LOCUS       NM_053074               3746 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus nucleoporin 62 (Nup62), mRNA.
ACCESSION   NM_053074
VERSION     NM_053074.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3746)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3746)
  AUTHORS   Huang,X., Yao,J., Liu,L., Chen,J., Mei,L., Huangfu,J., Luo,D.,
            Wang,X., Lin,C., Chen,X., Yang,Y., Ouyang,S., Wei,F., Wang,Z.,
            Zhang,S., Xiang,T., Neculai,D., Sun,Q., Kong,E., Tate,E.W. and
            Yang,A.
  TITLE     S-acylation of p62 promotes p62 droplet recruitment into
            autophagosomes in mammalian autophagy
  JOURNAL   Mol Cell 83 (19), 3485-3501 (2023)
   PUBMED   37802024
  REMARK    GeneRIF: S-acylation of p62 promotes p62 droplet recruitment into
            autophagosomes in mammalian autophagy.
REFERENCE   3  (bases 1 to 3746)
  AUTHORS   Trapannone,R., Romanov,J. and Martens,S.
  TITLE     p62 and NBR1 functions are dispensable for aggrephagy in mouse ESCs
            and ESC-derived neurons
  JOURNAL   Life Sci Alliance 6 (11), e202301936 (2023)
   PUBMED   37620146
  REMARK    GeneRIF: p62 and NBR1 functions are dispensable for aggrephagy in
            mouse ESCs and ESC-derived neurons.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3746)
  AUTHORS   Zhao,J., Wang,W., Yan,K., Zhao,H., Zhang,Z., Wang,Y., Zhu,W. and
            Chen,S.
  TITLE     RNA-seq reveals Nup62 as a potential regulator for cell division
            after traumatic brain injury in mice hippocampus
  JOURNAL   PeerJ 11, e14913 (2023)
   PUBMED   36908815
  REMARK    GeneRIF: RNA-seq reveals Nup62 as a potential regulator for cell
            division after traumatic brain injury in mice hippocampus.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3746)
  AUTHORS   Heduschke,A., Ackermann,K., Wilhelm,B., Mey,L., Bonaterra,G.A.,
            Kinscherf,R. and Schwarz,A.
  TITLE     GDF-15 Deficiency Reduces Autophagic Activity in Human Macrophages
            In Vitro and Decreases p62-Accumulation in Atherosclerotic Lesions
            in Mice
  JOURNAL   Cells 10 (9), 2346 (2021)
   PUBMED   34571994
  REMARK    GeneRIF: GDF-15 Deficiency Reduces Autophagic Activity in Human
            Macrophages In Vitro and Decreases p62-Accumulation in
            Atherosclerotic Lesions in Mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3746)
  AUTHORS   Suntharalingam,M. and Wente,S.R.
  TITLE     Peering through the pore: nuclear pore complex structure, assembly,
            and function
  JOURNAL   Dev Cell 4 (6), 775-789 (2003)
   PUBMED   12791264
  REMARK    Review article
REFERENCE   7  (bases 1 to 3746)
  AUTHORS   Levesque,L., Guzik,B., Guan,T., Coyle,J., Black,B.E., Rekosh,D.,
            Hammarskjold,M.L. and Paschal,B.M.
  TITLE     RNA export mediated by tap involves NXT1-dependent interactions
            with the nuclear pore complex
  JOURNAL   J Biol Chem 276 (48), 44953-44962 (2001)
   PUBMED   11579093
REFERENCE   8  (bases 1 to 3746)
  AUTHORS   Di Cristofano,A., Niki,M., Zhao,M., Karnell,F.G., Clarkson,B.,
            Pear,W.S., Van Aelst,L. and Pandolfi,P.P.
  TITLE     p62(dok), a negative regulator of Ras and mitogen-activated protein
            kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl)
  JOURNAL   J Exp Med 194 (3), 275-284 (2001)
   PUBMED   11489947
REFERENCE   9  (bases 1 to 3746)
  AUTHORS   Sattler,M., Verma,S., Pride,Y.B., Salgia,R., Rohrschneider,L.R. and
            Griffin,J.D.
  TITLE     SHIP1, an SH2 domain containing polyinositol-5-phosphatase,
            regulates migration through two critical tyrosine residues and
            forms a novel signaling complex with DOK1 and CRKL
  JOURNAL   J Biol Chem 276 (4), 2451-2458 (2001)
   PUBMED   11031258
REFERENCE   10 (bases 1 to 3746)
  AUTHORS   Cordes,V., Waizenegger,I. and Krohne,G.
