LOCUS       NM_001403545            7290 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus nuclear mitotic apparatus protein 1 (Numa1),
            transcript variant 2, mRNA.
ACCESSION   NM_001403545 XM_006507173
VERSION     NM_001403545.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7290)
  AUTHORS   Nutter,C.A., Kidd,B.M., Carter,H.A., Hamel,J.I., Mackie,P.M.,
            Kumbkarni,N., Davenport,M.L., Tuyn,D.M., Gopinath,A., Creigh,P.D.,
            Sznajder,L.J., Wang,E.T., Ranum,L.P.W., Khoshbouei,H., Day,J.W.,
            Sampson,J.B., Prokop,S. and Swanson,M.S.
  TITLE     Choroid plexus mis-splicing and altered cerebrospinal fluid
            composition in myotonic dystrophy type 1
  JOURNAL   Brain 146 (10), 4217-4232 (2023)
   PUBMED   37143315
REFERENCE   2  (bases 1 to 7290)
  AUTHORS   He,S., Gillies,J.P., Zang,J.L., Cordoba-Beldad,C.M., Yamamoto,I.,
            Fujiwara,Y., Grantham,J., DeSantis,M.E. and Shibuya,H.
  TITLE     Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate
            mitotic and male meiotic spindle bipolarity
  JOURNAL   Nat Commun 14 (1), 1715 (2023)
   PUBMED   36973253
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7290)
  AUTHORS   Cai,S., Si,N., Wang,Y. and Yin,N.
  TITLE     Transcriptomic analysis of the upper lip and primary palate
            development in mice
  JOURNAL   Front Genet 13, 1039850 (2023)
   PUBMED   36685938
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7290)
  AUTHORS   Capizzi,M., Carpentier,R., Denarier,E., Adrait,A., Kassem,R.,
            Mapelli,M., Coute,Y. and Humbert,S.
  TITLE     Developmental defects in Huntington's disease show that axonal
            growth and microtubule reorganization require NUMA1
  JOURNAL   Neuron 110 (1), 36-50 (2022)
   PUBMED   34793694
  REMARK    GeneRIF: Developmental defects in Huntington's disease show that
            axonal growth and microtubule reorganization require NUMA1.
REFERENCE   5  (bases 1 to 7290)
  AUTHORS   Moreci,R.S. and Lechler,T.
  TITLE     KIF18B is a cell type-specific regulator of spindle orientation in
            the epidermis
  JOURNAL   Mol Biol Cell 32 (21), ar29 (2021)
   PUBMED   34432485
REFERENCE   6  (bases 1 to 7290)
  AUTHORS   Wang,X., Yang,Y., Duan,Q., Jiang,N., Huang,Y., Darzynkiewicz,Z. and
            Dai,W.
  TITLE     sSgo1, a major splice variant of Sgo1, functions in centriole
            cohesion where it is regulated by Plk1
  JOURNAL   Dev Cell 14 (3), 331-341 (2008)
   PUBMED   18331714
REFERENCE   7  (bases 1 to 7290)
  AUTHORS   Van Thuan,N., Wakayama,S., Kishigami,S. and Wakayama,T.
  TITLE     Donor centrosome regulation of initial spindle formation in mouse
            somatic cell nuclear transfer: roles of gamma-tubulin and nuclear
            mitotic apparatus protein 1
  JOURNAL   Biol Reprod 74 (5), 777-787 (2006)
   PUBMED   16407502
REFERENCE   8  (bases 1 to 7290)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 7290)
  AUTHORS   Thut,C.J., Rountree,R.B., Hwa,M. and Kingsley,D.M.
  TITLE     A large-scale in situ screen provides molecular evidence for the
            induction of eye anterior segment structures by the developing lens
  JOURNAL   Dev Biol 231 (1), 63-76 (2001)
   PUBMED   11180952
REFERENCE   10 (bases 1 to 7290)
  AUTHORS   Hilditch-Maguire,P., Trettel,F., Passani,L.A., Auerbach,A.,
            Persichetti,F. and MacDonald,M.E.
  TITLE     Huntingtin: an iron-regulated protein essential for normal nuclear
            and perinuclear organelles
  JOURNAL   Hum Mol Genet 9 (19), 2789-2797 (2000)
   PUBMED   11092755
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167240.5.
