LOCUS       NM_021512               9229 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus nucleoporin 160 (Nup160), transcript variant 1, mRNA.
ACCESSION   NM_021512
VERSION     NM_021512.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9229)
  AUTHORS   Li,Y., Xu,C., Zhao,F., Liu,Q., Qiu,X., Li,M., Yang,Y., Yu,S.,
            Tong,H., Zhang,L., Chen,B., Qu,L. and Yu,Z.
  TITLE     Podocyte-specific Nup160 knockout mice develop nephrotic syndrome
            and glomerulosclerosis
  JOURNAL   Hum Mol Genet 33 (8), 667-676 (2024)
   PUBMED   38224683
  REMARK    GeneRIF: Podocyte-specific Nup160 knockout mice develop nephrotic
            syndrome and glomerulosclerosis.
REFERENCE   2  (bases 1 to 9229)
  AUTHORS   Xie,J., Yuan,Y., Yao,G., Chen,Z., Yu,W. and Zhu,Q.
  TITLE     Nucleoporin 160 (NUP160) inhibition alleviates diabetic nephropathy
            by activating autophagy
  JOURNAL   Bioengineered 12 (1), 6390-6402 (2021)
   PUBMED   34533106
  REMARK    GeneRIF: Nucleoporin 160 (NUP160) inhibition alleviates diabetic
            nephropathy by activating autophagy.
REFERENCE   3  (bases 1 to 9229)
  AUTHORS   Sakuma,S., Raices,M., Borlido,J., Guglielmi,V., Zhu,E.Y.S. and
            D'Angelo,M.A.
  TITLE     Inhibition of Nuclear Pore Complex Formation Selectively Induces
            Cancer Cell Death
  JOURNAL   Cancer Discov 11 (1), 176-193 (2021)
   PUBMED   32988961
REFERENCE   4  (bases 1 to 9229)
  AUTHORS   Wang,P., Zhao,F., Nie,X., Liu,J. and Yu,Z.
  TITLE     Knockdown of NUP160 inhibits cell proliferation, induces apoptosis,
            autophagy and cell migration, and alters the expression and
            localization of podocyte associated molecules in mouse podocytes
  JOURNAL   Gene 664, 12-21 (2018)
   PUBMED   29704630
  REMARK    GeneRIF: Knockdown of NUP160 impairs mouse podocytes, i.e.
            inhibiting cell proliferation, inducing apoptosis, autophagy and
            cell migration of mouse podocytes, and altering the expression and
            localization of podocyte associated molecules
REFERENCE   5  (bases 1 to 9229)
  AUTHORS   Nikolova,V., Delimitreva,S., Chakarova,I., Zhivkova,R.,
            Hadzhinesheva,V. and Markova,M.
  TITLE     Dynamics of Lamins B and A/C and Nucleoporin Nup160 during Meiotic
            Maturation in Mouse Oocytes
  JOURNAL   Folia Biol (Praha) 63 (1), 6-12 (2017)
   PUBMED   28374669
  REMARK    GeneRIF: While the distribution patterns of both lamins closely
            paralleled the respective stages of mitosis, Nup160 localization in
            metaphase oocytes corresponded to that in mitotic prometaphase
            rather than metaphase.
REFERENCE   6  (bases 1 to 9229)
  AUTHORS   Suntharalingam,M. and Wente,S.R.
  TITLE     Peering through the pore: nuclear pore complex structure, assembly,
            and function
  JOURNAL   Dev Cell 4 (6), 775-789 (2003)
   PUBMED   12791264
  REMARK    Review article
REFERENCE   7  (bases 1 to 9229)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 9229)
  AUTHORS   Ruivenkamp,C.A., van Wezel,T., Zanon,C., Stassen,A.P., Vlcek,C.,
            Csikos,T., Klous,A.M., Tripodis,N., Perrakis,A., Boerrigter,L.,
            Groot,P.C., Lindeman,J., Mooi,W.J., Meijjer,G.A., Scholten,G.,
            Dauwerse,H., Paces,V., van Zandwijk,N., van Ommen,G.J. and
            Demant,P.
  TITLE     Ptprj is a candidate for the mouse colon-cancer susceptibility
            locus Scc1 and is frequently deleted in human cancers
  JOURNAL   Nat Genet 31 (3), 295-300 (2002)
   PUBMED   12089527
REFERENCE   9  (bases 1 to 9229)
  AUTHORS   Vasu,S., Shah,S., Orjalo,A., Park,M., Fischer,W.H. and Forbes,D.J.
