LOCUS       NM_001408097            7431 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus nucleoporin 214 (Nup214), transcript variant 2, mRNA.
ACCESSION   NM_001408097 XM_006497945
VERSION     NM_001408097.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7431)
  AUTHORS   Saito,S., Cigdem,S., Okuwaki,M. and Nagata,K.
  TITLE     Leukemia-Associated Nup214 Fusion Proteins Disturb the
            XPO1-Mediated Nuclear-Cytoplasmic Transport Pathway and Thereby the
            NF-kappaB Signaling Pathway
  JOURNAL   Mol Cell Biol 36 (13), 1820-1835 (2016)
   PUBMED   27114368
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7431)
  AUTHORS   Echeverria,P.C., Mazaira,G., Erlejman,A., Gomez-Sanchez,C., Piwien
            Pilipuk,G. and Galigniana,M.D.
  TITLE     Nuclear import of the glucocorticoid receptor-hsp90 complex through
            the nuclear pore complex is mediated by its interaction with Nup62
            and importin beta
  JOURNAL   Mol Cell Biol 29 (17), 4788-4797 (2009)
   PUBMED   19581287
REFERENCE   3  (bases 1 to 7431)
  AUTHORS   Masuda,T., Kai,N., Sakuma,C., Kobayashi,K., Koga,H. and Yaginuma,H.
  TITLE     Laser capture microdissection and cDNA array analysis for
            identification of mouse KIAA/FLJ genes differentially expressed in
            the embryonic dorsal spinal cord
  JOURNAL   Brain Res 1249, 61-67 (2009)
   PUBMED   19026994
REFERENCE   4  (bases 1 to 7431)
  AUTHORS   Lupu,F., Alves,A., Anderson,K., Doye,V. and Lacy,E.
  TITLE     Nuclear pore composition regulates neural stem/progenitor cell
            differentiation in the mouse embryo
  JOURNAL   Dev Cell 14 (6), 831-842 (2008)
   PUBMED   18539113
REFERENCE   5  (bases 1 to 7431)
  AUTHORS   Olsson,M., Scheele,S. and Ekblom,P.
  TITLE     Limited expression of nuclear pore membrane glycoprotein 210 in
            cell lines and tissues suggests cell-type specific nuclear pores in
            metazoans
  JOURNAL   Exp Cell Res 292 (2), 359-370 (2004)
   PUBMED   14697343
REFERENCE   6  (bases 1 to 7431)
  AUTHORS   Suntharalingam,M. and Wente,S.R.
  TITLE     Peering through the pore: nuclear pore complex structure, assembly,
            and function
  JOURNAL   Dev Cell 4 (6), 775-789 (2003)
   PUBMED   12791264
  REMARK    Review article
REFERENCE   7  (bases 1 to 7431)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   8  (bases 1 to 7431)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 7431)
  AUTHORS   van Deursen,J., Boer,J., Kasper,L. and Grosveld,G.
  TITLE     G2 arrest and impaired nucleocytoplasmic transport in mouse embryos
            lacking the proto-oncogene CAN/Nup214
  JOURNAL   EMBO J 15 (20), 5574-5583 (1996)
   PUBMED   8896451
REFERENCE   10 (bases 1 to 7431)
  AUTHORS   Pilz,A., Woodward,K., Povey,S. and Abbott,C.
  TITLE     Comparative mapping of 50 human chromosome 9 loci in the laboratory
            mouse
  JOURNAL   Genomics 25 (1), 139-149 (1995)
   PUBMED   7774911
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928893.10.