            
            On Apr 1, 2022 this sequence version replaced XM_006507173.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               AC167240.5         90890-91111         c
            223-293             AC167240.5         47757-47827         c
            294-379             AC167240.5         37396-37481         c
            380-459             AC167240.5         34555-34634         c
            460-542             AC167240.5         33479-33561         c
            543-623             AC167240.5         32489-32569         c
            624-711             AC167240.5         31895-31982         c
            712-829             AC167240.5         30427-30544         c
            830-987             AC167240.5         29653-29810         c
            988-1105            AC167240.5         29272-29389         c
            1106-1223           AC167240.5         29067-29184         c
            1224-1364           AC167240.5         28632-28772         c
            1365-1487           AC167240.5         27010-27132         c
            1488-4847           AC167240.5         23548-26907         c
            4848-4889           AC167240.5         22871-22912         c
            4890-4958           AC167240.5         17653-17721         c
            4959-5078           AC167240.5         15997-16116         c
            5079-5297           AC167240.5         15695-15913         c
            5298-5455           AC167240.5         15433-15590         c
            5456-5702           AC167240.5         14128-14374         c
            5703-5931           AC167240.5         13098-13326         c
            5932-6068           AC167240.5         12329-12465         c
            6069-6245           AC167240.5         11862-12038         c
            6246-6362           AC167240.5         11561-11677         c
            6363-6566           AC167240.5         11266-11469         c
            6567-7290           AC167240.5         10248-10971         c
FEATURES             Location/Qualifiers
     source          1..7290
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.7 cM"
     gene            1..7290
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /note="nuclear mitotic apparatus protein 1"
                     /db_xref="GeneID:101706"
                     /db_xref="MGI:MGI:2443665"
     exon            1..222
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /inference="alignment:Splign:2.1.0"
     exon            223..293
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..6578
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /note="isoform a is encoded by transcript variant 2"
                     /codon_start=1
                     /product="nuclear mitotic apparatus protein 1 isoform a"
                     /protein_id="NP_001390474.1"
                     /db_xref="GeneID:101706"
                     /db_xref="MGI:MGI:2443665"
                     /translation="MTLHATRAATLLSWVNSLHVADPVETVLQLQDCSIFIKIINTIH
                     DTKEGQQILQQPLPERLDFVCSFLQKNRKHPSSTQCLVSVQKVIEGSEMELAKMIMLF
                     LYQSTMSSRNLRDWEQFEYGVQAELAVILKFMLDHEESLNLTEDLESFLEKVPYTHAS
                     TLSEELSPPSHQTKRKIRFLEIQRIASSSSENNFLSGSPSSPMGDILQTPQFQMRRLK
                     KQLADERSNRDDLELELSESLKLLTEKDAQIAMMQQRIDHLALLNEKQAASSQEPSEL
                     EELRGKNESLTVRLHETLKQCQNLKTEKSQMDRKISQLSEENGDLSFKVREFANHLQQ
                     LQGAFNDLIEEHSKASQEWAEKQARLENELSTALQDKKCLEEKNEILQGKLSQLEDQA
                     TRLQESPAPEKGEVLGDALQLDTLKQEAAKLATDNTQLQTRVETLECERGKQEAQLLA
