LOCUS       NM_026341               2542 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus nudix hydrolase 13 (Nudt13), transcript variant 2,
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_026341
VERSION     NM_026341.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2542)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2542)
  AUTHORS   Abdelraheim,S.R., Spiller,D.G. and McLennan,A.G.
  TITLE     Mouse Nudt13 is a Mitochondrial Nudix Hydrolase with NAD(P)H
            Pyrophosphohydrolase Activity
  JOURNAL   Protein J 36 (5), 425-432 (2017)
   PUBMED   28755312
REFERENCE   3  (bases 1 to 2542)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159106.3, BB838132.1, BY034640.1, AK014204.1, AK161922.1 and
            BE987250.1.
            
            On Jan 18, 2018 this sequence version replaced NM_026341.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040807.1, AK017031.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC159106.3         131416-131418
            4-13                BB838132.1         1-10
            14-350              BY034640.1         1-337
            351-1283            AK014204.1         574-1506
            1284-2523           AK161922.1         1234-2473
            2524-2542           BE987250.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..2542
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 11.5 cM"
     gene            1..2542
                     /gene="Nudt13"
                     /gene_synonym="4933433B15Rik"
                     /note="nudix hydrolase 13"
                     /db_xref="GeneID:67725"
                     /db_xref="MGI:MGI:1914975"
     exon            1..103
                     /gene="Nudt13"
                     /gene_synonym="4933433B15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            104..196
                     /gene="Nudt13"
                     /gene_synonym="4933433B15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1172
                     /gene="Nudt13"
                     /gene_synonym="4933433B15Rik"
                     /EC_number="3.6.1.22"
                     /note="isoform 2 is encoded by transcript variant 2;
                     nucleoside diphosphate-linked moiety X motif 13; nudix
                     motif 13; NAD(P)H pyrophosphatase NUDT13, mitochondrial;
                     nudix (nucleoside diphosphate linked moiety X)-type motif
                     13"
                     /codon_start=1
                     /product="NAD(P)H pyrophosphatase NUDT13, mitochondrial
                     isoform 2"
                     /protein_id="NP_080617.2"
                     /db_xref="CCDS:CCDS36815.1"
                     /db_xref="GeneID:67725"
                     /db_xref="MGI:MGI:1914975"
                     /translation="MSLYCRTFFRRKSFGCYRLLSTYVTKARYLFELKEDEEACRKAQ
                     KTGVFYLFHDLDPLLQASGHRYLVPRLSRAELEGLLGKFGQDSQRIEDSVLVGCSEQQ
                     EAWFALDLGLKSASSSRASLPKSEMEAELGGSFIKLRQALFQLNSVDSSLLFTAQALL
                     RWHDGHQFCSKSGQPTQKNVAGSKRVCPSSKIIYYPQMAPVVITLVSDGARCLLARQS
                     SFPKGLYSALAGFCDIGESVEETVHREVAEEVGLEVENIQYSASQHWPFPNSSLMIAC
                     HATVKPGHTEIQVNLKELEAAAWFSLDEVTTALRRKGSLALQPSEASPLLLPPKLAIA
                     HHLIKKWVETRSCSSLAA"
     exon            197..336
                     /gene="Nudt13"
                     /gene_synonym="4933433B15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            337..471
                     /gene="Nudt13"
                     /gene_synonym="4933433B15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            472..578
                     /gene="Nudt13"
                     /gene_synonym="4933433B15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            579..704
                     /gene="Nudt13"
                     /gene_synonym="4933433B15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            705..816
                     /gene="Nudt13"
