LOCUS       NM_153136               3856 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus nudix hydrolase 18 (Nudt18), transcript variant 1,
            mRNA.
ACCESSION   NM_153136
VERSION     NM_153136.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3856)
  AUTHORS   Tamplin,O.J., Cox,B.J. and Rossant,J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
REFERENCE   2  (bases 1 to 3856)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122268.5, AK157937.1 and AK089446.1.
            
            On Feb 6, 2018 this sequence version replaced NM_153136.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157937.1, AK155086.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AC122268.5         202147-202172
            27-2762             AK157937.1         5-2740
            2763-2763           AK089446.1         2528-2528
            2764-3739           AK157937.1         2742-3717
            3740-3856           AK089446.1         3505-3621
FEATURES             Location/Qualifiers
     source          1..3856
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.32 cM"
     gene            1..3856
                     /gene="Nudt18"
                     /note="nudix hydrolase 18"
                     /db_xref="GeneID:213484"
                     /db_xref="MGI:MGI:2385853"
     exon            1..287
                     /gene="Nudt18"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1097
                     /gene="Nudt18"
                     /EC_number="3.6.1.58"
                     /note="isoform 1 is encoded by transcript variant 1; mutT
                     homolog 3; 2-hydroxy-dADP phosphatase;
                     7,8-dihydro-8-oxoguanine phosphatase; 8-oxo-dGDP
                     phosphatase NUDT18; nudix (nucleoside diphosphate linked
                     moiety X)-type motif 18"
                     /codon_start=1
                     /product="8-oxo-dGDP phosphatase NUDT18 isoform 1"
                     /protein_id="NP_694776.2"
                     /db_xref="CCDS:CCDS27258.1"
                     /db_xref="GeneID:213484"
                     /db_xref="MGI:MGI:2385853"
                     /translation="MATEGLAGALATVLGGKGLLVQSCDSEPAGKPLFPVRLRKNVCY
                     VVLAVFLNEQDEVLMIQEAKRECRGTWYLPAGRMEPGETIVEAMQREVKEEAGLLCEP
                     VTLLSVEERGASWIRFVFLARPTGGVLKTSKDADSESLQAGWYPRVSLPTPLRAHDVL
                     HLVELGAKFCQQAMHPLILPQELPCSVVCQRLVTTFTTVQSVWVLVGTVGTPHLPITA
                     CGFTPMEQRGGIKVAILRLLQECLTLHSLAVETKGLLGLQHLGRDHVDGVCLNVLVTV
                     AFRNPGIQDEPPKIRGENYFWWKVLEEDLQKLLLYRLQESSVIPLSR"
     exon            288..501
                     /gene="Nudt18"
                     /inference="alignment:Splign:2.1.0"
     exon            502..3856
                     /gene="Nudt18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1430..1435
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nudt18"
                     /note="hexamer: AGTAAA"
     polyA_site      1449
                     /gene="Nudt18"
                     /note="major polyA site"
     regulatory      1671..1676
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nudt18"
                     /note="hexamer: AATAAA"
     polyA_site      1693
                     /gene="Nudt18"
     regulatory      2750..2755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nudt18"
                     /note="hexamer: AATAAA"
     polyA_site      2774
                     /gene="Nudt18"
ORIGIN      
        1 gtgttagtct tggccctcaa gtcaggggag ggggcgaggg cgccgcggcc caccgcagct
       61 caggtcccgg ccgcttgcct ccgggggtct ggcaggtccc ggcttgccac ctccccggag
      121 acttgatggc cacggagggc ctggcagggg cgcttgccac cgtgctgggg ggaaaggggt
      181 tgctggtgca gagctgtgac tcggagccgg ctgggaagcc gctgtttccc gtgcggctgc
      241 ggaagaatgt ctgctacgtg gtgctggccg tgttcctcaa cgagcaggat gaggtgttga
      301 tgatacagga ggccaagagg gaatgccggg ggacatggta cctccctgca ggaagaatgg
      361 aaccaggaga aaccatcgtg gaggccatgc agcgggaggt gaaggaggag gcagggctgc
      421 tctgtgagcc agtgacactg ctgtccgtgg aggagagggg cgcctcctgg atccgctttg
      481 tgttcctcgc tcgaccaaca ggcggagttc tcaagacttc caaagatgct gattctgagt
