LOCUS       NM_019837               2171 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus nudix hydrolase 3 (Nudt3), transcript variant 1, mRNA.
ACCESSION   NM_019837 XM_915103 XM_923572 XM_923579 XM_923590
VERSION     NM_019837.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2171)
  AUTHORS   Koopmans,F., van Nierop,P., Andres-Alonso,M., Byrnes,A.,
            Cijsouw,T., Coba,M.P., Cornelisse,L.N., Farrell,R.J.,
            Goldschmidt,H.L., Howrigan,D.P., Hussain,N.K., Imig,C., de
            Jong,A.P.H., Jung,H., Kohansalnodehi,M., Kramarz,B., Lipstein,N.,
            Lovering,R.C., MacGillavry,H., Mariano,V., Mi,H., Ninov,M.,
            Osumi-Sutherland,D., Pielot,R., Smalla,K.H., Tang,H., Tashman,K.,
            Toonen,R.F.G., Verpelli,C., Reig-Viader,R., Watanabe,K., van
            Weering,J., Achsel,T., Ashrafi,G., Asi,N., Brown,T.C., De
            Camilli,P., Feuermann,M., Foulger,R.E., Gaudet,P., Joglekar,A.,
            Kanellopoulos,A., Malenka,R., Nicoll,R.A., Pulido,C., de
            Juan-Sanz,J., Sheng,M., Sudhof,T.C., Tilgner,H.U., Bagni,C.,
            Bayes,A., Biederer,T., Brose,N., Chua,J.J.E., Dieterich,D.C.,
            Gundelfinger,E.D., Hoogenraad,C., Huganir,R.L., Jahn,R.,
            Kaeser,P.S., Kim,E., Kreutz,M.R., McPherson,P.S., Neale,B.M.,
            O'Connor,V., Posthuma,D., Ryan,T.A., Sala,C., Feng,G., Hyman,S.E.,
            Thomas,P.D., Smit,A.B. and Verhage,M.
  TITLE     SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the
            Synapse
  JOURNAL   Neuron 103 (2), 217-234 (2019)
   PUBMED   31171447
REFERENCE   2  (bases 1 to 2171)
  AUTHORS   Williams,M.J., Eriksson,A., Shaik,M., Voisin,S., Yamskova,O.,
            Paulsson,J., Thombare,K., Fredriksson,R. and Schioth,H.B.
  TITLE     The Obesity-Linked Gene Nudt3 Drosophila Homolog Aps Is Associated
            With Insulin Signaling
  JOURNAL   Mol Endocrinol 29 (9), 1303-1319 (2015)
   PUBMED   26168034
  REMARK    GeneRIF: studies revealed abundant Nudt3 mRNA and protein
            expression in the mouse brain, including reward- and
            feeding-related regions of hypothalamus and amygdala, and Nudt3
            mRNA expression was up-regulated in hypothalamus and brainstem of
            food-deprived mice.
REFERENCE   3  (bases 1 to 2171)
  AUTHORS   Song,M.G., Bail,S. and Kiledjian,M.
  TITLE     Multiple Nudix family proteins possess mRNA decapping activity
  JOURNAL   RNA 19 (3), 390-399 (2013)
   PUBMED   23353937
REFERENCE   4  (bases 1 to 2171)
  AUTHORS   Chu,C., Alapat,D., Wen,X., Timo,K., Burstein,D., Lisanti,M.,
            Shears,S. and Kohtz,D.S.
  TITLE     Ectopic expression of murine diphosphoinositol polyphosphate
            phosphohydrolase 1 attenuates signaling through the ERK1/2 pathway
  JOURNAL   Cell Signal 16 (9), 1045-1059 (2004)
   PUBMED   15212765
  REMARK    GeneRIF: Ectopic expression of murine DIPP1 (muDIPP1)inhibits
            signal transduction through the ERK1/2 pathway.
