LOCUS       NM_026497               3572 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus nudix hydrolase 12 (Nudt12), transcript variant 1,
            mRNA.
ACCESSION   NM_026497
VERSION     NM_026497.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3572)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3572)
  AUTHORS   Sharma,S., Grudzien-Nogalska,E., Hamilton,K., Jiao,X., Yang,J.,
            Tong,L. and Kiledjian,M.
  TITLE     Mammalian Nudix proteins cleave nucleotide metabolite caps on RNAs
  JOURNAL   Nucleic Acids Res 48 (12), 6788-6798 (2020)
   PUBMED   32432673
REFERENCE   3  (bases 1 to 3572)
  AUTHORS   Wu,H., Li,L., Chen,K.M., Homolka,D., Gos,P., Fleury-Olela,F.,
            McCarthy,A.A. and Pillai,R.S.
  TITLE     Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic
            Surveillance of NAD-Capped RNAs
  JOURNAL   Cell Rep 29 (13), 4422-4434 (2019)
   PUBMED   31875550
  REMARK    GeneRIF: Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic
            Surveillance of NAD-Capped RNAs.
REFERENCE   4  (bases 1 to 3572)
  AUTHORS   Grudzien-Nogalska,E., Wu,Y., Jiao,X., Cui,H., Mateyak,M.K.,
            Hart,R.P., Tong,L. and Kiledjian,M.
  TITLE     Structural and mechanistic basis of mammalian Nudt12 RNA deNADding
  JOURNAL   Nat Chem Biol 15 (6), 575-582 (2019)
   PUBMED   31101919
REFERENCE   5  (bases 1 to 3572)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3572)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 3572)
  AUTHORS   Abdelraheim,S.R., Spiller,D.G. and McLennan,A.G.
  TITLE     Mammalian NADH diphosphatases of the Nudix family: cloning and
            characterization of the human peroxisomal NUDT12 protein
  JOURNAL   Biochem J 374 (Pt 2), 329-335 (2003)
   PUBMED   12790796
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK002641.1 and CT009564.11.
            
            On Feb 9, 2019 this sequence version replaced NM_026497.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002641.1, AK083846.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2280              AK002641.1         2-2281
            2281-3572           CT009564.11        129972-131263       c
FEATURES             Location/Qualifiers
     source          1..3572
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 30.64 cM"
     gene            1..3572
                     /gene="Nudt12"
                     /gene_synonym="0610016O18Rik"
                     /note="nudix hydrolase 12"
                     /db_xref="GeneID:67993"
                     /db_xref="MGI:MGI:1915243"
     exon            1..105
                     /gene="Nudt12"
                     /gene_synonym="0610016O18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            106..317
                     /gene="Nudt12"
                     /gene_synonym="0610016O18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1500
                     /gene="Nudt12"
                     /gene_synonym="0610016O18Rik"
                     /EC_number="3.6.1.22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peroxisomal NADH pyrophosphatase NUDT12; nudix (nucleoside
                     diphosphnudix (nucleoside diphosphate linked moiety
                     X)-type motif 12ate linked moiety X)-type motif 12; nudix
                     motif 12; nucleoside diphosphate-linked moiety X motif 12;
