LOCUS       NM_018815               7043 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus nucleoporin 210 (Nup210), mRNA.
ACCESSION   NM_018815
VERSION     NM_018815.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7043)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7043)
  AUTHORS   Sulic,A.M., Das Roy,R., Papagno,V., Lan,Q., Saikkonen,R.,
            Jernvall,J., Thesleff,I. and Mikkola,M.L.
  TITLE     Transcriptomic landscape of early hair follicle and epidermal
            development
  JOURNAL   Cell Rep 42 (6), 112643 (2023)
   PUBMED   37318953
REFERENCE   3  (bases 1 to 7043)
  AUTHORS   Sakuma,S., Zhu,E.Y., Raices,M., Zhang,P., Murad,R. and
            D'Angelo,M.A.
  TITLE     Loss of Nup210 results in muscle repair delays and age-associated
            alterations in muscle integrity
  JOURNAL   Life Sci Alliance 5 (3), e202101216 (2021)
   PUBMED   34911810
  REMARK    GeneRIF: Loss of Nup210 results in muscle repair delays and
            age-associated alterations in muscle integrity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7043)
  AUTHORS   Amin,R., Shukla,A., Zhu,J.J., Kim,S., Wang,P., Tian,S.Z.,
            Tran,A.D., Paul,D., Cappell,S.D., Burkett,S., Liu,H., Lee,M.P.,
            Kruhlak,M.J., Dwyer,J.E., Simpson,R.M., Hager,G.L., Ruan,Y. and
            Hunter,K.W.
  TITLE     Nuclear pore protein NUP210 depletion suppresses metastasis through
            heterochromatin-mediated disruption of tumor cell mechanical
            response
  JOURNAL   Nat Commun 12 (1), 7216 (2021)
   PUBMED   34903738
  REMARK    GeneRIF: Nuclear pore protein NUP210 depletion suppresses
            metastasis through heterochromatin-mediated disruption of tumor
            cell mechanical response.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7043)
  AUTHORS   de Barros Mucci,D., Kusinski,L.C., Wilsmore,P., Loche,E.,
            Pantaleao,L.C., Ashmore,T.J., Blackmore,H.L., Fernandez-Twinn,D.S.,
            Carmo,M.D.G.T.D. and Ozanne,S.E.
  TITLE     Impact of maternal obesity on placental transcriptome and
            morphology associated with fetal growth restriction in mice
  JOURNAL   Int J Obes (Lond) 44 (5), 1087-1096 (2020)
   PUBMED   32203108
REFERENCE   6  (bases 1 to 7043)
  AUTHORS   Olsson,M., Scheele,S. and Ekblom,P.
  TITLE     Limited expression of nuclear pore membrane glycoprotein 210 in
            cell lines and tissues suggests cell-type specific nuclear pores in
            metazoans
  JOURNAL   Exp Cell Res 292 (2), 359-370 (2004)
   PUBMED   14697343
  REMARK    GeneRIF: Expression of gp210 mRNA and protein was seen in mouse
            embryonic stem (ES) cells, supporting the view of cell-type
            specific NPCs in metazoans and suggesting the gp210 gene is
            regulated by specific control elements not shared by other
            nucleoporins.
REFERENCE   7  (bases 1 to 7043)
  AUTHORS   Suntharalingam,M. and Wente,S.R.
  TITLE     Peering through the pore: nuclear pore complex structure, assembly,
            and function
  JOURNAL   Dev Cell 4 (6), 775-789 (2003)
   PUBMED   12791264
  REMARK    Review article
REFERENCE   8  (bases 1 to 7043)
  AUTHORS   Bitard,J., Daburon,S., Duplomb,L., Blanchard,F., Vuisio,P.,
            Jacques,Y., Godard,A., Heath,J.K., Moreau,J.F. and Taupin,J.L.
  TITLE     Mutations in the immunoglobulin-like domain of gp190, the leukemia
            inhibitory factor (LIF) receptor, increase or decrease its affinity
            for LIF
  JOURNAL   J Biol Chem 278 (18), 16253-16261 (2003)
   PUBMED   12601009
REFERENCE   9  (bases 1 to 7043)
  AUTHORS   Voisin,M.B., Bitard,J., Daburon,S., Moreau,J.F. and Taupin,J.L.
