LOCUS       NM_172288               5823 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Mus musculus nucleoporin 133 (Nup133), mRNA.
ACCESSION   NM_172288
VERSION     NM_172288.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5823)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5823)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5823)
  AUTHORS   Souquet,B., Freed,E., Berto,A., Andric,V., Auduge,N.,
            Reina-San-Martin,B., Lacy,E. and Doye,V.
  TITLE     Nup133 Is Required for Proper Nuclear Pore Basket Assembly and
            Dynamics in Embryonic Stem Cells
  JOURNAL   Cell Rep 23 (8), 2443-2454 (2018)
   PUBMED   29791854
  REMARK    GeneRIF: Nup133 is dispensable for interphase and postmitotic
            nuclear pore complex scaffold assembly in pluripotent mouse
            embryonic stem cell.
            Erratum:[Cell Rep. 2018 Nov 13;25(7):1994. doi:
            10.1016/j.celrep.2018.11.012.. PMID: 30428363]
REFERENCE   4  (bases 1 to 5823)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 5823)
  AUTHORS   Bolhy,S., Bouhlel,I., Dultz,E., Nayak,T., Zuccolo,M., Gatti,X.,
            Vallee,R., Ellenberg,J. and Doye,V.
  TITLE     A Nup133-dependent NPC-anchored network tethers centrosomes to the
            nuclear envelope in prophase
  JOURNAL   J Cell Biol 192 (5), 855-871 (2011)
   PUBMED   21383080
REFERENCE   6  (bases 1 to 5823)
  AUTHORS   Lupu,F., Alves,A., Anderson,K., Doye,V. and Lacy,E.
  TITLE     Nuclear pore composition regulates neural stem/progenitor cell
            differentiation in the mouse embryo
  JOURNAL   Dev Cell 14 (6), 831-842 (2008)
   PUBMED   18539113
REFERENCE   7  (bases 1 to 5823)
  AUTHORS   Suntharalingam,M. and Wente,S.R.
  TITLE     Peering through the pore: nuclear pore complex structure, assembly,
            and function
  JOURNAL   Dev Cell 4 (6), 775-789 (2003)
   PUBMED   12791264
  REMARK    Review article
REFERENCE   8  (bases 1 to 5823)
  AUTHORS   Vasu,S., Shah,S., Orjalo,A., Park,M., Fischer,W.H. and Forbes,D.J.
  TITLE     Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA
            export
  JOURNAL   J Cell Biol 155 (3), 339-354 (2001)
   PUBMED   11684705
REFERENCE   9  (bases 1 to 5823)
  AUTHORS   Belgareh,N., Rabut,G., Bai,S.W., van Overbeek,M., Beaudouin,J.,
            Daigle,N., Zatsepina,O.V., Pasteau,F., Labas,V., Fromont-Racine,M.,
            Ellenberg,J. and Doye,V.
  TITLE     An evolutionarily conserved NPC subcomplex, which redistributes in
            part to kinetochores in mammalian cells
  JOURNAL   J Cell Biol 154 (6), 1147-1160 (2001)
   PUBMED   11564755
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123825.5 and AC147266.6.
