LOCUS       NM_134010               3111 bp    mRNA    linear   ROD 13-DEC-2024
DEFINITION  Mus musculus nucleoporin 107 (Nup107), transcript variant 1, mRNA.
ACCESSION   NM_134010
VERSION     NM_134010.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3111)
  AUTHORS   Kim,S., Phan,S., Tran,H.T., Shaw,T.R., Shahmoradian,S.H.,
            Ellisman,M.H., Veatch,S.L., Barmada,S.J., Pappas,S.S. and
            Dauer,W.T.
  TITLE     TorsinA is essential for neuronal nuclear pore complex localization
            and maturation
  JOURNAL   Nat Cell Biol 26 (9), 1482-1495 (2024)
   PUBMED   39117796
REFERENCE   2  (bases 1 to 3111)
  AUTHORS   Olthof,A.M., White,A.K., Mieruszynski,S., Doggett,K., Lee,M.F.,
            Chakroun,A., Abdel Aleem,A.K., Rousseau,J., Magnani,C.,
            Roifman,C.M., Campeau,P.M., Heath,J.K. and Kanadia,R.N.
  TITLE     Disruption of exon-bridging interactions between the minor and
            major spliceosomes results in alternative splicing around minor
            introns
  JOURNAL   Nucleic Acids Res 49 (6), 3524-3545 (2021)
   PUBMED   33660780
REFERENCE   3  (bases 1 to 3111)
  AUTHORS   Sachani,S.S., Landschoot,L.S., Zhang,L., White,C.R.,
            MacDonald,W.A., Golding,M.C. and Mann,M.R.W.
  TITLE     Nucleoporin 107, 62 and 153 mediate Kcnq1ot1 imprinted domain
            regulation in extraembryonic endoderm stem cells
  JOURNAL   Nat Commun 9 (1), 2795 (2018)
   PUBMED   30022050
  REMARK    GeneRIF: Nucleoporins 107, 62 and 153 mediate Kcnq1ot1 imprinted
            domain regulation in extraembryonic endoderm stem cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3111)
  AUTHORS   Ren,Y., Diao,F., Katari,S., Yatsenko,S., Jiang,H.,
            Wood-Trageser,M.A. and Rajkovic,A.
  TITLE     Functional study of a novel missense single-nucleotide variant of
            NUP107 in two daughters of Mexican origin with premature ovarian
            insufficiency
  JOURNAL   Mol Genet Genomic Med 6 (2), 276-281 (2018)
   PUBMED   29363275
REFERENCE   5  (bases 1 to 3111)
  AUTHORS   Kim,C.E., Perez,A., Perkins,G., Ellisman,M.H. and Dauer,W.T.
  TITLE     A molecular mechanism underlying the neural-specific defect in
            torsinA mutant mice
  JOURNAL   Proc Natl Acad Sci U S A 107 (21), 9861-9866 (2010)
   PUBMED   20457914
REFERENCE   6  (bases 1 to 3111)
  AUTHORS   Lupu,F., Alves,A., Anderson,K., Doye,V. and Lacy,E.
  TITLE     Nuclear pore composition regulates neural stem/progenitor cell
            differentiation in the mouse embryo
  JOURNAL   Dev Cell 14 (6), 831-842 (2008)
   PUBMED   18539113
REFERENCE   7  (bases 1 to 3111)
  AUTHORS   Suntharalingam,M. and Wente,S.R.
  TITLE     Peering through the pore: nuclear pore complex structure, assembly,
            and function
  JOURNAL   Dev Cell 4 (6), 775-789 (2003)
   PUBMED   12791264
  REMARK    Review article
REFERENCE   8  (bases 1 to 3111)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135019.3.
