttaa aacttggttc caggagtaca
     1201 tgaacagcaa ggatagaaga ttgtctccag ctacagaaaa caaactccga cttcactacc
     1261 gcagagccct caggaacaac acagacccct acaagagagc tgtgtactgt attattggga
     1321 gatgcgatat caccgacaat cagagtgaag tagccgacaa gactgaggac tacctatggt
     1381 taaaattgaa ccaggtgtgt tttgatgatg acggcaccag ctcaccacaa gacaggctca
     1441 ctctctcaca gttccagaag cagctgctag aagactatgg cgagtcccac ttcacggtga
     1501 accagcagcc cttcctctac tttcaagtgc tgttcctgac tgcacagttt gaagctgcca
     1561 ttgccttcct cttccgcatg gagcggctgc gctgccatgc tgtccatgtg gccctggtgc
     1621 tgtttgagct aaagctgctt ttaaagtcct ctggacagag tgctcaactc ctcagccacg
     1681 agcctggcga ccctccctgc atgcgacggc tgaactttgt gcgtctgctc atgctctaca
     1741 cccgcaagtt tgagtccacg gacccaagag aagccctcca gtacttttac ttcctcaggg
     1801 atgagaaaga cagtcaagga gaaaacatgt ttctgcgctg tgtgagcgag cttgtgatag
     1861 aaagtcgaga gtttgatatg attcttggaa aactagagaa cgatggaagt agaaagcctg
     1921 gagttataga taagtttacc agtgacacaa agcctattat caacaaagtt gcttcggtgg
     1981 cagaaaacaa aggactgttt gaagaggcag cgaagcttta tgaccttgct aagaatgctg
     2041 acaaggtgct ggagctgatg aacaagctgc taagccctgt tgtcccacag atcagcgccc
     2101 cacagtctaa caaagaaagg ctgaagaaca tggccctctc cattgcggag aggtacagag
     2161 ctcagggaat aagtgcaaat aagtttgtgg actctacatt ctatctcctc ttggacctga
     2221 tcaccttttt tgacgagtat cacagtggtc atattgacag agcctttgat attattgacc
     2281 gcttgaagct ggtgcctctg aatcaggaga gtgtggaaga aagggtggct gccttcagaa
     2341 acttcagtga tgaaatcaga cacaacctct cagaagttct tctcgccacc atgaacatcc
     2401 tgttcacaca gtttaagagg ctcaaaggaa caagtccatc ttcagcaacc aggccccagc
     2461 gagtcattga agaccgtgac tctcaactcc gaagtcaagc cagagccctg attacctttg
     2521 ctgggatgat accgtaccgg acgtcggggg acactaatgc caggctggtg cagatggagg
     2581 tcctcatgaa ttaagcgctg tgtttgatgg ggtctgggac tgcacactgt cagtatatta
     2641 ggcacgtggg ccagctgggg tgggtttcca gttttgtttc tgttgtgttg tgttttgttt
     2701 tttgtattat gtatttttgt caataccaat aaatttcttt gatttgtatt tcttttaaac
     2761 attctttttc cttttttttt tcctttaaaa ttttaggttg ttttcttgtt ttggggtgtg
     2821 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtatttact tgggaaatgt tgtccacagt
     2881 tgttttgggg ccagagaatg agaggctaca taggtgtgta aatctggaca atgtgacttt
     2941 aaatgattaa aaaaaattac ccacc
//
