LOCUS       NM_016918               3455 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus nudix hydrolase 5 (Nudt5), transcript variant 1, mRNA.
ACCESSION   NM_016918
VERSION     NM_016918.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3455)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3455)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3455)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 3455)
  AUTHORS   Song,M.G., Li,Y. and Kiledjian,M.
  TITLE     Multiple mRNA decapping enzymes in mammalian cells
  JOURNAL   Mol Cell 40 (3), 423-432 (2010)
   PUBMED   21070968
REFERENCE   5  (bases 1 to 3455)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3455)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 3455)
  AUTHORS   Yang,H., Slupska,M.M., Wei,Y.F., Tai,J.H., Luther,W.M., Xia,Y.R.,
            Shih,D.M., Chiang,J.H., Baikalov,C., Fitz-Gibbon,S., Phan,I.T.,
            Conrad,A. and Miller,J.H.
  TITLE     Cloning and characterization of a new member of the Nudix
            hydrolases from human and mouse
  JOURNAL   J Biol Chem 275 (12), 8844-8853 (2000)
   PUBMED   10722730
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928924.12.
            
            On Mar 21, 2023 this sequence version replaced NM_016918.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088222.1, BC004571.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AL928924.12        59199-59331
            134-236             AL928924.12        68762-68864
            237-304             AL928924.12        69926-69993
            305-354             AL928924.12        74973-75022
            355-462             AL928924.12        76247-76354
            463-558             AL928924.12        77525-77620
            559-660             AL928924.12        78293-78394
            661-669             AL928924.12        80179-80187
            670-723             AL928924.12        80300-80353
            724-3455            AL928924.12        82035-84766
FEATURES             Location/Qualifiers
     source          1..3455
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 3.62 cM"
     gene            1..3455
                     /gene="Nudt5"
                     /note="nudix hydrolase 5"
                     /db_xref="GeneID:53893"
                     /db_xref="MGI:MGI:1858232"
     exon            1..133
                     /gene="Nudt5"
                     /inference="alignment:Splign:2.1.0"
     exon            134..236
                     /gene="Nudt5"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..833
                     /gene="Nudt5"
                     /EC_number="3.6.1.13"
                     /EC_number="3.6.1.58"
                     /EC_number="2.7.7.96"
                     /note="isoform a is encoded by transcript variant 1;
                     ADP-sugar pyrophosphatase; nudix motif 5; nucleoside
                     diphosphate-linked moiety X motif 5; 8-oxo-dGDP
                     phosphatase; nuclear ATP-synthesis protein NUDIX5; nudix
                     (nucleoside diphosphate linked moiety X)-type motif 5"
                     /codon_start=1
                     /product="ADP-sugar pyrophosphatase isoform a"
                     /protein_id="NP_058614.1"
                     /db_xref="CCDS:CCDS15667.1"
                     /db_xref="GeneID:53893"
                     /db_xref="MGI:MGI:1858232"
                     /translation="METRESTESSPGKHLVTSEELISEGKWVKFEKTTYMDPTGKTRT
                     WETVKLTTRKGKSADAVSVIPVLQRTLHHECVILVKQFRPPMGSYCLEFPAGFIEDGE
                     SPEAAALRELEEETGYKGEVAECSPAVCMDPGLSNCTTHVVTVTINGDDAGNVRPKPK
                     PGDGEFMEVISLPKNDLLTRLDALGAEQHLTVDAKVYAYGLALKHANSKPFEVPFLKF
                     "
     exon            237..304
                     /gene="Nudt5"
                     /inference="alignment:Splign:2.1.0"
     exon            305..354
                     /gene="Nudt5"
                     /inference="alignment:Splign:2.1.0"
     exon            355..462
                     /gene="Nudt5"
                     /inference="alignment:Splign:2.1.0"
     exon            463..558
                     /gene="Nudt5"
                     /inference="alignment:Splign:2.1.0"
     exon            559..660
                     /gene="Nudt5"
                     /inference="alignment:Splign:2.1.0"
     exon            661..669
                     /gene="Nudt5"
                     /inference="alignment:Splign:2.1.0"
     exon            670..723
                     /gene="Nudt5"
                     /inference="alignment:Splign:2.1.0"
     exon            724..3455