  TITLE     Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA
            export
  JOURNAL   J Cell Biol 155 (3), 339-354 (2001)
   PUBMED   11684705
REFERENCE   10 (bases 1 to 9229)
  AUTHORS   Belgareh,N., Rabut,G., Bai,S.W., van Overbeek,M., Beaudouin,J.,
            Daigle,N., Zatsepina,O.V., Pasteau,F., Labas,V., Fromont-Racine,M.,
            Ellenberg,J. and Doye,V.
  TITLE     An evolutionarily conserved NPC subcomplex, which redistributes in
            part to kinetochores in mammalian cells
  JOURNAL   J Cell Biol 154 (6), 1147-1160 (2001)
   PUBMED   11564755
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL935132.13 and AL714026.13.
            
            On Mar 21, 2023 this sequence version replaced NM_021512.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF104415.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-256               AL935132.13        121667-121922
            257-751             AL935132.13        123466-123960
            752-863             AL935132.13        124224-124335
            864-1074            AL935132.13        128374-128584
            1075-1297           AL935132.13        129425-129647
            1298-1376           AL935132.13        131746-131824
            1377-1491           AL935132.13        133558-133672
            1492-1650           AL935132.13        134519-134677
            1651-1728           AL935132.13        137505-137582
            1729-1826           AL935132.13        138284-138381
            1827-1911           AL935132.13        141092-141176
            1912-1980           AL935132.13        142312-142380
            1981-2064           AL935132.13        144568-144651
            2065-2235           AL935132.13        144865-145035
            2236-2335           AL935132.13        146465-146564
            2336-2501           AL935132.13        146833-146998
            2502-2629           AL935132.13        147511-147638
            2630-2790           AL935132.13        148263-148423
            2791-2924           AL935132.13        151375-151508
            2925-2995           AL935132.13        152585-152655
            2996-3155           AL935132.13        153275-153434
            3156-3225           AL935132.13        154485-154554
            3226-3324           AL935132.13        156397-156495
            3325-3444           AL935132.13        158226-158345
            3445-3540           AL935132.13        162046-162141
            3541-3635           AL935132.13        162266-162360
            3636-3732           AL935132.13        162451-162547
            3733-3838           AL935132.13        162640-162745
            3839-3999           AL714026.13        2198-2358
            4000-4060           AL714026.13        3038-3098
            4061-4171           AL714026.13        4345-4455
            4172-4295           AL714026.13        4620-4743
            4296-4397           AL714026.13        6610-6711
            4398-4539           AL714026.13        10687-10828
            4540-4665           AL714026.13        13789-13914
            4666-4770           AL714026.13        14114-14218
            4771-9229           AL714026.13        16423-20881
FEATURES             Location/Qualifiers
     source          1..9229
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 50.32 cM"
     gene            1..9229
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /note="nucleoporin 160"
                     /db_xref="GeneID:59015"
                     /db_xref="MGI:MGI:1926227"
     exon            1..256
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            257..751
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            752..863