REFERENCE   5  (bases 1 to 2171)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 2171)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131800.4 and AC127341.3.
            
            On Mar 21, 2007 this sequence version replaced NM_019837.1.
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform 1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF264064.1, BC046805.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-366               AC131800.4         45623-45988         c
            367-477             AC131800.4         19260-19370         c
            478-522             AC127341.3         202887-202931       c
            523-607             AC127341.3         201683-201767       c
            608-2171            AC127341.3         199066-200629       c
FEATURES             Location/Qualifiers
     source          1..2171
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 14.59 cM"
     gene            1..2171
                     /gene="Nudt3"
                     /gene_synonym="1110011B09Rik; Dipp; Dipp1"
                     /note="nudix hydrolase 3"
                     /db_xref="GeneID:56409"
                     /db_xref="MGI:MGI:1928484"
     exon            1..366
                     /gene="Nudt3"
                     /gene_synonym="1110011B09Rik; Dipp; Dipp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..774
                     /gene="Nudt3"
                     /gene_synonym="1110011B09Rik; Dipp; Dipp1"
                     /EC_number="3.6.1.52"
                     /EC_number="3.6.1.59"
                     /EC_number="3.6.1.62"
                     /EC_number="3.6.1.10"
                     /EC_number="3.6.1.61"
                     /note="isoform 1 is encoded by transcript variant 1;
                     diphosphoinositol polyphosphate phosphohydrolase 1;
                     DIPP-1; ap6A hydrolase; endopolyphosphatase; m7GpppX
                     diphosphatase; nudix (nucleotide diphosphate linked moiety
                     X)-type motif 3; diadenosine 5',5'''-P1,P6-hexaphosphate
                     hydrolase 1; nudix (nucleoside diphosphate linked moiety
                     X)-type motif 3; m7GpppN-mRNA hydrolase; diadenosine
                     hexaphosphate hydrolase"
                     /codon_start=1
                     /product="diphosphoinositol polyphosphate phosphohydrolase
                     1 isoform 1"
                     /protein_id="NP_062811.1"
                     /db_xref="CCDS:CCDS28566.1"
                     /db_xref="GeneID:56409"
                     /db_xref="MGI:MGI:1928484"
                     /translation="MMKLKSNQTRTYDGDGYKKRAACLCFRSESEEEVLLVSSSRHPD
                     RWIVPGGGMEPEEEPSVAAVREVCEEAGVKGTLGRLVGIFENQERKHRTYVYVLIVTE
                     VLEDWEDSVNIGRKREWFKIEDAIKVLQCHKPVQASYFETLRQGYPANNGTPVVPTTY
                     SSSVSGIR"
     exon            367..477
                     /gene="Nudt3"
                     /gene_synonym="1110011B09Rik; Dipp; Dipp1"
                     /inference="alignment:Splign:2.1.0"
     exon            478..522
                     /gene="Nudt3"
                     /gene_synonym="1110011B09Rik; Dipp; Dipp1"
                     /inference="alignment:Splign:2.1.0"
     exon            523..607
                     /gene="Nudt3"
