LOCUS       NM_172394               2452 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus nucleoporin 88 (Nup88), transcript variant 1, mRNA.
ACCESSION   NM_172394 XM_903209
VERSION     NM_172394.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2452)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2452)
  AUTHORS   Khalaf,B., Roncador,A., Pischedda,F., Casini,A., Thomas,S.,
            Piccoli,G., Kiebler,M. and Macchi,P.
  TITLE     Ankyrin-G induces nucleoporin Nup358 to associate with the axon
            initial segment of neurons
  JOURNAL   J Cell Sci 132 (18) (2019)
   PUBMED   31427429
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2452)
  AUTHORS   Naylor,R.M., Jeganathan,K.B., Cao,X. and van Deursen,J.M.
  TITLE     Nuclear pore protein NUP88 activates anaphase-promoting complex to
            promote aneuploidy
  JOURNAL   J Clin Invest 126 (2), 543-559 (2016)
   PUBMED   26731471
REFERENCE   4  (bases 1 to 2452)
  AUTHORS   Takahashi,N., van Kilsdonk,J.W., Ostendorf,B., Smeets,R.,
            Bruggeman,S.W., Alonso,A., van de Loo,F., Schneider,M., van den
            Berg,W.B. and Swart,G.W.
  TITLE     Tumor marker nucleoporin 88 kDa regulates nucleocytoplasmic
            transport of NF-kappaB
  JOURNAL   Biochem Biophys Res Commun 374 (3), 424-430 (2008)
   PUBMED   18621024
  REMARK    GeneRIF: Nup88 regulates the activity of NF-kappaB at the level of
            nucleocytoplasmic transport.
REFERENCE   5  (bases 1 to 2452)
  AUTHORS   Andres-Hernando,A., Lanaspa,M.A., Rivard,C.J. and Berl,T.
  TITLE     Nucleoporin 88 (Nup88) is regulated by hypertonic stress in kidney
            cells to retain the transcription factor tonicity enhancer-binding
            protein (TonEBP) in the nucleus
  JOURNAL   J Biol Chem 283 (36), 25082-25090 (2008)
   PUBMED   18606815
  REMARK    GeneRIF: Nup88 is up-regulated in response to hypertonic stress and
            acts to retain TonEBP in the nucleus, activating transcription of
            critical osmoprotective genes.
REFERENCE   6  (bases 1 to 2452)
  AUTHORS   Suntharalingam,M. and Wente,S.R.
  TITLE     Peering through the pore: nuclear pore complex structure, assembly,
            and function
  JOURNAL   Dev Cell 4 (6), 775-789 (2003)
   PUBMED   12791264
  REMARK    Review article
REFERENCE   7  (bases 1 to 2452)
  AUTHORS   Watters,J.W. and Dietrich,W.F.
  TITLE     Genetic, physical, and transcript map of the Ltxs1 region of mouse
            chromosome 11
  JOURNAL   Genomics 73 (2), 223-231 (2001)
   PUBMED   11318612
  REMARK    Erratum:[Genomics 2002 Mar;79(3):462]
REFERENCE   8  (bases 1 to 2452)
  AUTHORS   Wertz,K. and Herrmann,B.G.
  TITLE     Large-scale screen for genes involved in gonad development
  JOURNAL   Mech Dev 98 (1-2), 51-70 (2000)
   PUBMED   11044607
REFERENCE   9  (bases 1 to 2452)
  AUTHORS   Temeles,G.L., Ram,P.T., Rothstein,J.L. and Schultz,R.M.
  TITLE     Expression patterns of novel genes during mouse preimplantation
            embryogenesis
  JOURNAL   Mol Reprod Dev 37 (2), 121-129 (1994)
   PUBMED   7545925
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK160619.1 and AK050893.1.
            
            On Feb 7, 2013 this sequence version replaced NM_172394.2.