  TITLE     Separate functions for the two modules of the membrane-proximal
            cytokine binding domain of glycoprotein 190, the leukemia
            inhibitory factor low affinity receptor, in ligand binding and
            receptor activation
  JOURNAL   J Biol Chem 277 (16), 13682-13692 (2002)
   PUBMED   11834739
  REMARK    GeneRIF: Separate functions for the two modules of the
            membrane-proximal cytokine binding domain of glycoprotein 190, the
            leukemia inhibitory factor low affinity receptor, in ligand binding
            and receptor activation
REFERENCE   10 (bases 1 to 7043)
  AUTHORS   Olsson,M., Ekblom,M., Fecker,L., Kurkinen,M. and Ekblom,P.
  TITLE     cDNA cloning and embryonic expression of mouse nuclear pore
            membrane glycoprotein 210 mRNA
  JOURNAL   Kidney Int 56 (3), 827-838 (1999)
   PUBMED   10469352
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK053417.1, AK173056.1 and DT908828.1.
            
            On Apr 4, 2008 this sequence version replaced NM_018815.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173056.1, AF113751.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AK053417.1         2-47
            47-7003             AK173056.1         1-6957
            7004-7043           DT908828.1         594-633
FEATURES             Location/Qualifiers
     source          1..7043
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 40.3 cM"
     gene            1..7043
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /note="nucleoporin 210"
                     /db_xref="GeneID:54563"
                     /db_xref="MGI:MGI:1859555"
     exon            1..209
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..5703
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /note="nuclear pore membrane protein 210; nuclear pore
                     membrane glycoprotein 210; nucleoporin Nup210; nuclear
                     pore protein gp210; pore membrane protein of 210 kDa;
                     nuclear envelope pore membrane protein POM 210;
                     nucleoporin 210; nuclear pore membrane glycoprotein 210;
                     nuclear pore membrane protein 210"
                     /codon_start=1
                     /product="nuclear pore membrane glycoprotein 210
                     precursor"
                     /protein_id="NP_061285.2"
                     /db_xref="CCDS:CCDS39565.1"
                     /db_xref="GeneID:54563"
                     /db_xref="MGI:MGI:1859555"
                     /translation="MARASLVQPALWALLLLQVVGPAAAAKLNIPKVLLPFTRATRVN
                     FTLEASEGCYRWSSTRPEVASIEPLGSSEQQCSQKAVVQARLTQPARLTSIIFAEDIT
                     TGQVLRCDAIVDLIHGIQIVSTTRELYLEDSPLELKIQALDSEGNTFSTLAGLVFDWT
                     IVKDTEANGFSDSHNALRILTFLESTYIPPSYISEMEKAAKQGDTILVSGMKTGSSKL
                     KARIQEAVYKNVRPAEVRLLILENILLNPAYDVYLLVGTSIHYKVQKIRQGKITELSM
                     PSDQYELQLQNSIPDPQGDPARPVAILTQDTSRVTAMQMGQSNLVLGHRSIRMQGASR
                     LPNSTIYVVEAGYLGFTVYPGDRWVLETGHLYAITIEVFDRSSNKVYPSDNIRIEAVL
                     PAEFFEVLSSSQNGSYHHIRAIQSGQTAISATLTSVVDQDGGVHVLQVPVWNQQEVDI
                     HIPITLYPSILTFPWQPKTGAYQYTIKAHGGSGNFSWSSSSSMVATVTVKGVMTTSGD
                     TGLSVIRAHDVQNPLHFGEMKVYVIEPSSMEFAPCQVEARVGHTLELPLTISGFMPGG
                     GSEVVTLSDCSHFDLVVEVENQGVFQPLPGRLPPGPEHCSGVKVKADAQGSTTLLVSY