  TITLE     Nuclear pore complex glycoprotein p62 of Xenopus laevis and mouse:
            cDNA cloning and identification of its glycosylated region
  JOURNAL   Eur J Cell Biol 55 (1), 31-47 (1991)
   PUBMED   1915419
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK171611.1 and AC158231.2.
            
            On Sep 1, 2015 this sequence version replaced NM_053074.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171611.1, AK171455.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2712              AK171611.1         2-2713
            2713-3746           AC158231.2         103502-104535
FEATURES             Location/Qualifiers
     source          1..3746
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.93 cM"
     gene            1..3746
                     /gene="Nup62"
                     /gene_synonym="D7Ertd649e; Nupc1; p62"
                     /note="nucleoporin 62"
                     /db_xref="GeneID:18226"
                     /db_xref="MGI:MGI:1351500"
     exon            1..396
                     /gene="Nup62"
                     /gene_synonym="D7Ertd649e; Nupc1; p62"
                     /inference="alignment:Splign:2.1.0"
     exon            397..3746
                     /gene="Nup62"
                     /gene_synonym="D7Ertd649e; Nupc1; p62"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2697..2702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nup62"
                     /gene_synonym="D7Ertd649e; Nupc1; p62"
                     /note="hexamer: AATAAA"
     polyA_site      2720
                     /gene="Nup62"
                     /gene_synonym="D7Ertd649e; Nupc1; p62"
                     /note="major polyA site"
     regulatory      3723..3728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nup62"
                     /gene_synonym="D7Ertd649e; Nupc1; p62"
                     /note="hexamer: AATAAA"
     polyA_site      3744
                     /gene="Nup62"
                     /gene_synonym="D7Ertd649e; Nupc1; p62"
ORIGIN      
        1 ggggttgtct ccttggagga aaaggggcag agggtctgtg aattagcgcg caggcgcaac
       61 ggcgcgcgag ccgaccttaa aagcccccaa attctccgga agcacgccct cctcctcccc
      121 gcccctcgca actcgagcct agtgcgcttg ctcagcggat gcgccggccg ccagcttccc
      181 tcttctgcgc ctgcgcgacc gtggttcctc acttcgtctc ccccgccccc accacgaggc
      241 tgacccgtga agccccgcga gctctgaaag ggcgggaaag gcagttggcg agggaggggc
      301 gagcggttac tcactccatg gcggcgaaaa ggcgaggagg caacggcggc ggcggcctcg
      361 gctgaagaga cggtgtgagc ggagagtgaa ggcgcgaaac ctccccaagg ttgcagacgc
      421 tgacggattt gccccagagt cgaagtagct gccacctgaa gattccacaa ccatgagtgg
      481 atttaacttt ggaggcaccg gggctcctgc tggcggcttt acatttggga ccgcaaagac
      541 tgcgaccacc acacctgcca ctggcttttc cttctctgct tctggcaccg gcaccggagg
      601 gtttaatttt gggactccct cccagccagc tgcgaccacc ccttccacca gcctcttctc
      661 actcaccaca cagaccccaa ccacacagac cccaggattc aactttggaa caacacctgc
      721 ttctggagga acaggcttct ccctggggat cagcacccca aagctcagcc tgagtaacgc
      781 agctgccaca ccagccacgg ccaacactgg cagctttggg cttggcagca gcaccctcac
      841 caatgccatc tcaagtggca gcacctccaa ccaggggaca gcccccactg gctttgtctt
      901 tggctcttct accacctctg ctccgtccac cggctccact gggttctcat tcaccagtgg
      961 cagtgcatcc cagcctggag cctctggctt cagccttggc tctgtgggta gctctgccca
     1021 gcccacagca ctgtctggct ctcccttcac accagccact ctggtgacta ctacagcagg