                     ERSRFEDEKQQLASLIADLQSSVSNLSQAKEELEQASQAQGAQLTAQLTSMTGLNATL
                     QQRDQELASLKEQAKKEQAQMLQTMQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAK
                     EQEATRQDHAQQLAIVAEAREASLRERDTARQQLETVEKEKDAKLESLQQQLQAANDA
                     RDNAQTSVTQAQQEKAELSQKIGELHACIEASHQEQRQVQARVTELEAQLKAEQQKTT
                     EREKVVQEKAQLQEQLRALEESLKITKGSLEEEKRRAADALKEQQCRATEMEAESRSL
                     MEQREREQKELEQEKAGRKGLEARIQQLEEAHQAETEALRHELAEATASQHRAESECE
                     RLIREVESRQKRFEARQQEEARYGAMFQEQLMALKGEKTGQEVQEEAVEIHSEGQPGQ
                     QQSQLAQLHASLAKAIQQVQEKEVRAQKLVDDLSALQEKMAATNKEVACLKTLVLKAG
                     EQQETASLELLKEPPRAANRASDQLGEQQGRPFSSTHAAVKAMEREAEQMGGELERLR
                     AALIKSQGQQQEERGQQEREVARLTQERGQAQADLAQEKAAKAELEMRLQNTLNEQRV
                     EFAALQEALAHALTEKEGTDQELAKLRGQEAAQRTELKELQQTLEQLKIQLVKKEKEH
                     PAGGASGEDASGPGTQSETAGKTDAPGPELQALRAEISKLEQQCQQQQQQVEGLTHSL
                     KSERACRAEQDKALETLQGQLEEKARELGHNQAASASAQRELQALRAKAQDHSKAEEE
                     WKAQVARGQQEAERKSSLISSLEEEVSILNRQVLEKEGESKELKRLVVAESEKSQKLE
                     ERLRLLQVETASNSARAAERSSALREEVQSLREEVEKQRVVSENSRQELASQAERAEE
                     LGQELKAWQEKFFQKEQALSALQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRFR
                     EELEQSKQAAGGLQAELMRAQRELGELGSLRQKIVEQERAAQQLRAEKASYAEQLSML
                     KKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRTDAETHLAEMRQEA
                     QSTSRELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSK
                     KLTEHDQASKVQQQKLKAFQAQRGESQQEVQRLQTQLNELQAQLSQKEQAAEHYKLQM
                     EKAKTHYDAKKQQNQKLQEQLQDLEELQKENKELRSEAERLGRELQQAGLKTKEAEQT
                     CRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQVKPQLDLSIDSLDLSLE
                     EGTPCSVASKLPRTQPDGTSVPGEPASPISQRLPPKVESLESLYFTPTPARGQAPLET
                     SLDSLGDAFPDSGRKTRSARRRTTQIINITMTKKLELEEPDSANSSFYSTQSAPASQA
                     NLRATSSTQSLARLGSPDDGNSALLSLPGYRPTTRSSARRSQARMSSGAPQGRNSFYM
                     GTCQDEPEQLDDWNRIAELQQRNRVCPPHLKTCYPLESRPTLSLATITDEEMKTGDPR
                     ETLRRASMQPAQIAEGVGITTRQQRKRVSSETHQGPGTPESKKATSCFPRPMTPRDRH
                     EGRKQSSTADTQKKAAPVLKQADRRQSMAFSILNTPKKLGNSLLRRGASKKTPAKVSP
                     NPRSGTRRSPRIATTTTGTATVATTPRAKGKVKH"
     exon            294..379
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /inference="alignment:Splign:2.1.0"
     exon            380..459
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /inference="alignment:Splign:2.1.0"
     exon            460..542
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /inference="alignment:Splign:2.1.0"
     exon            543..623
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /inference="alignment:Splign:2.1.0"
     exon            624..711
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /inference="alignment:Splign:2.1.0"
     exon            712..829
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /inference="alignment:Splign:2.1.0"
     exon            830..987
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1105
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1223
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1364
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1487
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..4847
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /inference="alignment:Splign:2.1.0"
     exon            4848..4889
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /inference="alignment:Splign:2.1.0"