                     THGHVHLDAKITLAAYLPLKAVDPSSVAVVTLGSSKEMLFEGGPRPWVLEPSKFFRNV
                     TSEDTGSISLSLLGPPASRNYQQHRVLMTCQALGEQVIALSVGNRPSLSNPFPAVEPT
                     VVKSICAPPSRLTLMPVYALPQLDLSCPLLQQNKQVVPVSSHRNPLLDLGAYDQQGRR
                     FDNFSSLSIQWESSRPLLASIELDQPMQLVSQDDGNGQKKLHGLQTVSVHEASGTTAI
                     SATATGYQQSHLSEARVKQPHDPLVPVSASIELILVEDVRVSPEEMTIYNHPGVQVEL
                     YITEGSGYFFLNTSTQDIIKVAYQDTRGVALVHPLLPGSSTVMVHDLCLAFPAPAKAI
                     IHVSDIQELYVRVVDKVEIGKAVKAYVRVLDFYKKPFLAKYFTFMDLKLQAASQIITL
                     VTLDEALDNYTATFLVHGVAIGQTSLSASVTDKSGQRVSSTPQQIEVFPPFRLIPRKV
                     TLIIGAMMQITSEGGPQPQSNILFSINNESVAAVSSSGLVRGLMVGNGSVLGVVQAVD
                     AETGKVIIVSQDLVEVEVLQLQAVRIRAPITRMRTGTQMPVFVTGITSNQSPFSFGNA
                     VPGLTFHWSVTKRDVLDLRGRHHEVSIRLPPQYNFAMNVYGRVKGRTGLRVVVKALDP
                     TAGQLHGLGKELSDEIQIQVFEKLRLLNPEIEAEQILMSPNSFIKLQTNRDGAAILSY
                     RVLDGPEKAPIVHTDEKGFLVSGSGIGVSTLEVIAQEPFGTNQTILVAVKVSPVSYLR
                     ISMSPVLHTQHKEALTALPLGMTVTFIVHFHDSSGDIFHAHNSVLNFATNRDDFVQIG
                     KGATNNTCIIRTVSVGLTLLHVWDVEHLGLSDFVPLPVLQAITPELSGAVVVGDILCL
                     ASVLTSLGGVSGTWSSSASHVLYVDPKTGVAIARDAGSVTVYYEIAGQLKTFKEIVVG
                     TPQKIVARRLHSAQTSIQEATASKVTVSVGDRSSNLLGECSPAQREAIEALHPESLIS
                     CQLQFKQDVFDFPACDVFTVEPGFDAALGQYLCSVTMRRLTDKQLKHLNMKKTSLAVT
                     ASIPSSYTSVEKVGAEVPFSPGLYANQAEILLSNHYTSSEVKVFGAVESLENLEVKSG
                     SPAVLAFVKEKSFGLPSFITYTVGVLDPTAGSQGPLSTALTFSSPATNQAITIPVTVA
                     FVLDRRGPGPYGASLLSHFLDSYQVMFFTFFALLAGTAVTIIAYHTVCAPRELASPLA
                     LTPRASPQHSPHYLASSPAAFNTLPSGRKASPPSGLWSPAYASH"
     exon            210..346
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            347..478
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            479..575
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            576..726
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            727..859
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1018
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1087
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1194
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1335
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1473
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1629
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1828
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1974
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2196
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2370
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2563
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            2564..2670
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            2671..2775
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..2877
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            2878..3006
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            3007..3134
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            3135..3270
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            3271..3333
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            3334..3513
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            3514..3594
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            3595..3726
