LOCUS       NM_029385               1606 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus nudix hydrolase 16 (Nudt16), mRNA.
ACCESSION   NM_029385 XM_001471758
VERSION     NM_029385.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1606)
  AUTHORS   Kim,H., Yoo,J., Lee,I., Kang,Y.J., Cho,H.S. and Lee,W.
  TITLE     Crystal structure of syndesmos and its interaction with Syndecan-4
            proteoglycan
  JOURNAL   Biochem Biophys Res Commun 463 (4), 762-767 (2015)
   PUBMED   26100207
  REMARK    GeneRIF: binding interaction between syndesmos and syn4(cyto) was
            characterized as a low-affinity interaction (Kd = 62 muM) by
            surface plasmon resonance and nuclear magnetic resonance
REFERENCE   2  (bases 1 to 1606)
  AUTHORS   Song,M.G., Li,Y. and Kiledjian,M.
  TITLE     Multiple mRNA decapping enzymes in mammalian cells
  JOURNAL   Mol Cell 40 (3), 423-432 (2010)
   PUBMED   21070968
  REMARK    GeneRIF: Like Dcp2, Nudt16 also regulates the stability of a subset
            of mRNAs including a member of the motin family of proteins
            involved in angiogenesis.
REFERENCE   3  (bases 1 to 1606)
  AUTHORS   Iyama,T., Abolhassani,N., Tsuchimoto,D., Nonaka,M. and Nakabeppu,Y.
  TITLE     NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency
            induces accumulation of single-strand breaks in nuclear DNA and
            growth arrest
  JOURNAL   Nucleic Acids Res 38 (14), 4834-4843 (2010)
   PUBMED   20385596
REFERENCE   4  (bases 1 to 1606)
  AUTHORS   Abolhassani,N., Iyama,T., Tsuchimoto,D., Sakumi,K., Ohno,M.,
            Behmanesh,M. and Nakabeppu,Y.
  TITLE     NUDT16 and ITPA play a dual protective role in maintaining
            chromosome stability and cell growth by eliminating dIDP/IDP and
            dITP/ITP from nucleotide pools in mammals
  JOURNAL   Nucleic Acids Res 38 (9), 2891-2903 (2010)
   PUBMED   20081199
REFERENCE   5  (bases 1 to 1606)
  AUTHORS   van der Zwaag,B., Burbach,J.P., Scharfe,C., Oefner,P.J.,
            Brunner,H.G., Padberg,G.W. and van Bokhoven,H.
  TITLE     Identifying new candidate genes for hereditary facial paresis on
            chromosome 3q21-q22 by RNA in situ hybridization in mouse
  JOURNAL   Genomics 86 (1), 55-67 (2005)
   PUBMED   15953540
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK009737.1, BC064048.1, AA204539.1 and BB027928.1.
            
            On or before Aug 8, 2008 this sequence version replaced
            XM_001471758.1, NM_029385.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.362739.1, BC064048.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AK009737.1         2-14
            14-1280             BC064048.1         1-1267
            1281-1600           AA204539.1         9-328
            1601-1606           BB027928.1         289-294
FEATURES             Location/Qualifiers
     source          1..1606
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 56.61 cM"
     gene            1..1606
                     /gene="Nudt16"
                     /gene_synonym="2310041H06Rik; 2810047L04Rik;
                     2900006H04Rik"
                     /note="nudix hydrolase 16"
                     /db_xref="GeneID:75686"
                     /db_xref="MGI:MGI:1922936"
     exon            1..163
                     /gene="Nudt16"
                     /gene_synonym="2310041H06Rik; 2810047L04Rik;
                     2900006H04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..613
                     /gene="Nudt16"
                     /gene_synonym="2310041H06Rik; 2810047L04Rik;
                     2900006H04Rik"
                     /EC_number="3.6.1.62"
                     /EC_number="3.6.1.64"
                     /note="nudix motif 16; nucleoside diphosphate-linked
