LOCUS       NM_198304               5688 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus nucleoporin 188 (Nup188), transcript variant 1, mRNA.
ACCESSION   NM_198304 XM_130085
VERSION     NM_198304.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5688)
  AUTHORS   Suntharalingam,M. and Wente,S.R.
  TITLE     Peering through the pore: nuclear pore complex structure, assembly,
            and function
  JOURNAL   Dev Cell 4 (6), 775-789 (2003)
   PUBMED   12791264
  REMARK    Review article
REFERENCE   2  (bases 1 to 5688)
  AUTHORS   Chu,C.C. and Paul,W.E.
  TITLE     Expressed genes in interleukin-4 treated B cells identified by cDNA
            representational difference analysis
  JOURNAL   Mol Immunol 35 (8), 487-502 (1998)
   PUBMED   9798653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL954388.5.
            
            On Aug 1, 2022 this sequence version replaced NM_198304.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096591.1, AK129073.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AL954388.5         10441-10495
            56-110              AL954388.5         20673-20727
            111-184             AL954388.5         22441-22514
            185-269             AL954388.5         24825-24909
            270-350             AL954388.5         25034-25114
            351-395             AL954388.5         26026-26070
            396-488             AL954388.5         28082-28174
            489-608             AL954388.5         28307-28426
            609-820             AL954388.5         31546-31757
            821-935             AL954388.5         33244-33358
            936-1136            AL954388.5         33903-34103
            1137-1226           AL954388.5         36625-36714
            1227-1292           AL954388.5         39141-39206
            1293-1412           AL954388.5         40513-40632
            1413-1539           AL954388.5         41206-41332
            1540-1692           AL954388.5         45907-46059
            1693-1819           AL954388.5         46197-46323
            1820-1907           AL954388.5         46511-46598
            1908-1984           AL954388.5         46696-46772
            1985-2099           AL954388.5         47545-47659
            2100-2220           AL954388.5         49253-49373
            2221-2287           AL954388.5         49498-49564
            2288-2416           AL954388.5         50475-50603
            2417-2556           AL954388.5         51473-51612
            2557-2663           AL954388.5         53332-53438
            2664-2870           AL954388.5         54582-54788
            2871-3040           AL954388.5         54872-55041
            3041-3110           AL954388.5         56410-56479
            3111-3178           AL954388.5         56845-56912
            3179-3374           AL954388.5         57295-57490
            3375-3452           AL954388.5         60349-60426
            3453-3538           AL954388.5         60667-60752
            3539-3684           AL954388.5         60957-61102
            3685-3866           AL954388.5         61249-61430
            3867-4067           AL954388.5         63524-63724
            4068-4160           AL954388.5         63841-63933
            4161-4319           AL954388.5         64614-64772
            4320-4457           AL954388.5         65717-65854
            4458-4532           AL954388.5         66398-66472
            4533-4790           AL954388.5         66558-66815
