LOCUS       NM_001411949            3684 bp    mRNA    linear   ROD 17-JUL-2024
DEFINITION  Mus musculus NUMB endocytic adaptor protein (Numb), transcript
            variant 7, mRNA.
ACCESSION   NM_001411949 XM_006515576
VERSION     NM_001411949.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3684)
  AUTHORS   De Gasperi,R., Csernoch,L., Dienes,B., Gonczi,M., Chakrabarty,J.K.,
            Goeta,S., Aslan,A., Toro,C.A., Karasik,D., Brown,L.M., Brotto,M.
            and Cardozo,C.P.
  TITLE     Septin 7 interacts with Numb to preserve sarcomere structural
            organization and muscle contractile function
  JOURNAL   Elife 12, 89424 (2024)
   PUBMED   38695862
  REMARK    GeneRIF: Septin 7 interacts with Numb to preserve sarcomere
            structural organization and muscle contractile function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3684)
  AUTHORS   Su,D., Li,Y., Zhang,W., Gao,H., Cheng,Y., Hou,Y., Li,J., Ye,Y.,
            Lai,Z., Li,Z., Huang,H., Li,J., Li,J., Cheng,M., Nian,C., Wu,N.,
            Zhou,Z., Xing,Y., Zhao,Y., Liu,H., Tang,J., Chen,Q., Hong,L.,
            Li,W., Peng,Z., Zhao,B., Johnson,R.L., Liu,P., Hong,W., Chen,L. and
            Zhou,D.
  TITLE     SPTAN1/NUMB axis senses cell density to restrain cell growth and
            oncogenesis through Hippo signaling
  JOURNAL   J Clin Invest 133 (20), e168888 (2023)
   PUBMED   37843276
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3684)
  AUTHORS   Liu,W., Xie,H., Liu,X., Xu,S., Cheng,S., Wang,Z., Xie,T.,
            Zhang,Z.C. and Han,J.
  TITLE     PQBP1 regulates striatum development through balancing striatal
            progenitor proliferation and differentiation
  JOURNAL   Cell Rep 42 (3), 112277 (2023)
   PUBMED   36943865
REFERENCE   4  (bases 1 to 3684)
  AUTHORS   Gulino,A., Di Marcotullio,L. and Screpanti,I.
  TITLE     The multiple functions of Numb
  JOURNAL   Exp Cell Res 316 (6), 900-906 (2010)
   PUBMED   19944684
  REMARK    Review article
REFERENCE   5  (bases 1 to 3684)
  AUTHORS   Bani-Yaghoub,M., Kubu,C.J., Cowling,R., Rochira,J.,
            Nikopoulos,G.N., Bellum,S. and Verdi,J.M.
  TITLE     A switch in numb isoforms is a critical step in cortical
            development
  JOURNAL   Dev Dyn 236 (3), 696-705 (2007)
   PUBMED   17253625
  REMARK    Erratum:[Dev Dyn. 2007 Apr;236(4):1158]
REFERENCE   6  (bases 1 to 3684)
  AUTHORS   Yoshida,T., Tokunaga,A., Nakao,K. and Okano,H.
  TITLE     Distinct expression patterns of splicing isoforms of mNumb in the
            endocrine lineage of developing pancreas
  JOURNAL   Differentiation 71 (8), 486-495 (2003)
   PUBMED   14641329
  REMARK    GeneRIF: mNumb splicing isoform has an inhibitory effect on Notch
            signaling, indicating its potential roles in the differentiation of
            pancreatic endocrine lineage.
REFERENCE   7  (bases 1 to 3684)
  AUTHORS   Dho,S.E., French,M.B., Woods,S.A. and McGlade,C.J.
  TITLE     Characterization of four mammalian numb protein isoforms.
            Identification of cytoplasmic and membrane-associated variants of
            the phosphotyrosine binding domain
  JOURNAL   J Biol Chem 274 (46), 33097-33104 (1999)
   PUBMED   10551880
REFERENCE   8  (bases 1 to 3684)
  AUTHORS   Dho,S.E., Jacob,S., Wolting,C.D., French,M.B., Rohrschneider,L.R.
            and McGlade,C.J.