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            3727..3885
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            3886..3977
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            3978..4152
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            4153..4328
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            4329..4549
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            4550..4686
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            4687..4810
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            4811..4957
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            4958..5208
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            5209..5425
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            5426..5521
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            5522..5605
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     exon            5606..7035
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7010..7015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /note="hexamer: AATAAA"
     polyA_site      7034
                     /gene="Nup210"
                     /gene_synonym="9830001L10; gp190; gp210; Pom210"
                     /note="major polyA site"
ORIGIN      
        1 gggcgcggga gcgcgcgccc gggcgctagc gaggccggga ggatggcgcg ggcctcacta
       61 gtgcagccgg cgctctgggc gctgctgttg ctgcaggtag tgggtcccgc cgcggccgcc
      121 aagcttaaca ttcccaaggt gctgctgccc ttcacgcggg ccacgcgcgt gaacttcact
      181 ctggaagctt ctgagggctg ctaccgctgg tcatccaccc ggccagaggt agccagcata
      241 gagccgttgg gctccagtga acagcagtgc tcccagaagg cagtggtgca ggcccgcttg
      301 acccagccag cccgcctgac cagcatcatc tttgcagaag acatcactac agggcaggtg
      361 ctgcgctgtg acgccatcgt tgatctcatc cacggcattc agattgtctc taccacccgt
      421 gagctctatc ttgaggactc tccactggag ctgaagatcc aggctctgga ctcagaaggg
      481 aataccttca gcaccttggc aggactggtc ttcgactgga caattgtgaa ggatacagag
      541 gccaatggat tctcagactc ccacaatgca ctccgcatcc tcaccttctt ggaatctacg
      601 tatatcccac cttcctacat ctcagagatg gagaaggcag ccaagcaggg cgacaccatc
      661 ctagtgtctg ggatgaagac tggaagctcc aagctcaagg ctcgaattca ggaggctgtc
      721 tataagaatg ttcgccctgc ggaagtcagg ctgctgatct tggagaacat ccttctgaat
      781 ccagcctatg atgtctacct gctggtggga acctccattc actacaaggt tcagaagatc
      841 aggcagggca agattacaga actctcaatg ccttctgatc aatatgagct gcagctccag
      901 aacagcatcc cagatcctca gggagacccc gcccgtcctg tggccatcct gacacaggac
      961 acatcaagag tcactgccat gcagatggga cagagcaacc tggtcctggg ccacaggagt
     1021 atccgtatgc aaggagcttc taggctcccc aacagcacca tctatgtggt tgaagccgga
     1081 tacctaggtt tcacagtcta ccctggtgac agatgggtgc ttgagactgg acatctgtat
     1141 gcaattacca tcgaagtatt tgataggtcc agcaacaagg tctacccatc tgacaacatc
     1201 cgaattgaag ctgtgcttcc tgctgagttt tttgaggttc tgtcgtcttc ccagaatggg
     1261 tcttatcatc acatcagggc tatccagagt ggccagacgg ccatcagtgc aaccctcacc
     1321 tctgtggtgg accaggacgg aggggtccat gtgcttcagg tacctgtgtg gaaccagcaa
     1381 gaagtggaca ttcatatccc catcacactc tatcccagca tcctgacatt tccatggcaa
     1441 ccaaagacag gcgcctatca gtataccata aaggcccatg ggggcagtgg gaacttcagc
     1501 tggtcttcgt caagctccat ggttgccaca gtcaccgtca agggggtcat gaccacaagt
     1561 ggtgacactg gcctcagtgt gatccgggcg cacgatgttc agaatcctct ccattttggc