     exon            4890..4958
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /inference="alignment:Splign:2.1.0"
     exon            4959..5078
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /inference="alignment:Splign:2.1.0"
     exon            5079..5297
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /inference="alignment:Splign:2.1.0"
     exon            5298..5455
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /inference="alignment:Splign:2.1.0"
     exon            5456..5702
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /inference="alignment:Splign:2.1.0"
     exon            5703..5931
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /inference="alignment:Splign:2.1.0"
     exon            5932..6068
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /inference="alignment:Splign:2.1.0"
     exon            6069..6245
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /inference="alignment:Splign:2.1.0"
     exon            6246..6362
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /inference="alignment:Splign:2.1.0"
     exon            6363..6566
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /inference="alignment:Splign:2.1.0"
     exon            6567..7290
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7266..7271
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /note="hexamer: AATAAA"
     polyA_site      7290
                     /gene="Numa1"
                     /gene_synonym="6720401E04Rik; NuMA"
                     /note="major polyA site"
ORIGIN      
        1 aatcgtgtct tcaccgtgcg agaaacaagt tgaggtgagg tgtggtccgg cgggctcgag
       61 gcggagcagc gcgcggccag gtaaccggcg cgggcccttg gctggcgtgc ggcctgggtg
      121 ctctcagggg acggctaggc ccagaggggg tgtgctgacc acgtcgatgc gagagaaagg
      181 tctccgtaac cgagggggaa aggagaacct acagggggcc aggtgagttg gagtgagcta
      241 gaatcagaaa gatgacactc catgccaccc gggcagctac gctcctttct tgggtgaaca
      301 gtctgcatgt tgctgacccc gtggagacag tgctgcagct ccaggactgc agcatcttca
      361 tcaagattat taacaccatc catgacacta aagaggggca acaaatccta cagcagccac
      421 taccggaaag actagacttt gtttgcagtt ttctacagaa aaatcggaaa catccttcat
      481 ctacacaatg cctggtatct gtgcagaaag tgatagaggg atccgagatg gaactggcca
      541 agatgataat gctgttttta tatcagtcca ccatgagctc cagaaacctc cgggactggg
      601 agcagtttga atatggggtt caggctgagt tagcggtcat cctgaagttt atgctggatc
      661 atgaggagtc gctaaacctt actgaggact tagagagttt cttggagaaa gttccttaca
      721 cccatgccag caccctctca gaagagcttt ctccacccag ccaccagacc aagaggaaga
      781 ttcgcttcct agaaatacag aggattgctt catcttccag tgagaacaac ttcctctcag
      841 gctctccatc ctcccctatg ggcgacatac tgcagacccc acagttccag atgagacgac
      901 tgaagaagca gctggcagac gagaggagca acagagatga cctggagctg gagctgtctg
      961 agagcctcaa gctcctcact gagaaggacg cgcagatcgc catgatgcag cagcgcattg
     1021 atcacctggc tctgctgaat gagaagcagg cagccagctc ccaggagccc agtgagcttg
     1081 aggagctccg aggcaagaat gaaagcctca ctgtgcggct gcatgagact ttgaagcagt
     1141 gtcagaacct gaagaccgag aagagccaga tggatcgaaa gattagccag ctttctgagg
     1201 agaatgggga cctttccttt aaggttcgag agtttgcaaa ccacttgcaa caacttcagg
     1261 gtgcattcaa cgacctgata gaggagcaca gcaaggcttc tcaggagtgg gcagagaagc
     1321 aggctcgtct ggaaaatgag ctcagcacag ccctccagga taagaaatgt cttgaagaga
     1381 agaatgaaat tcttcaggga aagctttccc agctggaaga tcaagcaact cggctgcagg
     1441 agagcccagc cccggagaag ggtgaggtgc taggagacgc cttgcagctg gacactctaa
     1501 agcaagaggc agccaaactt gccacagaca acacccagct ccaaacccgc gtagagacac
     1561 tggagtgtga acgtggcaag caggaagccc agctgcttgc tgaacggagc cgctttgaag