            4791-4922           AL954388.5         66947-67078
            4923-4996           AL954388.5         67300-67373
            4997-5126           AL954388.5         67486-67615
            5127-5688           AL954388.5         67727-68288
FEATURES             Location/Qualifiers
     source          1..5688
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 21.49 cM"
     gene            1..5688
                     /gene="Nup188"
                     /note="nucleoporin 188"
                     /db_xref="GeneID:227699"
                     /db_xref="MGI:MGI:2446190"
     exon            1..55
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..5303
                     /gene="Nup188"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nucleoporin NUP188 homolog"
                     /codon_start=1
                     /product="nucleoporin NUP188 isoform 1"
                     /protein_id="NP_938046.2"
                     /db_xref="CCDS:CCDS15878.1"
                     /db_xref="GeneID:227699"
                     /db_xref="MGI:MGI:2446190"
                     /translation="MAAAAGGPCVRSSRELWTILLGRSALRELNQIEAELNKYWQRLL
                     EGLSYYKPPSPSSAERVKANKDVASPLKELGLRVSKFLGLDEEQSVQLLQCYLQEDYR
                     GTRDSLKTVLQDERQSQALTLKIADYYYEERTCILRCVLHLLTYFQDERHPYRAEYAD
                     CVDKLEKELVLKYRQQFEELYRTEAPTWETHGNLMTERQVSRWLVQCLREQSMLLEII
                     FLYYAYFEMAPSDLLVLTKMFKEQGFGSRQTSRHLVGGTMDPFVDRIGYFSALILVEG
                     MDIESLHKYALDDRRELHQFAQDGLICQDMDRAMLTLGDIPHHAPVLLAWALLRHTLS
                     PEETSSVVRKIGGTAIQLNVFQYLTRLLRSLASGGNDCTTSTACMCVYGLLSFALTSL
                     ELHTLGNQQDVIDTACEVLADPSLPELFWGTEPTSGLGIILDSVCGMFPHLLSPLLQL
                     LRALVSGKSTAKKVYSFLDKMSFYNELHKHKPHDVLSHEDGTLWRRQTPKLLYPLGGQ
                     TNLRIPQGTVGQVMLDDRAYLVRWEYSYSSWTLFTCEIEMLLHVVSTADVIQHCQRVK
                     PIIDLVHKVISTDLSIADCLLPITSRIYMLLQRLTTVISPPVNVIASCVNCLTVLAAR
                     NPAKVWTDLRHTGFLPFVAHPVSNMTQMISAEGMNAGGYGSLLMNSEQPQGEYGVTIA
                     FLRLVTTLVKGQLGSTQSQGLVPCVMFVLKEMLPSYHKWRYNSHGVRELIGCLILELI
                     HAILNLCQETELHSSHTPSLPSLCICSLAYTEAGQTVISIMGIGVDTIDMVMAAQPRS
                     DGPEGQGQGQLLIKTVKLAFSVTNNVIRLKPPSNVVSPLEQALTQHGAHGNNLIAVLA
                     KYIYHRHDPALPRLAIQLLKRLATVAPMSVYACLGSDAAAIRDAFLTRLQSKIEDMRI
                     KVMILEFLTVAVETQPGLIELFLNLEVKDGSNGSKEFSLGVWSCLHVVLELIDSQQQD
                     RYWCPPLLHRAAIAFLHALWQDRRDSAMLVLRTKPKFWENLTSPLFGTLSPPSETSEP
                     SVLETCALIMKIICLEIYYVVKGSLDQSLKDTLKKFSSEKRFAYWSGYVKSLAVYMAD
                     TEGSSCTSLLEYQMLVSAWRILLIIAASHADVMHLTDMAVRRQLFLDVLDGTKALLLV
                     AASVNCLRLGSMMCTLLLILLRQWKRELGAVEKILGPLTEILEGVLQADQQLMEKTKA
                     KVFSAFITVLQMKELRVGDIPQYSQLVLNVCETLQEEVIALFDQTRHSLASDSAAEDK
                     DSMETDDCPRPRHKDQRDGVCVLGLHLAKELCEVDEDGDSWLQVTRRLPILPTLLTTL
                     EVSLRMKQNLHFTEAALHLLLTLARTQQGATAVAGAGITQSICLPLLSVYQLSSNGTG
                     QTPSTSRKSLDAPSWPGVYRLSMSLMERLLKTLRYNFLTEALDFVGVHQERTLQCLNA
                     VKTVQSLACLEEADHTVGFILQLSHFRKEWHFHLPQLMRDVQVNLGYLCQACTSLLHS
                     RKMLQHYLQNKNGDGLPSAVTPRAQRPSTTTTTTTTTTALATPAGCSSKQPTADTEAS
                     EQRALHTVQYGLLKILSRTLAALRHFTPDVCQILLDQSLDLAEYNFLFALSFTTPTFD
                     SEVAPSFGTLLATVNVALNMLGELDKKKESLTQAVGLSTQAEGTRTLKSLLMFTMENC
                     FYLLISQAVRYLRDPAVHPRDKQRMKQELSSELSTLLSSLSRYFRRGAPSSPAAGVLP