  TITLE     The mammalian numb phosphotyrosine-binding domain. Characterization
            of binding specificity and identification of a novel PDZ
            domain-containing numb binding protein, LNX
  JOURNAL   J Biol Chem 273 (15), 9179-9187 (1998)
   PUBMED   9535908
REFERENCE   9  (bases 1 to 3684)
  AUTHORS   Zhong,W., Jiang,M.M., Weinmaster,G., Jan,L.Y. and Jan,Y.N.
  TITLE     Differential expression of mammalian Numb, Numblike and Notch1
            suggests distinct roles during mouse cortical neurogenesis
  JOURNAL   Development 124 (10), 1887-1897 (1997)
   PUBMED   9169836
REFERENCE   10 (bases 1 to 3684)
  AUTHORS   Zhong,W., Feder,J.N., Jiang,M.M., Jan,L.Y. and Jan,Y.N.
  TITLE     Asymmetric localization of a mammalian numb homolog during mouse
            cortical neurogenesis
  JOURNAL   Neuron 17 (1), 43-53 (1996)
   PUBMED   8755477
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC133183.3 and AC132954.4.
            
            On Sep 13, 2022 this sequence version replaced XM_006515576.3.
            
            Summary: This gene encodes a conserved protein that is distributed
            asymmetrically during cell division in the developing embryo. The
            encoded protein participates in cell fate decisions by interacting
            with the Notch receptor. Loss of function of this gene results in
            severe defects in neural development and loss of viability.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jan 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.76356.1,
                                           SRR14777534.732160.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AC133183.3         142965-143038
            75-219              AC132954.4         8798-8942
            220-304             AC132954.4         30086-30170
            305-445             AC132954.4         43252-43392
            446-520             AC132954.4         53614-53688
            521-553             AC132954.4         60319-60351
            554-628             AC132954.4         74250-74324
            629-769             AC132954.4         77369-77509
            770-974             AC132954.4         81626-81830
            975-1268            AC132954.4         84304-84597
            1269-1418           AC132954.4         85953-86102
            1419-1565           AC132954.4         88267-88413
            1566-3684           AC132954.4         89456-91574
FEATURES             Location/Qualifiers
     source          1..3684
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 38.89 cM"
     gene            1..3684
                     /gene="Numb"
                     /gene_synonym="Nb"
                     /note="NUMB endocytic adaptor protein"
                     /db_xref="GeneID:18222"
                     /db_xref="MGI:MGI:107423"
     exon            1..74
                     /gene="Numb"
                     /gene_synonym="Nb"
                     /inference="alignment:Splign:2.1.0"
     exon            75..219
                     /gene="Numb"
                     /gene_synonym="Nb"
                     /inference="alignment:Splign:2.1.0"
     exon            220..304
                     /gene="Numb"
                     /gene_synonym="Nb"
                     /inference="alignment:Splign:2.1.0"
     exon            305..445
                     /gene="Numb"
                     /gene_synonym="Nb"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..2281
                     /gene="Numb"
                     /gene_synonym="Nb"
                     /note="isoform 1 is encoded by transcript variant 7;
                     protein numb homolog; numb gene homolog"
                     /codon_start=1
                     /product="protein numb homolog isoform 1"