                     /gene_synonym="1110011B09Rik; Dipp; Dipp1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..2171
                     /gene="Nudt3"
                     /gene_synonym="1110011B09Rik; Dipp; Dipp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1138..1143
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nudt3"
                     /gene_synonym="1110011B09Rik; Dipp; Dipp1"
                     /note="hexamer: ATTAAA"
     polyA_site      1175
                     /gene="Nudt3"
                     /gene_synonym="1110011B09Rik; Dipp; Dipp1"
ORIGIN      
        1 ccaaaatggc ggcgcggtcg tcgtcggggg cggcggcggt agagggggcg gtggcggtgg
       61 cgacggcggc cgtgacggcg gcgcagggcc tgggccgggg gcaatgaggc tgtcccgccg
      121 cggagccgtg tagcggacac acagaccctc ctccccgccc tctcgatcga gcctggggcg
      181 cgcgcgcgcg cggccgcccg cctgcagcag gctccccttc cctggactcc gaggccccgc
      241 acggcacccc ccacccgggc ccggaggatg atgaagctca agtcgaacca gacccgcacc
      301 tacgacggcg acggctacaa gaagcgggcc gcgtgcctgt gcttccgcag cgagagcgag
      361 gaggaggtgc tgcttgtgag cagtagccgc catccagacc gatggattgt ccccggagga
      421 ggcatggagc ctgaggagga gccaagtgtg gcagctgtcc gggaagtgtg tgaggaggct
      481 ggagtgaaag ggacactggg aagactagtt ggaatttttg agaaccagga gaggaagcac
      541 aggacctacg tgtatgtgct catcgtcacg gaggtgctgg aagactggga ggactcggtg
      601 aacatcggaa ggaagagaga gtggtttaaa atagaagacg ccataaaggt gctgcagtgt
      661 cacaagcccg tgcaggcgtc atactttgag acgttgaggc aaggctaccc tgccaacaac
      721 ggcacccctg tggtgcccac cacctactcc agctccgtgt caggcatcag atgactgcag
      781 acttctgtaa gagccggaga gtggaaagca gactgaagca tggctctcct caccacccct
      841 cacctcacgg ccttctctgt cacccaggca tggcgggcag tggagagggg acactgaggt
      901 gctgctgtgg gctgtggcgg gaggcgggtg ggtgtggcag ggtgggaact cttttttctc
      961 ttcctgaggg tggggctggg tgtaactcac aagcactttc ctgcatgccc gatcctcccc
     1021 gctcgctcac cctgccctga gagggcacct ccctctcctt cttgggttcc gaagcactcc
     1081 catttgtctc gtcccggcct ggccagatat ttcctctgaa tttttttttt ttttttcatt
     1141 aaaagacacc catgtgcgat gaaactttct aaaaatctgt cctgtgctgt gctgttgagt
     1201 cccttaggtt gaccacgctc ccttgggacg cacctgtcca cacattgcac actgtcacgg
     1261 gacacgtaaa taagcggcgt agaacgagga gctcaactgt tcaggttctc aaagttttgg
     1321 gttttttttt tccttttttt ttctcagata tttctggttt gaagcccctc actcttcaca
     1381 tttgtttaat gctagtaact tggcgggctt ccctgtcctc tgttcccagc catgccgagc
     1441 ccggccacct tgctctcact cctgggaccc tggccttctg tctctaggct attcctgtgc
     1501 caaggaaaac agaagggaac ctgttttctt tctgttacga agcctggaaa acagtgagag
     1561 aaactgaatt ctgtccgata ggctcacagt aggctttaaa ctgtcaccct caatgtcgca
     1621 gaaaccgggc actgtgtctg tcctgctggc tggagattct ttctgtaatg ctatttattg
     1681 ctgacatagc ctctcttacc cttatatgcc ttccaccatg ctgacctggc tgtggcccca
     1741 cgctctgcag ccattctgca tagtcctgtc cccacgccga gaggccccac gacgtcctga
     1801 gaatacatgg ggagcagtgt gagcatgtat gtgccaaggg gggaccaaga gcttgctcaa
     1861 aagggacatt agctttctgt ctgctcggtg tgagaggtca tctggaagag gggcccaccg
     1921 gtgaccctct ggctccggtt ggtattttat agaggttttg tgccgaactc cccagccagt
     1981 tgtggtggtt agtcgggaag taaagggtcc tgggaggggc cttgagcaag gagggcaaga
     2041 ggggagctag gcctggctta gcgtgggtgc ttgggactct ttgtggcatt gcctatgttg
     2101 aaacgtagcc aagatgtgaa ttgaaaatag tacttctctt tatttaaaaa ctaataaata
     2161 ctcaaacttt g
//
