LOCUS       NM_175749               6021 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus nucleoporin 153 (Nup153), mRNA.
ACCESSION   NM_175749
VERSION     NM_175749.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6021)
  AUTHORS   Colussi,C., Bertozzi,A., Leone,L., Rinaudo,M., Sollazzo,R.,
            Conte,F., Paccosi,E., Nardella,L., Aceto,G., Puma,D.D.L.,
            Ripoli,C., Vita,M.G., Marra,C., D'Ascenzo,M. and Grassi,C.
  TITLE     Nucleoporin 153 deficiency in adult neural stem cells defines a
            pathological protein-network signature and defective neurogenesis
            in a mouse model of AD
  JOURNAL   Stem Cell Res Ther 15 (1), 275 (2024)
   PUBMED   39227892
  REMARK    GeneRIF: Nucleoporin 153 deficiency in adult neural stem cells
            defines a pathological protein-network signature and defective
            neurogenesis in a mouse model of AD.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6021)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6021)
  AUTHORS   Kadota,S., Ou,J., Shi,Y., Lee,J.T., Sun,J. and Yildirim,E.
  TITLE     Nucleoporin 153 links nuclear pore complex to chromatin
            architecture by mediating CTCF and cohesin binding
  JOURNAL   Nat Commun 11 (1), 2606 (2020)
   PUBMED   32451376
  REMARK    GeneRIF: Nucleoporin 153 links nuclear pore complex to chromatin
            architecture by mediating CTCF and cohesin binding.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6021)
  AUTHORS   Khalaf,B., Roncador,A., Pischedda,F., Casini,A., Thomas,S.,
            Piccoli,G., Kiebler,M. and Macchi,P.
  TITLE     Ankyrin-G induces nucleoporin Nup358 to associate with the axon
            initial segment of neurons
  JOURNAL   J Cell Sci 132 (18) (2019)
   PUBMED   31427429
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6021)
  AUTHORS   Leone,L., Colussi,C., Gironi,K., Longo,V., Fusco,S., Li Puma,D.D.,
            D'Ascenzo,M. and Grassi,C.
  TITLE     Altered Nup153 Expression Impairs the Function of Cultured
            Hippocampal Neural Stem Cells Isolated from a Mouse Model of
            Alzheimer's Disease
  JOURNAL   Mol Neurobiol 56 (8), 5934-5949 (2019)
   PUBMED   30689197
  REMARK    GeneRIF: These data uncover a novel role for Nup153 in neural stem
            cells from animal model of Alzheimer's disease.
REFERENCE   6  (bases 1 to 6021)
  AUTHORS   Olsson,M., Scheele,S. and Ekblom,P.
  TITLE     Limited expression of nuclear pore membrane glycoprotein 210 in
            cell lines and tissues suggests cell-type specific nuclear pores in
            metazoans
  JOURNAL   Exp Cell Res 292 (2), 359-370 (2004)
   PUBMED   14697343
REFERENCE   7  (bases 1 to 6021)
  AUTHORS   Suntharalingam,M. and Wente,S.R.
  TITLE     Peering through the pore: nuclear pore complex structure, assembly,
            and function
  JOURNAL   Dev Cell 4 (6), 775-789 (2003)
   PUBMED   12791264
  REMARK    Review article
REFERENCE   8  (bases 1 to 6021)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 6021)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 6021)
  AUTHORS   Smitherman,M., Lee,K., Swanger,J., Kapur,R. and Clurman,B.E.
  TITLE     Characterization and targeted disruption of murine Nup50, a
            p27(Kip1)-interacting component of the nuclear pore complex
  JOURNAL   Mol Cell Biol 20 (15), 5631-5642 (2000)
   PUBMED   10891500
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK086847.1, CF898039.1, CA326562.1, CK638380.1, CF897724.1,
            AK044947.1, BM950067.1 and AK031006.1.