     1621 acgaaaagca gcagctggcc agcttgattg ctgaccttca gagctccgtc tctaacctca
     1681 gccaggccaa agaggagtta gagcaagcct cccaggccca aggggctcag ctcactgccc
     1741 agttgacctc tatgacaggg ctcaatgcca ccctgcagca gcgagatcaa gagctggcca
     1801 gtctgaaaga acaggccaaa aaggaacagg ctcagatgct acagaccatg caagagcaag
     1861 aacaggctgc ccagggcctc cgccagcagg tggagcagct gagcagcagc ctgaagctga
     1921 aggagcagca attagaagag gcagccaagg agcaggaggc aaccagacag gatcacgccc
     1981 agcaactggc catcgttgct gaggctcgag aggcctctct aagggaacgg gatactgctc
     2041 gccagcagct agaaacagtg gagaaggaga aggatgccaa gctagagagt ctgcagcagc
     2101 aacttcaggc tgccaatgat gctagggaca atgcgcagac ctcggtcaca caggctcagc
     2161 aggaaaaggc agagctgagc caaaagatag gagagcttca tgcctgcatt gaagcttccc
     2221 accaggaaca gcgtcaggtt caagctcgtg tgacagagct agaagcccag ctgaaagctg
     2281 agcagcaaaa aacaactgag cgagaaaagg tggttcagga gaaggcccag ctccaggagc
     2341 agctccgggc ccttgaggag tctttgaaga ttaccaaagg cagccttgaa gaagagaaac
     2401 gcagggctgc agatgccctg aaggagcagc agtgccgtgc cactgagatg gaggcagagt
     2461 ctcgaagcct gatggagcag cgggagcggg aacagaagga gttagagcaa gagaaggctg
     2521 ggcgaaaggg gctggaggcc cggatacagc agcttgaaga ggctcatcag gctgagactg
     2581 aagccttgcg gcatgagctg gcagaggcca cagcttccca gcacagagct gagagtgagt
     2641 gtgagcggct catcagagag gttgagagcc ggcagaagcg gtttgaagct agacagcaag
     2701 aggaggcaag gtacggtgcc atgttccagg aacagctgat ggctttgaaa ggggagaaga
     2761 ctggccaaga ggtccaggag gaggcagtag agatccacag tgaaggccag ccaggccagc
     2821 agcagagtca gctagcccag cttcatgcca gtctggccaa agccatccag caggtccagg
     2881 agaaggaagt gagagcacag aagctggtag atgatctctc agctctgcag gagaagatgg
     2941 ctgccactaa caaggaggtg gcctgtctga agaccttggt gctcaaggca ggtgagcagc
     3001 aggaaacagc ctcacttgag ctgctcaaag agcccccgag agctgcaaac agagcgtctg
     3061 accagctagg agaacagcag ggacggccat tctctagtac acacgcagca gtaaaagcta
     3121 tggagcgtga agctgagcag atgggcggtg aactggagag gctgcgggca gcactgatca
     3181 agagccaggg ccagcagcaa gaggagcgtg ggcaacagga gagggaggta gcacggctga
     3241 cccaggagcg gggccaggcc caggctgacc tggctcagga gaaggcagcc aaggcagagc
     3301 tggagatgcg actgcagaac accctcaatg agcagcgtgt ggagtttgct gccctacagg
     3361 aagcactggc ccatgccctg acagaaaagg aagggacaga ccaagagctt gccaaacttc
     3421 gagggcagga ggcagctcaa agaacagagc tgaaggagct tcaacagact ttggaacagc
     3481 tgaaaataca gttagtgaag aaagaaaaag agcaccctgc agggggtgcc agtggagaag
     3541 atgcttctgg cccaggaacc cagtcggaga cagctggaaa gacagatgca ccaggccctg
     3601 agttgcaggc acttcgggca gagatcagta agctagagca gcagtgtcag cagcagcagc
     3661 aacaggtgga aggcctgaca cacagcctca agtctgagcg ggcttgccgg gccgagcaag
     3721 acaaagccct ggagacactg cagggccagt tagaagagaa ggctcgagag ctagggcata
     3781 atcaggctgc ctcagcttca gctcagagag agttgcaagc cctccgtgct aaagcccagg
     3841 accatagcaa agctgaggaa gagtggaagg cccaggtagc ccggggccag caggaggctg
     3901 aaagaaaaag cagtcttatc agcagcttgg aagaggaggt atccatcctg aatcgccaag
     3961 tcctagagaa ggaaggggag agcaaggagt tgaagcgcct ggttgtagct gaatccgaga
     4021 agagccagaa gctggaagag aggctgcgcc tgcttcaagt agaaacagcc agcaatagtg
     4081 ccagggcagc agaacgcagc tcagctctac gagaggaggt ccagagcctc cgggaagagg
     4141 tggagaaaca gcgtgtagtt tcagagaact cgcggcagga gttggcctca caagcagagc
     4201 gagctgagga gttgggccaa gaattgaagg cctggcagga gaagtttttc cagaaggagc
     4261 aagctctctc tgccctgcag ctggagcaca ccagcacaca ggccctggta agtgagctgc
     4321 tgcctgccaa gcacctttgt cagcagctgc aagctgagca agcggctgcc gagaagcgct
     4381 tccgggagga gctcgagcag agcaagcagg cagctggtgg gctccaggca gagctgatgc