            
            On Mar 24, 2023 this sequence version replaced NM_134010.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057591.1, AK088303.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AC135019.3         101331-101429       c
            100-191             AC135019.3         99194-99285         c
            192-278             AC135019.3         98701-98787         c
            279-397             AC135019.3         96520-96638         c
            398-542             AC135019.3         93722-93866         c
            543-646             AC135019.3         90684-90787         c
            647-774             AC135019.3         90048-90175         c
            775-823             AC135019.3         89405-89453         c
            824-895             AC135019.3         86320-86391         c
            896-984             AC135019.3         85856-85944         c
            985-1063            AC135019.3         84938-85016         c
            1064-1177           AC135019.3         83183-83296         c
            1178-1268           AC135019.3         82003-82093         c
            1269-1345           AC135019.3         81782-81858         c
            1346-1405           AC135019.3         80061-80120         c
            1406-1551           AC135019.3         79103-79248         c
            1552-1600           AC135019.3         78915-78963         c
            1601-1670           AC135019.3         75061-75130         c
            1671-1789           AC135019.3         74638-74756         c
            1790-1828           AC135019.3         73044-73082         c
            1829-1979           AC135019.3         72458-72608         c
            1980-2092           AC135019.3         70750-70862         c
            2093-2195           AC135019.3         69972-70074         c
            2196-2356           AC135019.3         67899-68059         c
            2357-2482           AC135019.3         66623-66748         c
            2483-2596           AC135019.3         65994-66107         c
            2597-2764           AC135019.3         60047-60214         c
            2765-3111           AC135019.3         59348-59694         c
FEATURES             Location/Qualifiers
     source          1..3111
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 66.32 cM"
     gene            1..3111
                     /gene="Nup107"
                     /note="nucleoporin 107"
                     /db_xref="GeneID:103468"
                     /db_xref="MGI:MGI:2143854"
     exon            1..99
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..2872
                     /gene="Nup107"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear pore complex protein Nup107; nucleoporin Nup107;
                     107 kDa nucleoporin"
                     /codon_start=1
                     /product="nuclear pore complex protein Nup107 isoform 1"
                     /protein_id="NP_598771.1"
                     /db_xref="CCDS:CCDS36068.1"
                     /db_xref="GeneID:103468"
                     /db_xref="MGI:MGI:2143854"
                     /translation="MDRSGFGGMSSPVIRDAEVTRTARKHSAHKRVLIQANQEDNFGT
                     ATPRSQIIPRTPSSFRQPFVTPSSRSLLRHPDISYILGTEGRSPRHTQSSGYLGNLSM
                     VTNLDDSNWAAAFSSQRLGLYTNTEHHSMTEDVNLSTVMLREDDPGEAASMSMFSDFL
                     HSFLKHSSTTVFDLVEEYENICGSQVNILSKIVSRATPGLQKFSKTASMLWLLQQEMV
                     TWRLLASLYRDRIQSSLEEENMFAIAGINASEKMVVETLFQRDSLVRQSQLVVDWLES
                     IAKDEIGEFSDNIEFYAKSVYWENTLHSLKQRQLLSHMGSTRPLVTELDPDAPIRQKL
                     PLDDLDREDEVRLLKYLFTLIRAGMTEEAQRLCKRCGQAWRAATLEGWKLYHDPNVNG
                     GTELEPVEGNPYRRIWKISCWRMAEDELFNKYERAIYAALSGNLKQLLPVCDTWEDTV
                     WAYFRVMVDSLVEQEIRTSVMTQDDSEELPREYMEANWTLEKVFEELQATDKKRVLEE
                     NQEHYHIVQKFLILGDVDGLMDEFSKWLSKSGSSLPGHLLRFMTHLILFLRTLGLQTK
                     EEVSIEVLKTYIQLLISEKHTSLIAFYTCHLPQDLAVAQYALFLEGVTEFEQRHQCLE
                     LAKEADLDVATITKTVVENICKKDNGEFSHHDLAPSLDTGTTEEDRLKIDVIDWLVFD
                     PAQRAEALRQGNAIMRKFLALKKHEAAKEVFVKIPQDSIAEIYNQWEEQGMESPLPAE
                     DDNAIREHLCIRAYLEAHETFNEWFKHMNSAPQKPTLLSQATFTEKVAYEHREKKYEM
                     DHNIWKGHLDALTADVKEKMYNVLLFVDGGWMVDVREDAEDDPERTHQMVLLRKLCLP
                     MLCFLLHTILHSTGQYQECLQLADMVSSERHKLYLVFSKEELRKLLQKLRESSLMLLD
                     QGLDPLGYEIQS"
     exon            100..191
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            192..278
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            279..397
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            398..542
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            543..646
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            647..774
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            775..823
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            824..895
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            896..984
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1063
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1177
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1268
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1345