     1621 gagatgaagg tgtatgtgat tgagcccagc agcatggagt ttgccccgtg ccaggtggag
     1681 gctcgagtgg gtcacaccct ggagctgccc ctgacaatca gtggcttcat gcccggtggg
     1741 ggcagtgagg tggtcaccct gagcgactgc tcccatttcg acctggtggt ggaggtggag
     1801 aaccagggtg tgttccagcc attgccaggg aggctgccgc caggacctga gcactgcagt
     1861 ggggtcaaag tgaaagctga tgcccaggga tctaccaccc tcctcgtgag ctacacacac
     1921 ggccatgtac acttggatgc aaagatcact cttgctgcct acctgcccct caaggctgtg
     1981 gatccctctt ctgttgctgt ggtgacccta ggctcctcaa aggaaatgct gtttgaagga
     2041 ggccccaggc catgggtcct ggaaccttcc aaattctttc ggaatgtcac ttctgaagac
     2101 acaggcagca tcagcctgtc tctcttgggt cctccagcct cccggaatta ccagcagcac
     2161 cgggtcctca tgacctgcca ggccttgggt gagcaggtca ttgctttgtc cgtggggaac
     2221 cggcccagcc tctctaaccc cttccctgct gtggagccca ctgtggtgaa gtccatctgt
     2281 gccccaccat ccaggctcac tctcatgcct gtctatgccc tcccgcagct ggacctatcc
     2341 tgcccattgc tgcagcagaa taagcaggtg gttccagtat ccagtcaccg taatcccctg
     2401 ttagacctgg gtgcctatga ccaacagggc cggcgattcg ataacttcag ctctctgagc
     2461 atccagtggg agtcctcccg gccattgctg gccagcattg agcttgacca gcccatgcag
     2521 ctggtatccc aggatgatgg gaatggccaa aagaaactac atggtttgca gacagtctcg
     2581 gttcacgagg catcaggaac cacagccatc tctgccacag cgactggcta ccagcagtcc
     2641 cacctgagcg aagccagagt gaagcaaccg catgaccctc tagtacctgt gtcagcctcc
     2701 attgaactta ttctcgtaga ggatgtgagg gtcagtccag aagaaatgac catttataac
     2761 catcctggtg tccaggtgga actctacatc acagaaggct ctggatactt cttcctcaac
     2821 acaagcaccc aggacatcat caaggtggcc taccaggaca cccggggcgt agctctggtg
     2881 caccctctgc tcccaggctc atcaactgtc atggtccatg acttgtgcct ggccttccca
     2941 gcccccgcaa aggccatcat tcacgtctcc gacatccagg agctctatgt tcgagtggtg
     3001 gacaaggtgg agatcgggaa ggctgtcaaa gcctacgtcc gtgtgttgga cttctacaag
     3061 aagcctttcc tggccaagta cttcaccttt atggacctga agctgcaagc agcctcccag
     3121 ataatcacgc tggtgactct ggatgaagct ctagacaact acacggccac attcctcgtg
     3181 catggtgtgg ccattggcca gaccagcctg tctgcaagcg tgacggacaa atctgggcag
     3241 agagtcagct ccaccccaca acaaatcgag gtcttccccc cattcagatt gatacccagg
     3301 aaggtgacac tgatcattgg agccatgatg cagatcacct ctgagggggg cccccagcct
     3361 cagtccaaca tcctcttctc catcaacaat gagagtgtgg cagcagtgag cagctctggg
     3421 ctggtgcgtg ggctcatggt cggcaatggc tctgtgctgg gagtcgtgca ggcggtggat
     3481 gcagagactg gcaaggtcat catcgtctcc caggatcttg tcgaagtaga ggtgctacag
     3541 ctccaggcag tgaggatccg tgccccaatc acacggatga ggaccgggac ccagatgcct
     3601 gtctttgtca ccggaatcac cagcaaccag agccctttct cctttggcaa tgctgtgcca
     3661 ggcctgacct tccactggtc tgtcaccaaa agggatgtcc tggaccttcg agggcggcac
     3721 catgaggtat ctatccggct cccgcctcag tataattttg ccatgaatgt gtatggccga
     3781 gtgaaaggtc ggactggact tcgggttgta gtcaaagctc tggaccccac agctggccag
     3841 ctgcatggtc tcggcaagga gctctcagat gagatccaaa ttcaggtatt tgaaaaactg
     3901 cggctgctga accctgaaat agaagcagaa caaatactaa tgtcacccaa ctcatttata
     3961 aagctgcaga caaacaggga tggtgcagcc attctgagct accgtgtcct tgatgggcct
     4021 gagaaggctc ccattgttca cactgatgag aaggggtttc tggtgtcggg ctctggaatt
     4081 ggagtgtcca ccctcgaagt gattgcacag gagcctttcg gcaccaacca gactatcctt
     4141 gtcgctgtaa aggtctctcc tgtttcatac ctgaggatct ccatgagccc agtcctgcac
     4201 actcagcaca aggaggcgct gacagctctg cctctgggga tgaccgtgac cttcattgtc
     4261 cacttccacg acagctctgg agacatcttc catgctcata attcagtcct caattttgcc