                     SPQGKATSLSKASPESQEPLIQLVQAFVRHVQR"
     exon            56..110
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            111..184
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            185..269
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            270..350
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            351..395
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            396..488
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            489..608
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            609..820
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            821..935
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1136
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1226
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1292
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1412
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1539
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1692
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1819
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1907
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..1984
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2099
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2220
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2287
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2416
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2556
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2663
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            2664..2870
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            2871..3040
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            3041..3110
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            3111..3178
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            3179..3374
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            3375..3452
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            3453..3538
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            3539..3684
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            3685..3866
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            3867..4067
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            4068..4160
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            4161..4319
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            4320..4457
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            4458..4532
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            4533..4790
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            4791..4922
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            4923..4996
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            4997..5126
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     exon            5127..5688
                     /gene="Nup188"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5668..5673
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nup188"
                     /note="hexamer: ATTAAA"
     polyA_site      5688
                     /gene="Nup188"
                     /note="major polyA site"
ORIGIN      
        1 ggggctgggc cgcgcgcgcg aagatggcgg ctgccgctgg tgggccgtgt gtgaggagca
       61 gtagagaact ctggacaatt ctacttggga ggtcagctct tagagaattg aatcagattg
      121 aggcggaact gaataaatat tggcagcggt tgttagaagg gctttcttac tacaaacctc
