LOCUS       NM_033080               1927 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus nudix hydrolase 19 (Nudt19), mRNA.
ACCESSION   NM_033080
VERSION     NM_033080.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1927)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1927)
  AUTHORS   Gorigk,S., Ouwens,D.M., Kuhn,T., Altenhofen,D., Binsch,C.,
            Damen,M., Khuong,J.M., Kaiser,K., Knebel,B., Vogel,H.,
            Schurmann,A., Chadt,A. and Al-Hasani,H.
  TITLE     Nudix hydrolase NUDT19 regulates mitochondrial function and ATP
            production in murine hepatocytes
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1867 (6), 159153 (2022)
   PUBMED   35367353
  REMARK    GeneRIF: Nudix hydrolase NUDT19 regulates mitochondrial function
            and ATP production in murine hepatocytes.
REFERENCE   3  (bases 1 to 1927)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1927)
  AUTHORS   Shumar,S.A., Kerr,E.W., Geldenhuys,W.J., Montgomery,G.E.,
            Fagone,P., Thirawatananond,P., Saavedra,H., Gabelli,S.B. and
            Leonardi,R.
  TITLE     Nudt19 is a renal CoA diphosphohydrolase with biochemical and
            regulatory properties that are distinct from the hepatic Nudt7
            isoform
  JOURNAL   J Biol Chem 293 (11), 4134-4148 (2018)
   PUBMED   29378847
REFERENCE   5  (bases 1 to 1927)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 1927)
  AUTHORS   Belknap,J.K., Phillips,T.J. and O'Toole,L.A.
  TITLE     Quantitative trait loci associated with brain weight in the BXD/Ty
            recombinant inbred mouse strains
  JOURNAL   Brain Res Bull 29 (3-4), 337-344 (1992)
   PUBMED   1393606
REFERENCE   7  (bases 1 to 1927)
  AUTHORS   Chaudhuri,A., Barbour,K.W. and Berger,F.G.
  TITLE     Evolution of messenger RNA structure and regulation in the genus
            Mus: the androgen-inducible RP2 mRNAs
  JOURNAL   Mol Biol Evol 8 (5), 641-653 (1991)
   PUBMED   1766361
REFERENCE   8  (bases 1 to 1927)
  AUTHORS   Saunders,A.M. and Seldin,M.F.
  TITLE     A molecular genetic linkage map of mouse chromosome 7
  JOURNAL   Genomics 8 (3), 525-535 (1990)
   PUBMED   1981054
REFERENCE   9  (bases 1 to 1927)
  AUTHORS   Saunders,A.M. and Seldin,M.F.
  TITLE     The syntenic relationship of proximal mouse chromosome 7 and the
            myotonic dystrophy gene region on human chromosome 19q
  JOURNAL   Genomics 6 (2), 324-332 (1990)
   PUBMED   2307474
REFERENCE   10 (bases 1 to 1927)
  AUTHORS   Snider,L.D., King,D. and Lingrel,J.B.
  TITLE     Androgen regulation of MAK mRNAs in mouse kidney
  JOURNAL   J Biol Chem 260 (17), 9884-9893 (1985)
   PUBMED   2410417
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CJ063443.1,
            AK011801.1, CX734133.1 and AA500841.1.
            
            On Apr 27, 2006 this sequence version replaced NM_033080.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138674.1, SRR1660817.152476.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-533               CJ063443.1         2-534
            534-1291            AK011801.1         390-1147
            1292-1779           CX734133.1         1-488               c
            1780-1927           AA500841.1         1-148               c
FEATURES             Location/Qualifiers
     source          1..1927
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 21.37 cM"
     gene            1..1927
                     /gene="Nudt19"
                     /gene_synonym="D7Rp2; D7Rp2-r; D7Rp2-s; D7Rp2e; RP2-r;
                     RP2-s"
                     /note="nudix hydrolase 19"
                     /db_xref="GeneID:110959"
                     /db_xref="MGI:MGI:94203"
     exon            1..775
                     /gene="Nudt19"
                     /gene_synonym="D7Rp2; D7Rp2-r; D7Rp2-s; D7Rp2e; RP2-r;
                     RP2-s"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1198
                     /gene="Nudt19"
                     /gene_synonym="D7Rp2; D7Rp2-r; D7Rp2-s; D7Rp2e; RP2-r;
                     RP2-s"
                     /EC_number="3.6.1.77"
                     /note="nucleoside diphosphate-linked moiety X motif 19,
                     mitochondrial; RP2p; nudix motif 19; androgen-regulated
                     protein RP2; testosterone-regulated RP2 protein; androgen
                     regulated gene RP2; renal CoA diphosphohydrolase;
                     acyl-coenzyme A diphosphatase NUDT19; nudix (nucleoside
                     diphosphate linked moiety X)-type motif 19"
                     /codon_start=1
                     /product="acyl-coenzyme A diphosphatase NUDT19 precursor"
                     /protein_id="NP_149071.2"
                     /db_xref="CCDS:CCDS21152.1"