     4321 actaacagag atgacttcgt gcagatcggc aagggtgcca ccaacaacac ctgcatcatc
     4381 cgcacagtca gtgtgggctt gacgctgctc catgtgtggg atgtggagca cctcggcctc
     4441 tccgacttcg taccactacc tgtcctacag gccatcaccc cagagttgtc tggagccgtg
     4501 gtggtgggtg acatcctctg tctggctagt gttcttacta gcctgggagg tgtctcaggg
     4561 acatggagct cctcagccag ccatgtcctc tacgttgacc ctaagacagg cgtggctata
     4621 gcccgagatg cagggtctgt gactgtttac tacgagatcg ctgggcagct gaagaccttc
     4681 aaggagatag tggtcggcac ccctcagaag attgtggccc gtcgcctcca ctctgcccag
     4741 accagtatcc aggaagccac agcctccaaa gtgactgtca gcgtgggaga caggagctct
     4801 aacctacttg gtgagtgctc ccctgcccag cgagaggcca ttgaagcctt gcaccccgag
     4861 tccctcatca gctgccaact ccagttcaag caagatgtct ttgacttccc tgcttgtgat
     4921 gtcttcaccg tggaaccagg atttgatgct gctctgggcc agtacctctg ctcggttact
     4981 atgcgcaggc tgacagataa gcaactgaag cacttgaaca tgaagaagac atcactggca
     5041 gtcactgcct ccatccccag cagttatacc tctgtagaga aggtgggagc tgaggtcccc
     5101 ttcagtccag ggctctatgc caaccaggca gaaatccttt tgagcaacca ctataccagc
     5161 tccgaggtca aagtctttgg tgctgtggag agtctggaaa acttggaggt gaaatctgga
     5221 tccccggcag tgctagcctt cgtgaaagag aagtcatttg ggctacccag cttcatcacg
     5281 tacacagtgg gtgtcttgga tcccacagct ggcagccagg gccctctgtc cactgccctg
     5341 accttctcca gccctgccac taaccaggcc atcaccattc cagtcaccgt ggcctttgtg
     5401 ttggatcgtc gtgggcctgg tccctatgga gccagcctcc tgtcacactt cctggactcc
     5461 tatcaagtca tgttcttcac cttttttgct ctgctggctg ggacagcagt caccattata
     5521 gcctaccata cagtctgtgc accccgggaa cttgcttcac ccctggccct cacgccccgt
     5581 gccagccctc agcacagccc ccactatctt gcctcatctc cggctgcttt caacacactg
     5641 ccttctggtc gcaaagccag ccctccctcg gggctctgga gcccagccta tgcctctcac
     5701 taggcaatgt gcagggctgg tattactaca cagctgaact gacacctgga cagaagggtc
     5761 actgtcattt tcacaccggg gtgaaaccac gcctgggccc taggccatcc tcactgccct
     5821 ggccgtgctg aatcactgcc tgattcacac aagcaaggga ttttaatttg tttgctttta
     5881 aatctctttc ccagtcttga gggtcagggc ttcctggttc cctccttctc atgtggtgtg
     5941 cagggtttgg gggtgctgct taatcttgta tttgttctgc tcgaggaagc tcgcttccct
     6001 gttcatggct tttgagtatt ggaagctgtt tctacatcat ctacagataa tgtcactgta
     6061 gtgatctcag ggaaaggatt ttctcatgac tcctggggtt tttgtggtgc ttggaataga
     6121 acccagggtt tcatacctgc ttggcaattg cttgtccatt ggcacatgtg cacaccagcc
     6181 ctttattgtg ggtttttttt gttattgttg ttgttgtttt ttgttttttg tttttttttt
     6241 catgaaaact cactcttctc cttatcctac tgctgctagg aaatgtgggg gacaagcaga
     6301 tgtggatgtc ccctagggga caccatgccc agagccctgt gctgactgag ccttcttact
     6361 gtgatagtta ctgagcctca gcagagtggc cctcccttca gagccccggg aggacttcgg
     6421 tcttgtttca gcagaagggc ttctgtcacc agggttggag tacctctcgc tctccctgag
     6481 gcagcttggg aatagccaca gcatcatcgg ccctgccctg cagccactgg cagggatctt
     6541 ctgatctctg ggtttgttct gagatgctgc tgtgacttgt ggagcagaga gacccagggt
     6601 catctgctca tctgccttgg aggacacaga atgcagtacc tcagtggatc tgagccaccc
     6661 tattggccct cctctccccc tcctctgcca ccagcactcg cctcgctagc ccaggagcga
     6721 agaggatgcc ttgggaatac gacgcatctt cacgtccaag ctcagggtca tggcctctgt
     6781 ttcaggtcca ggtgctgtgg tgctgtcaga atgagccaga gactcacctc caagtggacg
     6841 tgtatgggca ccacgtcacc aagagttgtt tgcctttgaa ggtcatgtgt gatcctttga
     6901 ggctgagcca taggatggac tttctggacg tgaggataga gtctttgtgc ccagccagcc
     6961 actcaatctc ccccgagagc tgttaatgga gtcttccctg catttgttta ataaagttct
     7021 gtgtagtttc ttaagaaaaa aaa
//