            
            Transcript Variant: This variant (1) uses two alternate splice
            sites in the coding region, compared to variant 2. The encoded
            isoform (1) is shorter, compared to isoform 2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK160619.1, BC032929.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2428              AK160619.1         2-2429
            2429-2452           AK050893.1         2980-3003
FEATURES             Location/Qualifiers
     source          1..2452
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 43.21 cM"
     gene            1..2452
                     /gene="Nup88"
                     /gene_synonym="Nup84; Prei2"
                     /note="nucleoporin 88"
                     /db_xref="GeneID:19069"
                     /db_xref="MGI:MGI:104900"
     exon            1..325
                     /gene="Nup88"
                     /gene_synonym="Nup84; Prei2"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..2251
                     /gene="Nup88"
                     /gene_synonym="Nup84; Prei2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear pore complex protein Nup88; 88 kDa nucleoporin;
                     preimplantation protein 2"
                     /codon_start=1
                     /product="nuclear pore complex protein Nup88 isoform 1"
                     /protein_id="NP_765982.2"
                     /db_xref="CCDS:CCDS36207.1"
                     /db_xref="GeneID:19069"
                     /db_xref="MGI:MGI:104900"
                     /translation="MAAAVGPLGDGELWQSWLPNHVVFLRLREGVRNQSPAEAEKPAA
                     STSPSCPSLPPHLPTRNLVFGLGGELFLWDAEGSAFLVVRLRGPSGGGVEPPLSQYQR
                     LLCINPPLFEIHQVLLSPTQHHVALIGSKGLMALELPQRWGKDSEFEGGKATVNCSTI
                     PIAERFFTSSTSLTLKHAAWYPSEMLDPHIVLLTSDNVIRIYSLREPQTPTKVIVLSE
                     AEEESLILNKGRAYTASLGETAVAFDFGPLVTVSKNIFEQKDRDVVAYPLYILYENGE
                     TFLTYVSLLHSPGNIGKLLGPLPMHPAAEDNYGYDACAILCLPCVPNILVIATESGML
                     YHCVVLEGEEEDDQTLEKSWDPRADFIPSLYVFECVELELALKLASGEDDPFASDFSC
                     PIKLHRDPKCPSRYHCSHEAGVHSVGLTWIHKLHKFLGSDEEDKDSLQELTAEQKCFV
                     EHILCTKPLPCRQPAPIRGFWIVPDILGPTMICITSTYECLIRPLLSTVHPASPPLLC
                     TQEDAEVAESPLRILAETPDSFEKHIKRILQRSAANPAFLKSSEKDLAPPPEECLQLI
                     SRATQVFREQYILKQDLAKEEIQRRVKLLCDQKRKQLEDLNYCREERKSLREMAERLA
                     DKYEEAKEKQEDIMNRMKKVLHSFHAQLPVLSDSERDMKKELQLIPDQLRHLGNAIKQ
                     VTMKKDYQQRKMEKVLSPQKPTITLSAYQRKCIQSILKEEGEHIREMVKQINDIRNHV
                     TF"
     exon            326..495
                     /gene="Nup88"
                     /gene_synonym="Nup84; Prei2"
                     /inference="alignment:Splign:2.1.0"
     exon            496..621
                     /gene="Nup88"
                     /gene_synonym="Nup84; Prei2"
                     /inference="alignment:Splign:2.1.0"
     exon            622..708
                     /gene="Nup88"
                     /gene_synonym="Nup84; Prei2"
                     /inference="alignment:Splign:2.1.0"
     exon            709..882
                     /gene="Nup88"
                     /gene_synonym="Nup84; Prei2"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1069
                     /gene="Nup88"
                     /gene_synonym="Nup84; Prei2"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1217
                     /gene="Nup88"
                     /gene_synonym="Nup84; Prei2"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1316
                     /gene="Nup88"
                     /gene_synonym="Nup84; Prei2"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1407
                     /gene="Nup88"
                     /gene_synonym="Nup84; Prei2"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1509
                     /gene="Nup88"
                     /gene_synonym="Nup84; Prei2"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1668
                     /gene="Nup88"
                     /gene_synonym="Nup84; Prei2"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1794
                     /gene="Nup88"
                     /gene_synonym="Nup84; Prei2"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1860
                     /gene="Nup88"
                     /gene_synonym="Nup84; Prei2"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..1941
