LOCUS       NM_001195674            2567 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus nuclear GTPase, germinal center associated (Nuggc),
            mRNA.
ACCESSION   NM_001195674 XM_983339
VERSION     NM_001195674.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2567)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2567)
  AUTHORS   Richter,K., Burch,L., Chao,F., Henke,D., Jiang,C., Daly,J.,
            Zhao,M.L., Kissling,G. and Diaz,M.
  TITLE     Altered pattern of immunoglobulin hypermutation in mice deficient
            in Slip-GC protein
  JOURNAL   J Biol Chem 287 (38), 31856-31865 (2012)
   PUBMED   22833677
  REMARK    GeneRIF: SLIP-GC protects replicating DNA from AID-mediated
            deamination of cytosines in both strands.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122274.4.
            
            On Sep 9, 2011 this sequence version replaced NM_001195674.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. The first exon is inferred based
            on a similar exon-intron structure of the related human gene,
            GeneID 389643.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AC122274.4         77388-77417
            31-91               AC122274.4         78824-78884
            92-196              AC122274.4         80260-80364
            197-305             AC122274.4         80911-81019
            306-528             AC122274.4         81932-82154
            529-759             AC122274.4         83253-83483
            760-969             AC122274.4         85515-85724
            970-1145            AC122274.4         89713-89888
            1146-1164           AC122274.4         91194-91212
            1165-1254           AC122274.4         91689-91778
            1255-1360           AC122274.4         95282-95387
            1361-1494           AC122274.4         96140-96273
            1495-1659           AC122274.4         107124-107288
            1660-1817           AC122274.4         110672-110829
            1818-1956           AC122274.4         112104-112242
            1957-2065           AC122274.4         113360-113468
            2066-2202           AC122274.4         113979-114115
            2203-2293           AC122274.4         117131-117221
            2294-2567           AC122274.4         120292-120565
FEATURES             Location/Qualifiers
     source          1..2567
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 34.34 cM"
     gene            1..2567
                     /gene="Nuggc"
                     /gene_synonym="Gm600; SLIP-GC"
                     /note="nuclear GTPase, germinal center associated"
                     /db_xref="GeneID:100503545"
                     /db_xref="MGI:MGI:2685446"
     CDS             1..2439
                     /gene="Nuggc"
                     /gene_synonym="Gm600; SLIP-GC"
                     /note="speckled-like pattern in the germinal center"
                     /codon_start=1
                     /product="nuclear GTPase SLIP-GC"
                     /protein_id="NP_001182603.2"
                     /db_xref="CCDS:CCDS56966.1"
                     /db_xref="GeneID:100503545"
                     /db_xref="MGI:MGI:2685446"
                     /translation="MDLDSMKSKEELGVAPLGTGYSSSFQGVSPADCDLFKEPVRKRR
                     RLHRDRQFQAFPSAEQSALKEYEKLECRTRRVLSNTYQKLIQSVFLDDSIPSGLKYLI
                     NRLLALIEKSPLEPVYVGFLGITGAGKSSLINALIRQAMFLPVSGESVCTSCIVQVSS
                     GCCEQYEAKIHLLSDQEWKAELKDLTKLLHRAEQSGEEEADLWDRDDATEEAAQKLRM
                     LYGHGAERRHYEELLRLKPRGRIPNSRTITLKAEEAGELSVKLDPYIRTRRRDWDGES