            
            On Jun 9, 2022 this sequence version replaced XM_006497945.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.1600.1,
                                           SRR17784647.1144395.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               AL928893.10        61026-61200
            176-371             AL928893.10        63092-63287
            372-523             AL928893.10        64356-64507
            524-722             AL928893.10        66282-66480
            723-793             AL928893.10        67102-67172
            794-857             AL928893.10        69203-69266
            858-961             AL928893.10        69715-69818
            962-1068            AL928893.10        74746-74852
            1069-1135           AL928893.10        75665-75731
            1136-1262           AL928893.10        76827-76953
            1263-1424           AL928893.10        77856-78017
            1425-1878           AL928893.10        81115-81568
            1879-2054           AL928893.10        82968-83143
            2055-2152           AL928893.10        84545-84642
            2153-2239           AL928893.10        89184-89270
            2240-2389           AL928893.10        89473-89622
            2390-2548           AL928893.10        90905-91063
            2549-2652           AL928893.10        93281-93384
            2653-2835           AL928893.10        96775-96957
            2836-2909           AL928893.10        97604-97677
            2910-2993           AL928893.10        97777-97860
            2994-3305           AL928893.10        103618-103929
            3306-3467           AL928893.10        104787-104948
            3468-3567           AL928893.10        106850-106949
            3568-3643           AL928893.10        111835-111910
            3644-3722           AL928893.10        113440-113518
            3723-3813           AL928893.10        117299-117389
            3814-3872           AL928893.10        117842-117900
            3873-5639           AL928893.10        119795-121561
            5640-5710           AL928893.10        124694-124764
            5711-5867           AL928893.10        125912-126068
            5868-6020           AL928893.10        129009-129161
            6021-6192           AL928893.10        133995-134166
            6193-6332           AL928893.10        137601-137740
            6333-6357           AL928893.10        138366-138390
            6358-7431           AL928893.10        138711-139784
FEATURES             Location/Qualifiers
     source          1..7431
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 21.97 cM"
     gene            1..7431
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /note="nucleoporin 214"
                     /db_xref="GeneID:227720"
                     /db_xref="MGI:MGI:1095411"
     exon            1..175
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..6391
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /note="isoform 2 is encoded by transcript variant 2;
                     nuclear pore complex protein Nup214; nucleoporin Nup214;
                     214 kDa nucleoporin"
                     /codon_start=1
                     /product="nuclear pore complex protein Nup214 isoform 2"
                     /protein_id="NP_001395026.1"
                     /db_xref="GeneID:227720"
                     /db_xref="MGI:MGI:1095411"
                     /translation="MGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSVLTI
                     SNKYGMLFAGGTNGLNVFPTKSLLIQNKPGDDPNKIVDTIQGLNVPMKFPVHHLALSC
                     DSLTLSACMMSSEYGSIIAFFDVRTFSNQAKPLKRPFTYHKVSNDASGMVNDMKWNPT