                     moiety X motif 16; m7GpppN-mRNA hydrolase; IDPase; IDP
                     phosphatase; inosine diphosphate phosphatase; nudix
                     (nucleoside diphosphate linked moiety X)-type motif 16"
                     /codon_start=1
                     /product="U8 snoRNA-decapping enzyme"
                     /protein_id="NP_083661.2"
                     /db_xref="CCDS:CCDS40751.1"
                     /db_xref="GeneID:75686"
                     /db_xref="MGI:MGI:1922936"
                     /translation="MEGHRKVELSEALALGPDWRHACHALLYAPDPRKLFGRIPMRFA
                     VLMQMRFDGRLGFPGGFVDAQDSCLEDGLNRELREELGEAMSAFRVERSDYRSSHIAA
                     RPRVVAHFYAKRLTLEQLQAVEARAPQAKDHGLEVLGLVRVPLYVLRDGEGGLPAFLE
                     NSFIGAAREQLLEALQDLKLLDPGIIAKLKIPDSK"
     exon            164..433
                     /gene="Nudt16"
                     /gene_synonym="2310041H06Rik; 2810047L04Rik;
                     2900006H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            434..1606
                     /gene="Nudt16"
                     /gene_synonym="2310041H06Rik; 2810047L04Rik;
                     2900006H04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      778..783
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nudt16"
                     /gene_synonym="2310041H06Rik; 2810047L04Rik;
                     2900006H04Rik"
                     /note="hexamer: GATAAA"
     polyA_site      797
                     /gene="Nudt16"
                     /gene_synonym="2310041H06Rik; 2810047L04Rik;
                     2900006H04Rik"
                     /note="major polyA site"
ORIGIN      
        1 agaacccgga agtgcgagcc tcgagatgga ggggcatcgg aaagtggagc tcagcgaggc
       61 cctggcgctc gggccggact ggcgccacgc ctgccatgcg ctgctctacg cgcccgaccc
      121 ccgcaagctg ttcggccgca tcccgatgcg cttcgccgtg ctgatgcaga tgcgctttga
      181 cgggcgcctg ggcttccctg gcggcttcgt ggacgcgcag gacagctgcc tggaggacgg
      241 gctgaaccgg gaactgcgcg aggagctggg cgaagcgatg tctgccttcc gcgttgaacg
      301 ctctgactac cgcagctcac acatcgcggc cagaccgcgc gtggtggccc acttctatgc
      361 caagcgcctg actctggaac agctgcaggc tgtggaagcc agggcacctc aagccaagga
      421 ccatgggctg gaggtgctgg gcctggtgcg ggtacccctg tacgtcctcc gtgatggtga
      481 gggaggcctg cctgcctttc tggagaattc cttcattgga gctgcccgag agcagctact
      541 agaagccctt caggacttga aacttctgga tcctggcatt attgcaaaac taaagatccc
      601 agattctaag tagaatcgga ccagcatgga cccctggaac ccagagggcc ttggtatgag
      661 ggagggaagg acaagtggtc tctctttggg gtataaagga ttgtaggtgg tgccagatta
      721 gcaacaggga aggatatgca ctgttttcaa cggaacacct tgtctggtgg cattagggat
      781 aaaaggcctt tgtagtatcc cagagtcctg ccttatacat ggacaaacag cctggaagct
      841 ccaggtatgt atatgtgtag ttcgtggtca cacacagcct gacacactgt catctgccca
      901 gtttaaccat gatgtggcat ttggcacatc ccactccttc cgggtaaatg ggagggtttc
      961 ttccccatcc gctgtaaggc tgctgtcctg tgtccagccc aacccatgcc tgttagggaa
     1021 gcaaaggaga tggcttcttt ctgagaattg tcctgtgtta cctggggctt gagcagagca
     1081 gtgggtttca gaaagtgacg taagggccta cccagccctg cgctctaact gagagttgga
     1141 attgtcaagg gcttcttagg aggcctgaga cctcagtcct gatacctgtc ttcctgcgtg
     1201 ttcatctttg agctcccatt gtctctgtct agcctgccct gcttaaaaaa aaacaaccaa
     1261 acaaacaaac caaaaaaaaa caaaaacaaa aacaaaaaaa aacctagagg catctggaag
     1321 agtaggctga tatctgggcc tccaagttcc agagcttttt caaaaggtac aggttaatac
     1381 ttgctcagtg ctaggtatgg tgacagaaat agagacccac tgctcttgtc tttaagactt
     1441 cacagtgagg agtgagcaca cagcatcata aagagcacta cacagtaaga agtagaagcc
     1501 ccttcagtca catggtgtcc gtgggaaccc tttactctgc cacgtcaaac ttatctgcat
     1561 gatgtataaa tttgtggttg ttgtgtccca gtaaaacacc aattaa
//