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1405
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1551
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1600
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1670
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1789
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1828
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1979
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2092
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2195
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2356
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2482
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            2483..2596
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2764
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..3111
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2953..2958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nup107"
                     /note="hexamer: AATATA"
     polyA_site      2972
                     /gene="Nup107"
     regulatory      3092..3097
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nup107"
                     /note="hexamer: AATAAA"
     polyA_site      3111
                     /gene="Nup107"
                     /note="major polyA site"
ORIGIN      
        1 gggtgtgctt ccggagagcg ggaaggctga aacgcggcgg ccaggctgca gtcaaagagt
       61 tgcaaggttc taggcggaga ccgctgaagc catggacagg agtggcttcg gggggatgtc
      121 atcccctgtg atccgggatg cggaggtgac gaggactgcc cggaagcaca gtgctcacaa
      181 aagagttcta attcaggcca accaagagga caattttggt actgctacac caagaagcca
      241 gatcattcct cgaacgccaa gctcctttcg acagcctttt gttactccat cgagccgaag
      301 cctactgaga cacccggata tttcctacat tcttggaacg gaagggaggt ctccccggca
      361 cacacagtct tctgggtact tgggaaatct ttctatggtg actaatcttg atgacagcaa
      421 ctgggcagct gcattctcat cccagcgttt agggctctac acaaacacag agcatcatag
      481 tatgaccgag gatgtgaacc taagtactgt catgctacgg gaagacgacc ctggagaggc
      541 tgcatccatg agcatgttct ctgatttcct gcactctttc ttgaagcact cttcaaccac
      601 agtctttgat ctcgtagaag aatatgaaaa tatttgtggt agtcaggtga atatcctcag
      661 taaaatagtg agccgcgcaa cgcctggact gcagaagttt tccaagacgg ccagtatgct
      721 ctggcttctc caacaggaga tggtcacatg gaggctgctc gcctctttgt acagagacag
      781 aatacagtct tcattagaag aggaaaatat gtttgcaatt gctggtatta atgccagcga
      841 gaagatggtt gtggaaacgc tgtttcagag ggactcactg gtccggcaga gccagttggt
      901 ggtagattgg ctagagagta ttgccaaaga tgaaatcgga gaattctcgg acaatattga
      961 gttttatgca aaatcagtgt attgggaaaa taccctccac tccttaaagc agcggcagct
     1021 actgtctcac atgggaagta cccggcctct ggtcaccgaa ctggacccag acgctcccat
     1081 tagacagaag ttgccactcg acgatctgga cagagaggac gaggtcagac tgctgaagta
     1141 cctcttcacg ctcatccgtg ctggcatgac agaggaggca caacggctct gtaaacggtg
     1201 tgggcaagca tggcgagctg caaccctgga aggctggaaa ctgtaccatg accctaatgt
     1261 taatggaggg acagagctag aacctgttga agggaatcca tatagacgca tctggaagat
     1321 tagttgctgg agaatggctg aagatgaact ttttaataaa tatgaaagag cgatttacgc
     1381 ggcactgagt gggaacctta agcagctcct tccagtctgt gacacgtggg aagacacggt
     1441 gtgggcctac ttccgggtga tggtggatag cctggtggag caggagattc ggacatcagt
     1501 aatgacgcag gatgacagtg aggagctccc tcgagagtac atggaagcca attggacctt
     1561 agaaaaagtt tttgaagaac ttcaagccac tgataaaaag agagttctgg aggagaatca
     1621 agagcattac catatagttc agaaattcct tatcctggga gacgttgatg gtttgatgga
     1681 tgaatttagc aaatggctgt ccaagagcgg aagcagtctg cccggacacc tgctccgctt
     1741 catgacacac ctcattctgt ttctccgcac cctaggcctc cagaccaagg aagaagtttc
     1801 cattgaagtt ctaaaaacat atatacagct gttaataagc gagaagcaca caagcctcat
     1861 agcgttctat acctgtcatc tgcctcaaga cctcgccgtg gcccagtatg ccttattttt
     1921 ggaaggtgtt acggaatttg agcagcggca ccagtgccta gagctggcta aggaagcaga
     1981 cttggatgtt gcgacgataa cgaaaactgt agttgagaat atttgcaaga aagataatgg
     2041 tgaatttagt caccatgacc tggctccatc cctagacact ggcactactg aggaggaccg
     2101 cctgaagatt gatgtgatcg actggctcgt gtttgacccg gcacagagag cggaagccct
     2161 gaggcaaggc aacgccatca tgaggaagtt cttagcatta aagaaacatg aagctgcaaa
     2221 agaagtgttt gtgaaaattc ctcaggattc catcgcagag atctataatc agtgggagga
     2281 gcaaggcatg gagagccctc ttcctgccga ggatgataac gccatccgag agcatttgtg
     2341 tatcagagcc tatctggaag cccatgaaac cttcaacgaa tggtttaaac atatgaattc
     2401 ggctccacag aaacctacat tactatctca agcaactttt acagagaaag tggcttatga
     2461 acacagagaa aagaaatacg agatggatca taatatttgg aaaggacatt tggatgccct
     2521 aactgctgat gtgaaggaga aaatgtacaa cgtcttgttg tttgttgatg gaggatggat
     2581 ggtggatgtc agagaggacg ccgaggacga ccctgagcgg acgcatcaga tggttttact
     2641 gaggaagctc tgtctcccca tgctgtgctt cctgcttcac accatactgc acagcaccgg
     2701 acagtaccag gagtgcctgc agctggccga catggtgtcc tctgagcgcc acaagctcta
     2761 tctggtgttt tctaaggaag aactaaggaa actgctgcag aagttaaggg agtcctctct
     2821 aatgctccta gaccaggggc tcgacccgct tggctatgaa attcagtcat aactcaccat
     2881 tctctgatgc ccatgactag aggaggatgc ttgcttgctt cgttgagttg cttggttggt
     2941 tggttttggt caaatatacg tatttgtaat tattggtttg tttgtttgtt tgtttttcct
     3001 ttggcattct tggggaaaat gtaaaattca ggcatttgga ttttgtatta tatcagtatt
     3061 tccttatgta ttttttaaat aaattataca aaataaattt tttgttctat a
//