            
            On Jan 31, 2022 this sequence version replaced NM_172288.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023915.1, AK029317.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-283               AC123825.5         61321-61603
            284-402             AC123825.5         63990-64108
            403-506             AC123825.5         66243-66346
            507-614             AC123825.5         69459-69566
            615-749             AC123825.5         71427-71561
            750-920             AC123825.5         72296-72466
            921-1076            AC123825.5         73615-73770
            1077-1147           AC123825.5         74444-74514
            1148-1295           AC123825.5         77087-77234
            1296-1443           AC123825.5         79598-79745
            1444-1601           AC123825.5         81200-81357
            1602-1693           AC123825.5         83380-83471
            1694-1857           AC123825.5         88089-88252
            1858-1952           AC123825.5         89659-89753
            1953-2177           AC123825.5         91605-91829
            2178-2300           AC123825.5         93049-93171
            2301-2400           AC123825.5         94218-94317
            2401-2652           AC123825.5         95175-95426
            2653-2786           AC123825.5         95970-96103
            2787-2945           AC147266.6         226940-227098       c
            2946-3081           AC147266.6         225075-225210       c
            3082-3200           AC147266.6         222947-223065       c
            3201-3281           AC147266.6         221405-221485       c
            3282-3346           AC147266.6         219743-219807       c
            3347-3435           AC147266.6         217790-217878       c
            3436-5823           AC147266.6         212314-214701       c
FEATURES             Location/Qualifiers
     source          1..5823
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 72.27 cM"
     gene            1..5823
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /note="nucleoporin 133"
                     /db_xref="GeneID:234865"
                     /db_xref="MGI:MGI:2442620"
     exon            1..283
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..3572
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /note="nucleoporin Nup133; 133 kDa nucleoporin"
                     /codon_start=1
                     /product="nuclear pore complex protein Nup133"
                     /protein_id="NP_758492.2"
                     /db_xref="CCDS:CCDS22765.1"
                     /db_xref="GeneID:234865"
                     /db_xref="MGI:MGI:2442620"
                     /translation="MFPSVSSPRTPGPGTRRGPLVGIGPTSTPRASRRGLSLGSAVNS
                     PVLFSPAGRRSSVSSRGTPTRIFPHHSISESVNYDVRVFGSSLPVKIMEALTMAEADE
                     QLSVHVDEGGWACLVCTEKLLIWKIAVSPVTKLSVCKELQLPPSDFHGSADLVALSYA
                     ATSGEVHSVQAVSVMVATKEGSIRYWPSLAREDTYSDTCVDLGGEKMCRFLTAVQGGS
                     FILSSVGSQLVRLIPESSGKIHQHVLPQGQGMLSGIGRRVSSLFGILSPTSDLMLASV
                     LWDRGGSSFYTLTSSNISKWELDDSSEKQVHSWDVHRTLKESITDAVWGSESNYEAIK
                     EGVNIQYLDLKQNCDGLLILAAAWHLGDSPCLVYYSVITVEDNGNQMSDAVTVEVTQY
                     NPPFQSEDLIACRLMVPNFSSQMTYLYMENAVFVCSTGTGKFSLPQEKIVFDTQGDGI
                     LGAGSCAGVPILFSRNSGLVSVTPRENVSLLAEDLEESLTSSVGGRGSESMVFETTTK
                     NETVAHEDKTKLLKAAFLQYCRKDLGRAQIMADELFSSHTDLDSDPELDKAVTQISVD
                     LIDDYPASDPRWAESVPQEAPGLSNTSLIILHQLEDKMKAHCLLVDFLHQVGLFRRLS
                     SYPIRGTPMSTRLLLCEHAEKLSAAITLKNHHSRLPDLVNSAILLALNKRECEVPNSL