                     /gene_synonym="4933433B15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            817..971
                     /gene="Nudt13"
                     /gene_synonym="4933433B15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            972..2526
                     /gene="Nudt13"
                     /gene_synonym="4933433B15Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1710
                     /gene="Nudt13"
                     /gene_synonym="4933433B15Rik"
                     /note="major polyA site"
     regulatory      2507..2512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nudt13"
                     /gene_synonym="4933433B15Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2526
                     /gene="Nudt13"
                     /gene_synonym="4933433B15Rik"
ORIGIN      
        1 gtcaatccca ctgggaaggg aaaagagaaa ccatttgaac ttgaacattt ggagtttcca
       61 ggggcgtgca gaccattggg gcatagaagg catctcgaaa agagaatcgg acaatgtctc
      121 tgtattgtag aacatttttc aggaggaaat cttttgggtg ctataggctg ctgtcaacct
      181 atgtcactaa ggcacgatac ttatttgaat tgaaggaaga tgaagaggcc tgcaggaagg
      241 ctcagaagac aggagtgttt tacctctttc atgacctgga tcctttgctc caggcgtcag
      301 gacatcgata cctggtgccc cggcttagcc gagcagagtt ggaagggctg ctgggtaagt
      361 tcggacagga ttcgcaaaga attgaagatt cggtgctggt tgggtgctcc gagcagcagg
      421 aagcatggtt tgctttggat ctaggtctga agagtgcctc ctccagccgt gcctccttgc
      481 cgaaatctga aatggaagca gagctgggag gttctttcat caagctgagg caggctcttt
      541 tccagctgaa ctcggtggac tcctccttgc tgttcacggc tcaggctctt ctccgctggc
      601 atgacggtca tcagttctgc agcaaaagtg ggcagcccac ccagaagaac gtggcgggca
      661 gcaagcgagt gtgtccctcc agtaaaatca tctattatcc acagatggcg cccgtagtga
      721 tcacactggt gtcagatggg gcccgctgcc tacttgcccg ccagagttcc tttcccaagg
      781 ggttatattc tgccctggca ggtttctgtg acataggtga aagtgtggaa gaaactgtcc
      841 atcgagaagt tgcggaagag gtgggcctgg aagtggaaaa catacagtac tctgcgtccc
      901 agcactggcc ctttcccaat agctcactca tgatcgcttg tcacgcaacc gtgaaaccag
      961 gacacacaga gattcaggtg aacttgaagg aactagaggc agccgcctgg ttcagtcttg
     1021 atgaggtgac cacagccctg aggagaaagg gctccttggc tctgcagccg agtgaggctt
     1081 ccccactgtt gctgcctccc aagttagcca ttgcccacca cttgattaag aagtgggtgg
     1141 agacgcggag ctgttcttcc ctggctgctt agctcaaatg gagccgtctg gatccctcct
     1201 gggcattgct gcagggcact ctggagatga cctgcgaagg gaggtgacaa agccttcccg
     1261 ggcagaggct ctctgagaag ttccactgcc taaagccttc taatgctcca ccaaaaatgt
     1321 tggtgtgaac tggatagagc agcttgtacc tgtacttgtc ccagctacca tggaggcgga
     1381 ggcagaggcg agagcgtcac ttttgcccag gacaacgggg gcaacatatt agacaccgtc
     1441 acttaaaaag aaaataaaaa ctgtaaggag aagagttgac tgatgagatg ctaacagtgc
     1501 aaagctgagg ggaggttgct gattggcttg agtgtagccc aaggctgtag gaacaaacat
     1561 cctctggcct ggactggctg atgttggatt tataggaact gccaaatgtg ccagggtgat
     1621 ttatcttact gccaaaatat taacagttct caactcacat ttgagttgct tctgtcctca
     1681 cagaaaaata acattttata tgctttcgaa ttcgtgtgaa ggtatatttt ttatgttatt
     1741 attatttgca taagtatttg cctgtgtgta tgtctctgca caacatgcat gcctagttcc
     1801 tgtggaggcc aaaagagggt gtgggtccct ggaactgaag ctagactttg gtgagctgcc
     1861 aaatgggtgc tgggaatcaa gcctgggtct tccagatgag cagcaccgag ccatctctcc
     1921 aacacctaca gacacgcact cccgtgtgtg gcagtcaaag gttgactttt tagtagccgt
     1981 tgttgctgca gatcaaacct agggcttcct gcttgataga gacatgctct accatggagg
     2041 cgcatcctca gcgcaaaagt tagggttctg tttttgtttt taagctctga agggatgagg
     2101 gaagtgggag cataggtctt ccttggagta ttctgcaggc gaccagaggt ggcgttcttt
     2161 tgaagtagct aaatcccaga agggtgcaag ataatttatg atttatactg tctttccttc
     2221 tcttgctcac tcagtttgtg acctagggaa aaagactaaa catgaaacac acacacacac
     2281 tgagggcgct gcttcaatga ggaattagtg aggataggca agcactaagc ctgaagcctg
     2341 aagcctgagt cgggattcct tcccacaaat atgaccctgc acccccttcc cttcccattg
     2401 tactagatgc agacctcatg catctaggcc agcctgtcac tgacctgtat cctagacccg
     2461 tgtcatctgt accttgccac tgtaagggag aagtttctct ggaggaatta aatttcaatg
     2521 cctttaaaaa aaaaaaaaaa aa
//