                     deNADding enzyme NUDT12; NAD-capped RNA hydrolase NUDT12;
                     nudix (nucleoside diphosphate linked moiety X)-type motif
                     12"
                     /codon_start=1
                     /product="NAD-capped RNA hydrolase NUDT12 isoform 1"
                     /protein_id="NP_080773.1"
                     /db_xref="CCDS:CCDS28933.1"
                     /db_xref="GeneID:67993"
                     /db_xref="MGI:MGI:1915243"
                     /translation="MSSVKRNPKKEMISELHSSAAEGNVAKLAGILSHSPSLLNETSE
                     NGWTALMYAARNGHPDVVQFLLEKGCDRSLVNKARQTALDIAAFWGYRHIANLLANAK
                     GGKKPWFLTNEVDECENYFSRTLLDRRSDKRNNSDWLQAKESHPTTVYLLFSDLNPLV
                     TLGGNKESSQQPEVRLCQLNYPDVKGYLAQPEKITLVFLGVELEMRKGSPAQAGGVPE
                     EEEDGLVAWFALGIEPGAAEEFKQRHENCYFLHPPMPALLQLKEKEAGVVAQARSVLA
                     WHSRYKFCPTCGSATKIEEGGYKRVCVRETCPSLQGVHNTSYPRVDPVVIMQVIHPDG
                     TKCLLGRQKRFPPGMFTCLAGFIEPGETIEDAVRREVEEESGVKVGHVQYVSCQPWPM
                     PSSLMIGCLAVAVSTEIKVDKNEIEDARWFTREQVVDVLTKGKQQAFFVPPSRAIAHQ
                     LIKHWVGMNPNL"
     exon            318..907
                     /gene="Nudt12"
                     /gene_synonym="0610016O18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1075
                     /gene="Nudt12"
                     /gene_synonym="0610016O18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1189
                     /gene="Nudt12"
                     /gene_synonym="0610016O18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1389
                     /gene="Nudt12"
                     /gene_synonym="0610016O18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..3572
                     /gene="Nudt12"
                     /gene_synonym="0610016O18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3357..3362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nudt12"
                     /gene_synonym="0610016O18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3382
                     /gene="Nudt12"
                     /gene_synonym="0610016O18Rik"
ORIGIN      
        1 gccggaagtc cggaaggctg actccaacgc cgggaaaact gacaactaag tttgccgagg
       61 agtcttccgt cgcaatcctg gtttctttcc ttcataatcc cttgggaaga aatgtcttct
      121 gttaaaagaa atcccaaaaa ggagatgatt tctgaactcc acagttcagc cgcagaggga
      181 aatgtcgcaa agttagcagg aatactcagc cattctccat ctcttctcaa tgagacttct
      241 gaaaatggat ggactgcttt aatgtacgcc gccaggaacg ggcatcccga tgtggtccag
      301 tttctgcttg agaaaggatg tgacagatca cttgtcaata aagcgaggca aaccgccctg
      361 gatattgctg cattttgggg ttataggcat atagctaact tgttagcaaa tgcaaaaggt
      421 gggaagaagc cctggttcct aaccaatgaa gtagacgagt gtgagaatta ttttagcaga
      481 acactactgg accggaggag tgacaaaaga aataattctg actggctgca agctaaagag
      541 agccacccca ccacagttta tctccttttc tcagacttga accccctggt taccctaggt
      601 ggtaataaag aaagctcgca gcagccggaa gtccggcttt gccagctgaa ctacccggat
      661 gtaaagggtt acttggctca gcctgagaag atcaccttgg tgttccttgg agtcgagctt
      721 gagatgagga aaggctcacc cgcccaggcg ggaggagtcc cagaggaaga ggaggacggt
      781 ttggttgctt ggtttgccct cggtattgaa cccggtgctg ctgaggagtt taagcaaaga
      841 catgaaaatt gttattttct ccacccgcca atgccagctc ttctgcagtt gaaagaaaag
      901 gaggctgggg tggtagctca agcaagatca gtgcttgcct ggcatagtcg atacaagttc
