LOCUS       NM_170591               3918 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus nucleoporin 58 (Nup58), transcript variant 1, mRNA.
ACCESSION   NM_170591
VERSION     NM_170591.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3918)
  AUTHORS   Leppek,K., Fujii,K., Quade,N., Susanto,T.T., Boehringer,D.,
            Lenarcic,T., Xue,S., Genuth,N.R., Ban,N. and Barna,M.
  TITLE     Gene- and Species-Specific Hox mRNA Translation by Ribosome
            Expansion Segments
  JOURNAL   Mol Cell 80 (6), 980-995 (2020)
   PUBMED   33202249
REFERENCE   2  (bases 1 to 3918)
  AUTHORS   Papin,J. and Subramaniam,S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
REFERENCE   3  (bases 1 to 3918)
  AUTHORS   Suntharalingam,M. and Wente,S.R.
  TITLE     Peering through the pore: nuclear pore complex structure, assembly,
            and function
  JOURNAL   Dev Cell 4 (6), 775-789 (2003)
   PUBMED   12791264
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK139895.1, AK146477.1, AC166113.3, AK040206.1, CJ220943.1 and
            EH096615.1.
            
            On Apr 17, 2018 this sequence version replaced NM_170591.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146477.1, BC026743.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-500               AK139895.1         30-529
            501-1974            AK139895.1         531-2004
            1975-2479           AK146477.1         1874-2378
            2480-2638           AC166113.3         11622-11780         c
            2639-3584           AK040206.1         331-1276
            3585-3887           CJ220943.1         99-401
            3888-3918           EH096615.1         5-35                c
FEATURES             Location/Qualifiers
     source          1..3918
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 31.62 cM"
     gene            1..3918
                     /gene="Nup58"
                     /gene_synonym="1700017F11Rik; mKIAA0410; Nupl1"
                     /note="nucleoporin 58"
                     /db_xref="GeneID:71844"
                     /db_xref="MGI:MGI:1919094"
     exon            1..317
                     /gene="Nup58"
                     /gene_synonym="1700017F11Rik; mKIAA0410; Nupl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1974
                     /gene="Nup58"
                     /gene_synonym="1700017F11Rik; mKIAA0410; Nupl1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nucleoporin p58/p45; nucleoporin-like protein 1; 58 kDa
                     nucleoporin; nucleoporin like 1"
                     /codon_start=1
                     /product="nucleoporin p58/p45 isoform 1"
                     /protein_id="NP_733479.1"
                     /db_xref="CCDS:CCDS27175.1"
                     /db_xref="GeneID:71844"
                     /db_xref="MGI:MGI:1919094"
                     /translation="MATGFSFGSGTLGSTTVAPGGTGAGSGFSFGTVASSTPSVGLNF
                     GSLGSSVTPASTSASAGGFGTGLFGSKPATGFTLGGTSAGTAATTSASTTGFSLGFSK
                     PAASATPFALPVTSTSASGLTLSSALTSTPAASTGFTLNNLGATPATTTTASTGLSLG
                     GALAGLGGSLFQSGNTATSGLGQNALSLSLGTTAPTSAASNEGLGGIDFSTSSDKKSD
                     KTGTRPEDSKALKDENLPPVICQDVENLQKFVKEQKQVQEEISRMSSKAMLKVQEDIK
                     ALKQLLSLAASGLQRNTLNIDKLKLETAQELKNAEIALRTQKTPPGLQHENTAPADYF
                     RILVQQFEVQLQQYRQQIEELENHLATQASNSHITPQDLSMAMQKIYQTFVALAAQLQ
                     SIHENVKVLKEQYLGYRKMFLGDAVDVFEARRTEAKKWQNAPRVTTGPTPFSTMPNAA
                     AVAMAATLTQQQQPATGPQPSLGVSFGTPFGSGIGTGLQSSGLGSSNLGGFGTSSGFG
                     CGTTGASTFGFGTTDKPSGSLSAGFGSSSTSGFNFSNPGITASAGLTFGVSNPASAGF
                     GTGGQLLQLKRPPAGNKRGKR"
     exon            318..460
                     /gene="Nup58"
                     /gene_synonym="1700017F11Rik; mKIAA0410; Nupl1"