            
            On Jul 23, 2009 this sequence version replaced NM_175749.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052173.1, SRR10223969.12700.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-801               AK086847.1         2-802
            802-956             CF898039.1         440-594
            957-1434            AK086847.1         959-1436
            1435-1957           CA326562.1         127-649
            1958-2468           CK638380.1         151-661
            2469-2878           CF897724.1         235-644
            2879-3416           AK044947.1         116-653
            3417-3689           BM950067.1         418-690
            3690-5819           AK044947.1         927-3056
            5820-6021           AK031006.1         2551-2752
FEATURES             Location/Qualifiers
     source          1..6021
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 24.3 cM"
     gene            1..6021
                     /gene="Nup153"
                     /gene_synonym="B130015D15Rik"
                     /note="nucleoporin 153"
                     /db_xref="GeneID:218210"
                     /db_xref="MGI:MGI:2385621"
     exon            1..490
                     /gene="Nup153"
                     /gene_synonym="B130015D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            491..713
                     /gene="Nup153"
                     /gene_synonym="B130015D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            714..962
                     /gene="Nup153"
                     /gene_synonym="B130015D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1102
                     /gene="Nup153"
                     /gene_synonym="B130015D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1231
                     /gene="Nup153"
                     /gene_synonym="B130015D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1348
                     /gene="Nup153"
                     /gene_synonym="B130015D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1393
                     /gene="Nup153"
                     /gene_synonym="B130015D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1447
                     /gene="Nup153"
                     /gene_synonym="B130015D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1594
                     /gene="Nup153"
                     /gene_synonym="B130015D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1641
                     /gene="Nup153"
                     /gene_synonym="B130015D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1768
                     /gene="Nup153"
                     /gene_synonym="B130015D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1903
                     /gene="Nup153"
                     /gene_synonym="B130015D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2002
                     /gene="Nup153"
                     /gene_synonym="B130015D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2087
                     /gene="Nup153"
                     /gene_synonym="B130015D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2210
                     /gene="Nup153"
                     /gene_synonym="B130015D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2816
                     /gene="Nup153"
                     /gene_synonym="B130015D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2817..3008
                     /gene="Nup153"
                     /gene_synonym="B130015D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3009..3884
                     /gene="Nup153"
                     /gene_synonym="B130015D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3885..4238
                     /gene="Nup153"
                     /gene_synonym="B130015D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4239..4511
                     /gene="Nup153"