                     /gene="Nudt5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3436..3441
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nudt5"
                     /note="hexamer: AATAAA"
     polyA_site      3455
                     /gene="Nudt5"
                     /note="major polyA site"
ORIGIN      
        1 gcacatcctc cttgcaccac gagaggcgcc ggtgtctcta gcggtggcgc ctgattctac
       61 ggagactgca gcttctgcct gatccttttt cctttcctcc tcaatccctt ccacatccca
      121 cagtttagtg tagcttgaac tttccacctg aggactgtgg aggccgacaa gtcgaaatgg
      181 agacccgaga atccacagag tcttctccag gcaagcacct tgttacctca gaggagttga
      241 tctcagaagg aaaatgggtc aaatttgaaa aaacaactta tatggatccc actggtaaaa
      301 ccagaacttg ggaaacagtg aaacttacaa ccaggaaggg aaaatctgct gatgccgtgt
      361 cggtcatacc tgtgctgcaa agaaccctgc accatgagtg cgtcatcctg gtgaagcagt
      421 tccggccccc gatgggcagc tactgcctgg agtttccagc agggttcatc gaagacggag
      481 aaagcccaga ggcggctgct cttcgggagc tggaggaaga aactggctac aaaggtgaag
      541 ttgcggaatg ctctccagct gtgtgcatgg atccaggctt gtcaaactgc accacacatg
      601 ttgtgacagt gaccatcaat ggagatgatg caggaaatgt aaggccaaaa cccaaaccag
      661 gggatggaga atttatggaa gtgatttctt taccaaagaa tgatctgctg acaagacttg
      721 acgctttggg agcagaacaa caccttacag tggatgccaa ggtctacgcc tacggtctgg
      781 ctctgaaaca cgccaactcg aagccattcg aagtgccctt cctcaaattt taaggccaag
      841 gaggacactg gccatgattt gtaaatgaaa ccatgcggcc ttcactattc agtgtattca
      901 attaagttca atgtaggtca taaatcagct tttttcgtaa aagcagcaca gatgcatgtg
      961 gtatggaatt ataattacag agaggatata accttcattt aaatttgtta aatactcatg
     1021 gaaatgagtg tatagttagg tatgtttaaa tttattaaac tcacctggtc tagaaggtga
     1081 gggtacttct caggaataga ctcaagctcc caattaggtc agctatttct acccataatt
     1141 cctaaaatca tgtactgaag tctgcaaata gctatttatt aggctcacat ttaaaaatta
     1201 ggttgggttt ttgttgtctt gttttaagac agggtatcgc catgtagccc tggctagcct
     1261 ggaacttctt ttgcagacca ggctggcttt gaactccgag cgattcatct gtctgtctct
     1321 gcctctccaa agttctggga ataaagatgt gtagcaccac acatggcaag caaaagaaga
     1381 cttgggggtt tttttgttgt tgttgttttt caagaaagag tttctctgtg taacagccct
     1441 ggggctgtct tggaacttag tctatagacc aggctcagct tgtactccga gatctgcctg
     1501 cctctgcctc ctgagtgttg ggattaaagg gcacacacca ccacacccag caaaaataag
     1561 agttttaaaa gagagacccc agtagggact taccagtttc tcctaattct aattaatgta
     1621 ctatatggga ttcatttggg tagtagatgt aaaatcaata cagcataaca tttgtggtca
     1681 aagtgtagct acttgtggta catgcttata atccaccgtt ggaggctgag gcaggaggat
     1741 cataaatgta gccagtttgg gttacattat gacactctat gtctcagaaa taattttttt
     1801 ttgaagattc attttttatt atagctaagt acactgtagc tgttttcaga cgcaccagaa
     1861 gagggcatca gatctcatta caggtagttg tgagccacca tgtggtttct gggatttgaa
     1921 ctccggacct tcggaagaac agtttgttgg tactcttacc tgctgagcca tcttttcagc
     1981 cctcagaaat aatttttaaa ctgtatttaa tattctcata aggccacttc attcctaaaa
     2041 gtgtaccaag ataatgcttc aatagtgaac atagttaatt cttaattttt tttttttttt
     2101 ttttttttgg tttttcgaga catggtttct ctgtatagtc ctggctgtcc tggaaactca
     2161 ctttgtagac caggctggcc tcgaactcag aaatccgcct gcctctgcct cccggagtgc
     2221 tgggattaaa ggcgtgcgcc accatgcccc gctaattctt aatatattaa aaatatatga
     2281 aaactcggga tccttccttc aagtgtgcac acacttcagt ttcctaacct tacctccgaa
     2341 aatattgttt tacaaaacta aacccatagg aaaaagatta acatggattc tacatatata
     2401 tggatgtcag tagccatgag tataggcagg tatattagcc aattatctga aacaatcaga
     2461 ctacacaaga aatgcagaaa tggtttctag tatatgctag gcctaaagtt cacccaggag
     2521 ttgttccagt gttctggctc tgctctggtc tgatgagctc tgctactgtg attacctcag
     2581 ctgattacat cagctcaaga aaggtcagtt cagccaccag cagcagtcgg catgatgctt
     2641 gttggccagc tcaacacgtt tgcaacctag gtccagggta gatcctggga accttataaa
     2701 agcgcttttc ccaggtacag taggtataga cgctaagtgt tattgccgac acacattttt
     2761 atgcacaaaa atgtaagctc tttatacaaa tctttatact ggacttctta aggatggaaa
     2821 taattctgga actttgtagt ccaagtctgc attcctaatg agtgtgaaaa ttaacaccca
     2881 gtatagcaca gtagccttcc ctgtgactct gacccttcca atgttttctt ttgtgtttat
     2941 aatcatggcc ctgtctcccc aaatatacca acttttgcct gtaagttccc taggacatct
     3001 atttcactgt gtcgtttcct tccctctttt gaaatgaaga cacaggctcc acacattcgt
     3061 cctttccata gagcaggtat aggaccaggt gcaataaaaa aaaatggcct tgagtatcgg
     3121 ccgagataca aggtgtaccc catcttccct ggcccctggg tctctttcct gtgggagtgt
     3181 aactgagaag tgacagctac atcttagacg tgtcagtagc acatttcatt accagggtct
     3241 gtacctcaga ggtagagcca gatctggagc tggccatctg gtgtcttcac tcctcacaac
     3301 tttttttcgt tcatttggaa aactcagaaa gtgggttcta aaatacaggg tgttctccag
     3361 tgtctgacct tagctcaagc taagttagcc ctacctcctg ttcctactga aaactgtact
     3421 tttgaaaata agtaaaataa agtatgtaca aagaa
//