     4441 gggcccagcg ggagctcgga gagctcggat ctttgcggca gaagatagtt gagcaggagc
     4501 gagcagccca gcagctgcgg gcagagaagg ccagctatgc agagcagctg agcatgctga
     4561 agaaggccca tggcctgctg gcagaggaga accgggggct gggagagcgg gccaaccttg
     4621 gccggcagtt tctggaagta gaactagatc aagcccggga gaaatatgtc caggagttgg
     4681 ctgctgtgcg tactgatgct gagacccact tggctgaaat gcgacaagaa gcacagagta
     4741 ctagccggga gctggaggtg atgactgcca agtacgaagg tgccaaggtg aaggtcctag
     4801 aggaaaggca gaggttccaa gaagagaggc agaaactcac tgcccaggtg gagcaactag
     4861 aggtatttca aagagagcag actaagcagg tggaagaact aagtaagaag ctgacagagc
     4921 atgaccaagc cagcaaggtg cagcaacaga agctaaaggc tttccaggcc cagagaggtg
     4981 aaagccagca agaggtccag cgcctccaga cccagctgaa cgagctgcag gcccagctga
     5041 gccagaagga gcaggcagct gagcattaca agctccagat ggagaaagcc aagacccatt
     5101 atgatgccaa gaagcagcag aaccaaaagc tgcaggaaca gcttcaagac ttggaggaac
     5161 tgcagaagga gaacaaggag ctgcggtctg aagctgaacg tctgggccgt gagctgcagc
     5221 aggcagggct gaagaccaag gaagctgaac agacctgccg tcaccttaca gcccaggtgc
     5281 gcagcctgga ggcccaggtt gcccatgcag accagcagct tcgtgacttg ggcaaattcc
     5341 aggtggcaac tgatgcctta aagagccgtg agcctcaagt gaaaccccag ctggacttaa
     5401 gtattgacag cctggatctg agtttggagg agggaacccc atgcagtgtg gctagcaagc
     5461 tgcctcgtac ccaaccagat ggtaccagtg tccctggaga gccagcttca cctatctccc
     5521 agcgcctgcc ccccaaagtg gaatccctgg agagcctcta cttcaccccc actcctgctc
     5581 ggggtcaggc ccccttggag actagccttg actctctggg ggatgccttc cctgactccg
     5641 gccgtaagac ccgctctgct cgccgccgta ccacacaaat catcaacatc actatgacca
     5701 agaaattaga attggaagag ccagacagcg ccaactcatc cttctacagc acgcagtctg
     5761 ctcctgcttc ccaggccaac ttgcgagcca cttcctccac tcagtctctg gcccgcttgg
     5821 gttctcctga tgatggcaac tccgctctgc ttagcctgcc tggctaccgg cctaccacac
     5881 gaagctctgc tcgtcgctcc caggccagga tgtccagtgg ggccccccaa gggaggaata
     5941 gcttctacat gggcacttgc caggatgagc ccgagcagct ggatgattgg aaccgcatcg
     6001 cagagttgca gcagcgcaac cgagtatgcc ccccgcacct gaagacctgc taccctctgg
     6061 agtccaggcc taccctgagc ctggccacca tcactgatga ggagatgaag actggagacc
     6121 ccagggaaac cttgcgtaga gccagcatgc agccagctca gattgctgag ggtgttggca
     6181 taactaccag gcagcagcgc aaacgagttt cctctgagac ccaccagggc cctggcactc
     6241 ctgagtccaa gaaagctacc agctgctttc cacgccccat gacccccagg gaccggcatg
     6301 aaggacgtaa gcagagcagc actgctgaca cccagaagaa agcagctcca gttctcaaac
     6361 aggcggaccg gcgtcagtca atggctttca gcatccttaa cacacctaag aagctgggaa
     6421 atagtcttct aaggcgagga gcttcaaaga agaccccagc aaaggtctcc cccaatcctc
     6481 gcagtggaac ccgccgttct ccacgcattg ccaccaccac aactggcact gctactgttg
     6541 ccaccactcc tcgggccaag ggcaaggtga agcattaaag agtcagcacc agtgcttacg
     6601 tggccccact gcattgtcag cactgacctt gcttggtcct ttccctcctg ctgtccctca
     6661 gtgccttctc tcagctccca ggccaatggc ggccagcctt ccccaagaca atgaggtttg
     6721 cctgcaccct ggcctgctac ctggactttg cctggtgcct tctaggcgtc tttcagagat
     6781 ggcccaggag gcttggagct tggacagtgt gtggtcttct ccctatcttg cctcctgatt
     6841 ttttttttct ccctccgttg ttgttttgga aaaaagtcta cttttccatc taactagatt
     6901 gagactggat tctttagccc agtcttcctt agtctctgga cctagaaggg accattggag
     6961 aagcaggctc tgcttctctg ttgttcctgg tggctgggcc ttagcagggg tctttgctct
     7021 tgaagcccag gattgggcat gacctggtag gagcctctgt tcttacctat ttccatatac
     7081 agctgcctgg aggatgcttt ttttccagga cagataggtt ctggatctca ggggtgagat
     7141 agggggcagc cttcaatggc agctcatact tcaccttccc cagacttgca ctggggtagg
     7201 atatggaacg atggggaggt ttttaagggc cggggatgga tcttttctaa atgttattac
     7261 ttgtaaataa agtctatttt tctcccttga
//