                     /gene_synonym="B130015D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4512..4680
                     /gene="Nup153"
                     /gene_synonym="B130015D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4681..6021
                     /gene="Nup153"
                     /gene_synonym="B130015D15Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcggcgcc agcggcctgg actgcggcag cgacggccag ggcgactgaa gaggagcctc
       61 tagcagcggg cggtcgagct aggcctcagc ggcgcccgga gctgctcgcg ccggcctcgg
      121 cgggagatct ccatagagac ggtgacaaac acagacgcgg gggtccgcac gcggccggcg
      181 ctcctcagcc acctcggggc cctcagccgc cgccaccgcc ttcctcgccg ccgcgcgcac
      241 tctcagttcc cgctcgctcc ctcgcggttc tcgctgtgtc tgtgtgtcgc ctagggccgg
      301 gcgggggagg ccctcaggcc gccgcctctg cctctcccgc ccgggagcgg tagtgggagg
      361 ccgcccaggc tccgccatgg cctcggaagc cggaggcata ggagggggcg gcggcggcgg
      421 caagatccgg actcgtcgtt gccaccaggg gccggtgaag ccttaccaac aggggcgacc
      481 ccaacaccag ggcattctta gcagggttac agaatctgtt aagaatattg taccagggtg
      541 gctacaaaga tacttcaaca agagtgaaaa tgcttgcagc tgttcaccag atgcagatga
      601 agttccaccc tggccagaaa atagagaaga tgagcatgcg atttatgcgg atgagaacac
      661 aaacactgat gatgggagaa tcacccctga ccctgcaggc agtaacacag aagaaccatc
      721 aacaaccagt actgcttcaa attatccaga tgtgttaaca agaccttctc ttcatcggag
      781 tcatctgaat ttctctgtgt tggaatcccc tgctttgcac tgtcagccgt ccacatcctc
      841 tgcgttccca atcggcagtt ctggattttc ccttgtgaag gagattaaag attctacctc
      901 tcagcatgat gatgataaca tctcaactac cagtgggttc tcttcaagag cttctgagaa
      961 agatatagct gtttcaaaga acacttccct gccacctttg tggtcccctg aagcagaacg
     1021 ttctcattca ctctcacagc atactgccat cagctccaaa aaaccagcat tcaacttgtc
     1081 tgcctttgga acactttcca cctcacttgg gaattcttca attcttaaaa caagtcagct
     1141 tggagactct cctttttatc ctggcaaaac aacatatgga ggggcagctg ctgctgtaag
     1201 acagaataaa gtacgaagta caccttacca ggctccagtt agaagacaga tgaaagctaa
     1261 gcagctcaat gcacagtctt atggtgtgac cagctcaaca gcacggcgga tactgcagtc
     1321 attagaaaag atgtcgagcc ctcttgcgga tgcaaaaaga attccatctg cagtttcttc
     1381 tcctctgaat tctcctcttg ataggagtgg gatagataac acagtttttc aggcaaaaaa
     1441 agaaaaggtg gactctcagt atccccctgt tcagagacta atgaccccaa agccagtttc
     1501 catagcaaca aatagaactg tctattttaa accatctctg accccatctg gtgacttaag
     1561 gaagactaat caaaggatag ataaaaagaa cagtactgta gatgaaaaaa gtatctcaag
     1621 acaaaataga gagcaagaaa gtggcttttc ataccccaat ttcagtattc ctgcagccaa
     1681 tggtttatct tctggagtag gtggtggagg tggcaagatg agaagagaga gaacacattt
     1741 tgttgctcct aaacctccag agaatgagga agtggaagca ccattgttac cgcaaatctc
     1801 tctaccaatc agcagttctt cactgcccac cttcagtttt agttcccctg tgacctcggc
     1861 ttctccttca ccagtcagct cttctcagcc attaccaaac aaggtacaga tgacctctct
     1921 gggcagcacg ggcagtcctg tgttcacatt ctcatctccc attgtaaaat ccacgcaggc
     1981 agctgtgctc cctccagcat ctattggatt tacatttagt gtgcctcttg caaaaactga
     2041 attttctggc tctaatagtt cttcagaaac agttttaagt agttcagccc aagatatcac
     2101 tgcagtgaat agttcaagct ataagaagcg aagtgctcct tgtgaggacc cctttacacc
     2161 tgcaaagatc ctgagagaag gaagtgttct agacattctg aaaacacctg gtttcgcatc
     2221 accaaaggtt gattctcctg ctcttcaacc cactaccaca agctcaatag tttatacaag
     2281 accagcaata agtacttttt cttctagtgg aattgagtat ggagaaagtt taaaagctgg
     2341 atcatcatgg cagtgtgaca catgtctcct ccagaacaaa gtcacagaca ataagtgtat
     2401 agcctgccaa gcagcaaaac tgcccctgaa agaaactgct aaacagactg ggactgggac
     2461 accaagcaaa agtgacaaac cagcctctac atcagggaca ggctttggag ataaatttaa
     2521 accagcaata ggaacttggg attgtgatac ctgtttagtg caaaataagc ccgaagcagt
     2581 aaaatgtgta gcctgtgaga cacctaagcc tggcactggt gtgaagcgag cccttacatt
     2641 gacagtggct tcagaaagtc ctgtgactgc ttcctcttct accactgtga caactggtac
     2701 actaggattt ggagataaat tcaaaaggcc tgtgggctct tgggagtgtc cagtctgctg
     2761 tgtttgtaat aaggcagaag acaacagatg tgtttcctgt acatctgaga aaccaggttt
     2821 ggtatctgcc tcaagcagca gccctgcccc tgtctctctg tcttctggag gctgtttagg