                     VPSMVAVCLADGSISVLQVTDVVKVCATLPPSTGVTCVCWSPKGKQLAVGKQNGTVVQ
                     YLPTLQEKKVIPCPPFYESDHPVRVLDVLWIGTYVFTIVYAGADGTLETCPDVVMALL
                     PKKEEKHPEIFVNFMEPCYSSCTERQHHYYLSYIEEWDLVLAASAASTEVSILARQND
                     QTNWESWLLEDSSRAELPVTDKSDDSLPMGVAIDYTNEVEVTINEEKTLPPAPVLLLL
                     STDGVLCPFYMINQNPGVRSLIKTLELISTEGERQPKSSGSFPGTPSSPQAPQNLDAP
                     ATASSPLPPVSAAPTSTFPMPSAAGSPSVFSFGPSSFKSSASVTGEPPLYPTGSDSSR
                     AAPGSGTSTFSFAPPSKGSLASTPAVAPVATSAAPFTFGFKPTLESTPMSSTPNTGMK
                     PSFPPSASSVKVNLNEKFTAVASSAPVHSSTSTPSVLPFSSSPKPTASGPLSHPTPLP
                     ASSSSMPLKSSVSPSPAAGRSTQTAPSSAPSTGQKSPRVNPPVPKSGSSQAKALQPPV
                     TEKQRPQWKDSDPVLAGIGEEIAHFQKELEELKARTAKACLQVGTSEEMKMLRTESDD
                     LHTFLFEIRETTESLHGDISTLKTTLLEGFAGVEEAREQHGRNHDSGYLHLLYKRPLD
                     PKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDRHLEQKKRQRRLIVPERETLFNTLA
                     NNREIINQQRKRLNQLVDSLQQLRLYNHTAPWSLPSALSTQSNSHSFDSDLECLLKTT
                     IESHTKPSPRVPGKLSPAKQAQLRNFLAKRKTPPVRSTAPASLSRSAFLSQRYYEDLD
                     EGSSASSVAQPLEGEDARPTCTSVAQPLEGEDAQPICKEEEAVVPVPRHAPVVRTPSI
                     QPSLLPQSMPFAKPHLIHSSSPAVMSSAVSTSATKVIPQGADSTMLATKTVKHGAPGP
                     SHTVAAPQAAAAAALRRQMASQAPAMSTLTESTLKTVPQVVNVQELRSNPSPPSAAMG
                     SAVQHSAAKTPHAVLTPVANSQAKQGSLINSFKPSGPTAASCQLSSGDKAVGQGTAKT
                     ESAATSTPSAAGQLNKPFSFASPGTFTFGTITPTPSSSFTATPGAGPPTKEPTQLEAF
                     SFGGGGKPFSEAIPGNSPATGATSAPSTSVTAASLEDSAPSSSKPAAPPETTVSSASS
                     KLETPPSKLGELLFPSSLAGETLGSFSGLRVGQAEDSTKPVSKASSTNLAGAQPAKPS
                     GVSFPNTSVLGKPVEPAVTSSVSPAPAAPASALNVSTSSSSATVFGSVPLTSAGPPGL
                     ISFGGAALASSKASFSFGNQQTSSSTASSATPTSTSVAPSLPASFPTLSFGGLLSSPS
                     ASSLPVSSGKSTEEAAPPAVPDKSDSSEVSATTPSLPVQPQSTQASLQTSDPVKKEPV
                     LVQTTDSSPSRPASSASFVASTESMPVTLGAPDSKIEAVSPASTFAGPGQAAVATAVL
                     PGAGSAATEASGTPTTSTVSSSSPTSATETAVFGTATSGSSVFTQPPAASSSSAFSQL
                     SSNTATAPSATPVFGQVAASITSTAAATPQASSSGFGSPAFGASAPGVFGQTAFGQTP
                     AFGQATSSPASGFSFSQPGFSSVPAFGQSVSSTPASTSANVFGATSSTSSPGSFSFGQ
                     ASTNTGGTLFGQNNPPAFGQSPGFGQGSSVFGGTSATTSTAAPSGFSFCQASGFGSSN
                     TGSVFGQAANTGGSVFGQQSSTSSGGVFGSGNATRGGGFFSGLGGKPSQDAANKNPFS
                     SAGGGFGSTAAPNTSNLFGNSGAKTFGGFGSSSFGEQKPAGTFSSGGGSVASQGFGFS
                     TPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAAS
                     AGGFGFGSSGNTASFGTLASQNAPTFGSLSQQTSGFGTPSSGFAGFGSGTGAFTFGSS
                     NSSVQGFGGWRS"
     exon            176..371
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            372..523
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            524..722
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            723..793
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            794..857
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            858..961
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1068
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1135
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1262
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1424
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1878
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2054
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2152
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2239
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2389
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2548
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2652
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..2835