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1074
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1297
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1376
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1491
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1650
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1728
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1826
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1911
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..1980
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2064
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2235
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2335
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2501
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2629
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2790
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            2791..2924
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            2925..2995
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            2996..3155
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            3156..3225
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            3226..3324
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            3325..3444
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..3540
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            3541..3635
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            3636..3732
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            3733..3838
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            3839..3999
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            4000..4060
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            4061..4171
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            4172..4295
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            4296..4397
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            4398..4539
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            4540..4665
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            4666..4770
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     exon            4771..9229
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5662..5667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /note="hexamer: AATAAA"
     polyA_site      5684
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /note="major polyA site"
     polyA_site      5716
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
     regulatory      5740..5745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /note="hexamer: AATGAA"
     polyA_site      5785
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
     regulatory      9176..9181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /note="hexamer: AATATA"
     regulatory      9190..9195
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
                     /note="hexamer: AATAAA"
     polyA_site      9195
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
     polyA_site      9229
                     /gene="Nup160"
                     /gene_synonym="160kDa; 2810011M03Rik; Gtl-13; Gtl1-13;
                     Gtl13; mKIAA0197"
ORIGIN      
        1 acagttatga tctcacgaga gcagccacca tgctgtgtcc aggaggcagt gtcgttacag
       61 cacaccttcc cgttcatctt gcattctttc tgccttgata gagattttga atatgtgggg
      121 gaaatgacac taacaacaag ttccccaaaa catatctcat tcacctagac caggctggcc
      181 ttaaattcag agatctacct gcatttgcct cctgtgtgct ggggttcaag atgtgtgcca
      241 ccaagccgca caacagaggc tggataacaa cttacacgcc aacgctctaa cggaggggaa
      301 ggttcccgca agctgggagt gtgcccgtca ggcctcttcc ccgcccgcgc ccgcttttca