     1081 agctacacag ccagctgctg ctgcacccac tgctgccacc accagtgcag ggtctacact
     1141 ctttgcttcc atagctgctg ctcctgcctc atccagtgct acagggctct ccctcccagc
     1201 tccggtgaca actgcagcaa ctcctagtgc tgggactttg ggcttcagcc tcaaggcccc
     1261 tggagcagct cctggtgcct ccaccaccag caccaccact accactacca ccactactac
     1321 cactgctgct gccgctgccg cctctaccac aaccactggc tttgccttaa gtctgaaacc
     1381 cctggtgtca gctggcccca gcagtgtagc agctactgct ctgcctgcct ccagcacagc
     1441 agctgggact gccacaggtc cagcgatgac ctatgcacag ctggaaagct tgatcaacaa
     1501 gtggagtctg gagctggaag atcaggagcg gcacttcctg cagcaggcca cacaggtcaa
     1561 tgcctgggac cgcacactga ttgagaatgg ggagaagatc accagcctgc accgagaggt
     1621 ggaaaaggtg aagctggatc agaagcgact ggaccaggag ctggacttta tcctgtcgca
     1681 gcagaaggag ctggaagacc tcctgagccc attggaggag tcagtgaagg agcaaagtgg
     1741 caccatatac cttcagcacg ctgatgagga gcgtgagaag acctacaagc tggctgagaa
     1801 cattgatgct cagctcaagc gcatggcaca ggacctcaag gatatcatcg agcacctgaa
     1861 catggctggt ggccctgcag acaccagtga cccattgcaa cagatctgca agatcctcaa
     1921 tgcacacatg gactctcttc agtgggtgga ccagagctct gccctgctgc agaggagggt
     1981 ggaggaggct agccgtgtat gtgagggccg gcgcaaggaa caggagcgca gtctgcgcat
     2041 tgcctttgac tagccacgcg tgagtggggg gaggggctcc ttgggttgca gggctgctgc
     2101 ctttcccgtg gttggttgtt gagaaaaatg ctctttgttt tgattccctg ttatcagaag
     2161 tgttttgcaa aggcatgatg ttcatggata taacctgtgt gctctggaga ccaatgtgaa
     2221 ggtcactgaa ctctcggcca gcatttaaag aacaagggca agtggtgaat ccagcgctcc
     2281 cttgcaagct tcagctctcc ttgtggcaga actcatcctt cagccactcc agtactactg
     2341 tgagggtgga taggtgctcc agacgagaga ctcacctggg gtggagacag gcttctgtgc
     2401 gtctctaatt cctgtcaagc ccgtgtcctc cagaggctct ggcacataga gtggagtcac
     2461 caaagcacca cttttgcact ggctacctct cactcctatc ttgtgcgctt ctgtggcagg
     2521 gactgactgc tgatacgtct ttgaggccaa agtggatgca gatttgcttc tgaatatccc
     2581 agtgtcaaac ctatcttaga tccacagtgg tgaagctggc agtcatgtct attttatttc
     2641 tctgcactct attgtagcct ttgtggtccc tgatcaaaat gtttgttgct tttctaaata
     2701 aaggaagatt tgtgaaacca gacttgctgt gagtatgggt agtgggtcca agctttggca
     2761 ggatagggca ggacacagct ggtgtggtgg tggtactcct atgccgcccg ggttggaagc
     2821 gctggctgag ccatagggcc cagtctctac cttcatgggg tgggcaggct gcaggtgtga
     2881 gaagagtcct gtctaccatt gtgcctaagt ggtaagtcat ccattaccct aatacgtgca
     2941 ggtgtcattg tgatgtcatc agcagtggga aatgaacact gaggggtgat ttccagatgc
     3001 tggtctcact taggcccggc acttggctat aggactgggg gaccttgaac cagcagtggg
     3061 gccacttggg tcatgttggg tcatgttggc acaggagaaa gctgggggtg ggatgagcgg
     3121 ctagatagag aggtagtcgc tcagtggcta agaacacagg ttggctgctc ttccaaggac
     3181 aggaccctat tttgattcaa tgcacccacg tggtagctta caaccaccct gtaattcagt
     3241 cccaggttat ctgacctctt ctgggcagct tgggtaccgt ctgcacatag tgcagagata
     3301 cacatgtagg cagagtcata aaatctcaaa gcgtaaagaa ctggcattgt gaacgcctgt
     3361 caccccagta ctctggaatt ccagatcatc ttgaactaca ttgctacata accacgtaga
     3421 ggcagggcca gtgaactggg aggacgcaag tcctgacgac cccagtggcc ttcctgtgat
     3481 gtgtgacatt tcattggtct aagacaggat ccccccactc tagcccaagt tcttgaattg
     3541 ttgtgaactt cctgccttag ccacctaagc tctaagacta tgggcaagac actacagccc
     3601 agccctgcac tccatgactt gactcccaat tgattatgat gcttaggtct cagttcctct
     3661 aaagatgtgt cttatataca tgattgtcat tggtgggctc aaacaataag ggtgtgcgtt
     3721 ttaataaaaa tgcattttaa tgtgtg
//