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            2836..2909
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..2993
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            2994..3305
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            3306..3467
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            3468..3567
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            3568..3643
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            3644..3722
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            3723..3813
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            3814..3872
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            3873..5639
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            5640..5710
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            5711..5867
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            5868..6020
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            6021..6192
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            6193..6332
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            6333..6357
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            6358..7431
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6580..6585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /note="hexamer: ATTAAA"
     polyA_site      6610
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /note="major polyA site"
     regulatory      7410..7415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
                     /note="hexamer: ATTAAA"
     polyA_site      7431
                     /gene="Nup214"
                     /gene_synonym="CAN; D2H9S46E"
ORIGIN      
        1 gcatctacca cgcgccgcgg gcgctgaggg aaggaagttg aggcctgagc ggcctgagct
       61 gtgtttgaaa ggccgcgggt ggcagcggca gcgccagcag cagctacttg aacaccctga
      121 aggcggcacg atgggagacg agatggatgc catgatccct gagcgggaga tgaaggactt
      181 tcagtttaga gcactgaaga aagtgaggat ctttgactct cctgaagagt tgcccaagga
      241 gcgctcgagt gtgcttacca tatccaataa gtatggtatg ctcttcgctg gtggcaccaa
      301 tggcttgaat gtttttccta ctaaaagcct tcttatccaa aataaacctg gagatgatcc
      361 caataaaatt gttgacacaa ttcaaggctt gaatgttcct atgaaattcc cagtccatca
      421 cctagcactg agctgtgata gtcttacact ctctgcctgc atgatgtcta gtgaatacgg
      481 ctccattata gctttttttg atgttcgcac attttcaaat caggctaaac cattgaaacg
      541 tccatttacc tatcacaagg tttcaaacga tgccagcgga atggtgaatg atatgaagtg
      601 gaaccccact gtcccttcca tggtggcagt ttgtctggct gatggcagta tttctgtctt
      661 gcaagttaca gatgtggtga aagtatgcgc cacacttcct ccttccacag gagtcacatg
      721 tgtatgctgg agccccaaag gaaagcagct ggcagtagga aagcagaatg gaactgtggt
      781 ccagtacctt cctactttgc aggaaaaaaa ggtcattcca tgtcctccat tttatgagtc
      841 agatcatcct gtcagagttc tggatgtgct atggattggt acatatgtct tcacgatagt
      901 ctatgctggt gcagatggaa ccttggagac ctgtccagat gtggtgatgg ctctactccc
      961 gaaaaaagaa gaaaagcatc cagaaatatt tgtgaacttc atggagccct gctacagcag
     1021 ctgcacagag agacaacatc attactacct cagctacatc gaggagtggg atttagtgct
     1081 ggcagcatct gcagcttcta cagaagttag catccttgct cgacaaaatg atcagactaa
     1141 ttgggaatct tggctgctgg aggactctag tcgagctgaa ctgcctgtga cagacaagag
     1201 tgatgactcc ttgcccatgg gtgttgccat agattatacc aatgaagtgg aagtcaccat
     1261 caatgaagaa aagactcttc cgcctgctcc ggttctcctg ttactttcaa cagatggtgt
     1321 gctttgtcca ttttatatga tcaaccaaaa tcctggggtt aggtccctaa tcaagacctt
     1381 ggaactgatc tcaacagaag gagagcgaca gcctaagtcc tcaggaagtt ttcctggtac
     1441 tccatcttcc cctcaagctc cacaaaacct ggacgctcca gcaacagcct cttcgcctct
     1501 tccacctgtg tccgctgctc ccacctccac cttccctatg ccctctgctg caggaagccc
