LOCUS       NM_001291044            1083 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus nudix hydrolase 6 (Nudt6), transcript variant 1, mRNA.
ACCESSION   NM_001291044 XM_006502583 XM_006502588 XM_006535458
VERSION     NM_001291044.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1083)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1083)
  AUTHORS   Ozkan,A., Bicer,A., Avsar,T., Seker,A., Toktas,Z.O., Bozkurt,S.U.,
            Basak,A.N. and Kilic,T.
  TITLE     Temporal expression analysis of angiogenesis-related genes in brain
            development
  JOURNAL   Vasc Cell 4 (1), 16 (2012)
   PUBMED   23020941
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669927.9.
            
            On or before Mar 22, 2014 this sequence version replaced
            XM_006535458.1, XM_006502583.1, XM_006502588.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145299.1, AF453428.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-255               AL669927.9         58540-58794         c
            256-459             AL669927.9         55899-56102         c
            460-515             AL669927.9         51558-51613         c
            516-570             AL669927.9         48706-48760         c
            571-1083            AL669927.9         44180-44692         c
FEATURES             Location/Qualifiers
     source          1..1083
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 18.46 cM"
     gene            1..1083
                     /gene="Nudt6"
                     /gene_synonym="Asfgf2b"
                     /note="nudix hydrolase 6"
                     /db_xref="GeneID:229228"
                     /db_xref="MGI:MGI:2387618"
     exon            1..255
                     /gene="Nudt6"
                     /gene_synonym="Asfgf2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..968
                     /gene="Nudt6"
                     /gene_synonym="Asfgf2b"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nucleoside diphosphate-linked moiety X motif 6; nudix
                     motif 6; antisense basic fibroblast growth factor B; nudix
                     (nucleoside diphosphate linked moiety X)-type motif 6"
                     /codon_start=1
                     /product="nucleoside diphosphate-linked moiety X motif 6
                     isoform 1"
                     /protein_id="NP_001277973.1"
                     /db_xref="CCDS:CCDS71237.1"
                     /db_xref="GeneID:229228"
                     /db_xref="MGI:MGI:2387618"
                     /translation="MWWVRRTRYWFSTLLYAGGARLRPGRRTASGGLETPGSCGAELQ
                     GELDRFGGVSVHLSRHHTLHGLDAAAFRRLLQAAIQQWRSEGRIAAWLHIPILQSHFI
                     APAASLGFCFHHAKPHSSTLTLWLGEGPSRLPGYATHQVGVAGAVFDVSTRKVLVVQD
                     RNKLKNMWKFPGGLSEPGEDIADTAVREVFEETGVKSEFRSLLSIRQQHRSPGAFGMS
                     DMYLVCRLQPRSFTINFCQQECLKCEWIDLENLARTKHTTPITSRVARLLLYGLREGF
                     DKIDLSMEELPAVYTGLFYKLYHRELPESYKAATGAD"
     exon            256..459
                     /gene="Nudt6"
                     /gene_synonym="Asfgf2b"
                     /inference="alignment:Splign:2.1.0"
     exon            460..515
                     /gene="Nudt6"
                     /gene_synonym="Asfgf2b"
                     /inference="alignment:Splign:2.1.0"
     exon            516..570
                     /gene="Nudt6"
                     /gene_synonym="Asfgf2b"
                     /inference="alignment:Splign:2.1.0"
     exon            571..1083
                     /gene="Nudt6"
                     /gene_synonym="Asfgf2b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1028..1033
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nudt6"
                     /gene_synonym="Asfgf2b"
                     /note="hexamer: CATAAA"
     regulatory      1060..1065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nudt6"
                     /gene_synonym="Asfgf2b"
                     /note="hexamer: AATAAA"
     polyA_site      1075
                     /gene="Nudt6"
                     /gene_synonym="Asfgf2b"
     polyA_site      1083
                     /gene="Nudt6"
                     /gene_synonym="Asfgf2b"
                     /note="major polyA site"
ORIGIN      
        1 ggagaacgga aaggctaggt gcagccatgt ggtgggtgag gaggacccgc tactggttct
       61 ccacattgct ttacgcgggc ggagccaggc tccggccggg gcggcgcaca gcctcgggcg
      121 gcctggagac cccgggctcc tgcggggccg agctacaagg cgagctggac agatttgggg
      181 gcgtctcggt gcacttgtcg cggcaccata cgttgcacgg gctggatgcc gccgccttcc
      241 ggaggctctt gcaggctgcc attcagcagt ggcgctcaga aggacggata gctgcctggc
      301 tacacatccc catcctgcag agccacttca ttgcccctgc tgcttccctg ggcttttgct
      361 tccaccacgc aaaaccccat tcctcaacac tgactctgtg gctgggagaa ggacccagca
      421 gactcccggg atatgctaca caccaagttg gagttgcagg tgctgtattt gatgttagca
      481 ccaggaaagt actggttgta caagatcgaa ataaattgaa aaacatgtgg aagtttccag
      541 gaggcctgtc ggagccagga gaagatattg cagacacagc agtccgagag gtttttgaag
      601 agactggtgt caagtcagaa ttcaggtccc tgttgagcat ccggcagcaa cacaggagcc
      661 ctggggcctt cgggatgtca gacatgtacc tggtctgccg cctgcagcct cgttccttca
      721 ctatcaactt ctgccagcag gaatgcttga agtgtgaatg gattgatcta gaaaacctgg
      781 cccggactaa acacacgacc cccatcacca gcagggtggc taggctactg ctgtatggac
      841 tcagggaagg gtttgacaaa attgacctca gcatggagga gctccctgca gtgtacacag
      901 gcctgttcta caaactctat cacagggagc tgccggagag ttacaaagcc gcaacgggag
      961 cagactgaat accagatttc aacctgacgc cagttttctc acatatgtta tgtccatggt
     1021 ggaaattcat aaatgtacat atttttaaat cctcttttca ataaaggaaa tatgtgaaca
     1081 aga
//