                     TPADVFFREVSQVDTICECLLEHEEQVLREVALVSQEWAEVAIDVNTVLKDMLQAATH
                     YRLNKSSMYSQEEVLGKEPEYVPWTATSGPSGIRTAVMRQHGIILKMVYPQADSKLRN
                     VVMEQLVALIDCFLDSYVSQLKSLEKSSDQERYSSLEVEYLQKRSELLSPLLTLGQYP
                     WAASLAEKYCDFDILVQMCEQTDNQARLQRYMTQFADQNFSDFLFRWYLEKGKRGKLL
                     SQPISQHGQLANFLQAHEHLSWLHEINSQELEKAHTTLLGLANMETRYFAKKKTLLGL
                     SKLAALASDISEDRLQEKIEAMAEQERFLLHQETLPEQLLTERQLSLSAMPVLTAPQL
                     ISLYICDENRRANEYDFKKALDLLEYIDEEEDVSIDDLKLEILCRALQRDDWSGSDGK
                     DDPIEVSKDSVFVKILQKLIKDGIQLSEYLPEVTDLLRAEQLGSLKSNSYFEFVLKAN
                     YEYYVQGQM"
     exon            284..402
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /inference="alignment:Splign:2.1.0"
     exon            403..506
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /inference="alignment:Splign:2.1.0"
     exon            507..614
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /inference="alignment:Splign:2.1.0"
     exon            615..749
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /inference="alignment:Splign:2.1.0"
     exon            750..920
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1076
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1147
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1295
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1443
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1601
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1693
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1857
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..1952
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2177
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2300
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2400
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2652
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..2786
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /inference="alignment:Splign:2.1.0"
     exon            2787..2945
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /inference="alignment:Splign:2.1.0"
     exon            2946..3081
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /inference="alignment:Splign:2.1.0"
     exon            3082..3200
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /inference="alignment:Splign:2.1.0"
     exon            3201..3281
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /inference="alignment:Splign:2.1.0"
     exon            3282..3346
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /inference="alignment:Splign:2.1.0"
     exon            3347..3435
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /inference="alignment:Splign:2.1.0"
     exon            3436..5823
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3619..3624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /note="hexamer: ATTAAA"
     polyA_site      3646
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /note="major polyA site"
     regulatory      3924..3929
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /note="hexamer: AATATA"
     polyA_site      3950
                     /gene="Nup133"
                     /gene_synonym="mermaid"
     regulatory      5612..5617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /note="hexamer: AATAAA"
     polyA_site      5641
                     /gene="Nup133"
                     /gene_synonym="mermaid"
     regulatory      5802..5807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nup133"
                     /gene_synonym="mermaid"
                     /note="hexamer: AATAAA"
     polyA_site      5823
                     /gene="Nup133"
                     /gene_synonym="mermaid"
