LOCUS       NM_024437               1099 bp    mRNA    linear   ROD 04-AUG-2024
DEFINITION  Mus musculus nudix hydrolase 7 (Nudt7), transcript variant 1, mRNA.
ACCESSION   NM_024437
VERSION     NM_024437.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1099)
  AUTHORS   Song,J., Kim,E.H., Yang,J.H., Kim,D., Robby,A.I., Kim,S.A.,
            Park,S.Y., Ryu,J.H. and Jin,E.J.
  TITLE     Upregulated FOXM1 stimulates chondrocyte senescence in
            Acot12-/-Nudt7-/- double knockout mice
  JOURNAL   Theranostics 13 (15), 5207-5222 (2023)
   PUBMED   37908734
  REMARK    GeneRIF: Upregulated FOXM1 stimulates chondrocyte senescence in
            Acot12[-/-]Nudt7[-/-] double knockout mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1099)
  AUTHORS   Vickers,S.D., Shumar,S.A., Saporito,D.C., Kunovac,A.,
            Hathaway,Q.A., Mintmier,B., King,J.A., King,R.D., Rajendran,V.M.,
            Infante,A.M., Hollander,J.M. and Leonardi,R.
  TITLE     NUDT7 regulates total hepatic CoA levels and the composition of the
            intestinal bile acid pool in male mice fed a Western diet
  JOURNAL   J Biol Chem 299 (1), 102745 (2023)
   PUBMED   36436558
  REMARK    GeneRIF: NUDT7 regulates total hepatic CoA levels and the
            composition of the intestinal bile acid pool in male mice fed a
            Western diet.
REFERENCE   3  (bases 1 to 1099)
  AUTHORS   Shumar,S.A., Kerr,E.W., Fagone,P., Infante,A.M. and Leonardi,R.
  TITLE     Overexpression of Nudt7 decreases bile acid levels and peroxisomal
            fatty acid oxidation in the liver
  JOURNAL   J Lipid Res 60 (5), 1005-1019 (2019)
   PUBMED   30846528
  REMARK    GeneRIF: The modulation of Nudt7 activity could contribute to the
            regulation of the peroxisomal CoA pool and peroxisomal lipid
            metabolism.
REFERENCE   4  (bases 1 to 1099)
  AUTHORS   Song,J., Baek,I.J., Chun,C.H. and Jin,E.J.
  TITLE     Dysregulation of the NUDT7-PGAM1 axis is responsible for
            chondrocyte death during osteoarthritis pathogenesis
  JOURNAL   Nat Commun 9 (1), 3427 (2018)
   PUBMED   30143643
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1099)
  AUTHORS   Shumar,S.A., Kerr,E.W., Geldenhuys,W.J., Montgomery,G.E.,
            Fagone,P., Thirawatananond,P., Saavedra,H., Gabelli,S.B. and
            Leonardi,R.
  TITLE     Nudt19 is a renal CoA diphosphohydrolase with biochemical and
            regulatory properties that are distinct from the hepatic Nudt7
            isoform
  JOURNAL   J Biol Chem 293 (11), 4134-4148 (2018)
   PUBMED   29378847
REFERENCE   6  (bases 1 to 1099)
  AUTHORS   Reilly,S.J., Tillander,V., Ofman,R., Alexson,S.E. and Hunt,M.C.
  TITLE     The nudix hydrolase 7 is an Acyl-CoA diphosphatase involved in
            regulating peroxisomal coenzyme A homeostasis
  JOURNAL   J Biochem 144 (5), 655-663 (2008)
   PUBMED   18799520
  REMARK    GeneRIF: Data suggest that NUDT7alpha function is tightly linked to
            peroxisomal CoASH/acyl-CoA homeostasis.
REFERENCE   7  (bases 1 to 1099)
  AUTHORS   Wu,Y. and Smas,C.M.
  TITLE     Wdnm1-like, a new adipokine with a role in MMP-2 activation
  JOURNAL   Am J Physiol Endocrinol Metab 295 (1), E205-E215 (2008)
   PUBMED   18492766
REFERENCE   8  (bases 1 to 1099)
  AUTHORS   Abdelraheim,S.R., Spiller,D.G. and McLennan,A.G.
  TITLE     Mammalian NADH diphosphatases of the Nudix family: cloning and
            characterization of the human peroxisomal NUDT12 protein
  JOURNAL   Biochem J 374 (Pt 2), 329-335 (2003)
   PUBMED   12790796
REFERENCE   9  (bases 1 to 1099)
  AUTHORS   Gasmi,L. and McLennan,A.G.
  TITLE     The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific
            for coenzyme A and its derivatives
  JOURNAL   Biochem J 357 (Pt 1), 33-38 (2001)
   PUBMED   11415433
REFERENCE   10 (bases 1 to 1099)
  AUTHORS   Cartwright,J.L., Gasmi,L., Spiller,D.G. and McLennan,A.G.