      541 ccctccaggc cggctggtac ccacgggtct ccctgcccac accgcttaga gcccatgatg
      601 ttctgcacct ggtagagcta ggcgccaaat tctgccaaca agccatgcac cctctcattc
      661 tgcctcaaga gctcccctgc agtgtggtct gccaacggct ggtgaccacc ttcacaacag
      721 tccagtcggt gtgggtgttg gtgggcacgg tggggacacc tcacttgccc atcactgcct
      781 gtggctttac ccctatggaa caaaggggcg gcatcaaggt ggccatcttg aggctcctac
      841 aggagtgtct gactctgcac agtttggcag tggagaccaa ggggttgctt gggttgcaac
      901 acctaggcag agaccatgtg gatggtgtct gcctgaatgt gctggtgacc gtggcttttc
      961 ggaacccagg aatccaagac gagcccccaa agattcgggg tgaaaactac ttttggtgga
     1021 aggtattaga ggaagattta caaaaactgc ttctgtacag actccaggaa tcttctgtga
     1081 tccccctgag cagatagaga gattccagca gggaccaaaa gctgagctgc cccctccctc
     1141 tgaggcagag aaaaggctgg cagtcaggga tctcattgca cattttgagg gggcagggac
     1201 cacacattga gcccaaaggg agggtgtctt gaatccactt ttcaagggct cagttctgag
     1261 ggcacacagt acttgtcttt taagttggtg aggaactttt tgaaccctaa atggcaccat
     1321 ctttgtccac tttggaaaag gctgcatgtc aatccttcca accccatagg aatgtagaga
     1381 gggatgggac atgggggacg catccctcag ggcagagtcc tcattgctga gtaaaaaggt
     1441 attgcttaac ctgcctgctt gcctaaatgt ctgtgtgggg aggatatggg gcactgtccc
     1501 acccacagtc acccaggtct ttcctcaccg tgtacacact gatgctatgc agggatgtaa
     1561 ggatcctgag gcagacatcg atgctcgctg aagcctcgac ccacccaggc tctttttagt
     1621 gttcctgtcc tgtcagggcg ggcgtgggac tttgaagtga ccacacccct aataaaagca
     1681 cagctcagac ctgtccaggt gttgaacggt tcggtctggt gaaactgcct agggaacaag
     1741 aaagagctga ggatgacacg ttggcctctg ccagtctttt tctctttgag cttcctgggc
     1801 tctgacctgt tccgtgtgct ctcggacctg gctttttggt ttttgttcat gtccctgtcc
     1861 tcagttcatg tcgcccaggc agactgtgaa ctcttataat gtagctggtg atgaccttga
     1921 ctcatccaga ttctgcagaa gtcaagccct tttatcaatg ggttacactc ccaggccagc
     1981 acaggattct gttttcttga gatagactct gcccacatag accaggctga cctcaatcaa
     2041 gtttgttgtg atcttcctgc ctccaattct tgagtcctgg gaatacagat gtgctccagc
     2101 atgctgctgc ttatcattag catcattatt attatctgat gaaagcttcg gagctggcga
     2161 ggtggctccg ctcagcagtt aagagcatat gcggctggct catgctgagg acctgagttt
     2221 ggtttccagt ccttgcacca agtggctcac aaccacctcc agcttcaggc tttctgaaac
     2281 cctctctagc ctctgagggc actcactcaa tgtgtacatc tcctatgcag acatacataa
     2341 ttaaaaatag aaatgaaaat gaaaatcaaa agcagttgga gcaaaggaaa tgtatcccat
     2401 gttgctaatc atcacattag atttctgatt ctgagcaagg agacgcactt cctagcattg
     2461 cttttcacag aggacagtag cttgaggagc cagaaaaact ccttgatcct tttcctagtg
     2521 ccccaggcct ctttggtaac catcttgtct ggtctctaga aagaggaatc ctccttagac
     2581 tccctgagga catagtttcc aaatgataaa ccaaagcgag gtatgatggc acacaccttt
     2641 tatcccagca ttcgggaggc agaggcagga ggatctctag gaatctatat agcaagttcc
     2701 aggacagcca gtactacata gtgaggccct atttcaaaaa ctagaacaaa ataaatgaag
     2761 tcttttctat tttatttttg gagtgctgtg ggttgaaccc aggggctcac acattttggg
     2821 ttaagcaggc tacctaatgg tctcactgaa aaccaaaacc ttttattcag gtcaggactc
     2881 ctccagttcc cccacacaca gagaagggca gtgacattca ctgccaccat ttagcctggt
     2941 ggcttttgat cctgagtaca catcactgtc acccagacag ttctcagttc tgtccaccca
     3001 ctagggtgac taagctgctg aaaccagctg ggagctggcg tgtgtgtgtg tgtgtgtgtg
     3061 tgtgtgtgtg tgtgtgtgtc tgtccaagcg catgagcagg cacatgcatg cacataagca
     3121 agagaaggag ggtgtcggga gccctgttct attgctttct actttattcc cgtgagacag
     3181 ggtctggtct atcactgaac ctggagctag actggcacac tgcaagctcc agtgatcctc
     3241 ctgtctcctt tacccatggc tctaggacgt cagatgtgta cgcagccaca ccttggcttc
     3301 ttacctgggt gatgggaata cagagaaacc catggctctg ttggcacttt caccccctga
     3361 gccatctccc cagctgggca ccagtatctc agaaagaagc ctagattatt cttaaaaggt
     3421 ctttttagat ttctgtttat gtgtgtgtgt gtgcacactc aagtgcaggc cctcagaggc
     3481 atcagatccc ctggagctgg cgctttgggc agttgaaggc ttccttacat tggtgctggg
     3541 aagcaaactt aggtcctctg cagtaagtgt gttactcact aagctgcctc tccaagtggt
     3601 tctagtaggc actattgaaa ccctgctgag gacctgcttc tcaaatctcc attgcccgac
     3661 cccctggata ctctttatga ttcagaatac tcattcccat accatttaga aaacagccga
     3721 tgtgggagtt gggcaccgga gtacacacct gtaactccag cactcaggag gctgagacga
     3781 aagggtccct atccagttca aagccatcct ggacatgtat ggagcatgac cctctcaaaa
     3841 gtccaaccca ccaacc
//
