LOCUS       NM_025839               1294 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus nudix hydrolase 16 like 1 (Nudt16l1), transcript
            variant 1, mRNA.
ACCESSION   NM_025839
VERSION     NM_025839.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1294)
  AUTHORS   Tsaousidou,E., Chrzanowski,J., Drane,P., Lee,G.Y., Bahour,N.,
            Wang,Z.B., Deng,S., Cao,Z., Huang,K., He,Y., Kaminski,M.,
            Michalek,D., Guney,E., Parmar,K., Fendler,W., Chowdhury,D. and
            Hotamisligil,G.S.
  TITLE     Endogenous p53 inhibitor TIRR dissociates systemic metabolic health
            from oncogenic activity
  JOURNAL   Cell Rep 43 (6), 114337 (2024)
   PUBMED   38861384
REFERENCE   2  (bases 1 to 1294)
  AUTHORS   Song,M.G., Li,Y. and Kiledjian,M.
  TITLE     Multiple mRNA decapping enzymes in mammalian cells
  JOURNAL   Mol Cell 40 (3), 423-432 (2010)
   PUBMED   21070968
REFERENCE   3  (bases 1 to 1294)
  AUTHORS   Phan,L.K., Lin,F., LeDuc,C.A., Chung,W.K. and Leibel,R.L.
  TITLE     The mouse mahoganoid coat color mutation disrupts a novel C3HC4
            RING domain protein
  JOURNAL   J Clin Invest 110 (10), 1449-1459 (2002)
   PUBMED   12438443
REFERENCE   4  (bases 1 to 1294)
  AUTHORS   Denhez,F., Wilcox-Adelman,S.A., Baciu,P.C., Saoncella,S., Lee,S.,
            French,B., Neveu,W. and Goetinck,P.F.
  TITLE     Syndesmos, a syndecan-4 cytoplasmic domain interactor, binds to the
            focal adhesion adaptor proteins paxillin and Hic-5
  JOURNAL   J Biol Chem 277 (14), 12270-12274 (2002)
   PUBMED   11805099
REFERENCE   5  (bases 1 to 1294)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK003241.1 and BQ030979.1.
            
            On Oct 24, 2015 this sequence version replaced NM_025839.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003241.1, AK007897.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1267              AK003241.1         2-1268
            1268-1294           BQ030979.1         1-27                c
FEATURES             Location/Qualifiers
     source          1..1294
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 2.48 cM"
     gene            1..1294
                     /gene="Nudt16l1"
                     /gene_synonym="1110001K21Rik; 5330437I08Rik; Sdos;
                     syndesmos"
                     /note="nudix hydrolase 16 like 1"
                     /db_xref="GeneID:66911"
                     /db_xref="MGI:MGI:1914161"
     exon            1..183
                     /gene="Nudt16l1"
                     /gene_synonym="1110001K21Rik; 5330437I08Rik; Sdos;
                     syndesmos"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..666
                     /gene="Nudt16l1"
                     /gene_synonym="1110001K21Rik; 5330437I08Rik; Sdos;
                     syndesmos"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein syndesmos; NUDT16-like protein 1;
                     tudor-interacting repair regulator protein; nudix
                     (nucleoside diphosphate linked moiety X)-type motif
                     16-like 1"
                     /codon_start=1
                     /product="tudor-interacting repair regulator protein
                     isoform 1"
                     /protein_id="NP_080115.1"
                     /db_xref="CCDS:CCDS27927.1"
                     /db_xref="GeneID:66911"
                     /db_xref="MGI:MGI:1914161"
                     /translation="MSTTTVPELKQISREEAMRLGPGWSHSCHAMLYAANPGQLFGRI
                     PMRFSVLMQMRFDGLLGFPGGFVDRRFWSLEDGLNRVLGLGLGGLRLTEADYLSSHLT
                     EGPHRVVAHLYARQLTLEQLHAVEISAVHSRDHGLEVLGLVRVPLYTQKDRVGGFPNF
                     LSNAFVSTAKYQLLFALKVLNMMPSEKLAEALASATEKQKKALEKLLPPSS"
     exon            184..444
                     /gene="Nudt16l1"
                     /gene_synonym="1110001K21Rik; 5330437I08Rik; Sdos;
                     syndesmos"
                     /inference="alignment:Splign:2.1.0"
     exon            445..1277
                     /gene="Nudt16l1"
                     /gene_synonym="1110001K21Rik; 5330437I08Rik; Sdos;
                     syndesmos"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1246..1251
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nudt16l1"
                     /gene_synonym="1110001K21Rik; 5330437I08Rik; Sdos;
                     syndesmos"
                     /note="hexamer: AATAAA"
     polyA_site      1270
                     /gene="Nudt16l1"
                     /gene_synonym="1110001K21Rik; 5330437I08Rik; Sdos;
                     syndesmos"
                     /note="major polyA site"
ORIGIN      
        1 gtttgggcag tgggcctgga gcacatcaag atgtcgacca cgacggttcc ggagctgaaa
       61 cagatcagtc gggaggaagc aatgcgcttg gggcccggct ggagtcattc atgccacgcc
      121 atgctatacg ccgccaaccc cgggcagctt ttcggacgta tccccatgcg tttctcagtg
      181 ctgatgcaga tgcgcttcga cgggctgcta ggctttcccg ggggtttcgt ggaccggcgc
      241 ttctggtcgc tggaggatgg cttgaatcgg gtgctgggcc tgggcctggg cggcctacgc
      301 cttaccgaag ctgattacct gagttcacac ctgactgagg gtccacaccg tgtggtggca
      361 catctgtacg cacggcagct gacattggaa caactgcatg ctgtggagat cagcgctgtg
      421 cactcacggg accacggtct ggaggtcctg ggccttgtac gggtcccact gtacacacag
      481 aaggatcgag taggcggctt tcctaacttt ctgagcaacg ccttcgtcag cactgccaaa
      541 tatcaacttc tatttgccct taaggtactc aacatgatgc cctcggaaaa gctggccgag
      601 gccttggcct cagcaacaga gaagcagaag aaggctctag aaaagctgct cccgccctca
      661 tcctgaggtg cttcttgtgc aggtccctgc cctcccttgg ctgtctctgc ccacaggccc
      721 tggaattccc gagacgcgtg ccttctagtg tgtttgcttt tgcatccctt ctgactgcaa
      781 gggacatgca ggcagctgtt catcattact gtcccaagca gtccctggga cctagctaca
      841 ctctcaggtt ggtcagtggg ggtgggcctg ggcctaactt ttcaagctga agatgctctc
      901 acccatccca gggctcaaac tgtcctgtgc gagtctgttc atgactagtg gagtcccagc
      961 tagagcccat tcttcgaagg caaccacttg gttggaacac agatcctgga ctggtcatgg
     1021 gttttgccca acagagatga cccacgttag accaaccctt ctttccctta gcccagagcc
     1081 tgacccagcg tggggcaaga tgtttatttg ggtgcttgtt ggatttctct gttagatttt
     1141 gttcttggtg tatgaactgt ggtttggttt cagaatggct gtgccccaca tgattttgtt
     1201 ttccccatgg gggcctctgt gaagctgagg aaggaagaag acaataataa agccattcct
     1261 ctgatgctca tgttgctaaa aaaaaaaaaa aaaa
//
