LOCUS       NM_028794               1492 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus nudix hydrolase 9 (Nudt9), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_028794 XM_908685
VERSION     NM_028794.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1492)
  AUTHORS   Carloto,A., Costas,M.J., Cameselle,J.C., McLennan,A.G. and
            Ribeiro,J.M.
  TITLE     The specific, submicromolar-Km ADP-ribose pyrophosphatase purified
            from human placenta is enzymically indistinguishable from
            recombinant NUDT9 protein, including a selectivity for Mn2+ as
            activating cation and increase in Km for ADP-ribose, both elicited
            by H2O2
  JOURNAL   Biochim Biophys Acta 1760 (10), 1545-1551 (2006)
   PUBMED   16860484
  REMARK    GeneRIF: ADP-ribose hydrolysis is catalysed by NDP-sugar/alcohol
            pyrophosphatases of differing specificity, including a highly
            specific, low-K(m) ADP-ribose pyrophosphatase.
REFERENCE   2  (bases 1 to 1492)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   3  (bases 1 to 1492)
  AUTHORS   Perraud,A.L., Shen,B., Dunn,C.A., Rippe,K., Smith,M.K.,
            Bessman,M.J., Stoddard,B.L. and Scharenberg,A.M.
  TITLE     NUDT9, a member of the Nudix hydrolase family, is an evolutionarily
            conserved mitochondrial ADP-ribose pyrophosphatase
  JOURNAL   J Biol Chem 278 (3), 1794-1801 (2003)
   PUBMED   12427752
REFERENCE   4  (bases 1 to 1492)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   5  (bases 1 to 1492)
  AUTHORS   Lin,S., Gasmi,L., Xie,Y., Ying,K., Gu,S., Wang,Z., Jin,H., Chao,Y.,
            Wu,C., Zhou,Z., Tang,R., Mao,Y. and McLennan,A.G.
  TITLE     Cloning, expression and characterisation of a human Nudix hydrolase
            specific for adenosine 5'-diphosphoribose (ADP-ribose)
  JOURNAL   Biochim Biophys Acta 1594 (1), 127-135 (2002)
   PUBMED   11825615
REFERENCE   6  (bases 1 to 1492)
  AUTHORS   Perraud,A.L., Fleig,A., Dunn,C.A., Bagley,L.A., Launay,P.,
            Schmitz,C., Stokes,A.J., Zhu,Q., Bessman,M.J., Penner,R.,
            Kinet,J.P. and Scharenberg,A.M.
  TITLE     ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed
            by Nudix motif homology
  JOURNAL   Nature 411 (6837), 595-599 (2001)
   PUBMED   11385575
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL714024.31, BY237462.1 and AK158058.1.
            
            On May 8, 2015 this sequence version replaced NM_028794.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158058.1, AK076500.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AL714024.31        91919-91941         c
            24-71               BY237462.1         2-49
            72-1492             AK158058.1         1-1421
FEATURES             Location/Qualifiers
     source          1..1492
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 50.54 cM"
     gene            1..1492
                     /gene="Nudt9"
                     /gene_synonym="1190002C07Rik; ADPR-PPase"
                     /note="nudix hydrolase 9"
                     /db_xref="GeneID:74167"
                     /db_xref="MGI:MGI:1921417"
     exon            1..283
                     /gene="Nudt9"
                     /gene_synonym="1190002C07Rik; ADPR-PPase"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..1229
                     /gene="Nudt9"
                     /gene_synonym="1190002C07Rik; ADPR-PPase"
                     /EC_number="3.6.1.13"
                     /note="nudix motif 9; ADP-ribose diphosphatase; nudix
                     (nucleoside diphosphate linked moiety X)-type motif 9;
                     ADP-ribose phosphohydrolase; adenosine diphosphoribose
                     pyrophosphatase; nucleoside diphosphate-linked moiety X
                     motif 9"
                     /codon_start=1
                     /product="ADP-ribose pyrophosphatase, mitochondrial"
                     /protein_id="NP_083070.2"
                     /db_xref="CCDS:CCDS19482.1"
                     /db_xref="GeneID:74167"
