LOCUS       NM_025539                929 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus nudix hydrolase 2 (Nudt2), mRNA.
ACCESSION   NM_025539
VERSION     NM_025539.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 929)
  AUTHORS   Laudenbach,B.T., Krey,K., Emslander,Q., Andersen,L.L., Reim,A.,
            Scaturro,P., Mundigl,S., Dachert,C., Manske,K., Moser,M.,
            Ludwig,J., Wohlleber,D., Kroger,A., Binder,M. and Pichlmair,A.
  TITLE     NUDT2 initiates viral RNA degradation by removal of 5'-phosphates
  JOURNAL   Nat Commun 12 (1), 6918 (2021)
   PUBMED   34824277
  REMARK    GeneRIF: NUDT2 initiates viral RNA degradation by removal of
            5'-phosphates.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 929)
  AUTHORS   Carmi-Levy,I., Motzik,A., Ofir-Birin,Y., Yagil,Z., Yang,C.M.,
            Kemeny,D.M., Han,J.M., Kim,S., Kay,G., Nechushtan,H., Suzuki,R.,
            Rivera,J. and Razin,E.
  TITLE     Importin beta plays an essential role in the regulation of the
            LysRS-Ap(4)A pathway in immunologically activated mast cells
  JOURNAL   Mol Cell Biol 31 (10), 2111-2121 (2011)
   PUBMED   21402779
  REMARK    GeneRIF: Ap4A hydrolase was found to translocate into the nuclei of
            mast cells following immunological activation; found its
            immunologically dependent association with importin beta
REFERENCE   3  (bases 1 to 929)
  AUTHORS   Yu,J., Farjo,R., MacNee,S.P., Baehr,W., Stambolian,D.E. and
            Swaroop,A.
  TITLE     Annotation and analysis of 10,000 expressed sequence tags from
            developing mouse eye and adult retina
  JOURNAL   Genome Biol 4 (10), R65 (2003)
   PUBMED   14519200
REFERENCE   4  (bases 1 to 929)
  AUTHORS   Bailey,S., Sedelnikova,S.E., Blackburn,G.M., Abdelghany,H.M.,
            Baker,P.J., McLennan,A.G. and Rafferty,J.B.
  TITLE     The crystal structure of diadenosine tetraphosphate hydrolase from
            Caenorhabditis elegans in free and binary complex forms
  JOURNAL   Structure 10 (4), 589-600 (2002)
   PUBMED   11937063
REFERENCE   5  (bases 1 to 929)
  AUTHORS   Abdelghany,H.M., Gasmi,L., Cartwright,J.L., Bailey,S.,
            Rafferty,J.B. and McLennan,A.G.
  TITLE     Cloning, characterisation and crystallisation of a diadenosine
            5',5''-P(1),P(4)-tetraphosphate pyrophosphohydrolase from
            Caenorhabditis elegans
  JOURNAL   Biochim Biophys Acta 1550 (1), 27-36 (2001)
   PUBMED   11738085
REFERENCE   6  (bases 1 to 929)
  AUTHORS   Vartanian,A., Alexandrov,I., Prudowski,I., McLennan,A. and
            Kisselev,L.
  TITLE     Ap4A induces apoptosis in human cultured cells
  JOURNAL   FEBS Lett 456 (1), 175-180 (1999)
   PUBMED   10452553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132532.1, AK018771.1 and CB845734.1.
            
            On Jan 31, 2006 this sequence version replaced NM_025539.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DV053465.1, AK132532.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-337               AK132532.1         2-338
            338-338             AK018771.1         336-336
            339-770             AK132532.1         340-771
            771-929             CB845734.1         346-504
FEATURES             Location/Qualifiers
     source          1..929
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 21.65 cM"
     gene            1..929
                     /gene="Nudt2"
                     /gene_synonym="2310051L06Rik; APAH1"
                     /note="nudix hydrolase 2"
                     /db_xref="GeneID:66401"
                     /db_xref="MGI:MGI:1913651"
     exon            1..33
                     /gene="Nudt2"
                     /gene_synonym="2310051L06Rik; APAH1"
                     /inference="alignment:Splign:2.1.0"
     exon            34..167
                     /gene="Nudt2"
                     /gene_synonym="2310051L06Rik; APAH1"
                     /inference="alignment:Splign:2.1.0"
     exon            168..848
                     /gene="Nudt2"
                     /gene_synonym="2310051L06Rik; APAH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      816..821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nudt2"
                     /gene_synonym="2310051L06Rik; APAH1"
                     /note="hexamer: AATAAA"
     polyA_site      835
                     /gene="Nudt2"
                     /gene_synonym="2310051L06Rik; APAH1"
                     /note="major polyA site"
ORIGIN      
        1 gttcgaggac cgcctcctgc ctctgggcta cggatagatc atggccctga gggcatgtgg
       61 cttgatcatc ttccgaagac accttattcc caagatggac aacagtacaa ttgaatttct
      121 gctgctgcag gcatcagacg gcattcatca ctggactcct cccaaaggcc atgtggaccc
      181 aggagagaat gacttagaaa cagccctgcg agagactcgg gaggaaacag gcatagaagc
      241 aagccaactg accatcattg aggggttcag aagggagctc aattacgtgg ccaggcagaa
      301 gcctaaaacg gtcatttact ggctggcaga agtgaaagac tacaatgtag agatccgcct
      361 ctcccaggag catcaagcct accgctggct ggggctggag gaggcctgcc agttggctca
      421 gttcaaggag atgaaggcaa cactccaaga aggacaccag tttctctgct ccacaccggc
      481 ctgagctgac cagaacaaat gcttccattg catccttaag ggtttttcaa gataaaccca
      541 cccttccatc cagggaagga tgcacgggtc atggcttgtt aacaaccaag agcagatagg
      601 ttagtgaaat taaaattaac tcggcactct caggtgacag caaggaagcc ctggattcaa
      661 tccctagcat agaaaataat gactttaaaa agtaaagcaa ggattttact ttaaaataat
      721 tactttcaaa gcaagaattt tagctaagtt aaaaaacaaa ggaggggtac ggttttttaa
      781 atgacagccc cgaagtatgt cttttgtcat ttataaataa actggaagca acgtacatgc
      841 cctttcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
      901 aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