                     /db_xref="GeneID:110959"
                     /db_xref="MGI:MGI:94203"
                     /translation="MSSSSSWRRAATVMLAAGWTHSSPAGFRLLLLQRAQNQRFLPGA
                     HVFPGGVLDAADSSPDWVRLFAPRHTPPRFGLGPEPPRQPPFPGLSHGDADPAALPDD
                     VALRICAIREAFEEAGVLLLRPRDAAPASQEPSQALSPPAGLAEWRSRVRSDPRCFLQ
                     LCAHLDCTPDIWALHDWGGWLTPYGRTIRRFDTTFFLCCLRDIPRVEPDVAEVVGYQW
                     LSPSEATECFLSKEIWLAPPQFYEMRRLENFASLSALYRFCSDRPSEVPEKWLPIILL
                     TSDGTIHLLPGDELYVKDSDFLEKNMSTDKKTEEIVKEGKVLNRVVIHSPYVYEIYMT
                     LPSENKHVYPRNYIVNKRCTAHL"
     exon            776..983
                     /gene="Nudt19"
                     /gene_synonym="D7Rp2; D7Rp2-r; D7Rp2-s; D7Rp2e; RP2-r;
                     RP2-s"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1922
                     /gene="Nudt19"
                     /gene_synonym="D7Rp2; D7Rp2-r; D7Rp2-s; D7Rp2e; RP2-r;
                     RP2-s"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1272..1277
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nudt19"
                     /gene_synonym="D7Rp2; D7Rp2-r; D7Rp2-s; D7Rp2e; RP2-r;
                     RP2-s"
                     /note="hexamer: CATAAA"
     polyA_site      1295
                     /gene="Nudt19"
                     /gene_synonym="D7Rp2; D7Rp2-r; D7Rp2-s; D7Rp2e; RP2-r;
                     RP2-s"
     regulatory      1372..1377
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nudt19"
                     /gene_synonym="D7Rp2; D7Rp2-r; D7Rp2-s; D7Rp2e; RP2-r;
                     RP2-s"
                     /note="hexamer: AGTAAA"
     polyA_site      1393
                     /gene="Nudt19"
                     /gene_synonym="D7Rp2; D7Rp2-r; D7Rp2-s; D7Rp2e; RP2-r;
                     RP2-s"
     regulatory      1889..1894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nudt19"
                     /gene_synonym="D7Rp2; D7Rp2-r; D7Rp2-s; D7Rp2e; RP2-r;
                     RP2-s"
                     /note="hexamer: ATTAAA"
     polyA_site      1915
                     /gene="Nudt19"
                     /gene_synonym="D7Rp2; D7Rp2-r; D7Rp2-s; D7Rp2e; RP2-r;
                     RP2-s"
                     /note="major polyA site"
ORIGIN      
        1 ctcccacaag taaacctccg gaagccgcca ggccggattt ttcaggccct caacatttat
       61 agggcttctg gacaccactc tacgacccgg ccacttccta agggggatct gaaggacgcc
      121 ggccatgagc agctcgagca gctggcggcg ggcagccacc gtgatgttgg cagcaggctg
      181 gacccactcg agcccggccg gcttccggct gctgcttctc cagcgagcac aaaaccagcg
      241 cttcttgccc ggcgcgcacg tcttcccggg cggcgtgctg gacgcggccg acagctcacc
      301 cgactgggtg cgtctgttcg cgcctcggca cacgccgccg cgcttcggcc taggcccgga
      361 gccccctcgg caacccccct tccccgggct gtcccacggc gacgcggacc ccgcggcgct
      421 gcccgatgac gtagcgctgc gcatctgtgc catccgcgaa gccttcgagg aggcgggggt
      481 gctgctcctg cggccgcggg acgcggctcc agcttctcag gagcccagtc aggcgctgtc
      541 gcctccggcc ggcctggccg aatggcgctc gcgcgtgcgc agtgacccgc gctgcttcct
      601 ccagctgtgt gcgcacctag actgcacgcc tgacatctgg gcgctgcacg actggggcgg
      661 atggctcacc ccgtatgggc gaaccatccg ccgtttcgac accaccttct tcctgtgctg
      721 cctgcgcgac attccgcgcg tggagcccga cgtggccgag gtggtgggct accagtggtt
      781 gtccccatca gaggcaactg aatgtttcct atcaaaagaa atctggctgg caccaccaca
      841 gttctatgaa atgagaagac ttgaaaactt tgcctctctc tctgctctgt atagattttg
      901 ttcggatcgc ccatcagaag tacctgagaa atggctgcca ataatacttt taacttctga
      961 tggcaccatc catcttctcc caggagatga gctgtatgtg aaagactcag acttcttgga
     1021 aaagaatatg tctactgaca aaaagactga agaaatcgtg aaggaaggca aagtccttaa
     1081 ccgagttgtg atccacagtc cctatgtgta cgaaatctac atgactcttc cgtcagagaa
     1141 taagcacgtg taccctagga actacatagt gaataagaga tgtactgccc acctgtaagc
     1201 cgcactactt atgtactgtt agcaaataat gaagattgac tgaacctgtc taaaaatcta
     1261 aggaatgtac ccataaaagt cacaatgagg tgttacctgt gtcatgtgtg ttttgggagc
     1321 ctctgccatt tgtcagactg cacagcaagc caaatgtaga atggacgaag tagtaaagct
     1381 cttgtcacca agatgaacgg tttcacgaca gttgttttat tagttgaaca ttggaaagtg
     1441 gtctcctgcc atcctctaac tgtcccacgc gttagcaggt ttcctggtgc gctgtggaga
     1501 ctgagccctg gctctcttac actttcgcag gaattgattc cgagatacct agttaaagag
     1561 tgctgagggt cagatgtgag aggactccca cttgctccct ggttggtagc cattttggca
     1621 ggttgtgaaa actgaggggc aggctttagc tagggtcttg agggatcgag tcttaactct
     1681 gtgccagcag ggtcctttgt ttctccatct gaggagatgc gagcagactt tgcctcaggt
     1741 ttctgcctcc aggaaggtcc cttgtttctt ctgtcgggct tttgatcaca gtaaggaaag
     1801 ttaatataaa taaacagtga tcatccttca aaggggatgt catggtcgtg ccatagaatc
     1861 aacttgataa ttaacataca gtatttgcat taaaaccaaa tgacattcat tttgacatcc
     1921 aaaaaaa
//