ORIGIN      
        1 gtcatctcta ggcgccttcc cgcccctcag gtgttcaagc tccgggcgcg cgaggttctc
       61 gctattagcc cgcgagtgcc gcttcctcca cgctctctgc aaacatgttt ccgagcgtct
      121 cctctccgcg aaccccaggg ccggggaccc gacgcggtcc gctagtcggg atcgggccca
      181 cgtccacgcc tagagcgagc aggaggggtc tgtctctggg atctgcggtt aactcgcccg
      241 tgctgttctc gcccgcaggc cggcgcagct cggtgagctc acgaggaacg cctactcgga
      301 tattccccca ccattccata tcagagtctg tgaactacga tgtgagagtg tttggatcat
      361 ctctccctgt taagatcatg gaagccctga caatggctga ggctgacgag cagctttctg
      421 tccatgtcga tgaaggtggg tgggcctgcc tggtatgcac ggagaagctc ctcatttgga
      481 agattgctgt gtcgcctgtc actaagttgt ctgtctgcaa agaactccag ctgcccccta
      541 gcgatttcca cgggagcgct gatttggtgg ccctgtctta tgctgcgacc tcaggtgaag
      601 tccattctgt gcaggctgtt tctgtcatgg ttgctaccaa agaggggtcc atccgctatt
      661 ggcccagcct cgccagggaa gacacctact cagacacctg tgtggatttg ggaggcgaga
      721 agatgtgcag gttcctgaca gcagtgcagg gaggaagttt catcctgtcc tccgtgggga
      781 gccagttggt tcgattgatt cctgaaagct caggaaagat tcaccagcat gtcctgcccc
      841 agggccaagg catgctctca gggattggcc ggagggtttc ttcccttttc gggattctgt
      901 cccctactag tgacctcatg ctggccagtg ttctgtggga cagaggagga tcaagtttct
      961 acaccctgac gagttcaaac atcagcaaat gggaactgga cgattcttca gagaagcagg
     1021 ttcacagctg ggatgtgcac aggaccctga aggagagcat caccgatgct gtttgggggt
     1081 ctgaaagtaa ctatgaagct attaaagaag gggtcaacat tcagtacttg gacttgaaac
     1141 aaaactgcga tgggctcctg attttggcag cagcgtggca cctgggagac agcccctgtc
     1201 ttgtctatta ctctgtgatc acggtggaag acaatggtaa ccagatgtca gatgcagtca
     1261 ccgtagaagt gactcagtat aacccccctt tccagtctga agacctgatc gcatgtcgat
     1321 tgatggtgcc aaacttttca agccagatga cctatcttta catggagaat gctgtctttg
     1381 tgtgctccac aggcactggg aagttttctc ttcctcagga aaagattgtc tttgatacac
     1441 aaggggatgg cattttgggc gctggctcct gtgctggtgt tcctatcctt ttctctagga
     1501 atagtggtct ggtgtctgtc actccaaggg aaaatgtatc cctgttagca gaagacctgg
     1561 aagagtcttt gacctcctca gttggtggac ggggcagtga gagtatggtt tttgagacca
     1621 ccacaaaaaa cgaaactgta gcccatgaag acaagacaaa actgcttaag gctgcatttc
     1681 tacagtactg caggaaagat ttgggccgcg ctcagataat ggctgatgag ctgttttcct
     1741 ctcacacgga tttggattcg gaccctgagc tagacaaggc cgtgactcag atcagtgtgg
     1801 acctgattga tgactacccg gcctcagacc cacgctgggc agagtctgtc ccccaggagg
     1861 cccctgggct gagcaacacc tcactgatca ttttgcacca gctggaggac aagatgaaag
     1921 ctcactgcct cttggtggac ttccttcacc aagtcggctt gtttagacgt ttgagctcct
     1981 atccaatcag agggacaccc atgtccaccc gactgctact ctgtgaacat gcagaaaagc
     2041 tgtcagctgc catcacacta aaaaaccacc actctcgact gccagacctg gtgaactcag
     2101 ctatcctgct cgccctgaac aagagggagt gtgaggttcc caacagcctg actcctgccg
     2161 atgtcttctt tcgagaggtg tcccaggtgg acactatctg tgagtgcctc ctggagcatg
     2221 aggaacaagt cctgcgtgaa gttgcgttgg tctctcagga gtgggcagag gtggcgatcg
     2281 acgtcaatac tgtcctcaag gacatgctac aggctgccac tcactaccgc ctaaacaaaa
     2341 gctctatgta cagtcaggaa gaggtactag ggaaggagcc agagtatgtg ccatggacag
     2401 ccacaagtgg tccatccggt atccgcacag cagtcatgcg ccagcacggg atcatcctga
     2461 agatggtata ccctcaggct gacagcaaac ttcggaacgt tgtcatggag cagcttgtgg
     2521 cactaattga ctgcttcctg gacagctacg tttcccagct gaagtcgcta gagaaatcca
     2581 gtgaccaaga acgatacagc agtctggaag tggagtacct gcagaaaaga tccgagctgc
     2641 tctcgcccct tctcacacta ggtcagtacc catgggcagc ttctctggca gagaagtatt
     2701 gtgactttga tatcctggtt cagatgtgtg aacagacaga caaccaagcc cgactccagc
     2761 gctacatgac ccagtttgct gaccagaatt tttcagattt tctctttcgt tggtacctgg
     2821 aaaaaggaaa gcggggaaaa ttgctgtctc agcccatttc tcagcatgga cagttggcaa
     2881 attttttgca agcccatgag catctcagct ggttacatga aattaatagt caggagttag