      361 aaatgaaaac acgcacagcc ccgcccctgc tcgaggccgt cgggaaaagg gcgccgccgc
      421 cgcagccgcc gcccgtctcc ggccgctccg aagtgaccgc gagtcaaggc atcttcttcc
      481 cgcctcagcc tcattctcgc ggtgaaaagc cgcagatgag cctccgaccc gcggtcctca
      541 ggcagccaaa atcgcgcaca cacatatccc cgcctcgcgc cacacccccg gaagtgacga
      601 gccgacgtga cccgcccttg tcccgtcagg cctcacggcg acggcgggaa gatggcggcg
      661 gcgggatccc tggaacggag cttcgtggaa ctgagcggag ctgaacgcga aaggcccagg
      721 cactttcggg aattcacagt ctgcgacatt gggactgcaa gtgccgcgtt tggaacggtg
      781 aagtacagtg agagcgctgg tggcttctat tatgtggaaa gtggcaagtt gttctccatc
      841 accaggaaca ggttcattca ttggaagact tctggggata cattggagct ggtggaagaa
      901 tcactggact taaatttgtt gaataatgct gttcgcctaa aattccaaaa ttacaacatc
      961 ttacccggtg gggttcatgt ctctgagact cagaatcatg tgataatctt aatattaacc
     1021 aatcagacag tgcacagatt aattttacca cacccttccc gtatgtacag aagtgagctg
     1081 gtaactgaaa gtcagatgca gtccatattt actgacattg gaaaagttga tttcagagat
     1141 ccttgcaact ctcagttaat tccatcagta cctgggctgt ccccgggttc caccacgtct
     1201 gcagcctggc ttagcagcga tggggaggct ctgttcgctc taccatctgc ttctggcggc
     1261 atcttcgttc ttaagctgcc tccttatgac gtacctggga tagcatcagt tgtggagctg
     1321 aaacagagtt ccgtgatgca gcgattactc acaggctgga tgcccacagc tataaggggt
     1381 gatcatgggc cttctgatcg tgctctgagt ctcgctgttc attgtgtgga acatgatgcc
     1441 tttatttttg ccctgtgtca ggatcataaa cttcggatgt ggtcttacaa ggaccaaatg
     1501 tgcctgatgg tggctgacat gctggaatat gtccctgtaa acaaagacct tcggctcact
     1561 gcaggaacag gacataaatt acggcttgcg tattctcctt ccatggggct ctacctagga
     1621 atatatatgc atgctccaaa acgaggacag ttctgcgttt tccagttggt gagcactgag
     1681 aataatcgct atagtttaga tcacatttct tccctgttca cttctcagga gacactagtc
     1741 gattttgcct taacctcaac ggatatctgg gccctgtggc atgatgctga gaaccaaaca
     1801 attgtgaaat atatcaactt cgaacataat gttgcaggtc agtggaatcc agtgtttatg
     1861 cagcctctac cagaagaaga aattgtcatc agagacgatc aagaccccag agaaatgtat
     1921 ttgcggagcc tttttacacc aggacacttc ataaatgcag ctttatgtaa agctttacag
     1981 attttctgcc gaggtaccga gaggaacttg gatctttcat ggaatgaact aaaaaaggaa
     2041 attactttag ctgttgaaaa tgagctccaa ggaagtgtga cggagtatga attctcccag
     2101 gatgaattcc gcactttaca acaggaattc tggtgcaagt tctatgcctg cgttctccag
     2161 tatcaggaag ccctctccca ccctcttgct ctacatttga atcctgtcac aaacatggtg
     2221 tgccttctca agaaggggta tctgtctttc ctggtgccat cttccttagt agatcattta
     2281 tatctcctgc ccgatgagca ccttttgaca gaggatgaga cgaccatatc agatgatgca
     2341 gatgtggcac gggacgtctt atgtcttata aaatgcctcc ggatgattgg agagtctgtt
     2401 accatggaca tggcagtttt gatggaaacc agttgttaca acttgcaatc tccagagaag
     2461 gctgcggaac acattttgga agatttgatc actattgatg tagaaaatgt gatggaagac
     2521 atttgtagta aactgcaaga gatcagaaac cccgtccatg ccattggact tcttatacgg
     2581 gaaatggatt atgaaacaga agtggaaatg gaaaaggggt tcgatccagc tcagcctttg
     2641 aacgttcgaa tgaatctttc ccagctctat ggtagtagca cagcaggata tattgtgtgt
     2701 cgaggtgtgt ataaaattgc cagcactcga ttcctgatct gccgagacct cttgatcttg
     2761 cagcagctat taacaaggct aggagatgca gtgatcttag gagctggtca gctctttcaa
     2821 gctcagcaag acctgctgca tcgcacagct cccctgctct tgtcttatta cctcattaag
     2881 tgggcaagtc agtgcttggc aactgatgtc cccgttgaca cactggagtc taatctacaa
     2941 catttgtcag ttctggaact aactgattct ggtgccttaa tggcaaataa actggtatct
     3001 agccctcaga caattatgga gttattcttc caagaagttg caagaaaaca aattatatct
     3061 catctcttct ctcaacccaa agcccctcta agccaaactg gattgaattg gcctgaaatg
     3121 attactgcag ttactggtta tttgttgcag cttttgtggc ctagcaaccc aggttgtctc
     3181 tttctagaat gtttgatggg gaattgccag tatgtacaat tgcaggatta tatccaacta
     3241 ctgcatccct ggtgtcaagt caatgttggg tcttgtcgct ttatgctggg acggtgttac