                     /protein_id="NP_001398878.1"
                     /db_xref="GeneID:18222"
                     /db_xref="MGI:MGI:107423"
                     /translation="MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYL
                     GHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKT
                     KDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGC
                     AFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQLQDAKK
                     AETDKTVVGPSVAPGNTAPSPSSPTSPTPDGTASSEMNNPHAIPRRHAPIEQLARQGS
                     FRGFPALSQKMSPFKRQLSLRINELPSTMQRKTDFPIKNTVPEVEGEAESISSLCSQI
                     TSAFSTPSEDPFSSAPMTKPVTLVAPQSPVLQANGTDSASHVLTAKPANTALAHVAMP
                     VRETNPWAHVPDAANKEIAAIHPGTEWGQSSGAASPGLFQAGHRRTPSEADRWLEEVS
                     KSVRAQQPQVSAAPLQPVLQPPPPAAIAPPAPPFQGHAFLTSQPVPVGVVPPLQPAFV
                     PTQSYPVANGMPYPASNVPVVGITPSQMVANVFGTAGHPQTTHPHQSPSLAKQQTFPQ
                     YETSSATTSPFFKPPAQHLNGSAAFNGVDNGGLASGNRHAEVPPGTCPVDPFEAQWAA
                     LESKSKQRTNPSPTNPFSSDLQKTFEIEL"
     exon            446..520
                     /gene="Numb"
                     /gene_synonym="Nb"
                     /inference="alignment:Splign:2.1.0"
     exon            521..553
                     /gene="Numb"
                     /gene_synonym="Nb"
                     /inference="alignment:Splign:2.1.0"
     exon            554..628
                     /gene="Numb"
                     /gene_synonym="Nb"
                     /inference="alignment:Splign:2.1.0"
     exon            629..769
                     /gene="Numb"
                     /gene_synonym="Nb"
                     /inference="alignment:Splign:2.1.0"
     exon            770..974
                     /gene="Numb"
                     /gene_synonym="Nb"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1268
                     /gene="Numb"
                     /gene_synonym="Nb"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1418
                     /gene="Numb"
                     /gene_synonym="Nb"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1565
                     /gene="Numb"
                     /gene_synonym="Nb"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..3684
                     /gene="Numb"
                     /gene_synonym="Nb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3631..3636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Numb"
                     /gene_synonym="Nb"
                     /note="hexamer: AATAAA"
     polyA_site      3664
                     /gene="Numb"
                     /gene_synonym="Nb"
     polyA_site      3684
                     /gene="Numb"
                     /gene_synonym="Nb"
                     /note="major polyA site"
ORIGIN      
        1 ggtggtggcg cttggtggct actggcggcg gaggtagagt ctgaggcgcc ggagttgttc
       61 agggccagcg gcagatttca gattttgcag cctaaggaac attttccagg ggagactgcc
      121 agtgcagcca ccttggcaac caagatcctg atccagagcc acatagccac agactggagt
      181 actggtgggc cacagtcctc aaataccttc tcaaggcaga tgaggaaact gacacttggt
      241 gaagttacga aatttgtcca aagtcacaca gcttgtaaaa ggcacagcca agattcagag
      301 ccaggttgta aaagttaaca tgaacaaact acggcaaagc ttcaggagaa agaaagacgt
      361 ttatgtccca gaggccagcc gtccacatca gtggcagaca gatgaagaag gagtccgcac
      421 tggaaagtgt agcttcccag ttaagtacct cggccacgta gaagttgatg agtcaagagg
      481 aatgcacatc tgtgaagatg ccgtaaagag attgaaagct gaaaggaagt tcttcaaagg
      541 cttctttgga aaaacgggaa agaaagcagt gaaggccgtt ctgtgggtgt cagcggatgg
      601 gctcagagtt gtggacgaga aaactaagga cctcatagtt gaccagacaa tagaaaaagt
      661 ttccttctgt gccccagata ggaactttga cagagccttt tcttacatat gtcgtgatgg