     2941 agaaggctca tacaacactg ctaggtttgg caaatatgga aactcgttac tttgcaaaga
     3001 aaaaaaccct tcttggcttg agtaaactgg cagctttagc ttcagacatt tcagaggaca
     3061 ggctgcaaga gaagattgaa gccatggctg agcaagagcg cttcctgcta caccaggaga
     3121 ccctgccaga gcagctgctg accgagagac agctgagtct tagtgcaatg cctgtgttga
     3181 ccgcaccaca actcatcagt ctgtatatct gtgacgaaaa cagaagagcc aatgagtatg
     3241 atttcaagaa agccttggac ttactggagt acattgatga ggaagaagat gtgagcattg
     3301 atgacctgaa gctggagatt ctgtgcagag cactgcagag agatgactgg tctggttcag
     3361 atggcaaaga tgatccaatc gaagtgtcta aagacagtgt gtttgtaaag atcttgcaga
     3421 aacttataaa agacggcatc cagctcagcg agtacttgcc agaggtgacg gacctactgc
     3481 gagcagagca gctgggaagc ctcaagtcca actcttactt tgagtttgtt ctgaaagcaa
     3541 attatgagta ttatgtccaa ggacagatgt gacatttgta gaaatggttg tttctaaaat
     3601 ttgtgtaaat atttgcttat taaaaaaaaa tattgaggcc aaaaaactta ggtctggatc
     3661 aacctgaagt ctgttttgtc tgcagcaacc aggttttcta tgctttatat gggagccgcg
     3721 atataaaagg aggggccctg atgctctttt tcagctgtaa ggtatttcct cctcctcttc
     3781 cacctgaagt cacccttgct tctgtgtagc tgcccttctc cagcctccct cggtccaaag
     3841 aggcagcaaa acaaaacagg ttgcctcgct ccccaactgg ttgtccaata ccagccctga
     3901 aaaaatataa gaatgtgtat aataatatac atgaatttac atgcaagtaa cgttctatgg
     3961 gctgagcaag tgtgtctgtt tatttgggtc agcaattaaa agatgctaca ggttggagag
     4021 cagggcagcg gaagtgagga agtgttggag atggcagggg acggggaaaa cagattgccc
     4081 tctgcatgtg gcactctggg agtctctgag aagctgatct cttggtcgga ggcaaaggga
     4141 agtgcctgct tagcaaagtg aagatgagat gtcactgatt tatactgtgg cctagaaacc
     4201 aaaaccctgg gtctaactcg ggagggtggg cagctggtaa ctcactggga atgttctcac
     4261 ttcctacatt gatttaaaaa ttacaagcaa ggggcagggc tggagagatg gctcagtggt
     4321 taagagcgct gtctactctt ccagaggact tgaattcaat tcccagcaac cacatggtgg
     4381 ctcactacca tctgtaatag gtcccagggc cctcttctgg tgtgtctgaa gacagtgaca
     4441 gtgtactcac atatataaaa taaatctttt ttaaaaaaaa agttaaaact taaaagccaa
     4501 aaaagccata tatatatgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     4561 tgtgtaaaat taaaggatta aaagtgtggg ccactgcatc catcaataat ggataagtct
     4621 taaagtgttt tagtaagatg tttgtgtggc tttctgagct gtcagtaagt tgtcattgct
     4681 accagatatg gtactggcat tgtctgtgac cccagtattg actcataaac ctaggatggt
     4741 ttctagtctc accgtagacg gtcccttcct aaacatcgta atgccaaggc tggtctaccc
     4801 agagatgttg ctctgagagc tctggccatg gcctacctgt ctgaagaagg gggctaaacc
     4861 tttatggcaa ctatcgcagc ttcagaatgg ttggcatgta aacttactcc agcagtaaaa
     4921 atgaaattaa gactttcagt gttgaatatc tttccctcct aagttttaaa aactggtcac
     4981 ataatccatc tctgaagaat gaatgatttg tttctaagtc aggtagctaa gactgtctcc
     5041 tggtacccgg tgtacattct tgggatcctt ctcttgttgg cctatccgtt agttcagcat
     5101 gaactagtta ggactgtgaa tggcagcagc cacccttgtc cctgaggtga gtgtgctgta
     5161 ttctgaggat gtgtgagtca gtcaggacct gaaagggccc tggcaacctg tacagagcac
     5221 agggggaaag gttttgttgt tttattctct tgactggatg ctatggggag agccagaggt
     5281 ctgcaagaca aattcatggt gtttcgggct gtcatggttg gtcccacatt ctgagtgttc
     5341 ccagtgtggc ctcccccacc actgccagtc tgtcctcaga atggcataat attcatgtat
     5401 aaaatacaat atatgttgaa aaacaatgtg tatatatgtt gtatatattt atcatatgtg
     5461 tatgatatgt gcatataaac tctggctggc ctcaaactct cagcccctgt gcctcagctt
     5521 cccaagtcct aaaactgcaa gtgtacacac cagccctggc tagaacaatt tttttaaggc
     5581 gtgtgaagcc tgacattgag ctcatatcca aaataaacac aagtaactgg tggacctgga
     5641 agctgggctt ctgttttgaa atgagcttca gtcgaccacc ttttgtattg tgtgggcaat
     5701 ggtgagtact tagcacacct ttggacttct gttctcagag gagctccagt tttccttctc
     5761 ctgctgggat ggcaggtcct tgcatgcatc tgcattgcct taataaaaac gaggttttct
     5821 ttt
//
