LOCUS       NM_025529                786 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus nudix hydrolase 8 (Nudt8), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_025529
VERSION     NM_025529.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 786)
  AUTHORS   Kerr,E.W., Shumar,S.A. and Leonardi,R.
  TITLE     Nudt8 is a novel CoA diphosphohydrolase that resides in the
            mitochondria
  JOURNAL   FEBS Lett 593 (11), 1133-1143 (2019)
   PUBMED   31004344
  REMARK    GeneRIF: Nudt8 is a novel CoA-degrading enzyme that resides in the
            mitochondria. Nudt8 specifically hydrolyzes CoA species and has a
            distinctive preference for manganese ions.
REFERENCE   2  (bases 1 to 786)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   3  (bases 1 to 786)
  AUTHORS   Gasmi,L. and McLennan,A.G.
  TITLE     The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific
            for coenzyme A and its derivatives
  JOURNAL   Biochem J 357 (Pt 1), 33-38 (2001)
   PUBMED   11415433
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK045197.1.
            
            On Apr 6, 2007 this sequence version replaced NM_025529.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK045197.1, AK002605.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-786               AK045197.1         2-787
FEATURES             Location/Qualifiers
     source          1..786
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19"
     gene            1..786
                     /gene="Nudt8"
                     /gene_synonym="2310039H17Rik"
                     /note="nudix hydrolase 8"
                     /db_xref="GeneID:66387"
                     /db_xref="MGI:MGI:1913637"
     exon            1..268
                     /gene="Nudt8"
                     /gene_synonym="2310039H17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..707
                     /gene="Nudt8"
                     /gene_synonym="2310039H17Rik"
                     /EC_number="3.6.1.77"
                     /note="nudix-type motif 8; nucleoside diphosphate-linked
                     moiety X motif 8, mitochondrial; nudix (nucleoside
                     diphosphate linked moiety X)-type motif 8; nudix motif 8"
                     /codon_start=1
                     /product="mitochondrial coenzyme A diphosphatase NUDT8"
                     /protein_id="NP_079805.1"
                     /db_xref="CCDS:CCDS29408.1"
                     /db_xref="GeneID:66387"
                     /db_xref="MGI:MGI:1913637"
                     /translation="MLPDGLSAEDEQRCRQLLARTTARLRSRPAAAAVLVPLCLVRGV
                     PALLYTLRSSRLVGRHKGEVSFPGGKCDPDDQDVIHTALRETQEELGLEVPKEHVWGV
                     LQPVYDREKATIVPVLANVGPLDLQSLRPNLEEVDEVFEMSLAHLLQTQNQGYTHFCQ
                     GGHFSYTLPVFLHGPHRVWGLTAVITELTLKLLAPGFYQPSLAVPELPRG"
     exon            269..401
                     /gene="Nudt8"
                     /gene_synonym="2310039H17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            402..479
                     /gene="Nudt8"
                     /gene_synonym="2310039H17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            480..786
                     /gene="Nudt8"
                     /gene_synonym="2310039H17Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      786
                     /gene="Nudt8"
                     /gene_synonym="2310039H17Rik"
                     /note="putative"
ORIGIN      
        1 gcgctggagc ttgcgcgctg cggcgttccc tccctagcgg gctgatcccc cactgtgtcc
       61 cggacgtctg ggacatgctg cctgatggcc tgtccgcgga ggacgagcag cgctgccggc
      121 agctgctagc acggaccact gcccggttac gctcgcggcc cgcagcggcc gcagtgcttg
      181 tgccgctgtg cctcgtgcgc ggggtccccg cgttgctcta cacgctgcgt tctagtcgcc
      241 tggttgggag acacaaaggg gaagtcagtt tcccaggcgg taagtgtgat cccgacgacc
      301 aagatgtaat acatacggcc cttcgggaga ctcaggagga gctgggccta gaggtgccca
      361 aggagcacgt gtggggtgtc ctgcagccag tgtatgaccg ggaaaaggca accatagtcc
      421 cagtacttgc caacgtgggc ccactggatc tgcagagcct taggcccaac cttgaggagg
      481 tggatgaagt atttgagatg tctctggccc acttgctgca gacacagaac caggggtata
      541 cccacttctg ccagggtggc cacttcagct acacactgcc tgtcttcttg catggaccac
      601 accgtgtctg gggcctcaca gctgtcatca ctgagctcac cctgaagctg ctggcccctg
      661 gcttctacca gccctcccta gctgttcctg agctgcctag gggttgaggc ctgcctggcc
      721 tttaagtgcc tctgccatca tttggccagg ctagtccaga accgattaaa agagtgtttg
      781 acagct
//