                     AETQIWPLIKYVEVILPKSALIPEGVVLVDIPGTGDFNSKRDKMWKKTIDKCSVIWVI
                     SDIERVSGGKTHEDLLSESIKACQRGFCRDIALVVTKTDKLHLQEYLRERKMGNQAIQ
                     SQREAVLQRNEIIKLQRKRMLKEKLKRKLPADSKVLEASDLVYTVSAHEYWQRTILTE
                     EESEIPKLREYIRKRILDKKRRLVTKYVTEAFGLLLLTDTLNTEESLLTEELNTGGLR
                     QFVEEKMELLEKAIEQCFARMEQPLQTGVQVAMTSYRRILGSCLVRSRGNQGFHQTLK
                     AVCLKNGVYASRTLARIDLNEALSQPIYDQIDPVFGGIFRDGKPTAPALMQHIDAFKH
                     SLEERMAEVGVRSGWKQDGYKRSFLIQEISAILGGLESHILRRKRKIYKSVTSSIQND
                     LKPCYEEAAQITGKKACERMKDVIRRGVERQVAEGLFERAQERMWHQFRQLKHGITEK
                     VKGSITTMLTLAAPQGVGLCKELADVRNEQKEMEKLYRSLREVAENAQLRRSMQDFLL
                     RMSPSKAGPHGTKL"
     exon            1..30
                     /gene="Nuggc"
                     /gene_synonym="Gm600; SLIP-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            31..91
                     /gene="Nuggc"
                     /gene_synonym="Gm600; SLIP-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            92..196
                     /gene="Nuggc"
                     /gene_synonym="Gm600; SLIP-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            197..305
                     /gene="Nuggc"
                     /gene_synonym="Gm600; SLIP-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            306..528
                     /gene="Nuggc"
                     /gene_synonym="Gm600; SLIP-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            529..759
                     /gene="Nuggc"
                     /gene_synonym="Gm600; SLIP-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            760..969
                     /gene="Nuggc"
                     /gene_synonym="Gm600; SLIP-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1145
                     /gene="Nuggc"
                     /gene_synonym="Gm600; SLIP-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1164
                     /gene="Nuggc"
                     /gene_synonym="Gm600; SLIP-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1254
                     /gene="Nuggc"
                     /gene_synonym="Gm600; SLIP-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1360
                     /gene="Nuggc"
                     /gene_synonym="Gm600; SLIP-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1494
                     /gene="Nuggc"
                     /gene_synonym="Gm600; SLIP-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1659
                     /gene="Nuggc"
                     /gene_synonym="Gm600; SLIP-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1817
                     /gene="Nuggc"
                     /gene_synonym="Gm600; SLIP-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1956
                     /gene="Nuggc"
                     /gene_synonym="Gm600; SLIP-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2065
                     /gene="Nuggc"
                     /gene_synonym="Gm600; SLIP-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2202
                     /gene="Nuggc"
                     /gene_synonym="Gm600; SLIP-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2293
                     /gene="Nuggc"
                     /gene_synonym="Gm600; SLIP-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2567
                     /gene="Nuggc"
                     /gene_synonym="Gm600; SLIP-GC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2528..2533
