LOCUS       NP_001342088             463 aa            linear   ROD 24-DEC-2024
DEFINITION  kinetochore protein Nuf2 [Mus musculus].
ACCESSION   NP_001342088 XP_006497021
VERSION     NP_001342088.1
DBSOURCE    REFSEQ: accession NM_001355159.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 463)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 463)
  AUTHORS   Yoshida,S., Nishiyama,S., Lister,L., Hashimoto,S., Mishina,T.,
            Courtois,A., Kyogoku,H., Abe,T., Shiraishi,A., Choudhary,M.,
            Nakaoka,Y., Herbert,M. and Kitajima,T.S.
  TITLE     Prc1-rich kinetochores are required for error-free acentrosomal
            spindle bipolarization during meiosis I in mouse oocytes
  JOURNAL   Nat Commun 11 (1), 2652 (2020)
   PUBMED   32461611
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 463)
  AUTHORS   Zhang,T., Zhou,Y., Qi,S.T., Wang,Z.B., Qian,W.P., Ouyang,Y.C.,
            Shen,W., Schatten,H. and Sun,Q.Y.
  TITLE     Nuf2 is required for chromosome segregation during mouse oocyte
            meiotic maturation
  JOURNAL   Cell Cycle 14 (16), 2701-2710 (2015)
   PUBMED   26054848
  REMARK    GeneRIF: Nuf2 is a critical regulator of meiotic cell cycle
            progression in mammalian oocytes.
REFERENCE   4  (residues 1 to 463)
  AUTHORS   Varma,D. and Salmon,E.D.
  TITLE     The KMN protein network--chief conductors of the kinetochore
            orchestra
  JOURNAL   J Cell Sci 125 (Pt 24), 5927-5936 (2012)
   PUBMED   23418356
  REMARK    Review article
REFERENCE   5  (residues 1 to 463)
  AUTHORS   Ciferri,C., Pasqualato,S., Screpanti,E., Varetti,G., Santaguida,S.,
            Dos Reis,G., Maiolica,A., Polka,J., De Luca,J.G., De Wulf,P.,
            Salek,M., Rappsilber,J., Moores,C.A., Salmon,E.D. and Musacchio,A.
  TITLE     Implications for kinetochore-microtubule attachment from the
            structure of an engineered Ndc80 complex
  JOURNAL   Cell 133 (3), 427-439 (2008)
   PUBMED   18455984
REFERENCE   6  (residues 1 to 463)
  AUTHORS   Wigge,P.A. and Kilmartin,J.V.
  TITLE     The Ndc80p complex from Saccharomyces cerevisiae contains conserved
            centromere components and has a function in chromosome segregation
  JOURNAL   J Cell Biol 152 (2), 349-360 (2001)
   PUBMED   11266451
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132467.1 and AK162249.1.
            
            On Sep 9, 2017 this sequence version replaced XP_006497021.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF326732.1, BC020026.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 76.84 cM"
     Protein         1..463
                     /product="kinetochore protein Nuf2"
                     /note="cell division cycle-associated protein 1"
                     /calculated_mol_wt=54463
     Region          1..385
                     /region_name="Interaction with the N-terminus of NDC80.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P69.2)"
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q9BZD4; propagated from
                     UniProtKB/Swiss-Prot (Q99P69.2)"
     Region          3..146
                     /region_name="Nuf2"
                     /note="Nuf2 family; pfam03800"
                     /db_xref="CDD:461057"
     Region          185..>457
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            247
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q99P69.2)"
     Region          386..463
                     /region_name="Interaction with the C-terminus of NDC80 and
                     the SPBC24-SPBC25 subcomplex. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P69.2)"
     CDS             1..463
                     /gene="Nuf2"
                     /gene_synonym="2410003C07Rik; Cdca1; NUF2R"
                     /coded_by="NM_001355159.1:235..1626"
                     /db_xref="CCDS:CCDS15463.1"
                     /db_xref="GeneID:66977"
                     /db_xref="MGI:MGI:1914227"
ORIGIN      
        1 metlsfpryn vaelvvhirn klltgadgkn lsksdflpnp ksdvlymiym kalqlvygvr
       61 lehfymmpmn ievtyphlme gflpvrslff ymdsfmpicr vndfeivdil nprtnrtsrf
      121 lsgiinfihf retclekcee fllqnkssmv rmqqlsnvhq ealmklekln tvpaeereef
      181 kqfmddiqel qhllneefrq kttllqeeya kmksdisekt khlneqklsl vslkevednl
      241 kskivdspek lknykdkmkg tvqklrsare kvmeqydiyr dsvdclpscq levqlyqkks
      301 qdladnrekl ssllkeslnl edqiesdsse lkklkteens lirmttvkke klatarfkin
      361 kkqedvkhyk qamiedcnkv qekrdavceq vttvnqeihk iksaiqqlrd tkkreilksq
      421 eifvnlksal ekyhegiekv aeersaklee ktaelkkrmv rmv
//