     2881 attggacaag tttaaaaagc ccgagggaag ctgggactgt gaagtgtgcc tagtgcaaaa
     2941 taaagcagac tctgccaagt gcatagcttg tgaaagtgca aagccaggca caaagtctga
     3001 gtttaaaggc ttcgggacat cttcatcttt aaatccagca ccctcagcct tcaaatttgg
     3061 tattccatcg tcctcttctg ggctttctca aactttgaca agcactggaa attttaaatt
     3121 tggagatcag ggaggattca aattaggcac ttcatctgac tctgggtcta caaacaccat
     3181 gaatacaaac tttaaatttt ctaaaccaac tggagacttt aaatttggag tgttatctga
     3241 ttctaaacct gaagaagtta aaaacgacaa caagaatgat aattttcagt ttggatcttc
     3301 ttctggctta accaacccag cttcttcagc tccgtttcag tttggggtat ctactcttgg
     3361 gcaacaagaa aagaaagagg agctgcctaa atcttcacct gcaggcttta gctttggtgc
     3421 aggtgttaat aaccccccta atgctgctat tgacaccaca gcgacctcag agaacaagag
     3481 cggcttcaac tttggaaccc tagacacaaa gagtgtctca gtgactcctt tcacatacaa
     3541 gacaacagaa gcaaagaaag aagacgcacc tgctaccaag ggtgggttca catttggtaa
     3601 agtgggctcc tcttctttgc catcttcctc aatgtttgtt ttgggaagga cagaggagaa
     3661 acagcaagaa cctgttactt ctacttctct ggtgtttggg aagaaagccg acagtgagga
     3721 gccaaagtgt cagccagtat tttcctttgg gaattcagag caaaccaaag atgagagctc
     3781 caagccgaca ttcagcttca gtgtggcaaa accatctggg aaggagtctg agcagctagc
     3841 caaggctact tttgcatttg gaaatcaaac caatacaaca actgatcaag gtgcagcaaa
     3901 gccagttttt agcttcttga acagcagttc ctctagttca agtgcaccag ccacttcatc
     3961 tagtggtggc atatttggta gttccacctc ttcctccaac ccacctgtgg cagcctttgt
     4021 gtttggacag gccagcaatc ctgtcagcag ctctgccttc ggtaacgctg ctgaatccag
     4081 tacatctcag tctttgctat ttcctcaaga gagcgagcca gccaccacgt ccagcactgc
     4141 cccagctgcc tctccctttg tatttgggac aggagccagc agtaatagtg tgtcttctgg
     4201 gttcactttt ggggctacaa ccacgtcaag ctcttcagga tcctcctttg tatttggcac
     4261 tggacattca gcaccatctg ccagtccagc atttggtgct aaccagactc caacatttgg
     4321 acaaagtcaa ggtgccagcc agcctaaccc gccaagcttt ggctctatct cgtcttcaac
     4381 agcattattt tctgctggtt ctcagcctgt accaccacct atatttggga cagtgtcaag
     4441 cagcagccaa cctcctgtgt ttggacagca gcctagtcag tctgcatttg gctctgggac
     4501 agctaatgcc agttcggttt tccaatttgg tagcagcact acgaatttca acttcacaaa
     4561 caataatcca tcaggagtgt tcacatttgg tgcaagtccc agcacgcctg cagcctcagc
     4621 ccagccctca ggttcagggg tcttttcatt cagccagtct ccagcatcat ttacagtggg
     4681 gtcaaatggg aaaaatatgt tctcttcttc cggaacttca gtttctggtc gcaagataaa
     4741 gactgctgtt agacgcaaga aataaaagtc acaaaggtgt tatacccaac agttttatca
     4801 acagctggtg ccctgctttc agatactgga ttgtactaca tgctgggctt atctgaagtc
     4861 agatctgcct aaggacttct ttaattttgg aattgtcctc ttttttttct ttatggaagt
     4921 cctgtcccca taacccattc tctttttgaa aataatagct agactggtga ctgactgatt
     4981 cttcagcaga aacattttat gatccagcac attattcact gattggcata gtctggctgt
     5041 acccaggaat agagcctgca cggtgaatgg ctttgtatag aacctgtctg caccgctatg
     5101 tgcattgata aagcgttaat ggagcgtgtt gaaattgtaa ttatatctgg ggaattctgt
     5161 atagattaga atcctgtata gattagagga cgttgaaatg aatgatttct atgcggagtt
     5221 tgtggtggtg tatgtgtgaa gtgagtaagt gggacgtatt gtgcacagaa aaattctgat
     5281 agagaaaacc tgattaaaga acggtccatc ctaaggactt gttagatcta gttcattctc
     5341 cacttaataa gtatatgcta tttctatatt ttcattctat caactgtctt gcctttttca
     5401 ttattttatt atgagacttc tgtaaataca attttgtttc tgtacctttt tggcataaca
     5461 taaatctgtg aacttgaaat tttaatttta tgttagacat atttttgttg tttgtttagt
     5521 cttgtctcag attttattat gtaaatccca ttattcaaag ttgcctaaat ccatttggaa
     5581 atctttaaaa aaaattgggg attcttaaag ttgaatttat tggcttttct gatccagttt
     5641 tgtttggacc aaaaaccagt attgtacaaa gtattaagca tatattttta tatttactga
     5701 aatggactgt ggtgactttg gataataagg aaaaagttta atattaaagc catgtttatt
     5761 acagtataat taacatgtta aaccatggga taaatgccat caataaaact ttatgaagca
     5821 aatttgttaa cagttttcat agtgaaggca cacaatatta atgggaaggg tggttgatta
     5881 gaaaccccaa agggtatgta tcaggtaagg cccaagagtt actggcgttt gcagaacaca
     5941 gaagatcccc tcctttctgc ctgctgctgt ctttacttaa tttgcacgta tattttctca
     6001 ttaaattttg aaaataaacg t
//