  TITLE     The Saccharomyces cerevisiae PCD1 gene encodes a peroxisomal nudix
            hydrolase active toward coenzyme A and its derivatives
  JOURNAL   J Biol Chem 275 (42), 32925-32930 (2000)
   PUBMED   10922370
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121999.3, AF338424.1 and AK004924.1.
            
            On Mar 1, 2014 this sequence version replaced NM_024437.3.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069843.1, AF338424.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AC121999.3         56606-56646         c
            42-572              AF338424.1         2-532
            573-670             AK004924.1         2269-2366
            671-1092            AF338424.1         631-1052
            1093-1099           AK004924.1         2789-2795
FEATURES             Location/Qualifiers
     source          1..1099
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 60.53 cM"
     gene            1..1099
                     /gene="Nudt7"
                     /gene_synonym="1300007B24Rik; 2210404C19Rik"
                     /note="nudix hydrolase 7"
                     /db_xref="GeneID:67528"
                     /db_xref="MGI:MGI:1914778"
     exon            1..127
                     /gene="Nudt7"
                     /gene_synonym="1300007B24Rik; 2210404C19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..803
                     /gene="Nudt7"
                     /gene_synonym="1300007B24Rik; 2210404C19Rik"
                     /EC_number="3.6.1.77"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coenzyme A diphosphatase; peroxisomal coenzyme A
                     diphosphatase NUDT7; nudix motif 7; nudix (nucleoside
                     diphosphate linked moiety X)-type motif 7; nucleoside
                     diphosphate-linked moiety X motif 7"
                     /codon_start=1
                     /product="peroxisomal coenzyme A diphosphatase NUDT7
                     isoform 1"
                     /protein_id="NP_077757.2"
                     /db_xref="CCDS:CCDS22687.1"
                     /db_xref="GeneID:67528"
                     /db_xref="MGI:MGI:1914778"
                     /translation="MSRPCGLPEPVRNNLIDDAKARLRKSDVGTRYSHLSSNKFSVLV
                     PLLARGGKLYLMFTVRSDKLKREPGEVCFPGGKRDPVDTDDTATALREAQEEVGLHPH
                     QVEVVSHLVPYVFDNDALVTPVVGFLDHNFQAQPNADEVKEVFFVPLDYFLHPQVYYQ
                     KQITQSGRDFIMHCFEYKDPETGVNYLIQGMTSKLAVLVALIILEQSPAFKIDFDLHD
                     LIPSCERTFLWRYSLSKL"
     exon            128..281
                     /gene="Nudt7"
                     /gene_synonym="1300007B24Rik; 2210404C19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            282..440
                     /gene="Nudt7"
                     /gene_synonym="1300007B24Rik; 2210404C19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            441..1099
                     /gene="Nudt7"
                     /gene_synonym="1300007B24Rik; 2210404C19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1074..1079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nudt7"
                     /gene_synonym="1300007B24Rik; 2210404C19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1094
                     /gene="Nudt7"
                     /gene_synonym="1300007B24Rik; 2210404C19Rik"
                     /note="major polyA site"
ORIGIN      
        1 attcctagct ggggctacta agcgcatgcg cgtcagaact atttgcttcc cgaagtctcc
       61 tgctgctagt aagaggaagt actgcagggc tgatgtcgcg accttgtgga ctcccggagc
      121 ctgtcagaaa caatctgata gatgatgcca aggctcgcct gagaaagtct gatgtcggga
      181 ccagatattc tcacctgtcc tctaataaat tctctgtcct tgtaccactg ctggccagag
      241 gaggaaagtt gtatttgatg ttcacggtcc gctcagacaa gctgaaaagg gaacctggag
      301 aagtctgctt ccctggagga aagagggacc cggtggacac agatgacaca gccactgctc
      361 tccgtgaagc ccaggaggag gtggggctgc atccccacca agtggaggtg gtctctcacc
      421 tggtgccata cgtatttgat aatgatgcac tggtaacccc cgtagtgggt tttctagacc
      481 acaacttcca ggcccaacct aatgctgatg aagtgaagga agtcttcttt gtgcctttgg
      541 actatttcct ccatccccaa gtctactacc agaagcaaat cacacagtct ggccgtgatt
      601 tcatcatgca ttgcttcgag tacaaagacc ctgagactgg tgtgaactac ctaatccagg
      661 gaatgacctc aaaactggct gtgttggtgg ccttaattat tttggaacaa agtcctgcct
      721 tcaagattga ttttgatctc catgacctga taccgtcttg tgaaaggacc ttcctttgga
      781 gatattcttt aagcaagttg tgaagaccct gaaacccaaa agaacgtaca tgaggttttt
      841 gtgtgagctt atgctcagaa caacagtgtt tagcaagtgg catctgacag gtgtgaatat
      901 tttcctacaa tgtggctgtg agatccttgc ctgacttcct gttgctgctt tagaacacta
      961 aaagtctttc aaaactggaa aaatgcactg gcaggggaga ataattttac ccatttaaaa
     1021 aaatggcacg atttttagtc atattaggga tatctgtcac atagtaggca cttaataaat
     1081 atttgtcaaa tatatggct
//