     1561 ttctgtgttc tcctttggcc cttcatcctt caagtcttct gcttctgtca ccggggagcc
     1621 cccactgtac cccactggct ccgacagctc cagagcagca ccaggctctg gcacctccac
     1681 tttctctttt gctcctcctt ccaaaggctc cctggcgtcg acccctgcag tggctcctgt
     1741 ggccacatct gctgctccct tcacttttgg ttttaagccc accttggaaa gcacacctat
     1801 gtccagtacc ccaaacacag ggatgaagcc ttcgttccct ccctcggcct cttcggtgaa
     1861 agtcaacctg aatgagaagt tcaccgctgt ggcctcctct gcacctgttc atagctccac
     1921 gagcacaccc tccgtgttgc cgttctcctc ctccccgaag ccaacggctt ctggaccact
     1981 cagccatcct acgcctctcc cagcatcatc cagctccatg cctttgaagt cttcggtctc
     2041 tccctcgcca gcagctggcc gctccactca gactgcgcca agttcagcac cctccacagg
     2101 gcagaaatca cccagggtaa accctccagt gccaaagtca ggttcttctc aggccaaggc
     2161 acttcagcct cctgtcacag agaaacagag gcctcagtgg aaagactcag accccgtgct
     2221 ggctgggatt ggagaggaga ttgcacactt ccagaaagaa ctagaggagt taaaggcccg
     2281 gaccgccaaa gcctgtctcc aggttggcac ctcagaagag atgaagatgc tgcggacaga
     2341 gtcagatgac ttgcacacct ttctttttga gattagagag accacagagt ctcttcatgg
     2401 agacataagt actctgaaaa caactttgct ggagggcttt gctggggtcg aagaagccag
     2461 agaacagcac ggaagaaatc acgactctgg gtatctccac ctgctttata aaagaccgct
     2521 ggatcccaag agcgaggccc agctccagga aattcgccgc cttcaccagt acgtgaaatt
     2581 tgctgtccag gatgtgaatg acgtcctaga cttagagtgg gatcggcatc tggagcagaa
     2641 gaagagacag aggcgcctaa ttgtgccaga acgagagaca cttttcaaca cgctagccaa
     2701 caaccgggag atcatcaacc agcagaggaa gaggctgaat cagctggtgg acagtctgca
     2761 gcagctccgt ctctataacc acacggcccc gtggagcctg ccctcagcgc tctcaactca
     2821 gagcaacagt cacagttttg acagtgacct tgaatgcctg ctaaaaacta ccattgaatc
     2881 tcacaccaag ccttctccca gagtgccagg taaattgtcc ccggcgaaac aggcccaact
     2941 gaggaacttc ttggccaaaa ggaagacccc accagtgagg tctactgctc cagccagcct
     3001 gtcccggtca gccttcctat ctcagaggta ctatgaagac ttagatgaag gcagctccgc
     3061 gtcatccgta gctcagcctc tggagggaga agatgcccgg ccaacctgca catctgtagc
     3121 tcagcctctg gagggagaag atgcccagcc aatctgcaaa gaggaagagg ctgtggtccc
     3181 agtacctcgg catgcccctg tggtccgcac accttctatc caacccagtc tcctgcctca
     3241 gtcgatgccc tttgcaaagc ctcacctgat ccatagttct tcacctgccg tgatgagctc
     3301 tgcagtctct acgtcagcca ccaaagttat tcctcaggga gcagacagca caatgctggc
     3361 aactaaaaca gtaaagcacg gtgcaccagg tccttcccac actgttgcag ctccccaggc
     3421 cgcagctgct gcagccctaa gacggcagat ggccagtcag gcaccagcta tgagcactct
     3481 gaccgaatca actctgaaga ctgtccctca ggtggtgaat gtacaggaac tgaggagtaa
     3541 tccctcgccc ccatctgcgg ccatgggttc tgccgtgcag cactcagcag ccaaaacacc
     3601 ccatgctgtg ttaacccccg tggctaacag ccaagccaag caggggtctc tgataaattc
     3661 tttcaagccg tcaggaccca cagcagcatc ctgtcagctg tcctctgggg ataaagctgt
     3721 aggtcaaggg acagccaaga cagagtccgc tgcgacctcg actccatctg ctgcaggaca
     3781 gctcaacaag cctttctcat tcgcctcccc agggaccttt acttttggga caatcacacc
     3841 aaccccatct tctagtttca ctgccacacc aggggcagga ccccctacta aagagccaac
     3901 ccagcttgag gcattctcat ttggcggggg aggcaaacct ttctctgagg ccattcctgg
     3961 gaactcccct gccacaggag caacatcggc acccagcact tctgtaacag ctgcctctct
     4021 ggaagactct gctccatcca gcagcaaacc tgcagctcct cctgaaacta ctgtgtcctc
     4081 tgcttctagc aaattggaaa ctccaccgtc caagttagga gagcttctgt tcccaagctc
     4141 tctagctgga gagacgctgg ggagcttctc gggcctgcgt gttggccaag ctgaggattc
     4201 tactaagcca gttagtaagg cctcctccac aaacctagct ggagcccagc cagctaagcc
     4261 ctcaggggtt agctttccta atacttcagt gttagggaag ccagtggagc ccgctgtgac
     4321 ctcctctgtg agccccgccc cagcagcacc agcctcagct ctgaatgtga gcactagcag
     4381 ttcctcagca actgtctttg gcagtgtgcc ccttaccagt gctggacctc ctgggctcat
     4441 cagttttggt ggggctgctt tggctagtag caaagctagt ttctcatttg gaaaccagca