      181 ccagtccaag ttcagctgaa agagtgaaag ctaataaaga cgtagcgtca cctctgaagg
      241 agctgggcct aagagtcagc aagttcttgg gtcttgatga agagcagagt gtgcagttac
      301 tgcagtgtta ccttcaggag gattacaggg gtactcggga ctcactaaag acagtcctgc
      361 aagatgagag gcagagccag gccttaaccc tgaagattgc agattattat tatgaagaaa
      421 gaacctgcat tcttcgttgt gtcttacacc ttctgacata tttccaagat gaacgccatc
      481 catacagggc ggaatatgct gactgtgttg acaaactgga gaaggaacta gttttaaagt
      541 accggcagca gtttgaggag ctgtatagaa cagaagcacc aacctgggag acgcatggca
      601 acctcatgac tgagcgtcag gtgtcgcggt ggttggttca gtgcctccgg gaacagtcca
      661 tgctgttaga aattattttc ctttattatg catacttcga gatggcacca agtgacctat
      721 tggtactaac caagatgttc aaggagcaag ggtttggtag taggcagacc agcaggcacc
      781 ttgtgggtgg aaccatggat ccttttgtag atcgcattgg gtacttcagt gccctcatcc
      841 tggtggaagg gatggacatc gagtccctgc acaagtacgc cttggatgac aggcgagagc
      901 tgcaccagtt tgctcaggat ggcctcatct gccaggacat ggaccgagcg atgttgacct
      961 tgggagacat tccgcaccac gcccctgtgc ttttagcctg ggctctcctc cgtcacacac
     1021 tgagcccaga agagaccagc agtgtggtca ggaagatagg gggcacggcc atccagctga
     1081 atgtgtttca gtacttgact cgactgcttc ggtcacttgc cagtggagga aatgattgca
     1141 ccacgagcac cgcctgcatg tgtgtctatg gtcttctctc ctttgccctc acctcactgg
     1201 agctgcacac actgggcaac cagcaggatg tcattgacac agcatgtgaa gtcctggcag
     1261 acccttccct tccagagctg ttctggggaa cagagccaac ctctggtctc gggatcattc
     1321 tggacagtgt gtgtgggatg tttccccatc tcctttcccc acttctgcaa ttgctccgag
     1381 ccctcgtgtc agggaagtcc actgccaaaa aagtgtacag cttcctggat aaaatgtctt
     1441 tctacaacga actccataag cacaagcccc atgatgtgct ctctcatgaa gatggaactc
     1501 tgtggcggag gcaaacaccc aaactcctgt accctctagg gggtcagacc aaccttcgca
     1561 ttcctcaggg cactgtgggc caagtcatgc tggatgacag ggcttacctt gtccgctggg
     1621 agtactctta cagcagctgg accctcttca cctgcgagat tgaaatgctg ctccacgttg
     1681 tctccacagc agatgtgatc cagcattgcc agcgggtcaa gcccatcatt gatttggttc
     1741 ataaggtcat cagcacagac ttgtccatag cagactgcct gctgcccatc acatcccgca
     1801 tctacatgct gttgcagcgg ctgacgacgg tgatctcccc tcctgtaaac gtcattgctt
     1861 cttgtgtcaa ctgcttaact gtcttggctg ctcgaaaccc agcaaaggtc tggactgatc
     1921 ttcgtcacac aggttttttg ccattcgtgg cccaccctgt ctccaacatg actcagatga
     1981 ttagtgcgga gggaatgaat gctggagggt atggcagcct tctgatgaac agtgagcagc
     2041 cccagggcga atatggggtc accattgcct ttctgcgcct ggtcaccacg cttgtcaagg
     2101 ggcagcttgg tagtacccag agccaaggcc tggtgccttg tgtgatgttc gtgttgaagg
     2161 agatgcttcc cagctaccac aaatggcgct acaactctca tggcgtgcga gagctgatag
     2221 gttgcctaat tctggagctg attcatgcaa tactgaacct gtgccaagag acagagctgc
     2281 atagcagcca cacacccagc ctgccttccc tctgcatctg cagcctggct tataccgaag
     2341 ctggacagac cgtcattagc atcatgggaa ttggtgtaga caccatagac atggtgatgg
     2401 ctgctcagcc ccgcagtgat gggccagaag gccaaggcca gggccaactg ctgatcaaga
     2461 cagtgaagct ggcgttctct gtcaccaaca atgttattcg gctgaaacct ccttctaatg
     2521 tggtttcacc cctggaacag gctctcacac aacatggtgc ccacgggaac aacctcattg
     2581 ctgtcctagc caagtacatc taccacagac atgacccagc cttgccacgt ctggccatcc
     2641 agctgctgaa acgcttggcc acggtggccc caatgtcagt gtatgcttgc ctgggcagtg
     2701 atgcagcggc catccgtgat gccttcctga cccgccttca gagcaagatt gaggacatgc
     2761 gcatcaaagt catgatcctg gagttcctga cagtggcggt agagacacag ccaggtctca
     2821 tcgagctgtt tctgaatctg gaggtgaagg atggcagcaa tggctccaag gaattcagcc
     2881 ttggtgtgtg gagctgtctc catgtggtgc tggagctgat tgattcccag cagcaagatc
