LOCUS       NM_001002929            2181 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus nucleoporin 85 (Nup85), mRNA.
ACCESSION   NM_001002929 XM_981300
VERSION     NM_001002929.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2181)
  AUTHORS   Wu,Y.C., Yan,Q., Yue,S.Q., Pan,L.X., Yang,D.S., Tao,L.S., Wei,Z.Y.,
            Rong,F., Qian,C., Han,M.Q., Zuo,F.C., Yang,J.F., Xu,J.J., Shi,Z.R.,
            Du,J., Chen,Z.L. and Xu,T.
  TITLE     NUP85 alleviates lipid metabolism and inflammation by regulating
            PI3K/AKT signaling pathway in nonalcoholic fatty liver disease
  JOURNAL   Int J Biol Sci 20 (6), 2219-2235 (2024)
   PUBMED   38617542
  REMARK    GeneRIF: NUP85 alleviates lipid metabolism and inflammation by
            regulating PI3K/AKT signaling pathway in nonalcoholic fatty liver
            disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2181)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2181)
  AUTHORS   Zhang,M., Tian,S.Y., Ma,S.Y., Zhou,X., Zheng,X.H., Li,B., Guo,G.Y.,
            Yu,J.H., Su,R., Yang,F.F., Hu,Y.N., Ma,G., Yang,H., Zheng,L.H.,
            Guo,C.C., Shang,Y.L., Wang,J.B. and Han,Y.
  TITLE     Deficient chaperone-mediated autophagy in macrophage aggravates
            inflammation of nonalcoholic steatohepatitis by targeting Nup85
  JOURNAL   Liver Int 43 (5), 1021-1034 (2023)
   PUBMED   36912786
  REMARK    GeneRIF: Deficient chaperone-mediated autophagy in macrophage
            aggravates inflammation of nonalcoholic steatohepatitis by
            targeting Nup85.
REFERENCE   4  (bases 1 to 2181)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2181)
  AUTHORS   Terashima,Y., Toda,E., Itakura,M., Otsuji,M., Yoshinaga,S.,
            Okumura,K., Shand,F.H.W., Komohara,Y., Takeda,M., Kokubo,K.,
            Chen,M.C., Yokoi,S., Rokutan,H., Kofuku,Y., Ohnishi,K., Ohira,M.,
            Iizasa,T., Nakano,H., Okabe,T., Kojima,H., Shimizu,A.,
            Kanegasaki,S., Zhang,M.R., Shimada,I., Nagase,H., Terasawa,H. and
            Matsushima,K.
  TITLE     Targeting FROUNT with disulfiram suppresses macrophage accumulation
            and its tumor-promoting properties
  JOURNAL   Nat Commun 11 (1), 609 (2020)
   PUBMED   32001710
  REMARK    GeneRIF: the chemokine signal regulator FROUNT is identified as a
            target to control tumor-associated macrophages.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2181)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2181)
  AUTHORS   Dietrich,J.E., Panavaite,L., Gunther,S., Wennekamp,S., Groner,A.C.,
            Pigge,A., Salvenmoser,S., Trono,D., Hufnagel,L. and Hiiragi,T.
  TITLE     Venus trap in the mouse embryo reveals distinct molecular dynamics
            underlying specification of first embryonic lineages
  JOURNAL   EMBO Rep 16 (8), 1005-1021 (2015)
   PUBMED   26142281
REFERENCE   8  (bases 1 to 2181)
  AUTHORS   Terashima,Y., Onai,N., Murai,M., Enomoto,M., Poonpiriya,V.,
            Hamada,T., Motomura,K., Suwa,M., Ezaki,T., Haga,T., Kanegasaki,S.
            and Matsushima,K.
  TITLE     Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated
            monocyte chemotaxis
  JOURNAL   Nat Immunol 6 (8), 827-835 (2005)
   PUBMED   15995708
  REMARK    GeneRIF: FROUNT links activated CCR2 to the
            PI(3)K-Rac-lamellipodium protrusion cascade in monocyte chemotaxis
REFERENCE   9  (bases 1 to 2181)
  AUTHORS   Suntharalingam,M. and Wente,S.R.
  TITLE     Peering through the pore: nuclear pore complex structure, assembly,
            and function
  JOURNAL   Dev Cell 4 (6), 775-789 (2003)
   PUBMED   12791264
  REMARK    Review article
REFERENCE   10 (bases 1 to 2181)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY032258.1, BC079856.1 and CF738553.1.