     3301 ctggttacgg gggaagtgca gaaggctctg gaatgtttct gtcaggcagc atctgaagtg
     3361 ggcaaagaag aatttttaga tcgcttgatc cgatcagagg acggggagat tgtgtccacc
     3421 cccaagttgc agtattatga taaggtttta cgtctactag acgttgttgg attgcctgag
     3481 ctggttattc agcttgctac atcagcaatt actgaagcag gtgatgactg gaaaagtcag
     3541 gctactttaa gaacatgcat tttcaaacat catttggact tgggtcataa tagccaagca
     3601 tatgaggcct tgacccaaat tccggactcc agcaggcagt tagactgttt gcgacagctg
     3661 gtggtggttc tatgtgaacg ctcccaactg caggatcttg tagagtttcc ctatgtgaat
     3721 ctgcataatg aggttgtagg aataattgaa tcacgtgcta gagctgtgga ccttatgact
     3781 cacaattact atgaacttct ttatgctttt cacatttacc gccataatta ccgaaaagct
     3841 ggtacagtga tgtttgaata tggtatgcgt cttggcagag aggtacgaac tcttcgggga
     3901 cttgagaagc aaggcaactg ttacctagcc gctatcaatt gtttacggct tattcgtcca
     3961 gagtatgcgt ggatcgtaca gccagcctct ggggcagtgt ctgatcgccc tggagcatct
     4021 cctaagcgga atcatgatgg cgagtgcaca gctgccccaa ccaatcggca aattgaaatt
     4081 ctggaattgg aagatctcga gaaagaatat tctttagctc gcattcgcct cacgttggct
     4141 cggcatgatc catcagtgat tgccattgca ggaagttcat cagcaaagga gatgagcgca
     4201 ctcttggttc aggctggcct ctttgatact gccatatcac tctgtcagac ttttactctt
     4261 ccattaacac cagtctttga agggcttgct ttcaagtgca ttaagttgca gtttggagga
     4321 gaagcagcac aaggagaagc gtggtcctgg ctagcaacca atcagctgtc gtctgtcatc
     4381 accaccaagg agtccagtgc tacagatgaa gcatggaggc tattgtcaac ttacttggaa
     4441 agatacaaag tccagaataa cttgtatcat cattgtgtga ttaacaagtt gttgtctcat
     4501 ggagttcctc tgcctaattg gcttataaac agttacaaga aggttgatgc tgccgagttg
     4561 cttcgtcttt acctgaacta tgacctttta gaagaagctg tggatttggt ctctgaatat
     4621 gtagatgctg tattaggaaa aggacatcag tactttggaa ttgagtttcc actgtcagca
     4681 acagccccga tggtatggct cccatactct tctattgacc agcttctcca ggctctggga
     4741 gagaacagtg ccaacagtca caacattata ctgtcccaga aaattcttga caaactagaa
     4801 gactaccagc aaaaagttga caaggcaacg cgagatttac tgtaccgtcg ggacttgtga
     4861 tctggatagc tgctcagctc tgtaaccttg gtgcctctta gggcttaaga ctacgctaca
     4921 gaaaccctgt cctcaaggcc agtttttcta actataaacg atgtgtctgg cgcccaagtc
     4981 tgcattctgc acaaacaaag aaaacaaagt caggaccgac cctgtgcttg cttgtggtgc
     5041 taacacggtt tctggttttc aaacttcgtc tctaacagct gcttttgtat atgattctca
     5101 acctttttca gagtttatat ttttttaaac taccgaagac atcctttatc tgcaaacaga
     5161 aactcacctt cacttcccgt aatagctaat ggttgttggt ttgttacagc tgaccaccaa
     5221 attgtcactg cgtatccttt catttttcct tacctttttt tatatttcag tggatttgtt
     5281 ttggtccaga actaacatct attttctgta ctgcaaacaa aggctagtgg ttttacatac
     5341 tcctttcatt atttattgta gagtttttca tatgaccgtc aataaagtat taggtaatat
     5401 gcatagatta agaataaatt atgaccagct ttttaaggaa aatatatttt gaatctggct
     5461 aaggctaaag ttgaaaaaaa ctaatgtcca tctataaaag aaacaaattt tcattttcaa
     5521 attgtattaa tttatgtgat ttataataat caagctggac ttgatcatac agttagtgtg
     5581 ataatatatt ggaccaaaat gggatttacc agtcagaatc agaaacattc atgcatacaa
     5641 actttgggaa aggtgaaaaa taataaaaat atcctttgat tttattctgt atattaagat
     5701 ttatctttta aggaaacaag tctctatact atttgtttga atgaatgccc tttgacatct
     5761 gtgtttttat aaactttaga acgtatactg ttaacatcct atttgttaca tagtttatag
     5821 ctctccaatg cagaatatga catgctatgg atgggccctt gcccttgaag ctttctaaac
     5881 ttacggctct ccactacagc ataaaaggca ctggcctgta ttcaaccatg ttcaattgta
     5941 gtctgaaaat tagcataccc tgtttctgcc atatctgaag agcaacaaat aagaggatag
     6001 cggtgctgcc tcgcagttca catagcactg cccagccttt cctgtgctaa ccgccatgtc
     6061 aaagccagtc tgatctccgc tttagtctac ccgtctcatt ttgattccag ccagagcaaa
     6121 gagacttgtg ctctcactgc aatgtgtttg ccgccgtggc tctgtgcttg ggtttactgt
     6181 accctgtgag gttttattag tccacagtaa ttagaccatg gcttgttttg ttttgttgtt
     6241 tgtttgtttg tttctgtcag aaagttgaaa ggctctctga gagtctagag aaatggctca