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nuggc"
                     /gene_synonym="Gm600; SLIP-GC"
                     /note="hexamer: AATAAA"
     polyA_site      2548
                     /gene="Nuggc"
                     /gene_synonym="Gm600; SLIP-GC"
                     /note="major polyA site"
ORIGIN      
        1 atggatttgg actctatgaa atccaaggag gagctcggag tagcacctct tgggaccggc
       61 tattccagtt cattccaagg cgtttcccct gctgactgcg atctgtttaa agaacctgtt
      121 aggaaaagac gcaggttgca tcgagaccgg caattccagg cctttccttc tgcagagcaa
      181 agtgctctta aggaatatga aaaactggag tgtcggacca ggagggtctt gagcaacact
      241 tatcagaaat tgattcagtc tgtcttcctg gatgacagca ttcccagcgg actcaagtat
      301 ctcataaacc ggcttcttgc cttgattgaa aaatccccac tggagccagt ctatgtgggg
      361 ttcttgggaa tcactggagc tggcaagagc tctctgatca atgccctcat ccggcaagca
      421 atgtttctgc ctgtgtctgg agaaagtgtt tgcacatcat gcatcgtaca agtgagctct
      481 ggctgctgtg agcagtatga ggccaaaatt caccttctgt ccgatcagga gtggaaggca
      541 gaactgaagg acttgactaa gctcctgcac agagcagagc agtctgggga agaggaggca
      601 gacttgtggg acagggatga tgcaacggaa gaagctgccc agaagctacg gatgctctat
      661 ggccatgggg cagaaaggag gcactacgag gagttgctaa ggctgaagcc cagagggagg
      721 attcccaact cgagaaccat cactctaaag gcagaggagg caggagagct atctgtcaaa
      781 ctggacccct acatcaggac caggaggaga gactgggatg gagaatcagc agagacacaa
      841 atctggccct tgatcaaata tgtggaagtg attcttccca aatctgcact gatcccagaa
      901 ggggttgtcc tggtagacat tccaggcaca ggagacttca acagcaagag ggataaaatg
      961 tggaaaaaga ccattgacaa gtgttccgtg atctgggtga tcagcgacat cgagcgagtt
     1021 tctggaggaa agacccatga agaccttctg agcgagagca tcaaagcctg ccagcgtggc
     1081 ttctgcaggg acatcgccct ggtggtcacc aaaacagaca aactccactt gcaggaatat
     1141 ctcagggaaa gaaagatggg aaatcaagct attcagagtc agagagaagc tgttctgcaa
     1201 agaaatgaaa taatcaaact acaaaggaag agaatgctca aggagaaatt gaagagaaaa
     1261 ctgccagctg actccaaggt tctggaagcc tcagatctgg tgtacacggt cagtgcccat
     1321 gagtactggc agcggaccat cctgactgag gaagaaagtg agatccccaa gttaagagaa
     1381 tatattagga aaaggatctt ggacaagaag aggaggctgg tgaccaagta cgtcacagaa
     1441 gcctttggcc tattgcttct cacagacacg ttaaacacgg aggaaagcct gctgactgaa
     1501 gaactgaaca cgggtggcct gcgacaattt gtagaggaga agatggagct gttggagaag
     1561 gccatcgagc agtgctttgc tcgaatggaa cagcccctgc agacaggggt ccaggtggcc
     1621 atgacttcct accgccgcat cctcgggtca tgcctggtga ggagcagagg aaaccaaggt
     1681 tttcaccaga ccctgaaagc agtttgcctg aaaaatgggg tctatgcctc cagaactctg
     1741 gccagaattg acctgaatga agccctgtct cagcctatct atgaccagat tgaccctgta
     1801 tttggaggca tttttaggga tgggaagccc actgcccctg ctctgatgca gcacatagat
     1861 gctttcaagc attccctgga ggagaggatg gcagaagttg gggttagaag tggctggaaa
     1921 caagatggat acaagagaag cttcctgatc caggagataa gcgccatcct gggaggcctg
     1981 gagagccaca tcctccggag gaaaaggaag atctataagt ctgtcaccag ctccatccaa
     2041 aacgacctga agccctgcta tgaagaggca gctcagatca ctggcaagaa agcatgcgag
     2101 agaatgaagg atgtcatcag gagaggggtg gagcggcagg tggctgaggg cttgtttgag
     2161 agggctcaag agaggatgtg gcaccagttt cgacagctga agcatggaat cactgagaag
     2221 gtcaagggca gcatcactac catgttaacc cttgctgcac cccagggagt tggactctgc
     2281 aaggagcttg cagatgtccg gaatgaacag aaggaaatgg aaaaactcta cagaagcctg
     2341 agggaggttg ctgagaacgc acagctgcgg aggagcatgc aagatttcct cctgcgaatg
     2401 tcccccagca aagccggccc ccatggaaca aaactttagt ttggggagga ggggcttttg
     2461 tctaaagaga tgaaaatagg cctggagcca aataaccaga attattgcta tttttttttt
     2521 gaaacagaat aaaaaacatt cctcctcatt tggactttct atataaa
//