     4501 gactagtagt agtacagcat catcagctac cccaacatcg acctcagttg ccccttccct
     4561 tccagcatct ttccctactt tgtcatttgg tggcctcctg agttcaccat cagcttcttc
     4621 cctgcccgtg tcctctggta agagtacaga ggaggcagca ccaccagctg ttcctgacaa
     4681 gtcagacagc agtgaagttt cagcaacaac accctcactt ccagtacagc cacagtcaac
     4741 ccaggcatct ctgcaaactt ctgaccctgt caaaaaagaa cctgttcttg tgcagaccac
     4801 agacagcagc cccagcagac cagcatcttc tgccagcttt gtggcatcca cagagtccat
     4861 gccagtaacc ctaggggccc ctgacagcaa gatagaggca gtgtctcctg cgtccacctt
     4921 tgcagggcct ggacaggctg ctgtggcaac agctgttctc ccaggagcag gctcggcagc
     4981 cactgaagca tcgggtaccc ctaccacctc cactgtctcc agcagtagcc caacttctgc
     5041 cacagagaca gctgtatttg ggactgccac atctggttcc tcagtcttta cacagccacc
     5101 tgctgccagt tctagctcag cgttcagcca gctctccagt aacacagcca ctgcgccctc
     5161 tgccacccct gtgtttgggc aagtggcagc cagcataacc agcacagccg ctgccacacc
     5221 acaggccagc agttcagggt ttggcagccc tgcatttggt gcttcagctc ctggagtgtt
     5281 cggacagaca gcatttgggc agaccccagc ctttgggcaa gcaacaagca gccctgccag
     5341 tggcttctcc ttcagccagc ctgggttcag ttccgtgcct gctttcggcc agtctgtctc
     5401 ctctaccccc gcatccacca gtgcaaatgt ctttggagcc acctcgagta ccagcagtcc
     5461 tggttccttc tcatttggac aggcttctac caatacagga gggacgctgt ttggtcaaaa
     5521 caaccctcct gcttttggtc agagccctgg ctttgggcag ggaagctctg tgtttggtgg
     5581 cacctcggcc actacctcta cagcagcacc ttcagggttt agcttttgtc aagcctccgg
     5641 ttttgggtct agtaatactg gttctgtgtt tggccaggca gccaacactg gtgggtcagt
     5701 ctttggccag cagtcatcca cttccagtgg tggcgtgttt gggtctggaa atgctacaag
     5761 agggggcggt ttcttcagtg gccttggagg aaaacccagc caggatgctg ccaacaaaaa
     5821 ccccttcagc tcagccggtg ggggctttgg atctacagct gccccaaata cctctaatct
     5881 gtttggaaac agtggagcta agacatttgg agggtttggc agctcatcct tcggggaaca
     5941 gaagcctgcc ggcacattca gctctggcgg tgggagcgta gcatcccaag gttttggatt
     6001 ttccactcca aataaaacag gtggcttcgg tgctgctcca gtgtttggca gccctcctac
     6061 ttttggggga tcccctgggt ttggaggggt gccagcattc ggttcagccc cagcctttac
     6121 aagccctctg ggctcgacgg gaggcaaagt gttcggagag ggtactgcgg ctgccagcgc
     6181 aggcggattc gggttcggga gcagcggcaa tactgcatcc ttcggtaccc tcgccagtca
     6241 gaacgcaccc accttcgggt ccttgtccca gcagacctca ggctttggga ccccgagcag
     6301 tggattcgct gggtttggat cgggcacagg agccttcacc tttggatcat ctaactcgtc
     6361 tgtccagggc ttcggtggct ggagaagctg agctgatgtc agcattccct caagttcctg
     6421 tgagctcctg tgcgcatccc tccacagcaa cagactgtca aaagaacttt ctcatgaaaa
     6481 cgctcagcca ggaagaaaca ctggagacca aagctcagca atgcttaact aactgcctgt
     6541 tccccgcttt caaattttac atcaagtttt tcgtctgcta ttaaagtgtt tggtctggtt
     6601 ctgcacagaa catctgggta tttatttggg tcacagccag agacattcct atggcttgag
     6661 gaaaccaagc cagtggtctc tgcccagtgg cattctgagt agagcccctc tacatggaaa
     6721 agagcagaat gtggcagaca cctccccacg ttaatgtcta tgccacatgt tctgtggttc
     6781 catgtcaggc tcctgtgagg gccccttcct tcacagccag ttctaagaca ggtatggcaa
     6841 acagaccagg gaggcagccg ctgagctgcc tgtcacctgc caccctgtct ctgctcctgc
     6901 atgctctgca tctgctgcca gttcccagtg cagaggcagt ctgctgatcg tctccataca
     6961 cagcatttgc agacctacaa acaccacgtc cttccttcac tgtttggaac ccacgactta
     7021 cggggacatc aacaagtcgc tgcaggcttg gacagtgtgc gaatccattt tagacatgct
     7081 tctttctctg ggtgcgttag ctttgagggc ctggcatgtt ctgctccttg ggctgtggag
     7141 tcctgtgcta ccaaagcctc tgcagagacc atctgtcacc tttcaggttc acaacatggc
     7201 actgctctgg actgggtcaa gggcagaggg aagagctgtg ggttggggtt tgtcatactg
     7261 gaaaggtttt ggttcctttg ttgttcaggg gttgttcttg tttttgagac agggcttccc
     7321 tgtgtagctg gctgtcctgg aacttgctct gtagaccagg ctggccttga actcagagaa
     7381 ctgcctacct ctgtctcctg agtgctggga ttaaaggcat gcccactacc a
//