      721 caccactcgg cgatggatct gtcattgttt catggctgtc aaagacacgg gggaaagact
      781 gagccacgcc gtgggctgtg cttttgcagc ctgtttagag cgtaaacaga agcgggagaa
      841 ggagtgtggc gtcactgcta cttttgatgc cagtagaacc actttcacaa gagaaggatc
      901 attccgtgtc acaactgcca ctgagcaagc cgaaagagag gagatcatga aacagttgca
      961 agatgccaag aaagctgaga cagacaagac agttgttggt ccatcagtgg ctcctggcaa
     1021 cactgctcca tccccatcct ctcccacctc tcccactccg gatggcactg catcttcaga
     1081 gatgaacaat ccccatgcta tcccacgccg gcatgcacca attgaacagc ttgctcgtca
     1141 aggctctttc cggggatttc ctgctcttag ccagaagatg tcacccttta aacgccagct
     1201 gtccctacgc atcaatgagt tgccttccac tatgcagagg aagaccgatt tcccaataaa
     1261 aaacacagtg cccgaggtgg aaggagaggc cgagagcatc agctccttgt gttcccagat
     1321 caccagtgcc ttcagcacgc cctctgagga ccccttctcc tccgccccaa tgaccaaacc
     1381 agtgacattg gtggcaccac agtctcctgt gttacaagct aatggcactg actcagcctc
     1441 ccatgtgctt actgctaagc cagccaatac tgctctagca cacgtagcaa tgcctgtccg
     1501 tgaaaccaac ccctgggccc atgtccctga tgctgctaac aaggaaattg cagccataca
     1561 tccggggact gagtggggtc agtcttctgg tgctgcctct ccaggtctct tccaggctgg
     1621 tcacagacgc actccctctg aagctgaccg ctggttagaa gaagtgtcaa agagtgtgcg
     1681 ggcccagcag cctcaggtct cagctgcccc tctgcagcca gttctccagc cgcctccgcc
     1741 cgccgccatt gcccctccag cacctccttt ccaaggacat gccttcctca cgtcccagcc
     1801 tgtgcccgtg ggtgtggtcc cacccctaca accagccttt gtccctaccc agtcctaccc
     1861 tgtggccaac gggatgccct acccagcctc taatgtgcct gtagtgggca tcaccccatc
     1921 ccagatggta gccaatgtgt ttggcactgc aggccaccct cagacaactc atccacatca
     1981 gtcgccaagc ctggccaagc agcagacatt ccctcaatat gagacaagta gtgctaccac
     2041 cagtcccttc tttaagcctc ctgctcagca cctcaatggt tctgcagctt tcaatggtgt
     2101 agacaatggt gggctagcct caggaaacag gcatgcagaa gtccctccag gcacctgccc
     2161 agtggatcct ttcgaagctc agtgggccgc actagaaagc aagtccaagc agcgtacaaa
     2221 tccttctcct accaaccctt tctccagtga cttacagaaa acatttgaaa tagaacttta
     2281 ggcagtctct gtgacaggtg ttttctgtac ttaggcaaga gcagggggtg gagggcaaag
     2341 gagcaaaggg gactttgttt gctttccaga tcagcacact tttcactaat cccagaggtc
     2401 ccaaggagca agtccaagca cagtccagca aggggtgacg tccacagaag tgaggcaagc
     2461 ctccctgggg aggactgccc tgcagctagg ctagagaagc caaggaaacc tggccttctg
     2521 gcccctctga ccctaacaaa tctctggcag cagagaggca gaagatctga agaggaatct
     2581 gtattcaaag cacatttact ggaatataaa acataacagg aagcaaaaca atctcccttt
     2641 atttttcagg ccagtcaccc gttcctccca gtcctgggct gtcttagcaa tcgctcgatg
     2701 gggacagtgt ggctgggtga agccaggcag gctatgctgc tgggttcacg ggagggcaca
     2761 gcagcagctg cccagtagag ctgtagtctg gggataaagc tgagcttcca ttttgagtta
     2821 cagaataaat attataaata tatatatata tatcaaaaag ccaaaatctt tatttttatg
     2881 cacctagaat attttaaata gttctcaata ttaaaaagta tgagttgtaa gtaatcttgc
     2941 caaaagtgag cgggttagat gtaagaaatt gtacataaga ttgatttatc attgatgcct
     3001 attgaagtaa aaaagaggaa gggttggaag ttgtaggcag gagccctggc ttgtttgtga
     3061 ccattcatgt taactagcac actgcgaaat ggtcataccg atgacccgtg cagtcactag
     3121 gtagtagttt taataagatg agcaagcagt gttgtcctgg ttttaaacct atggtgaaat
     3181 tctaatgtca tcatttgaat ggaatcaaat ctatgctcta gagaatgtat gttgaatctt
     3241 ttacatatca ttgcaatttc cttatgttaa tcctttagca ttacggtgac aatgacataa
     3301 tcatatccag aaaagggaac gcaggctatt gtgtcggttt gtaatgtggg tcttaatggg
     3361 ctctgtcctt gaagttttgt tcccataagt tttacaggga tgagattctg gcttctgtgc
     3421 tgtgtgtgtc tgtgtcccct tctgccccaa ccatgaacag agcatcccat gccagttgca
     3481 gctacttgac catgggtaac aacatgagac cccatctcat ttttactttt gaacgttggc
     3541 cttacaatca aatgtaagtt atatatacat atatatatac acatatatat atatttgtac
     3601 tgatgagaat ttataatctg ctttaacaaa aataaatgtt cgtggtagag cttttgccca
     3661 tgaagggctg ttcttatttg caaa
//