                     /gene="Nup88"
                     /gene_synonym="Nup84; Prei2"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2068
                     /gene="Nup88"
                     /gene_synonym="Nup84; Prei2"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2187
                     /gene="Nup88"
                     /gene_synonym="Nup84; Prei2"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2452
                     /gene="Nup88"
                     /gene_synonym="Nup84; Prei2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2385..2390
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nup88"
                     /gene_synonym="Nup84; Prei2"
                     /note="hexamer: AATAAA"
     polyA_site      2408
                     /gene="Nup88"
                     /gene_synonym="Nup84; Prei2"
                     /note="major polyA site"
     regulatory      2414..2419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nup88"
                     /gene_synonym="Nup84; Prei2"
                     /note="hexamer: AATAAA"
     polyA_site      2433
                     /gene="Nup88"
                     /gene_synonym="Nup84; Prei2"
                     /note="major polyA site"
ORIGIN      
        1 aatcctgagc tgttagttca agatggcggc tgccgtgggg cccttgggcg atggggagct
       61 gtggcagagc tggcttccta accacgtcgt gttcttgcgg ctccgcgagg gcgtaagaaa
      121 ccagagtcca gccgaagcgg agaagccagc ggcttcgact tcaccctcgt gcccgtctct
      181 gccgccgcat ttgccgacga gaaacctggt cttcggcctc ggaggggaac tgtttctgtg
      241 ggacgcagaa ggcagcgcct tcttggtggt tcgccttcga ggccccagcg gtggtggcgt
      301 ggagcctcct ctctcccagt atcagagatt actctgcatt aatccaccct tgtttgaaat
      361 ccatcaagtc ttgttgagtc caacccaaca tcatgtagca cttatcggaa gtaaaggact
      421 tatggcatta gaattacctc agaggtgggg gaaggactct gaatttgaag gtggaaaagc
      481 aactgtgaat tgtagcacca tcccgattgc tgagagattt ttcaccagct ctacctctct
      541 gactctgaag catgctgcat ggtatccaag tgagatgctg gatccccaca tagtgctgtt
      601 gacatcagac aacgtgataa gaatttattc tctccgtgag ccccagacac ccactaaggt
      661 gattgtactt tcagaagcag aagaggaaag tttaatactc aataaaggaa gagcatatac
      721 agcgtctcta ggagagactg cagtggcgtt tgacttcggg cccctggtaa ccgtctcaaa
      781 gaatatattt gaacagaaag acagagatgt ggtggcgtat ccactgtaca tcctgtatga
      841 gaatggggag accttcctta cctacgtgag cctgttacac agcccaggga atattgggaa
      901 gctgttgggc ccactgccta tgcatcctgc agctgaagat aactacggtt acgatgcctg
      961 tgctatactc tgtttgccct gtgttccaaa tatcttagta attgcgactg agtcaggaat
     1021 gctgtaccac tgtgttgtac tagagggaga agaagaagat gaccaaacgt tagaaaagtc
     1081 ctgggatccc agggctgact tcatcccttc tctgtacgtg tttgagtgtg ttgagttaga
     1141 gcttgccctg aagctggcat ctggagagga cgatcccttt gcctctgact tttcctgccc
     1201 aattaaactg cacagagatc ccaagtgtcc ttcgagatac cactgcagcc atgaagctgg
     1261 cgtgcacagt gtggggctga cttggattca caaactgcac aaatttcttg gatcggatga
     1321 agaagataag gatagtttac aagaactcac tgctgagcag aaatgctttg tggagcacat
     1381 tctttgtaca aagccattgc cgtgcaggca gccagctcca attcgaggat tctggatcgt
     1441 cccagacatc ctggggccca caatgatctg catcaccagt acctatgaat gtctcatacg
     1501 gcctttatta agtacagtcc acccagcatc tcctcccctg ctctgtaccc aagaagatgc
     1561 tgaagttgca gagtctccac tgcgcattct ggctgaaact ccagactcct ttgagaagca
     1621 tattaaaaga atcttgcagc gtagtgctgc caacccagca tttctcaaat catctgaaaa
     1681 ggatttggct ccccctcccg aggagtgtct tcagcttatc agcagagcca cccaggtgtt
     1741 ccgagaacag tacattctca agcaggacct ggccaaggag gagattcagc ggagggtcaa
     1801 attattatgt gaccaaaaga ggaaacaact cgaagatctc aattactgtc gagaggaaag
     1861 gaaaagtctc cgggaaatgg ctgagcgctt agctgacaaa tatgaggaag ccaaagaaaa
     1921 acaagaagat atcatgaaca ggatgaaaaa agtgcttcac agttttcatg ctcagctccc
     1981 agttctctct gacagtgaga gagacatgaa gaaagagtta cagctgatac ctgatcaact
     2041 gcgacatcta ggcaacgcca tcaaacaggt tactatgaaa aaagattatc aacagcggaa
     2101 gatggaaaaa gtgctgagtc ctcagaaacc caccattact ctcagtgcct accagcgaaa
     2161 gtgcattcag tccatcctga aagaagaggg tgaacacata agggaaatgg tgaagcaaat
     2221 caatgacatc cgaaatcatg tcaccttctg acaccacctg gaatgaacat aacttgaagg
     2281 ctgtaaaaca aacagggagc actgtttaat ttataaagga gcattttgga taagatttgg
     2341 tgtggttatt cttttgttat tcctttttgt tattatttct gttaaataaa tttatttatt
     2401 caaataaagt ttgaataaat ttttattcaa aaatttgact ttgctttaca at
//