     6301 gtggttccac aggctggcca ctcttccaaa gaaccggagt acgagtccta tgcagctcac
     6361 cgtcaccgta acaccagctc caggggctcc gacaccctct ctaaactcca ctggcacctg
     6421 cactcatgta cacacagaaa cacataagtc aaaataatat aaaaatcgtt gatgttgttg
     6481 ttgctgtctt aaaggttctg ttaggctagg agtgtgtggc tcactgatag aacatttgct
     6541 tagcagatcc aaggccctca atccccagca ccagaggcat atagtaaaat gtaactgcaa
     6601 tggctgtaac agatgtcctg actggtatac tagatttggt agggctgagt gccaaggcct
     6661 ttgtttgatc cccaatacca caaagggaga aggaaaatga tagtaacatg gagttttcat
     6721 attgatattt ttttaccaga tatattactg tcattattgt aacattgcaa aatttgctat
     6781 acaaatttta tagtgtatac aaacacacta cttttttaat aattcctttc ctttgccagc
     6841 cctccccact ggatcccagc tgcctaaaac ccttagggtc tgccaggata agtggtacac
     6901 acctttaatc ctagtgctag ggaggcagaa gcaggaggac ctctgtgagt ttgtggccac
     6961 cgtgttgtac atagtgagtt ccaagacggc cgggactatg tagagagacc ctagagaccc
     7021 tgtctccaaa aagaaaaaag aaaaaaaccc ttgggtcagt tgtcaccggt cagtactagc
     7081 ctttgtccct tttgtgactc tagttactca gtaggtctca gccctggcta ttttgtttcc
     7141 taaaacttca ctgaaccccc aggggcaggg gagacacaaa attacagatt tggagatagc
     7201 tcatctctta ggaataccag agttcacttc ccagtaccac caccaaccag ctctttagct
     7261 ccaggagata taaaagcctt caggtctcct gaagcacttg tgtatgtagg acagaggcag
     7321 agacaggtgg gtctctgtga gtctgaggac tacatagtaa taccatttca aacaacagca
     7381 acaacaagca aagcaaagta cctgaaagat cctttttttc catttcctcc aatataagat
     7441 ttcatgtatc ccaagctggc ctagaactca ctgtaaccaa agatgatctt gaatttctgc
     7501 tcctcttgcc tctgcctcta aagggttagg attagttata accagcacac ccagtttccc
     7561 ccggtctctg tgtgctgtcg tctagaactc tacctactaa gctgcatccc aagctccagt
     7621 tgaagacctt aattggcttt ttgagattat tagagtcaaa tgactggttg ttctgtgaaa
     7681 catgctgcag ggctagagag agttcagtaa aatgtcagct ttatgaccta gtccaggctc
     7741 ctaggctaca cacatatggt catatatgct tgtgatgccc atgctggagg gtagagacag
     7801 gatccctgtg gtgctggcca gccagactag cctactcggt aagatccaga ctaggagatc
     7861 ctgactcaaa aacaaaacaa caaggacatt tcctacaaaa tgacacctga gacctgagct
     7921 tgacctctcg ccgccacata catacaggta cacccgcata tagagggaaa cacacaaaca
     7981 caaaaatatg tgttgtgggc tgaagagatg gctcaggggt caagcacaat tcccagcaac
     8041 cacatggtgg ctcacaacca tctgtaatgg gatctgatgc cctcttctgg gtgtctgaag
     8101 acagctacag tgtactcatg tacataaaat aaaaaaaatt ttttttaatt atttttaaaa
     8161 aaaaatcaaa aaataaatgt gaaaggcaat ttgctctagg caatgatggt ggcacattcc
     8221 tttgatcccc gaactcagga ggcagaggta cgtggatttc tgtgagttaa aggccagcct
     8281 ggtcttcaga acaagttcca ggacagccag gactacacag aaaccttctc tgaaaagaaa
     8341 aaaaaaaaag aggaagaaga aagcaagcaa gcaaaagaaa acagtgttct tgttgaagtt
     8401 agctactttc ctttaaagtc agataacttt gtttcagatt tgtgatgtgg aacactagag
     8461 ctaagtgact gtttggtttt ggtcaggtat aatgcaggcg ctaaagccaa agcatttcct
     8521 gtaaatccta cttggcagaa caaaagctta aaatcctgag ttcagtaatc tgcagcacag
     8581 caaaactagg ggagaagact ggcattagca gactctcctc agttctcaac tactgcaaac
     8641 gctaacacta ttcaaatgaa tatggatgga atttatattt aaatagcaaa aagaaaagta
     8701 cccatgaaca caataagata ctttaatctg catttttcat tagcacatag tttttattac
     8761 aaagatttct aaatttatga gtattttgcc ttaatgtaca tatgtccata atgtgtgtct
     8821 ctggtgatca tggggccaga gaagggagca tcagaatccc tggagctggc gttagatggt
     8881 ggtgaagccc cagtgtgtgc tgatggaagc cccagtgtgt gctgggaccc agacctgggt
     8941 cctctgcaag agctctcaac ccgagccatc tctctagccc cgtcacagaa acttctaaag
     9001 tgtcctttaa ttgcccttgt ttttcctaat catagtactt aaaaccatag atattcctgt
     9061 attactgggt tctccataca cctctgaata tataaatagc ttactaactt ctcattgtat
     9121 ctactcagat ctgtaagtaa gaagccaatt tattgtgcaa ataacctatg atttgaatat
     9181 aggtatttca ataaaccagg cttcgtggtt tatatgaacc tccataaaa
//