                     /inference="alignment:Splign:2.1.0"
     exon            461..610
                     /gene="Nup58"
                     /gene_synonym="1700017F11Rik; mKIAA0410; Nupl1"
                     /inference="alignment:Splign:2.1.0"
     exon            611..748
                     /gene="Nup58"
                     /gene_synonym="1700017F11Rik; mKIAA0410; Nupl1"
                     /inference="alignment:Splign:2.1.0"
     exon            749..859
                     /gene="Nup58"
                     /gene_synonym="1700017F11Rik; mKIAA0410; Nupl1"
                     /inference="alignment:Splign:2.1.0"
     exon            860..884
                     /gene="Nup58"
                     /gene_synonym="1700017F11Rik; mKIAA0410; Nupl1"
                     /inference="alignment:Splign:2.1.0"
     exon            885..950
                     /gene="Nup58"
                     /gene_synonym="1700017F11Rik; mKIAA0410; Nupl1"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1125
                     /gene="Nup58"
                     /gene_synonym="1700017F11Rik; mKIAA0410; Nupl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1205
                     /gene="Nup58"
                     /gene_synonym="1700017F11Rik; mKIAA0410; Nupl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1324
                     /gene="Nup58"
                     /gene_synonym="1700017F11Rik; mKIAA0410; Nupl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1407
                     /gene="Nup58"
                     /gene_synonym="1700017F11Rik; mKIAA0410; Nupl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1609
                     /gene="Nup58"
                     /gene_synonym="1700017F11Rik; mKIAA0410; Nupl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1708
                     /gene="Nup58"
                     /gene_synonym="1700017F11Rik; mKIAA0410; Nupl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1804
                     /gene="Nup58"
                     /gene_synonym="1700017F11Rik; mKIAA0410; Nupl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..3892
                     /gene="Nup58"
                     /gene_synonym="1700017F11Rik; mKIAA0410; Nupl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3863..3868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nup58"
                     /gene_synonym="1700017F11Rik; mKIAA0410; Nupl1"
                     /note="hexamer: AATAAA"
     polyA_site      3887
                     /gene="Nup58"
                     /gene_synonym="1700017F11Rik; mKIAA0410; Nupl1"
                     /note="major polyA site"
ORIGIN      
        1 agtgcgttcg gcgcgcgggc ggtgtcgcgc atgcgttcgc ctgtggctcc gcccactccg
       61 ccctcgcctt gccgcaccgc cgcttggggt tgtttcccac ccggtacccg ctgggcacca
      121 gctatgtggc acgtccctct tcggcagtga agggacagaa gcgtcctagg cctctccacc
      181 ctagctgacg ccttcgcgcc aagggccgcc atggccacgg ggttctcctt cgggtctggg
      241 accctcggct ccaccactgt ggcccccggc gggaccggag cgggcagcgg cttctccttc
      301 gggaccgtcg cgtctagcac accttctgtg ggactcaact ttggatctct tggaagctct
      361 gtgaccccag catctacatc tgcttcagct ggtggttttg gaacaggcct ctttggatct
      421 aagcctgcca ctggatttac tctaggagga acaagtgcag gaacagcagc aacaacatct
      481 gcgtctacaa caggcttcag tttaggattc agtaaacctg cggcatctgc cacaccattt
      541 gccctgcctg tcacttctac ctcagctagt ggtcttactc tctcatctgc tctgacatca
      601 actccagcag catccacagg atttactttg aataacttgg gagcaacacc agccacaact
      661 acaacagcat caactgggct ttctttaggg ggagccttag ctggtttggg aggttcactt
      721 tttcagagtg gaaacacagc aacatcaggt ctcggacaaa atgctttaag cttgtctttg
      781 ggaactacag cacctacttc agctgccagc aatgaaggcc ttggtggtat agactttagt
      841 acctcatcag ataagaagag tgataaaacg ggaacaaggc cagaggacag taaagcactg