     2941 gatactggtg cccacctctg ttgcatcgtg cagctattgc cttccttcat gccctgtggc
     3001 aagaccgtag ggacagtgca atgcttgtcc tcagaaccaa acccaagttt tgggagaatt
     3061 taacaagtcc gctgtttgga actctctctc ctccttcaga gacatctgag cccagtgtcc
     3121 tggaaacctg tgccctgatc atgaagataa tatgtttgga gatatactat gtagttaagg
     3181 gctcgttaga ccagtcatta aaagatacac tcaagaagtt ctccagtgag aaacgctttg
     3241 cctactggtc agggtacgtc aagtctttgg cagtttacat ggctgacaca gagggcagca
     3301 gttgcacgtc cctgctagag tatcagatgc tggtctccgc ctggaggata cttctcatca
     3361 ttgctgccag tcacgcagac gtcatgcact tgactgacat ggcagtgcgg cgccagctgt
     3421 ttcttgatgt gcttgatggg accaaagcat tactccttgt ggcagcatct gtgaactgcc
     3481 tccggctggg ctccatgatg tgcaccctgc tgcttatcct cctacgccag tggaagagag
     3541 agctgggtgc tgtggagaaa atccttgggc ccttgacaga gatcctggaa ggggtgcttc
     3601 aggcagacca gcagctcatg gaaaagacca aggccaaggt gttctctgca ttcatcacag
     3661 tgttacagat gaaggagctg cgagtcggtg atatccccca gtactcccag ctggtgctga
     3721 acgtctgtga gactctccaa gaagaggtga ttgcactctt tgatcagacc cgccacagcc
     3781 tggcatccga cagcgctgcc gaggacaagg acagcatgga gacagatgac tgccctcggc
     3841 cccggcacaa ggaccagcgt gatggggtgt gtgtcctggg actgcatctg gctaaggagc
     3901 tctgtgaggt ggatgaggat ggggactcat ggttgcaggt gacccgaagg ctccccattc
     3961 tgcccacgct gctcaccacg ctggaggtga gcctccgcat gaagcagaac ctgcatttta
     4021 ctgaggctgc gctgcacctg ctcctcaccc tggctcgaac ccagcaagga gccacagcag
     4081 tggctggagc tggcatcacc cagagcatct gtttgcccct cttgagtgta taccagctta
     4141 gcagcaatgg cacaggacag acacctagca cctctcgaaa gtccctggat gccccatcct
     4201 ggccaggagt ctaccgcctg tccatgtcct taatggagcg attgctcaag actctacgct
     4261 acaatttcct gacggaggct ctagactttg tgggtgtcca tcaagaacgg accttgcagt
     4321 gtctcaatgc cgtgaagaca gtgcagagtc tagcctgcct ggaggaagca gatcacaccg
     4381 tgggcttcat cctacaactg tcccacttca ggaaggagtg gcacttccat ctgcctcagc
     4441 tcatgcgtga tgttcaggtg aacctgggtt acttgtgcca ggcctgtacc tccctcctgc
     4501 acagccgcaa gatgctgcag cactacctac agaacaaaaa tggtgatggc ctcccttcag
     4561 ctgtcactcc ccgagctcag cggccatcca ccaccaccac caccaccacc accaccaccg
     4621 ctctggctac cccagctggc tgctcctcca agcagcctac tgctgacact gaggcctcag
     4681 aacagcgagc cttacacaca gtccagtatg ggcttctcaa gattctcagc aggaccctgg
     4741 cagccctgcg ccacttcact ccggatgtct gccagatcct gttggaccag tccctggatc
     4801 ttgctgagta caacttcctc tttgccctaa gttttaccac tcccaccttt gactctgaag
     4861 tggctccctc cttcggaacc ctcttggcca cagtgaacgt ggccctcaac atgcttggag
     4921 agctggacaa gaaaaaggaa tccctcaccc aggctgtggg actcagcaca caagcagaag
     4981 ggacccgaac attaaagtcc ctcctgatgt tcaccatgga gaactgcttc tacctgctca
     5041 tctcccaagc agtacgctac ctcagggacc cggctgtgca cccccgggac aagcagcgga
     5101 tgaagcagga gctgagctcg gagctgagca cgttgctttc cagcctctca cgatacttca
     5161 gaaggggggc ccccagctcc cctgctgctg gagtcctgcc ctcaccacag ggcaaggcca
     5221 cctctctctc caaagccagc ccagaatctc aggagcctct gatccaactt gtgcaagcct
     5281 ttgtccggca cgtgcagaga tagggcgccg actgctgtct acctgctgct cctaccaacc
     5341 tgcactgcag cctgggtaga gggcgctgcc accacaaggc cagccactga gcaggcagct
     5401 cccttcgtcg tcctcctgcc cacccgctga cattattttt atatagctaa agaggtcaac
     5461 agcacgggca gggagccaag gggctgggtg ctcagactct taacaatatc ccaaggtggc
     5521 ccctttcctc cgagcattcc catggcactt caccagccag ggaggccctg ggtgctggca
     5581 gcacaggaga gtcctgtgtg tagtgagggt tttccatgat ctattcttgc agtttttttg
     5641 gtaataccgt ggtctattta tacaaatatt aaaagtgctg tttataga
//