                     /db_xref="MGI:MGI:1921417"
                     /translation="MAGRSLGQAVATVSLSVALASVTVRSSACRAVPAPRNTFPTCGF
                     HLNANIMSGSNGAKENSHNKARTSPYPGSKVERSQVPNEKVGWLVEWQDYNPVEYTAV
                     SVLAGPQWADPQISESNFSPKFNEKDGHVERKSQNGLYEIENGRPRNPAGRTGLVGRG
                     LLGRWGPNHAADPIITRWKRDESGNKITHPVSGKCILQFVAIKRKDCGEWAIPGGMVD
                     PGEKISATLKREFGEEALNSLQKSSAEKREIEEKLHALFSQEHLVIYKGYVDDPRNTD
                     NAWMETEAVNYHDETGETMDNLTLEAGDDAGKVKWVDISDQLKLYASHSQFIKLVAEK
                     RDAHWSEDHAADSRGL"
     exon            284..523
                     /gene="Nudt9"
                     /gene_synonym="1190002C07Rik; ADPR-PPase"
                     /inference="alignment:Splign:2.1.0"
     exon            524..619
                     /gene="Nudt9"
                     /gene_synonym="1190002C07Rik; ADPR-PPase"
                     /inference="alignment:Splign:2.1.0"
     exon            620..706
                     /gene="Nudt9"
                     /gene_synonym="1190002C07Rik; ADPR-PPase"
                     /inference="alignment:Splign:2.1.0"
     exon            707..818
                     /gene="Nudt9"
                     /gene_synonym="1190002C07Rik; ADPR-PPase"
                     /inference="alignment:Splign:2.1.0"
     exon            819..965
                     /gene="Nudt9"
                     /gene_synonym="1190002C07Rik; ADPR-PPase"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1050
                     /gene="Nudt9"
                     /gene_synonym="1190002C07Rik; ADPR-PPase"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1492
                     /gene="Nudt9"
                     /gene_synonym="1190002C07Rik; ADPR-PPase"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1466..1471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nudt9"
                     /gene_synonym="1190002C07Rik; ADPR-PPase"
                     /note="hexamer: AATAAA"
     polyA_site      1483
                     /gene="Nudt9"
                     /gene_synonym="1190002C07Rik; ADPR-PPase"
                     /note="major polyA site"
ORIGIN      
        1 cgcggtcgcg cgtcgggtac gtcgtggggc tgctggcgcc gccggccagc ggcgctgggg
       61 gagcgcggcc gggtcctagt gcccgctggc tgcaggttcg gggctcaagg cggggctccg
      121 ggcgaggccg gccacctccg aaccctcgcg ggccgcgcgc caggcgccag gcgccgatgg
      181 ccggccgctc cctggggcag gcggtagcca ccgtgtcgct ctcggtggcc ctcgcgtcag
      241 tgactgtccg gtcctcagcc tgccgcgccg tccccgcacc cagaaacaca tttccaacct
      301 gtgggttcca ccttaacgcc aacatcatgt ctggttctaa tggtgccaaa gagaattccc
      361 acaacaaggc ccggacttct ccttacccag gttcaaaagt cgagcgaagt caggttccga
      421 atgagaaggt gggctggctc gttgagtggc aggactacaa cccagtggag tacaccgcgg
      481 tctctgtcct ggctggaccc cagtgggcgg accctcagat cagtgaaagc aacttctctc
      541 ccaagtttaa tgaaaaggac gggcatgttg agagaaagag ccagaatggc ctgtatgaga
      601 ttgaaaacgg aagacccaga aaccctgcag ggaggacagg actggttggc cggggtcttc
      661 tggggagatg gggcccaaat catgccgcag atcctattat aaccaggtgg aaaagggacg
      721 agagcgggaa taagatcaca caccctgtct ctgggaaatg catcttgcag ttcgttgcca
      781 tcaagaggaa agactgtgga gagtgggcaa tcccgggggg gatggtggac cccggagaga
      841 agatcagtgc caccctgaaa agggagtttg gtgaagaagc cctgaactcg ttacagaagt
      901 ccagtgccga gaagagagag atcgaggaga aactgcacgc gctcttcagc caagagcatc
      961 tcgtgatata taaggggtat gttgacgacc ctcggaacac tgacaatgcg tggatggaga
     1021 cggaagccgt gaactaccat gatgaaacag gggagaccat ggacaacctc accctggagg
     1081 ccggagatga cgcagggaag gtgaagtggg tggacatcag cgaccagctc aagttgtacg
     1141 ccagtcactc tcagttcatc aaactcgtgg cagagaaacg agatgcccac tggagcgagg
     1201 accacgccgc tgacagccgt gggctatagc ctgtccccgt gagccagccg ctgcaggctg
     1261 tactgcagac agaagggcca cagaactgac accccacaga ggccacctgg aaatgcttgc
     1321 aacagggtga aatgcctgga tacgatgaag aaccctgaat gtacagcttt cttctcaaag
     1381 ggattagaga ctgtcatttt gtatagattt aagcatgtcc gaacaaaatt taaataacta
     1441 atgttctttg aaaaattgta gttgcaataa atataaaacc caattgctgg tg
//