      901 aaagatgaaa acctgcctcc tgtcatctgt caggatgttg aaaacctcca gaaatttgtc
      961 aaggaacaga aacaagtcca agaagaaatt agccgaatgt cttccaaagc aatgcttaaa
     1021 gtccaggaag acatcaaggc cctgaagcag cttctgtcat tggctgccag tgggttgcag
     1081 aggaatacac tcaatattga caaactgaag ttagaaactg ctcaggagtt aaagaatgcc
     1141 gaaatagctt taagaaccca gaaaacacca cctggactcc aacatgaaaa cacagctcct
     1201 gctgactact tcagaatatt ggttcagcag tttgaggtac agcttcagca gtacaggcag
     1261 cagattgaag aactagaaaa ccatcttgcc actcaagcca gtaattcaca tataactcct
     1321 caagatttat caatggctat gcagaaaatt tatcaaacat ttgtagcttt agccgcacaa
     1381 cttcaatcta ttcatgaaaa tgtcaaggtg cttaaagaac agtatctcgg ctacagaaaa
     1441 atgtttttgg gtgatgctgt ggatgtgttt gaagccagga gaacagaagc caagaagtgg
     1501 cagaatgcac ccagagttac tactggaccc actcctttca gcaccatgcc aaacgcagca
     1561 gccgttgcca tggctgcaac acttacacag cagcaacagc ctgctacagg gccacagccg
     1621 tctctgggag ttagttttgg aacgccattc ggctcaggta ttggcactgg cttgcaatca
     1681 agtggcttag gttcttcaaa ccttggagga tttggaacta gctctggttt cggatgcggt
     1741 accacagggg cctccacatt tggatttgga acaacagata aaccctcagg aagtcttagt
     1801 gcaggctttg gcagctcaag tacgtctggg tttaacttca gcaatcctgg catcacggca
     1861 tcagctggtt tgacatttgg ggtatccaat cctgcatctg cggggtttgg aacaggagga
     1921 caactccttc aattgaagag acctccagct ggaaacaaaa gaggaaagag ataaacatac
     1981 gggtcgatgt gttggccgtg cttagctggc tgccgctcat tctatgattc tatttttcta
     2041 acgatgtagt aattgaactg catctcggga gatttataac attttgatat tcctcactct
     2101 ggaacttgaa ctttgtttac cttaccaaac atctttcttg tgaattcaaa atccagttgc
     2161 agttttggtt gctctttttt ttgattctcc atgtaagaaa tgttgtgatt aaattaccaa
     2221 ttgatagtgg tgggaaaaaa atccatcaac ctaagcctat gatctatcct agtactaata
     2281 gcaatgtttc tgttgctgag gtttatgctg tgaatacatg cacattggtt tcttatgcag
     2341 atggtataaa ctctagggcc tgtgctagaa gtagtttgtt ccttgacaag gccttttgaa
     2401 ctgtgctgca gggcatcttg tggatatgta tgtaattata tagagagtaa tgcacacaat
     2461 gtgtgcacat aaaatatata tttacacacc tacaactcct gcctcagact gttatccttt
     2521 ttagtgtatt tagttattca ctctttatga tttagatcct cagcgcttat aaaaggagta
     2581 acttggggtg cctggtcact tcatttgttt attagacaga agtgattctt gatataagta
     2641 tttaacccat tcaacttcat tgaccccact cttctgtttt tatttatacc ttgaccctta
     2701 ggagctactt taactgagga atgctctaag gctcatcaaa cagattttag aaacctttac
     2761 taccctatat atattctcat gctaccatta tgagaatctt ttttgtaaag gagatggact
     2821 tttaggagtg tatgtgaact ccagagtgat gttctggggc aaagagctac taagccaaat
     2881 tgaatctatg caggtggagg atgcaatgtt aattcagtaa caacttgctt agctgtttca
     2941 atacagaatt cttcttatag ggctattgag aaaccaaatg aagtggcttc tgagcctctt
     3001 aatgtgctga gtcttaatct ggactagaga aactacattt tagggaaact ctttgtaccc
     3061 actataaacg tgctggtttg aagagtggtg gagctccagg gagtgctcag aggtgtgtca
     3121 ggttgtctgt gtgacctctg tctgtactgc cgatcctggt gttgagtgag taaacaccac
     3181 tgtgaagaga attcattgcc ttaggaccgt gacagcgtga aagtagtttt caggtggaat
     3241 gaacacatgg aattgcacgg aaatagttta atttttttac atagaaggtt ttgtatataa
     3301 tgtttatcag tgaatacttt caggatcatt ttcactaagg cacctttttt ttattttatt
     3361 caaaacaggt ctggtgtaca tacatacgaa catacataca tacatatttt agtataatgt
     3421 tacttgggtt tgattataaa aattgttggt ctgttttatt tatctgcata taacagtgat
     3481 tggcattcct gaatttaata tttgcatctt gacgcattaa aataaggaga gttatttgtc
     3541 tctgagcact aaacatttgt atatttttgt aattctgcaa ccctcagtcc agactatggg
     3601 ggaggatagg aaaaaggtgt gctttggcat tttaaattac catcagagtt acatatacaa
     3661 ttacaaaaat actgctttgt tcgtttttta agtacattgt attatgctgc aaatatctga
     3721 atatttatat ttctctgggt tatttttttc tttatataca ttttcatatg ttgaaccact
     3781 ggagacttgt agcattcatt tgtggtagga gtcagagtgt tgtctttgtc tcctttgtct
     3841 tcgccttgtc tattgtggaa ataataaaat ttgttagttg ctttgaatct ttaaaaaaaa
     3901 aaaaaaaaaa aaaaaaaa
//