      961 tgcccaacct gtggcagtgc gactaaaatt gaggaaggag gctacaaaag agtgtgtgta
     1021 cgagagactt gccctagtct ccaaggcgtc cacaacacat cttacccgag agttgatcca
     1081 gtcgtaatta tgcaggtcat ccatccagat ggaaccaaat gtcttctagg caggcaaaag
     1141 cgattccccc cgggcatgtt cacatgtctt gctggattta tagagcccgg ggagacaata
     1201 gaagatgctg tgcggagaga ggtggaagag gaaagtggag tcaaagttgg ccatgttcag
     1261 tatgtctctt gtcaaccatg gccaatgccc tcctcgttaa tgattggctg tttagctgtg
     1321 gcagtgtcta cagaaattaa agttgacaag aatgaaatag aggatgcccg atggttcact
     1381 agagaacagg ttgtggacgt tcttaccaaa gggaagcagc aagcattctt tgtgccacca
     1441 agccgagcta tcgcacatca gttaatcaaa cactgggtgg gaatgaaccc caatctctaa
     1501 atgaaaaata ctagcctctg ttggagtact actgaatttt taacactact tatttctcaa
     1561 gaaagagtag atatatttat tgatctttag aatcttataa cataaaactt gggagcttca
     1621 aaaatattgt aagtgttctt tctattatta acaacagaat tcatagtttc ataaactgga
     1681 gcgatgcctc gagattttcg taaatttgga ggctgcctgt gaacattttt gttgtgtttc
     1741 ccaattttat ctcagaaaac taactgtatt tctaccaaga aagaccatgt tgggatgaag
     1801 tgtgctccat aaacgagata aaccttagtt catctcatgg aaagagcgga ttccttgtgg
     1861 gagataggag tcaaaagaac tcggatgaat tttgagcttt tgtgtatctt tagtgatcca
     1921 attatcattc tcctgacttt ctgttccagt ggtcgtactg ttgcagtgtc actcctagtg
     1981 tcatctgagc agtgttggca atgattgtta ttttaacact ttacccatta ctgatctcag
     2041 aatcctgtac ccatgggtag agaactaaag aacaggtgca caccattgta tctgggacgg
     2101 cacagttaca tcccaagcca actcctacat ctctctgttt tacttaaaat tgctattaag
     2161 acacgtgatg actatccaat tcttcacctg actcttaaca ttttagaaag gaatttctga
     2221 aggtcagaaa ctacatacca agccaatagt aatttacata ttaaataaag cactaactgt
     2281 atttaatttt gtatgaggga tatatttgtt ttggcaaaat aatataggaa ctgatgtcaa
     2341 tactgactgt atcaaaatac aatatcttcg cattggcctt ttttgtcata tgctcagatc
     2401 cttaagtagt acaccttaga atgtggtcac taagctctag agaaagctat tgcagatttt
     2461 cacagttttc ccatgtagat tattgtatta ctaaaagtgt ctatagaata aggagccaga
     2521 aaatggctct gtcattaagg tgcttgctgt gcaagcatga gtacttgagt tccgatcctc
     2581 tgcaaccctt tcagcagctg tgtttagtaa tattgaactc taagcccagc cctaaagaag
     2641 cagaggtatg aggatcctgg gggcttgttg gccagacagt ctggtgagtc actgagcgca
     2701 ataacaggcc ttgtctcagc acacaaggcg gaaagctgga gagggaccag aggtgaagag
     2761 caccttttgt tcctgtggag gaccagagtt taattcccaa gatcctcctc aggtaggcca
     2821 caaccacatg caactacaac ttcagggatc caacaccccc ttctggcctc tgcaggcgtc
     2881 tctgacacag acacataact agaatgatcg aggtacacac ctgacttcta tctctgttct
     2941 acacacacac acacacacac acacacacac acacacacac actaggtaaa acagagtgat
     3001 gctaagaaga attaacttag cttatcaaat gtttttaatt caaaatgtaa gtataatact
     3061 taaaatttat ttaacctaaa taatgtaact ttcttttatt ttttttctac taatgaatac
     3121 tattgctcag cagttaatga aggcttacta aaatcagagc tttgaccaaa ataaaaccta
     3181 cacaggacat ttatatatat ggtaaattgg acctatataa ttatattaaa agaatatatt
     3241 ttgagtgtta tgaaatatgg ttagctgaag ttcatctttg cttcaaatat gcttttaata
     3301 tttgtccatt cctgaattgc attataaact cccatgttgt taacgttcaa tagcaaaata
     3361 aaatgcacgt gttaaaaatg tacaaattta gtttcaaatt cctactgtac ttggttaaat
     3421 tcgtgagtaa attgctgttt ttaatgatca ttcctaagtt ttgacattgg agaggtgagg
     3481 atatactgta aatataaatc gttaaccagt tagcaagggg caagtgtcac acaagtattc
     3541 aataaaaatc aacataacaa ctaattaaaa tg
//