            
            On Jan 27, 2011 this sequence version replaced NM_001002929.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK017632.1, BC079856.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BY032258.1         2-26
            26-2141             BC079856.1         1-2116
            2142-2181           CF738553.1         309-348
FEATURES             Location/Qualifiers
     source          1..2181
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.87 cM"
     gene            1..2181
                     /gene="Nup85"
                     /gene_synonym="frount; Pcnt1"
                     /note="nucleoporin 85"
                     /db_xref="GeneID:445007"
                     /db_xref="MGI:MGI:3046173"
     exon            1..119
                     /gene="Nup85"
                     /gene_synonym="frount; Pcnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            120..213
                     /gene="Nup85"
                     /gene_synonym="frount; Pcnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            214..376
                     /gene="Nup85"
                     /gene_synonym="frount; Pcnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            377..447
                     /gene="Nup85"
                     /gene_synonym="frount; Pcnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            448..491
                     /gene="Nup85"
                     /gene_synonym="frount; Pcnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            492..561
                     /gene="Nup85"
                     /gene_synonym="frount; Pcnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            562..683
                     /gene="Nup85"
                     /gene_synonym="frount; Pcnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            684..818
                     /gene="Nup85"
                     /gene_synonym="frount; Pcnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            819..941
                     /gene="Nup85"
                     /gene_synonym="frount; Pcnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1073
                     /gene="Nup85"
                     /gene_synonym="frount; Pcnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1180
                     /gene="Nup85"
                     /gene_synonym="frount; Pcnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1264
                     /gene="Nup85"
                     /gene_synonym="frount; Pcnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1330
                     /gene="Nup85"
                     /gene_synonym="frount; Pcnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1482
                     /gene="Nup85"
                     /gene_synonym="frount; Pcnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1600
                     /gene="Nup85"
                     /gene_synonym="frount; Pcnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1701
                     /gene="Nup85"
                     /gene_synonym="frount; Pcnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1853
                     /gene="Nup85"
                     /gene_synonym="frount; Pcnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1955
                     /gene="Nup85"
                     /gene_synonym="frount; Pcnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2159
                     /gene="Nup85"
                     /gene_synonym="frount; Pcnt1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2119..2124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nup85"
                     /gene_synonym="frount; Pcnt1"
                     /note="hexamer: AATAAA"
     regulatory      2135..2140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nup85"
                     /gene_synonym="frount; Pcnt1"
                     /note="hexamer: AATATA"
     polyA_site      2141
                     /gene="Nup85"
                     /gene_synonym="frount; Pcnt1"
                     /note="major polyA site"
     polyA_site      2159
                     /gene="Nup85"
                     /gene_synonym="frount; Pcnt1"
ORIGIN      
        1 ctctttggca gctgtctgtg agcgggaggc ctgagcgcag agaagcggcc gcgcggcagg
       61 gtcccagccg cggggggcac ggcgctatgg aggagctcga ctgcgagccc gcagtaactt
      121 ggattccagg tgtgaattcc aagaagaagc aaatgtgttt tgactggggc cccggcgaga
      181 tgcttctgtg tgaaacttcc ttcaaccaaa caggcaaatc agagaaggtg ccgagctgcc
      241 cttttatcta catcatacgg aaagatgtgg atgtttactc tcaaattttg agaaaactct
      301 tcaatgaatc ccatggaatc tttgttggcc tgcaaaaaat tgaggaagaa ctgtcgggga
      361 agtccaggaa agctcaattg gttcgagtga gtaaaaatta ccgttcagtc atacgggcct
      421 gtatggaaga aatgcatcag gttgcaattg ctgctaaaga tccagccagt ggccggcagt
      481 tcagcagcca ggtctccatt ttgtcagcca tggagctcat ttggaacctg tgtgagattc
      541 tctttattga agtagcacca gctggccctc tcctccttca ccttcttgac tgggtccgac
      601 tgcacgtgtg cgaggtggac agtttgtcgg cagatgtcct gggcggtgac aacccaagca
      661 agcatgaaaa cttctgggac ctggtgactg ttctggtgct tcagggccgg ctcgatgagg
      721 cacggcagat gctagccaaa gaagctgatg ccaacccctc ttgtgcaggc atgtgccgcg
      781 tccttgggga cctgatgagg acaatgccca ttctcagccc tggcaatact cagacactga
      841 cagagttgga gctgaagtgg cagcactggc gtgaggagtg tgaaagacac ttacaagaca
      901 acacatttgc agccaacccc cgtctggagt ctctctgcaa gatcatgctg ggagatgagg
      961 ccgccttgtt ggagcagaag gagcttctga gcaactggta ccatttctta gtgacgaggc
     1021 tgctgtactc taaccccaca gtgaagccca ttgacctgca cttctatgcc cagtccagcc
     1081 tagacatgtt tcttggaggt gagagcagtc cagaaccact ggacaacatc ttgatggcgg
     1141 cctttgagtt cgacattcac caggtgatca aagagtgcag catcgccctg agcaactggt
     1201 ggttcgtagc tcacctcaca gaccttttgg atcactgcag actcctccag tcacacaatc
     1261 tctattttgg ttctaacatg agagaattcc tcctgctgga gtacgcctca ggactgtttg
     1321 ctcaccacag cctgtggcag ctgggggtgg actactttga ttactgcccg gagctaggcc
     1381 gagtttcctt ggagctgcac attgagcgga ttcctctcaa cacagagcag aaagccttga
     1441 aggtgctgag gatttgtgag cagcggcaga tgactgagca agttaaaagc atctgtaaga
     1501 tcttggccat gaaggctgtt cgtaataacc gcttgggctc agcactctcc tggagcatcc
     1561 gtgccaaaga tgctgccttt gccacactcg tatctgacag attcctccgg gattactgtg
     1621 agagaggctg cttttctgac ttggatctca ttgacaatct ggggtcagcc atgatgctca
     1681 gtgatcgact gacgtttctg ggaaagtacc gggagttcca cagactgtac ggggagaagc
     1741 gctttggtga cgctgcttct cttctgctgt ccctcatgac ctctcagatt gcacctcgtt
     1801 ctttctggat gactctgctc acagatgccc ttcctctttt ggaacagaaa caggtgattt
     1861 tttcagcaga gcagacatat gagctgatgc ggtgcctgga agacttggcc tcagggaggc
     1921 cagagtgtgg tgaacctgat gcccagcgac tgcaggatga cgacatagag accaccaagg
     1981 tggagatgct gagactggct cttgcccgga atcttgctcg ggcaattata agggaaggct
     2041 cactggaggg ttcctgagag aagatgagga cagttgcaat atagtaactt tgtatggcaa
     2101 tgtaaataga ttttaaagaa taaattgttt tgcaaatata agaccaattg ttaatcctaa
     2161 aaaaaaaaaa aaaaaaaaaa a
//
